INTRODUCTION

OLOBET 5 contains Olopatadine which belongs to the group of medicines called Mast cell stabilizers. It is used to manage allergic rhinitis, hives (raised red patches on the skin), and itching associated with skin diseases. Allergic rhinitis is the inflammation of mucous membranes of nose in sensitized individuals when inhaled allergenic particles contact mucous membranes and induce a response mediated by antibodies (IgE). Symptoms include clear fluid from nose, sneezing, nasal congestion, allergic inflammation of eye, itchy eyes, ears or nose.

Olopatadine works by stabilizing certain inflammatory cells and blocking the H1 receptor, thus blocking the release of histamine, which is responsible to promote inflammatory reactions like allergies.

Before taking OLOBET 5, inform your doctor if you have any liver or kidney diseases, history of allergic reactions, or if you are taking any other medicines. OLOBET 5 should be used in pregnant or breastfeeding women only if considered necessary by your doctor. OLOBET 5 is not recommended for use in infants, so consult child’s doctor for advice and it should be used with caution in elderly patients (aged 65 years and above). The most common side effects of taking OLOBET 5 are sleepiness, feeling generally unwell, dry mouth, stomach pain and discomfort. Contact your doctor if any of the symptoms worsen.

USES OF OLOBET 5

Used to manage:

• allergic rhinitis
• hives
• itching associated with skin diseases

HOW OLOBET 5 WORKS

OLOBET 5 works by stabilizing certain inflammatory cells and blocking the H1 receptor, thus blocking the release of histamine, which is responsible to promote inflammatory reactions like allergies.

DIRECTIONS FOR USE

Take OLOBET 5 as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF OLOBET 5

HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the stomach pain does not improve, contact your doctor.

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before using OLOBET 5, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicines.

Overdosage:

If you or anyone else accidentally take too much of OLOBET 5, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep OLOBET 5 out of reach of children
• Store below 25°C

FAQs ABOUT OLOBET 5

What if I forget to take a dose of OLOBET 5?

If you forget to take a dose of OLOBET 5, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for a forgotten dose.

Can I stop taking OLOBET 5 on my own?

Continue taking OLOBET 5 until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. In such case, contact your doctor right away.

Can OLOBET 5 cause stomach pain?

Stomach pain is a common side effect of OLOBET 5. In such case, try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the stomach pain does not improve, contact your doctor.

What precautions do I need to follow while taking OLOBET 5?

Patients taking OLOBET 5 must inform their doctor about their pre-existing conditions like liver or kidney diseases, history of allergic reactions, or if you are taking any other medicines. Patients should also inform if they are pregnant, breast-feeding, or having any allergies. Contact your doctor right away if you have any unusual symptoms.

Can OLOBET 5 be taken in pregnancy?

OLOBET 5 should be used in pregnant women only if considered necessary by your doctor as its safety in pregnancy is not yet established. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking this medicine. Inform your doctor immediately if you become pregnant during management with OLOBET 5.

Can I take other medicines along with OLOBET 5?

Before taking OLOBET 5, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and cause serious side effects.

REFERENCES

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Allergic Rhinitis. Pharmacotherapy Handbook. Ninth edition. Page - 813.

2. Takashi Hashimoto, Norito Ishii, Takahiro Hamada, Teruki Dainichi, Tadashi Karashima, Takekuni Nakama, Shinichiro Yasumoto. Effects of Olopatadine Hydrochloride, a Histamine Receptor Antagonist, on Histamine-Induced Skin Responses. Dermatology Research and Practice. [Revised in July 2010] [Accessed on 4th July 2022] https://www.hindawi.com/journals/drp/2010/638051/

3. Hideyuki Yamamoto, Takechiyo Yamada, Seita Kubo, Yoko Osawa, Yuichi Kimura, Myonmi Oh, Dai Susuki, Tetsuji Takabayashi, Masayuki Okamoto, Shigeharu Fujieda. Efficacy of oral olopatadine hydrochloride for the management of seasonal allergic rhinitis: A randomized, double-blind, placebo-controlled study. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 2010. [Accessed on 4th July 2022] https://pubmed.ncbi.nlm.nih.gov/20819319/

4. PubChem Compound Summary for CID 5281071, Olopatadine. National Center for Biotechnology Information. July 2022. [Accessed on 4th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Olopatadine#section=Mechanism-of-Action

5. Ohara. Olopatadine. [Revised in December 2014] [Accessed on 4th July 2022] https://www.ohara-ch.co.jp/appendix/pdf/inc03/oropatadine2.5T-SIE.pdf , https://www.ohara-ch.co.jp/appendix/pdf/inc03/olopatadine5T-SIE.pdf

6. Hetero Labs Limited. Allenil Tablet (Olopatadine). [Accessed on 4th July 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2449.pdf

7. Central Drugs Standard Control Organization (CDSCO). [Accessed on 4th July 2022] https://cdscoonline.gov.in/CDSCO/Drugs

USEFUL DIAGNOSTIC TESTS

• Nasal cytology
• Percutaneous skin test