Introduction About OME 30 CAPSULE

OME 30 CAPSULE is a combination of Domperidone and Omeprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. It is used to manage peptic ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome (tumours in pancreas causing the stomach to secrete more acid).

OME 30 CAPSULE is effective in managing peptic ulcer caused either due to stomach infection (H. pylori infection) or due to prolong use of non-steroidal anti-inflammatory drugs (such as ibuprofen, aceclofenac). OME 30 CAPSULEacts by reducing the production of gastric acid. It also speeds up the movement of food from the stomach to the intestines, thereby reducing the signs of nausea, vomiting and acid reflux. Due to these actions, it can also reduce the unpleasant signs of GI tract such as nausea, vomiting, indigestion, burping, bloating, acidity or heartburn. OME 30 CAPSULEis suitable for use both in adults and in children (aged 12 years or above weighing 35 kg or more). It should be taken at least 15-30 minutes before meals. During management with OME 30 CAPSULEyour doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects.

Before taking OME 30 CAPSULEinform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones. OME 30 CAPSULEis not recommended for use in patients having bleeding from the gut. Consult your doctor before taking OME 30 CAPSULEif you are pregnant or breastfeeding. The most common side effects of taking OME 30 CAPSULEare dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you. You must also inform your doctor immediately if you experience any abnormal signs such as unusual tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat, fragile bones, bloody stools or vomits or sudden weight loss.

Uses Of OME 30 CAPSULE

It is used in adults and in children (aged 12 years or older weighing 35 kg or more) to manage:

• Peptic ulcers
• Gastrointestinal Reflux disease (GERD)
• Zollinger-Ellison syndrome (tumours in pancreas causing the stomach to secrete more acid)
• Nausea and Vomiting
• Acidity, Heartburn, Indigestion, Burping, Bloating

How OME 30 CAPSULE Works

OME 30 CAPSULE contains two medicines namely domperidone and omeprazole. Domperidone works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord. This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centres and the brain which reduces the onset of nausea and vomiting. Omeprazole is a proton pump inhibitor. It reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach. By reducing stomach acid production, OME 30 CAPSULEmanages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion).

How to use OME 30 CAPSULE

Take OME 30 CAPSULE15-30 minutes before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking OME 30 CAPSULEunless your doctor advice you to stop.

Side Effects Of OME 30 CAPSULE

How To Manage Side Effects

Constipation

Taking OME 30 CAPSULEwith meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Try to take OME 30 CAPSULEwith or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.

Warning & Precautions

Pregnancy

Monitoring required

OME 30 CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

Breastfeeding

Monitoring required

OME 30 CAPSULE may pass through breast milk. Therefore, it should be used in breastfeeding women only if it is considered necessary by the physician. Consult your doctor for advice.

Driving and Using Machines

Use with Caution

OME 30 CAPSULE does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by OME 30 CAPSULE.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking OME 30 CAPSULE, as it could aggravate your existing condition.

Kidney

Use with Caution

OME 30 CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

OME 30 CAPSULE is not recommended for use in patients with moderate or severe liver impairment. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take OME 30 CAPSULEif you are allergic to Domperidone, Omeprazole or to any other proton pump inhibitors (such as rabeprazole, pantoprazole).

Heart Disease

Contraindicated

OME 30 CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure. Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

OME 30 CAPSULE should be used in children and adolescents (aged 12 years or above, weighing 35kg or more). It is not recommended for use in children and adolescents (aged below 12 years). However, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

OME 30 CAPSULE should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking OME 30 CAPSULEinform your doctor if you are taking any of the following medicines such as:

• other medicines used to manage gastrointestinal problems (Ex. cisapride, dolasetron, prucalopride, diphemanil)
• medicines used to manage heart problems or hypertension (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
• medicines used to manage HIV infection (Ex. atazanavir, nelfinavir, saquinavir)
• medicines used to manage fungal infections (such as ketoconazole, itraconazole, posaconazole)
• medicines used for blood thinning (Ex. warfarin and phenprocoumon)
• medicines used to manage hepatitis C infection (Ex. telaprevir)
• antipsychotics (used to manage mental illness) Ex. haloperidol, pimozide, sertindole
• antidepressants (used to manage depression) Ex. escitalopram or citalopram, fluvoxamine, St. John’s wort
• antibiotics (used to manage bacterial infections) Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin
• medicines used to manage malaria (Ex. halofantrine, lumefantrine)
• antihistamines (used to manage allergies) Ex. mizolastine, mequitazine
• medicines used to manage cancer (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
• methotrexate (a medicine used to manage cancer and auto-immune disease)
• bepridil (a medicine used to manage hypertension)
• methadone (a medicine used to relieve pain)
• diazepam (a medicine used to manage epilepsy, anxiety and to induce sleep)
• phenytoin (a medicine used to manage epilepsy)
• cilostazol (a medicine used to manage pain and spasms of calf muscles)
• clopidogrel (a medicine used to manage blood clots)
• tacrolimus or mycophenolate mofetil (used to manage graft rejection)
• pentamidine (a medicine used to manage parasite infections)
• rifampicin (a medicine used to manage tuberculosis)

Overdosage:

If you or anyone else accidentally took more OME 30 CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture.

Synopsis

More Information

FAQs About OME 30 CAPSULE

References

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page-666 & 651.

2. Wang, Fengxiu, Xiaoqi Zhang and Jinqiang Wang. Effects of domperidone in combination with omeprazole in the treatment of chronic superficial gastritis. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March-April 2017. [Accessed on 27th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432694/

3. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021]. [Accessed on 27th October 2022] https://www.medicines.org.uk/emc/files/pil.556.pdf

4. Teva pharma. Omeprazole. [Revised in June 2021] [Accessed on 27th October 2022] https://products.tevauk.com/mediafile/id/51245.pdf

5. Central Drugs Standard Control Organization. Domperidone SR Tablet. [Revised in January 2003]. Omeprazole (20mg) enteric coated + domperidone (30mg) S.R. capsule. [Revised in March 2005] [Accessed on 27th October 2022] https://cdscoonline.gov.in/CDSCO/Drugs

6. Torrent Pharmaceutical Ltd. DOMSTAL O 10mg, 10mg. [Revised in June 2020] [Accessed on 27th October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1387.pdf

7. Torrent Pharmaceutical Ltd. DOMSTAL PLUS. [Revised in November 2016] [Accessed on 27th October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2521.pdf

8. Torrent Pharmaceutical Ltd. DOMSTAL RD 10, 20mg. [Revised in March 2022] [Accessed on 27th October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1388.pdf

9. Invision Medi science Pvt Ltd. OMICOOL - DXR Caps. [Accessed on 27th October 2022] http://www.invisionmedi.com/category/omicool-dxr.htm

10. Leeford Healthcare Ltd. Omefol-D. [Accessed on 27th October 2022] https://www.leeford.in/product/23/omefol-d

11. Ikon Remedies. Omepep-RD Tablets. [Accessed on 27th October 2022] https://www.ikonremedies.com/product/omipep-rd-tablets/

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 23 Sep 2024 | 05:25 PM(IST)