Introduction About MYDRIASOL PLUS OPHTHALMIC SOLUTION

MYDRIASOL PLUS OPHTHALMIC SOLUTION is a combination of Phenylephrine and Tropicamide which belongs to the group of medicines called Nasal decongestants and Anticholinergics respectively. It is used for mydriasis and cycloplegia in diagnostic procedures. It is used directly on the eyelids to produce dilation of pupil before diagnostic and therapeutic procedures.

Dilated pupils (mydriasis) is a condition when the black centre of the eyes becomes larger than normal. The condition may be caused by dilating eye drops from an eye exam. The eye drops used for dilation cause your pupils to widen, allowing in light and giving your doctor a better view of your eye. Eye dilation helps your doctor in diagnosing common diseases and conditions, possibly at their earliest stages.

Remove contact lenses before using this medicine. Do not drive vehicles immediately after using MYDRIASOL PLUS OPHTHALMIC SOLUTION as it may cause blurred vision making it difficult to ride vehicles. MYDRIASOL PLUS OPHTHALMIC SOLUTION is not recommended for patients with high risk for glaucoma (narrow anterior chamber angle). MYDRIASOL PLUS OPHTHALMIC SOLUTION should be used with caution in patients with inflamed eyes.

Avoid concomitant use of cardiac medicines along with MYDRIASOL PLUS OPHTHALMIC SOLUTION. There is no proper information regarding the use of MYDRIASOL PLUS OPHTHALMIC SOLUTION and should be used with caution in pregnant women. MYDRIASOL PLUS OPHTHALMIC SOLUTION should be used with caution in breast-feeding women. MYDRIASOL PLUS OPHTHALMIC SOLUTION should be used with caution in children below 1 year of age and in elder patients. The most common side effects of MYDRIASOL PLUS OPHTHALMIC SOLUTION are stinging, blurred vision, sensitive to light, redness, watery eye, increased intraocular pressure, local irritation and oedema.

Uses Of MYDRIASOL PLUS OPHTHALMIC SOLUTION

• It is used directly on the eyelids to produce dilation of pupil before diagnostic and therapeutic procedures

How MYDRIASOL PLUS OPHTHALMIC SOLUTION Works

MYDRIASOL PLUS OPHTHALMIC SOLUTION works by dilating the pupils in the eye. Phenylephrine produces dilation effects (mydriasis) by narrowing the blood vessels and muscles present in the eye. Tropicamide blocks and stops the narrowing of the smooth muscles of eye causing dilation of pupil (mydriasis). Thus, both react by producing mydriatic effect necessary for diagnostic and therapeutic purposes.

How to use MYDRIASOL PLUS OPHTHALMIC SOLUTION

Use MYDRIASOL PLUS OPHTHALMIC SOLUTION as directed by your physician. It is for ophthalmic use only. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.

Side Effects Of MYDRIASOL PLUS OPHTHALMIC SOLUTION

How To Manage Side Effects

Headache

Take some rest, in a quiet place avoid using user mobile phones and other electronic devices for a while. Drink enough amount of water, dehydration may lead you to develop a headache. If the symptom does not improve, contact your doctor.

Warning & Precautions

Pregnancy

Consult your doctor

There are no adequate and well-controlled studies in pregnant women. Consult your doctor before using MYDRIASOL PLUS OPHTHALMIC SOLUTION.

Breastfeeding

Consult your doctor

There are no adequate and well-controlled studies in breastfeeding women. Consult your doctor before using MYDRIASOL PLUS OPHTHALMIC SOLUTION.

Driving and Using Machines

Use with Caution

Do not drive or handle heavy machines if you experience side effects like dizziness, drowsiness, tired or if you have blurred vision while using MYDRIASOL PLUS OPHTHALMIC SOLUTION.

Allergy

Contraindicated

Do not use MYDRIASOL PLUS OPHTHALMIC SOLUTION if you are allergic to Phenylephrine or Tropicamide or to any other ingredients of this medicine.

Heart Disease

Contraindicated

MYDRIASOL PLUS OPHTHALMIC SOLUTION is not recommended for use in patients with heart diseases and irregular heartbeat. Consult your doctor before using.

Use In Pediatrics

Consult your doctor

Pediatric patients less than 1 year of age due to increased risk of systemic toxicity contraindicated. Consult your doctor before using MYDRIASOL PLUS OPHTHALMIC SOLUTION.

Use In Geriatrics

Use with Caution

MYDRIASOL PLUS OPHTHALMIC SOLUTION should be used with caution in elder patients. Consult your doctor before using the medicine.

Interactions

A. Drug-Drug interactions:

Before using MYDRIASOL PLUS OPHTHALMIC SOLUTION, inform your doctor if you are taking any of the following medicine:

• medicines used to manage hypertension (Ex. atenolol, propanolol, enalapril, amlodipine)
• medicines used to manage depression and mental illness (Ex. sertraline, citalopram, escitalopram, selegiline, rasagiline, amitriptyline, trimipramine)
• halothane (used as anaesthesia)
• atropine (used to manage low blood pressure)
• medicines used to manage heart diseases (Ex. digoxin, quinidine)

Overdosage:

If you or anyone else accidentally uses more of MYDRIASOL PLUS OPHTHALMIC SOLUTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include flushing dryness of the skin, rash, blurred vision, irregular pulse, fever, abdominal swelling in infants, convulsions, hallucinations, headache, anxiety, nausea, vomiting and irregular heartbeat.

Synopsis

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References

1. K.D. Tripathi Drugs Acting on Ans Essentials of Pharmacology seventh edition 2013 Page no-118.

2. Park, Ji-Hyun et al. The comparison of mydriatic effect between two drugs of different mechanism March 2009 NCBI: National Library of Medicine, PubMed articles. [Accessed on 25th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655751/

3. Cipla med. [Revised in August 2020] [Accessed on 25th May 2022] https://ciplamed.com/content/itrop-plus-eye-drops

4. Optho life sciences Tropicamide 0.8% w/v, Phenylephrine HCl 2.5% w/v. [Accessed on 25th May 2022] https://www.optholifesciences.com/mydriatics

5. Eyekare kilitch. Tropicamide IP 1% w/v. Phenylephrine Hydrochloride IP 5% w/v. [Accessed on 25th May 2022] https://eyekarekilitch.com/proDetails.asp?id=29&product=TROPIEYE

6. Intas Tropicamide - 0.8% + Phenylephrine Hcl - 5.0%. [Accessed on 25th May 2022] https://www.intaspharma.com/products/