INTRODUCTION

NOZIA contains Ramosetron which belongs to the group of medicines called 5-HT3 (Serotonin) receptor antagonists. It is used to prevent and manage nausea and vomiting associated with chemotherapy or surgical procedure in adults.

Before receiving NOZIA inform your doctor if you have any problems with liver, kidney or heart and any other medical conditions. NOZIA is not recommended for use in pregnant and breast-feeding women. Also, it is not recommended for use in children due to lack of safety and effectiveness.

NOZIA should be used with caution in elderly patients (aged 65 years and above). The most common side effects of receiving NOZIA are headache, dizziness, and constipation. Consult your doctor if any of the side effect worsens.

USES OF NOZIA

• To prevent and manage nausea and vomiting associated with chemotherapy or surgical procedure in adults

HOW NOZIA WORKS

NOZIA effectively prevents nausea and vomiting by blocking the serotonin 5-HT3 receptor present in the gastrointestinal mucosa.

DIRECTIONS FOR USE

NOZIA will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will determine the appropriate dose and duration for you depending on your age, body weight and medical condition.

SIDE EFFECTS OF NOZIA

HOW TO MANAGE SIDE EFFECTS

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid taking caffeine or its related product. Inform your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. If this does not help, inform your doctor for receiving alternate management for constipation.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before receiving NOZIA, inform your doctor if you are taking this medicine:

• fluvoxamine (used to manage depression and obsessive-compulsive disorder)

Overdosage:

NOZIA will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, contact your doctor immediately

SYNOPSIS

MORE INFORMATION

• Store at room temperature

FAQs ABOUT NOZIA

What is NOZIA and why is it given?

NOZIA contains Ramosetron which belongs to the group of medicines called 5-HT3 (Serotonin) receptor antagonists. It is used to prevent and manage nausea and vomiting associated with chemotherapy or surgical procedure in adults  

Is it safe to receive NOZIA during pregnancy?

NOZIA is not recommended for use in pregnant women. Consult your doctor for advice before receiving NOZIA if you are pregnant or planning to get pregnant.

Can NOZIA be used in children?

NOZIA is not recommended for use in children due to lack of safety and effectiveness. Consult child’s doctor for advice to select a suitable alternative therapy for your child depending upon medical condition.

Can NOZIA be used in breast-feeding women?

NOZIA is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Consult your doctor before receiving NOZIA  

What are the side effects of receiving NOZIA?

The most common side effects of receiving NOZIA are headache, dizziness and constipation. Consult your doctor if any of the side effect worsens or does not improve.

REFERENCES

1. KD Tripathi. Anti-emetic, prokinetic and digestant drugs. Essentials of Medical Pharmacology. Eighth edition. 2019. Page- 718

2. Ramosetron Hydrochloride. NIH. National Center for Advancing Translational Sciences (NCATS) Inxight Drugs. [Accessed on 26th July 2022] https://drugs.ncats.io/drug/9551LHD87E

3. Sanmukhani JJ, Pawar P, Mittal R. Ramosetron hydrochloride for the prevention of cancer chemotherapy induced nausea and vomiting: The Indian experience. South Asian Journal of Cancer. April 2014. [Accessed on 26th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014645/

4. Fujii Y, Saitoh Y, Tanaka H, Toyooka H. Ramosetron for preventing postoperative nausea and vomiting in women undergoing gynecological surgery. Pubmed gov. February 2000. [Accessed on 26th July 2022] https://pubmed.ncbi.nlm.nih.gov/10648342/

5. Li SC, Wang Y, Choi SJ, Jung YS, Han KH, Chung IB, Lee SH. Scheduled injection of ramosetron for prevention of nausea and vomiting following single-port access total laparoscopic hysterectomy: a prospective randomized study. Obstetrics and Gynecology Science. September 2019. [Accessed on 26th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737055/