Introduction About NOZIA TABLET

NOZIA TABLET contains Ramosetron which belongs to the group of medicines called 5-HT3 (Serotonin) receptor antagonists. It is used to manage nausea and vomiting due to chemotherapy and diarrheal IBS (Irritable Bowel Syndrome) in men. Irritable bowel syndrome (IBS) is a gastrointestinal disorder that affects the intestine. Symptoms include stomach ache, diarrhoea or constipation, and bloating.

NOZIA TABLET is not recommended for use in patients with ischemic colitis, constipation or constipation-predominant irritable bowel syndrome, large intestine carcinoma and inflammatory bowel disease, infectious enteritis or history of abdominal surgery.

NOZIA TABLET is generally not recommended for use in pregnant and breast-feeding women and in children and adolescents (less than 18 years of age). It should be used with caution in elderly patients (aged 65 years and above).

The most common side effects of taking NOZIA TABLET is constipation. Consult your doctor immediately if the symptom or side effect gets worse.

Uses Of NOZIA TABLET

Manage:

• diarrheal irritable bowel syndrome in men
• nausea and vomiting due to chemotherapy

How NOZIA TABLET Works

NOZIA TABLET effectively manages nausea and vomiting by blocking the serotonin 5-HT3 receptor present in the gastrointestinal mucosa. It also manages irritable bowel syndrome by inhibiting the 5-HT3 receptor present in the myenteric plexus (which regulates bowel's movement).

How to use NOZIA TABLET

Take NOZIA TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Depending on your age, body weight, and medical condition, your doctor will determine the appropriate dose and duration of the management for you.

Side Effects Of NOZIA TABLET

How To Manage Side Effects

Constipation

Eat fibre rich foods such as fresh fruits, vegetables and cereals. Drink more water and exercise regularly. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Contraindicated

NOZIA TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking it.

Breastfeeding

Contraindicated

NOZIA TABLET is generally not recommended for use in breastfeeding women as it is not known whether it passes through breast milk. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take NOZIA TABLET if you are allergic to Ramosetron or any other ingredients of this medicine.

Use In Pediatrics

Contraindicated

NOZIA TABLET is generally not recommended for use in children and adolescents (under 18 years of age), due to lack of safety and effectiveness for them. Consult child’s doctor for advice.

Use In Geriatrics

Use with Caution

NOZIA TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.  

Interactions

A. Drug-Drug interactions:

Before taking NOZIA TABLET, inform your doctor if you are taking this medicine:

• fluvoxamine (medicines used to manage depression and obsessive-compulsive disorder)

Overdosage:

If you or anyone else accidentally take too much of NOZIA TABLET, consult your doctor immediately or visit the nearby hospital.  

Synopsis

More Information

• Keep NOZIA TABLET out of reach of children
• Store at room temperature

FAQs About NOZIA TABLET

Q: What is NOZIA TABLET used for?

A: NOZIA TABLET is used to manage nausea and vomiting due to chemotherapy and diarrheal irritable bowel syndrome in men. Consult your doctor for advice before taking NOZIA TABLET.  

Q: Can I use NOZIA TABLET during breast-feeding?

A: No, NOZIA TABLET is generally not recommended for use in breastfeeding women as it is not known whether it passes through breast milk. Consult your doctor for advice before taking NOZIA TABLET.

Q: Can NOZIA TABLET be used in children?

A: No, NOZIA TABLET is generally not recommended for use in children and adolescents (under 18 years of age) because there is no information on its safety and effectiveness in pediatric population. Consult child’s doctor for advice.

Q: How does NOZIA TABLET work?

A: NOZIA TABLET effectively manages nausea and vomiting by blocking the serotonin 5-HT3 receptor present in the gastrointestinal mucosa. It also manages irritable bowel syndrome by inhibiting the 5-HT3 receptor present in the myenteric plexus (which regulates bowel's movement). 

Q: Does NOZIA TABLET cause constipation?

A: Yes, NOZIA TABLET may cause constipation in some individuals. To manage this effect, eat fibre rich foods in your diet such as fresh fruits, vegetables and cereals. Drink more water and exercise regularly. Consult your doctor for receiving alternate management for constipation if the symptom gets worse.

References

1. KD Tripathi MD. Anti-emetic, prokinetic and digestant drugs. Essentials of Medical Pharmacology 8th edition. 2019. Page- 718.

2. Qingqing Qi, Yan Zhang, Feixue Chen, Xiuli Zuo and Yanqing Li. Ramosetron for the Treatment of Irritable Bowel Syndrome with Diarrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. BMC Gastroenterology Journal. January 2018. [Accessed on 26th July 2022] https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0734-2#citeas

3. Toshimi Chiba, Kazunari Yamamoto, Shoko Sato, Kazuyuki Suzuki. Long-term Efficacy, and Safety of Ramosetron in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome. Clinical and Experimental Gastroenterology. July 2013. [Accessed on 26th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728153/

4. Astellas Pharma Inc. Ramosetron Hydrochloride. May 2015. Pharmaceuticals and Medical Devices Agency (PMDA). [Accessed on 26th July 2022] https://www.pmda.go.jp/files/000216189.pdf

Useful Diagnostic Tests

• Anti-cytolethal distending toxin B (CdtB)
• Anti-vinculin