INTRODUCTION

NOSTRA 5MG contains Norethisterone which belongs to the group of medicines called Hormonal Replacement Therapy. It is used to manage menstrual irregularities (such as heavy periods, painful periods and irregular periods) in females.

It can also be used to manage endometriosis (tissue growth outside the uterus), breast cancer and symptoms of pre-menstrual syndrome such as mood disturbances, headache and breast pain in women.

Before taking NOSTRA 5MG, inform your doctor if you have asthma, diabetes, hypertension, liver, kidney, or heart problems. You must also inform your doctor if you have unexplained vaginal bleeding, a history of repeated miscarriages, blood clot problems, migraine headaches or epilepsy before taking NOSTRA 5MG as a precaution.

NOSTRA 5MG is not recommended for use in pregnant women. Inform your doctor before taking NOSTRA 5MG if you are a woman who had repeated miscarriages or developed jaundice or excessive skin itching during their pregnancy.

NOSTRA 5MG is not a contraceptive (birth control pill), therefore it cannot prevent you from becoming pregnant. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while taking NOSTRA 5MG.

The most common side effects of taking NOSTRA 5MG are dizziness, weight gain, nausea and vaginal bleeding. Consult your doctor if they trouble you. Also, inform your doctor immediately if you experience sudden chest pain, difficulty in breathing, severe headache, or severe pain and tenderness in your legs.

USES OF NOSTRA 5MG

It is used to:

• Manage heavy periods, painful periods, irregular periods
• Manage endometriosis (tissue growth outside the uterus)
• Manage symptoms of pre-menstrual syndrome (PMS) such as headache, breast pain, tiredness and mood disturbances
• Manage breast cancer
• Delay your next periods

HOW NOSTRA 5MG WORKS

NOSTRA 5MG is a synthetic progestin which works by mimicking the effects of a naturally occurring female sex hormone called progesterone. This helps in regulating the growth and shedding of the womb which in turn reduces menstrual irregularities. It also reduces the onset the pre-menstrual syndrome, controls the abnormal (excess) growth of uterine tissues and reduces the incidence of cancer in the female body.

DIRECTIONS FOR USE

Always take NOSTRA 5MG as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take NOSTRA 5MG for the stipulated duration mentioned by your doctor to achieve better results.

SIDE EFFECTS OF NOSTRA 5MG

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take NOSTRA 5MG with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if your nausea worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Stomach pain:

Try to take rest and relax. Eat and drink fluids slowly or try to have frequent smaller meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking NOSTRA 5MG, inform your doctor if you are taking any of the following medicine

• Medicines used to manage epilepsy (Ex. phenytoin, carbamazepine)
• medicines used to manage bacterial infections (such as tetracyclines, co-trimoxazole and rifampicin)
• medicines used to manage viral infections (Ex. ritonavir, nelfinavir)
• medicines used to manage cancer (Ex. cisplatin, carboplatin, letrozole)
• medicines used to manage pain and inflammation (non-steroidal anti-inflammatory drugs such as diclofenac, naproxen, ibuprofen)
• medicines used to manage high blood pressure (Ex. atenolol, propranolol, amlodipine, captopril, enalapril)
• aminoglutethimide (a medicine used to manage Cushing’s syndrome)
• cyclosporin (a medicine used to suppress immune functions)
• St John’s wort (a herbal preparation used to manage depression)

Overdosage:

If you or anyone else accidentally took more NOSTRA 5MG, consult your doctor immediately. Overdosage may cause side effects such as vaginal bleeding, feeling sick or enlargement of the breast.

SYNOPSIS

MORE INFORMATION

• Keep NOSTRA 5MG out of reach of children
• Store NOSTRA 5MG at room temperature

FAQs ABOUT NOSTRA 5MG

What is the use of NOSTRA 5MG?

NOSTRA 5MG is a hormonal medicine used to manage menstrual irregularities (such as heavy periods, painful periods and irregular periods) in females. It can also be used to manage endometriosis (tissue growth outside the uterus), breast cancer and symptoms of pre-menstrual syndrome such as mood disturbances, headache and breast pain in women.

How NOSTRA 5MG works?

NOSTRA 5MG is a synthetic progestin which works by mimicking the effects of a naturally occurring female sex hormone called progesterone. This helps in regulating the growth and shedding of the womb which in turn reduces menstrual irregularities. It also reduces the onset of pre-menstrual syndrome, controls the abnormal (excess) growth of uterine tissues and reduces the incidence of cancer in the female body.

Can I use NOSTRA 5MG to stop menstruation?

Yes. NOSTRA 5MG may also be used to control prolonged or heavy menstrual periods. Your periods may stop within 2-3 days of NOSTRA 5MG. If it did not stop, contact your doctor for advice.

Can I take NOSTRA 5MG during pregnancy?

NOSTRA 5MG should not be used in pregnant women and in women who are planning to become pregnant. Therefore, consult your doctor before taking it.

What are the side effects of taking NOSTRA 5MG?

The most common side effects of taking NOSTRA 5MG are dizziness, weight gain, nausea, stomach pain and vaginal bleeding. Consult your doctor if they trouble you. Also, inform your doctor immediately if you experience sudden chest pain, difficulty in breathing, severe headache, or severe pain and tenderness in your legs.

What are the precautions that I need to follow while taking NOSTRA 5MG?

Before taking NOSTRA 5MG, inform your doctor if you have asthma, diabetes, hypertension, liver, kidney, or heart problems. You must also inform your doctor if you have unexplained vaginal bleeding, a history of repeated miscarriages, blood clot problems, migraine headaches or epilepsy before taking NOSTRA 5MG as a precaution. Inform your doctor before taking NOSTRA 5MG if you are a woman who had repeated miscarriages or developed jaundice or excessive skin itching during their pregnancy. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while taking NOSTRA 5MG. Consult your doctor immediately if you experience sudden chest pain, difficulty in breathing, severe headache, or severe pain and tenderness in your legs after taking NOSTRA 5MG.

Is NOSTRA 5MG a contraceptive?

NOSTRA 5MG is not a contraceptive (birth control pill), therefore it cannot prevent you from becoming pregnant. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while taking NOSTRA 5MG.

Can NOSTRA 5MG delay my periods?

Yes, NOSTRA 5MG may prevent your periods from occurring until you stop taking the tablets. Once you complete the management it may take at least 3 days to start your periods usually and consult your doctor if you don’t get periods after the management course.

NOSTRA 5MG causes blood clots?

Yes. NOSTRA 5MG has the potential to form blood clots within the body. Therefore, consult your doctor immediately if you experience sudden chest pain, difficulty in breathing, severe headache, or severe pain and tenderness in your legs, as it could be a sign of blood clot.

REFERENCES

1. KD. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of medical pharmacology. Seventh edition. 2013. Page – 316-323.
2. Joshua Dean, Katherine J. Kramer, Fauzia Akbary, Shaunte Wade, Maik Hüttemann, Jay M. Berman and Maurice-Andre Recanati. Norethindrone is superior to combined oral contraceptive pills in short-term delay of menses and onset of breakthrough bleeding: a randomized trial. BMC Women’s Health. BMC Part of Springer Nature. May 2019. [Accessed on 5th September 2022]. https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-019-0766-6
3. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 5th September 2022] https://www.medicines.org.uk/emc/files/pil.1494.pdf
4. Duramed Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in July 2007] [Accessed on 5th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018405s023lbl.pdf