INTRODUCTION

NIZOCLIN contains Ketoconazole belongs to the group of medicines called antifungals. It is used to manage fungal and yeast infections of the skin in adults. It binds to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall.

Wet the affected area and use NIZOCLIN. Avoid getting the soap in the mouth, eyes, and nose. It is for external use only. It is recommended for the use in children and adolescents. Do not use this soap, if you have eye infections. It can be used in pregnant or breastfeeding women. Consult your doctor before using this soap. Tell your doctor if you are using any of the other topical medicines. The most common side effects include burning sensation, irritation and reddening of the skin.

USES OF NIZOCLIN

• Manage fungal infections in the body

HOW NIZOCLIN WORKS

NIZOCLIN binds to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall.

DIRECTIONS FOR USE

Wet the affected area and use NIZOCLIN. Avoid getting the soap in the mouth, eyes, and nose. It is for external use only.

SIDE EFFECTS OF NIZOCLIN

HOW TO MANAGE SIDE EFFECTS

Skin irritation:

Avoid bath in hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are using any of the other topical medicines.

SYNOPSIS

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT NIZOCLIN

Can NIZOCLIN be used in pregnant women?

Yes. It is safe for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

How does NIZOCLIN kill fungus?

It kills fungi and yeasts by causing holes to appear in cell membranes, allowing essential constituents of cells to leak out. It kills fungi and yeast cells and helps to clear up the infection.

REFERENCES

1. Hadeer Sinawe; Damian Casadesus, Ketoconazole, [Revised on Jun 2020] [Accessed 11 Dec 2020] https://www.ncbi.nlm.nih.gov/books/NBK559221/

2. Jan van cutsem; The antifungal activity of ketoconazole; [Revised on Jan 1983] [Accessed 11 Dec 2020] https://www.amjmed.com/article/0002-9343(83)90508-9/fulltext

3. Franchesca D Choi, Margit L W Juhasz, Natasha Atanaskova Mesinkovska, Topical ketoconazole: a systematic review of current dermatological applications and future developments, [Revised on Dec 2019] [Accessed 11 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/30668185/

4. K.D.Tripathi, Essentials of medical pharmacology, ANTIMICROBIAL DRUGS, Chapter 57 – ANTIFUNGAL DRUGS, 7th edition 2013, Page – 792.

5. Glenmark Pharmaceuticals s.r.o., U.S. Food and Drug Administration; [Revised on July 2013] [Accessed 11 Dec 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018533s040lbl.pdf

6. Janssen Pharmaceutica NV; Electronic Medicines Compendium (EMC); [Revised on Mar 2019] [Accessed 11 Dec 2020] https://www.medicines.org.uk/emc/files/pil.970.pdf