Introduction About OLMISTRUM MT 25 TABLET

OLMISTRUM MT 25 TABLET is a combination of Metoprolol and Olmesartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure). It can also be used to reduce the risk of heart attack (myocardial infarction), stroke, chest pain (angina) and uneven heartbeat (arrhythmia).

Before taking OLMISTRUM MT 25 TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, thyroid problems, asthma, poor blood circulation, psoriasis, allergic reactions or gout as a precaution.

OLMISTRUM MT 25 TABLET is not recommended for use in patients with severe low blood pressure, uncontrollable heart failure or heart block. It is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby.

The most common side effects of taking this medicine are low blood pressure, slow or fast heart rate, cold hands and feet, headache, dizziness, nausea, diarrhoea, constipation, sore throat, cough, high blood cholesterol levels and swollen ankles. Consult your doctor if any of these side effect worsens.

Uses Of OLMISTRUM MT 25 TABLET

• Manage Hypertension (high blood pressure)
• Prevents heart attack, stroke, angina (chest pain) and arrhythmia (uneven heartbeat)

How OLMISTRUM MT 25 TABLET Works

OLMISTRUM MT 25 TABLET is an antihypertensive medicine. It relaxes the blood vessels supplying the heart and various other organs of the body. This allows blood to flow more smoothly across the blood vessels. It also reduces the heart rate and force of contraction of heart muscles. Collectively, these actions reduce the strain on the heart and helps the heart to pump more blood with less pressure.

How to use OLMISTRUM MT 25 TABLET

Take OLMISTRUM MT 25 TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking this medicine without consulting your doctor. 

Side Effects Of OLMISTRUM MT 25 TABLET

How To Manage Side Effects

Constipation

Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Take OLMISTRUM MT 25 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Warning & Precautions

Pregnancy

Contraindicated

OLMISTRUM MT 25 TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, inform your doctor before taking OLMISTRUM MT 25 TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with this medicine, stop taking it and consult your doctor immediately.

Breastfeeding

Contraindicated

OLMISTRUM MT 25 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking OLMISTRUM MT 25 TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking OLMISTRUM MT 25 TABLET as it might make you feel dizzier and drowsier.

Kidney

Use with Caution

OLMISTRUM MT 25 TABLET should be used with caution in patients with kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.

Liver

Consult your doctor

OLMISTRUM MT 25 TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take OLMISTRUM MT 25 TABLET if you are allergic to Metoprolol or Olmesartan.

Lungs

Contraindicated

OLMISTRUM MT 25 TABLET is not recommended for use in patients with severe asthma or chronic obstructive pulmonary disease. Therefore, consult your doctor for advice before taking it.

Heart Disease

Consult your doctor

OLMISTRUM MT 25 TABLET is not recommended for use in patients with severe heart problems (such as heart block, uncontrollable heart failure, sick sinus syndrome or a very slow or uneven heartbeat). It should be used with caution in patients with other heart problems (such as a recent heart attack, or angina attack, irregular heart rhythm, enlarged heart muscles, or surgery in the heart within the last 4 months). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking OLMISTRUM MT 25 TABLET inform to your doctor, if you are taking any of these medicines:

• other medicines used to manage elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, verapamil, diltiazem, losartan, valsartan, clonidine, moxonidine, methyldopa, rilmenidine, propafenone)
• lithium, St. John’s wort (medicines used to manage depression)
• potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
• non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, sulindac, ibuprofen, aspirin
• colesevelam (a medicine used to manage high blood cholesterol levels)
• antacids (medicines used to neutralize stomach acid) Ex. aluminium hydroxide, magaldrate
• medicines that can depress the brain such as barbiturates (Ex. phenobarbital)
• medicines used to manage depression (such as fluoxetine, paroxetine, bupropion)
• medicines used to manage mental illnesses (such as thioridazine)
• antihistamines (used to manage allergic reactions) such as diphenhydramine
• medicines used to manage malaria (such as hydroxychloroquine, mefloquine)
• ritonavir (a medicine used to manage HIV infection)
• terbinafine (a medicine used to manage fungal infection)
• cimetidine (a medicine used to manage stomach ulcers)
• medicines used to manage uneven heartbeat (such as digoxin, disopyramide, quinidine or amiodarone)
• adrenaline (a medicine used to stimulate heart functions)
• phenylpropanolamine (a medicine used to reduce the swelling of the nasal mucosa)
• beta blockers used for glaucoma (such as timolol, pindolol, labetalol)
• ergotamine (a medicine used for migraine headache)
• medicines used to manage angina (such as nitroglycerin)
• anaesthetics (used to cause numbness or loss of sensation) such as lidocaine, sevoflurane, halothane
• medicines used to manage diabetes (such as insulin, metformin, glimepiride, teneligliptin, pioglitazone)
• rifampicin (a medicine used to manage tuberculosis)
• alpha blockers (used to manage high blood pressure and benign prostatic hyperplasia) such as prazosine, tamsulosin, terazosin, doxazosin

Overdosage:

If you or anyone else accidentally took more OLMISTRUM MT 25 TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, decreased heartbeat, dizziness, problems in breathing, vomiting, feeling faint and fits.

