Introduction About OLMETOP 20 AM TABLET

OLMETOP 20 AM TABLET is used for the management of high blood pressure among patients who remain unresponsive to therapy with either olmesartan or amlodipine alone. It is a combination of Amlodipine and Olmesartan, which belongs to the group of medicines called Antihypertensive agents.

During management with OLMETOP 20 AM TABLET, your doctor might check your kidney function, blood pressure, and electrolyte (Ex. potassium) concentration in your blood at regular intervals to avoid the risk of unwanted side effects. Avoid consumption of grapefruit or grapefruit juice while taking the medicine, as it could lead to an unpredictable decrease in blood pressure. Before taking OLMETOP 20 AM TABLET, inform your doctor if you have any liver, kidney, or heart disease. It is not recommended in early pregnancy and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage.

It is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. OLMETOP 20 AM TABLET is not recommended for use in children and adolescents (aged under 18 years) due to a lack of safety data. It should be taken with caution in elderly patients (aged 65 years or older). The most common side effects are headache, dizziness, tiredness, edema, sore throat, and constipation. Consult your doctor if any of the side effects worsen.

Uses Of OLMETOP 20 AM TABLET

• It is used for the management of high blood pressure among patients who remain unresponsive to therapy with either olmesartan or amlodipine alone

How OLMETOP 20 AM TABLET Works

OLMETOP 20 AM TABLET effectively reduces elevated blood pressure, where Olmesartan acts by inhibiting the actions of angiotensin-II (a peptide hormone that causes narrowing of blood vessels and an increase in blood pressure) at the angiotensin-II receptors of the kidneys, and Amlodipine acts by blocking the influx of calcium in the blood vessels by inhibiting the voltage-gated calcium channels, thus causing vascular smooth muscle relaxation, vasodilation, and a marked decrease in blood pressure.

How to use OLMETOP 20 AM TABLET

• Take OLMETOP 20 AM TABLET as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of OLMETOP 20 AM TABLET for you depending upon your age, body weight, and disease condition

Side Effects Of OLMETOP 20 AM TABLET

Common Side Effects of OLMETOP 20 AM TABLET:

• dizziness
• headache
• tiredness
• sore throat, runny nose, cough
• diarrhea, constipation, abdominal pain, or indigestion

Stop taking OLMETOP 20 AM TABLET and contact your doctor immediately if you experience any of the following side effects:

• severe allergic reactions (such as skin rash with itching and swelling of the face, mouth, and/or larynx)
• signs of hypotension (such as severe dizziness or light-headedness and fainting)
• severe, persistent diarrhea with substantial weight loss
• yellowing of the whites of the eyes, dark urine, and itching of the skin

Warning & Precautions

Pregnancy

Contraindicated

It is not recommended in early pregnancy and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage.

Breastfeeding

Contraindicated

It is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.

Driving and Using Machines

Use with Caution

Do not drive or operate any tools or machines if you experience dizziness, sleepiness, or headache after taking the medicine.

Alcohol

Consult your doctor

Avoid consuming alcohol while taking this medicine, as it could aggravate your dizziness and tiredness.  

Kidney

Consult your doctor

OLMETOP 20 AM TABLET is not recommended for use in patients with impaired kidney function and should be used with caution in patients with kidney problems or with a surgical history of kidney transplant.

Liver

Consult your doctor

OLMETOP 20 AM TABLET is not recommended for use in patients with severe liver problems (such as biliary obstruction, gallstones, and jaundice) and should be used with caution in patients with liver disease.  

Allergy

Contraindicated

Do not take OLMETOP 20 AM TABLET if you are allergic to Olmesartan, Amlodipine, or any other ingredients of this medicine.

Heart Disease

Contraindicated

OLMETOP 20 AM TABLET is not recommended for use in patients with heart disease (such as aortic stenosis (narrowing of the aorta), cardiogenic shock, circulatory failure, or heart attack).

Use In Pediatrics

Contraindicated

OLMETOP 20 AM TABLET is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data.  

Use In Geriatrics

Use with Caution

OLMETOP 20 AM TABLET should be taken with caution in elderly patients (aged 65 years or older). Proper dose adjustments and careful monitoring of blood pressure and kidney function are required in such patients.  

