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Introduction About NOACNE A GEL
NOACNE A GEL is used in the management of acne (pimple). It contains a combination of Adapalene and Clindamycin, which belongs to the group of medicines called topical retinoids and lincomycin antibiotics.
Adapalene is a form of vitamin A that acts as an antiacne agent by binding directly to the receptor of the skin, which increases the rate of cell turnover (cell regeneration) and decreases oil secretion, preventing clogging of the hair follicles and pores and also decreasing swelling and inflammation. Clindamycin works by binding to the ribosomal unit of the bacteria and disrupting the production of the protein essential for its survival.
Before recommending NOACNE A GEL, your doctor may advise you to have tests to understand your existing condition in order to plan effective management methods. Stay well hydrated and protect your skin from exposure to sunlight or UV light.
Do not apply NOACNE A GEL if you are allergic to adapalene or clindamycin, have a disorder of the digestive system (colitis), a disorder of the immune system, or have bruises, cuts, or burns on the skin. The common side effects of using this medicine may include dry skin, burning, itching, redness or irritative sensation of the skin, scaling, peeling of the skin, etc.
Uses Of NOACNE A GEL
- To manage acne
How NOACNE A GEL Works
Adapalene, a form of vitamin A, works as an antiacne medicine by attaching directly to the skin's receptor, which increases cell turnover (cell regeneration) and decreases oil secretion, preventing blockage of the hair follicles and pores. It also reduces swelling and inflammation of the skin. Clindamycin works by attaching to the bacteria's ribosomal unit and disrupting the production of a protein required for its very own survival.
How to use NOACNE A GEL
Apply NOACNE A GEL as advised by your doctor. It is for external use on the skin only. Avoid applying NOACNE A GEL around or onto your eyes, including eyelids.
Side Effects Of NOACNE A GEL
Common
- Dryness of the skin
- Burning, itching, and redness of the skin
- Scaling and/or peeling of the skin
Uncommon
- Flaring of the acne
- Sunburns
- Local skin reaction
Stop using this medicine and contact your doctor immediately if you experience any of the following side effects:
- Severe allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue, and other parts of the body, difficulty breathing or wheezing, blisters on the skin, sore throat, fever, headache, etc.)
How To Manage Side Effects
Dry Skin
Apply a good-quality moisturizer regularly after bathing and throughout the day to lock in moisture. Drink plenty of water to keep your skin hydrated from the inside out. Use a humidifier to add moisture to the air in your home. Avoid harsh soaps, detergents, and skincare products that contain alcohol, fragrances, or other irritants. Use a broad-spectrum sunscreen to protect your skin from sun damage. Wear soft, breathable fabrics like cotton to avoid irritation, and protect your skin from cold, dry air with appropriate clothing and accessories like gloves and scarves. Eat a balanced diet rich in omega-3 fatty acids, vitamins, and antioxidants to support skin health. Consult your doctor if dry skin worsens.
Skin rash Or Itching
Keep the affected area clean and dry and avoid scratching to prevent further irritation or infection. Apply calamine lotion to help reduce itching and inflammation. Applying cool compresses and wearing loose, breathable clothing can also provide relief. If the rash persists, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedNOACNE A GEL is not recommended for use by pregnant women. Consult your doctor for advice if you are pregnant or suspect or plan to be pregnant.
Breastfeeding
Use with CautionNOACNE A GEL is to be used with caution by breastfeeding mothers after consulting their doctor. The safe use of NOACNE A GEL in breastfeeding women and breastfed babies is not established.
Driving and Using Machines
SafeNOACNE A GEL may not interfere with your ability to drive or use the machine. However, protect your skin from the sun or UV light while traveling and follow the appropriate protective measures recommended by your doctor.
Alcohol
Consult your doctorThe risks associated with consuming alcohol are not known. It’s advised to avoid the consumption of alcohol while using NOACNE A GEL, as it could aggravate your existing condition.
Allergy
ContraindicatedTalk to your doctor if you are allergic to adapalene and/or clindamycin.
Use In Pediatrics
ContraindicatedNOACNE A GEL is not recommended for use in children less than 12 years of age. Consult your doctor for advice.
Use In Geriatrics
Use with CautionNOACNE A GEL should be used with caution in the elderly (above 65 years of age) after consulting your doctor for advice.
Others
NOACNE A GEL is not recommended for use if you have:
- Cuts or bruises on the skin
- Sunburns
- Skin conditions like eczema (itching, dry, and red skin)
Interactions
A. Drug-Drug interactions:
- Medicated soap for skin, other cosmetic products with a high concentration of alcohol, astringents, sulphur
- Topical Antipruritic and Antiseptic (Ex. resorcinol)
- Keratolytic agent (Ex. salicylic acid)
- Muscle relaxants (Ex. atracurium, cisatracurium, and succinylcholine)
B. Drug-Food interaction:
The interaction of foods with NOACNE A GEL is not known. Consult your doctor for diet advice.