Synopsis

More Information

• Keep OLMISTRUM MT 25 TABLET out of reach of children
• Store OLMISTRUM MT 25 TABLET at room temperature

FAQs About OLMISTRUM MT 25 TABLET

Q: What are the uses of OLMISTRUM MT 25 TABLET?

A: OLMISTRUM MT 25 TABLET is used to manage hypertension. It can also be used to manage the risk of heart attack, stroke, angina and arrhythmia.

Q: What type of a medicine is OLMISTRUM MT 25 TABLET?

A: OLMISTRUM MT 25 TABLET is an antihypertensive medicine. It slows down your heartbeat and reduces force of contraction of the heart. It also relaxes the blood vessels supplying the heart and various other organs of the body. Collectively, it reduces the strain on the heart and helps the heart to pump blood more smoothly with less pressure.

Q: What happens when I stop taking OLMISTRUM MT 25 TABLET?

A: Do not stop taking OLMISTRUM MT 25 TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take OLMISTRUM MT 25 TABLET for the stipulated duration recommended by your doctor to achieve maximum results.

Q: What is the best time to take OLMISTRUM MT 25 TABLET?

A: OLMISTRUM MT 25 TABLET can be taken with or without meals. Your doctor will decide the best time for you to take OLMISTRUM MT 25 TABLET based on your age, body weight and disease condition.

Q: What to do if I forgot to take a dose of OLMISTRUM MT 25 TABLET?

A: If you forgot to take a dose of OLMISTRUM MT 25 TABLET, take it as soon as you remember. However, if it is time for the next dose of OLMISTRUM MT 25 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of OLMISTRUM MT 25 TABLET to compensate the missed ones.

Q: What precautions should be followed while taking OLMISTRUM MT 25 TABLET?

A: Before taking OLMISTRUM MT 25 TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, asthma thyroid problems, asthma, low blood pressure, poor blood circulation or dehydration as a precaution. Do not take this medicine if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.

Q: Can I consume alcohol while taking OLMISTRUM MT 25 TABLET?

A: Avoid consumption of alcohol while taking OLMISTRUM MT 25 TABLET as it might make you feel dizzier and drowsier.

Q: What happens if I accidentally take more OLMISTRUM MT 25 TABLET?

A: If you or anyone else accidentally took more OLMISTRUM MT 25 TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, decreased heartbeat, problems in breathing, vomiting, feeling faint and fits.

Q: Can I take OLMISTRUM MT 25 TABLET daily?

A: Take OLMISTRUM MT 25 TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take OLMISTRUM MT 25 TABLET every day or not.

Q: Is OLMISTRUM MT 25 TABLET safe to use in diabetic patients?

A: OLMISTRUM MT 25 TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking OLMISTRUM MT 25 TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.

Q: What are the side effects of OLMISTRUM MT 25 TABLET?

A: The most common side effects of taking this medicine are low blood pressure, slow or fast heart rate, cold hands and feet, headache, dizziness, nausea, diarrhoea, constipation, sore throat, cough, high blood cholesterol levels and swollen ankles. Consult your doctor if any of these side effect worsens.

Q: Can I stop taking OLMISTRUM MT 25 TABLET once my symptoms subside?

A: No. Do not stop taking OLMISTRUM MT 25 TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take OLMISTRUM MT 25 TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.

Q: Can OLMISTRUM MT 25 TABLET be taken during pregnancy?

A: GBNKEYWORD] is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, inform your doctor before taking it. If you accidentally become pregnant while undergoing therapy with OLMISTRUM MT 25 TABLET, stop taking it and consult your doctor immediately.

Q: Is OLMISTRUM MT 25 TABLET safe to use in kidney disease?

A: OLMISTRUM MT 25 TABLET should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.

Q: Can the use of OLMISTRUM MT 25 TABLET affect the liver?

A: Yes. OLMISTRUM MT 25 TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.

References

1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma & Cardiovascular drugs. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 148 & 507.

2. Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che, and Michael R. Hamblin. Management of Hypertension Using Olmesartan Alone or in Combination. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2017. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446820/

3. XiaoLiang Cheng, Min Zhu, Qing Liu, Zhenxia Feng, and Yong Meng. Effectiveness of Metoprolol in Improving Cardiac and Motor Functions in Patients with Chronic Heart Failure: A Prospective Study. NIH.  National Library of Medicine, National center for biotechnology information. August 2020. [Accessed on 25th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457782/

4. Zentiva k.s. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 25th January 2023] https://www.medicines.org.uk/emc/files/pil.12971.pdf

5. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 25th January 2023] https://www.medicines.org.uk/emc/files/pil.5199.pdf

6. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 25th January 2023] https://www.medicines.org.uk/emc/files/pil.9886.pdf

7. Torrent Pharmaceuticals Ltd. Olsar-M. [Revised in June 2021]. [Accessed on 25th January 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2965.pdf

8. Central Drugs Standard Control Organization. Metoprolol succinate ER 25mg+50mg + Olmesartan 20/20mg. July 2010. [Accessed on 25th January 2023] https://cdscoonline.gov.in/CDSCO/Drugs

9. Leeford Healthcare Pvt Ltd. Omnipress-M. [Accessed on 25th January 2023] https://www.leeford.in/product/1476/omnipres-m

Useful Diagnostic Tests

• Kidney Function Test