Interactions

A. Drug-Drug interactions:

Before taking the medicine, inform your doctor if you are taking any of these medicines:

• Angiotensin-converting enzyme (ACE) inhibitors (Ex. enalapril, lisinopril, ramipril) or aliskiren
• Potassium-containing medicines (Ex. potassium supplements, salt substitutes containing potassium (Ex. losartan potassium)
• Diuretics (Ex. spironolactone)
• Non-steroidal anti-inflammatory drugs (Ex. ibuprofen, aspirin, diclofenac)
• Antacids (Ex. aluminium hydroxide or magnesium hydroxide)
• Bile acid sequestrants (Ex. colesevelam, simvastatin)
• Anti-viral agents (Ex. ritonavir, nelfinavir, or indinavir)
• Antifungal agents (Ex. ketoconazole or itraconazole)
• Immunosuppressants (Ex. tacrolimus, sirolimus, temsirolimus, everolimus, and cyclosporin)
• Anticoagulants (Ex. heparin)
• Anti-manic agents (Ex. Lithium)
• Calcium-channel blockers (Ex. Diltiazem, Verapamil)
• Antibiotics (Ex. Rifampicin, Erythromycin or Clarithromycin)
• St. John’s wort
• Skeletal muscle relaxants (Ex. Dantrolene)

B. Drug-Food interaction:

Avoid eating grapefruit or consuming grapefruit juice while taking OLMETOP 20 AM TABLET, as it could lead to an increase in the levels of amlodipine in the blood, which may lead to an unpredictable decrease in blood pressure.

Overdosage:

If you or anyone else accidentally takes too much of OLMETOP 20 AM TABLET, contact your doctor immediately or go to a hospital right away. Overdosage symptoms include low blood pressure, dizziness, and a fast or slow heartbeat.

Synopsis

More Information

FAQs About OLMETOP 20 AM TABLET

References

1. KD. Tripathi. Antihypertensive Drugs and Drugs Affecting Renin Angiotensin System and Plasma Kinins. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 562-563 & 505-508.

2. Randa Hilal-Dandan. Renin and angiotensin. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 738-739.

3. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and hypertension. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 755-760.

4. Gerald G. Briggs and Roger K. Freeman. A & O. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 196-198 & 2852-2853.

5. Daiichi Sankyo, Inc.: Parallel-Group Comparison of Olmesartan (OLM), Amlodipine (AML), and Hydrochlorothiazide (HCTZ) in Hypertension. NIH U.S. National Library of Medicine, ClinicalTrials.gov. [Revised in January 2019] [Accessed on 1st July 2024]  click here

6. Henry Punzi, Joel M Neutel, Dean J Kereiakes, Ali Shojaee, William F Waverczak, Robert Dubiel, and Jen-Fue Maa. Efficacy of amlodipine and olmesartan medoxomil in patients with hypertension: the AZOR Trial Evaluating Blood Pressure Reductions and Control (AZTEC) study. NIH, National Library of Medicine, National Center for Biotechnology Information. PuMed.gov. August 2010. [Accessed on 1st July 2024]  click here

7. Henry Punzi, Ali Shojaee, William F Waverczak, Jen-Fue Maa. Efficacy of amlodipine and olmesartan medoxomil in hypertensive patients with diabetes and obesity. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed.gov. June 2011. [Accessed on 1st July 2024]  href = "https://pubmed.ncbi.nlm.nih.gov/21649842/"target="_blank"> click here

8. Daiichi Sankyo Europe GmbH. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 1st July 2024]  click here

9. Torrent Pharmaceuticals Ltd., Olmetor AM. Torrentian.com. [Revised in October 2019]. [Accessed on 1st July 2024]  click here

10. Cipla Ltd. Olmecip AM Tablets (Olmesartan medoxomil + Amlodipine). Ciplamed.com. [Revised in February 2020]. [Accessed on 1st July 2024]  click here

11. John Lee Pharmaceuticals Pvt. Ltd. Omten-40 AM. [Accessed on 1st July 2024]  click here

Useful Diagnostic Tests

• ECG at Home
• ECG + BP Check at Home
• Full Body Checkup with ECG & BP at Home
• Comprehensive Cardiac Risk Screening with 12 Lead ECG and BP

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 19 Nov 2024 | 04:09 PM(IST)