Overdosage:
If you use NOACNE A GEL in excess of what is recommended, you may experience dryness, scaling, redness, and discomfort in the skin. Contact your doctor immediately for advice.
Synopsis
| Drug | : | Adapalene, Clindamycin |
| Pharmacological Category | : | Topical retinoids and antibiotics |
| Therapeutic Indication | : | To manage acne |
| Dosage Forms | : | Gel (topical), Gel, Cream, Ointment |
More Information
Storage
- Keep out of reach of children
- Store at room temperature
FAQs About NOACNE A GEL
Q: Can NOACNE A GEL be used to manage scars on the skin?
A: Yes. Adapalene is a kind of vitamin A that reduces swelling and inflammation while also managing acne scars. Azithromycin is used to manage infections that cause skin infections to worsen.
Q: How should I apply NOACNE A GEL?
A: Apply NOACNE A GEL as advised by your doctor. It is for external use on the skin only. Avoid applying NOACNE A GEL around or onto your eyes, including eyelids.
Q: Can NOACNE A GEL result in skin peeling?
A: Yes. Dryness of the skin, burning, itching, redness of the skin, skin irritation, scaling, and possibly peeling of the skin are all possible side effects of using this medicine.
Q: Can NOACNE A GEL cause skin dryness?
A: Yes. Your skin may get dry as a result of taking this medication. Maintain hydration and use the moisturizer that your doctor has prescribed.
Q: How long can I use NOACNE A GEL?
A: Use NOACNE A GEL as advised by your doctor. Generally, it’s recommended for use depending on the severity of the existing skin condition.
Q: What is NOACNE A GEL used for?
A: NOACNE A GEL is used in the management of acne (pimple). It contains a combination of adapalene and clindamycin, which belong to the group of medicines called topical retinoids and lincomycin antibiotics.
Q: Can I stop using NOACNE A GEL on my own?
A: No. It is not recommended to stop using NOACNE A GEL on your own, as it may worsen the existing skin condition. Consult your doctor for advice.
Q: What are the side effects of using NOACNE A GEL?
A: The common side effects of using this medicine may include dry skin, burning, itching, redness or irritative sensation of the skin, scaling, peeling of the skin, etc.
Q: How does NOACNE A GEL work?
A: NOACNE A GEL containsadapalene, a form of vitamin A that works as an antiacne medicine by attaching directly to the skin's receptor, which increases cell turnover (cell regeneration) and decreases oil secretion, preventing blockage of the hair follicles and pores. It also reduces swelling and inflammation of the skin. Clindamycin works by attaching to the bacteria's ribosomal unit and disrupting the production of a protein required for its very own survival.
Q: Is NOACNE A GEL safe during pregnancy?
A: NOACNE A GEL is not recommended for use by pregnant women. Consult your doctor for advice if you are pregnant or suspect or plan to be pregnant.
References
1. KD. Tripathi. Drugs acting on skin and mucous membranes and Antimicrobial drugs. Essentials of Medical Pharmacology. 8th Edition. 2019. Page – 953 to 954 & 805.
2. Laurence Brunton, Bruce Chabner, Bjorn Knollman. Dermatological Pharmacology. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th Edition. 2006. Page-1809.
3. Lee's Pharmaceutical Limited. U.S. National Library of Medicine (ClinicalTrails.gov). A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris. [Revised in 28th April 2020] [Accessed on 12th June 2024] https://clinicaltrials.gov/ct2/show/NCT03615768
4. Bausch Health US, LLC. Clindamycin gel. U.S National Library of Medicine (NIH) [Revised in January 2020] [Accessed on 12th June 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f7b4e985-719a-4547-b624-94612d520991&type=display#c6576601-4d00-4643-a764-5a6752bc8a8f
5. Galderma (UK) Limited. Adapalene. [Revised in March 2021] [Accessed on 12th June 2024] https://www.medicines.org.uk/emc/files/pil.921.pdf
6. Galderma Laboratories, L.P. Adapalene gel. [Revised in February 2018] [Accessed on 12th June 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a0031324-92a6-4c11-90e2-c2818f7278ec&type=display
7. Alembic Pharmaceuticals, Inc., National Library of Medicine (NIH). Adapalene gel [Revised in November 2021] [Accessed on 12th June 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a3b6f3c3-d615-4b00-a76f-134b75e30a50&type=display
Useful Diagnostic Tests
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