Modlip AM Tablet 10'S
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Introduction About MODLIP AM TABLET
MODLIP AM TABLET is a combination of S(-)Amlodipine and Atorvastatin which belongs to the group of medicines called Antihypertensives and Antihyperlipidemics respectively. It is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke, angina and other heart problems.
Before taking MODLIP AM TABLET inform your doctor if you have any lung, liver, kidney or heart problems (apart from hypertension such as heart failure). You must also inform your doctor if you have diabetes, thyroid disorders, muscle problems or alcoholism as a precaution.
MODLIP AM TABLET is not suitable for use in patients with severe hypotension (low blood pressure). Do not take MODLIP AM TABLET if you are pregnant or breastfeeding without consulting your doctor.
Along with the management, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results. Avoid consuming alcohol or grapefruit juice while taking MODLIP AM TABLET as it may make this medicine less effective.
Talk to your doctor before taking MODLIP AM TABLET if you are already taking any antibiotics (such as Fusidic acid) to manage any existing infections. The most common side effects of taking MODLIP AM TABLET are swelling of ankles or other body parts, headache, dizziness, sleepiness, tiredness, constipation, muscle cramps, throat pain, neck pain, joint pain and back pain. Contact your doctor if any of these side effects trouble you.
Uses Of MODLIP AM TABLET
- Manage hypertension (high blood pressure)
- Manage hyperlipidemia (high blood cholesterol levels)
- Prevents the risk of heart attack, stroke, angina or related health problems
How MODLIP AM TABLET Works
MODLIP AM TABLET contains two medicines namely S(-)Amlodipine and Atorvastatin. S(-)Amlodipine is a vasodilator. It relaxes the blood vessels supplying the heart and other vital organs of the body. As a result, it improves blood flow and oxygen supply to the heart which reduces strain on the heart and improves heart functions.
Atorvastatin is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.
Collectively, this medicine reduces blood pressure and blood cholesterol levels and manages you from their associated risks.
How to use MODLIP AM TABLET
Take MODLIP AM TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. MODLIP AM TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking MODLIP AM TABLET without consulting your doctor.
Side Effects Of MODLIP AM TABLET
Common
- edema (swelling of the ankles or other body parts)
- headache, dizziness, sleepiness
- palpitations (fast heartbeat)
- flushing (redness and warmth of the skin)
- stomach pain, nausea, diarrhea, constipation, indigestion
- changes in bowel habit
- tiredness, weakness
- visual disturbances, double vision
- inflammation of the nasal passages
- throat pain, nose bleeds
- increase in blood sugar levels
- increase in blood creatine kinase
- headache
- joint pain, muscle pain and back pain
- liver problems
Uncommon
- anxiety, depression
- insomnia (sleeplessness)
- changes in taste
- tingling sensation in limbs, loss of pain sensation
- ringing in the ears
- low blood pressure
- increased sweating
- increased urination at night
- inability to obtain an erection, enlargement of the breasts in men
- weight gain or decrease in weight
- anorexia (loss of appetite)
- loss of memory
- neck pain, muscle fatigue
- raised temperature
Rare
- confusion
- cholestasis (yellowish discoloration of the skin and whites of the eyes)
- tendon injury
Stop taking MODLIP AM TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath (signs of heart attack)
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
- unexplained muscle pain or weakness, especially if accompanied by fever, weakness, or reddish-brown urine (rhabdomyolysis)
- unexpected bleeding or bruising
How To Manage Side Effects
Nausea and Vomiting
Take MODLIP AM TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Headache
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume excessive alcohol. Reduce looking into bright light and try to get adequate sleep. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Warning & Precautions
Pregnancy
MODLIP AM TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with MODLIP AM TABLET. However, if you accidentally become pregnant while taking MODLIP AM TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
MODLIP AM TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking MODLIP AM TABLET.
Alcohol
Avoid consumption of alcohol while taking MODLIP AM TABLET as it could increase the risk of side effects.
Kidney
MODLIP AM TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
MODLIP AM TABLET is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take MODLIP AM TABLET if you are allergic to Atorvastatin or S(-)Amlodipine.
Lungs
MODLIP AM TABLET should be used with caution in patients with lung diseases (such as severe respiratory failure). Therefore, consult your doctor before taking it.
Heart Disease
MODLIP AM TABLET is not recommended for use in patients with severe heart problems such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having a history of recent heart attack or heart failure. Therefore, consult your doctor before taking it.
Others
MODLIP AM TABLET is not recommended for use if you:
- have severe low blood pressure (hypotension)
Before taking MODLIP AM TABLET, inform your doctor if you:
- have severe uncontrollable increase in blood pressure (hypertensive crisis)
- have an unexplained muscle pain
- had any muscle problems in the past
- have improper functioning of thyroid gland
- have personal or family history of muscle problems
- are alcoholic
- have diabetes
- are overweight
- have a previous history of stroke with bleeding the brain
- have small holes or pockets in the brain due to previous stroke
Use in pediatrics:
MODLIP AM TABLET should be used in children and adolescents (aged 10 years or older) only if prescribed by the physician. Your doctor will decide the correct dose of MODLIP AM TABLET depending on your child’s age, body weight and health condition.
Use in geriatrics:
MODLIP AM TABLET should be used with caution in elderly patients (aged 70 years or older). Therefore, consult your doctor for advice before taking it.
Interactions
A. Drug - Drug interactions:
Before taking MODLIP AM TABLET, inform your doctor if you are taking any of the following medicines such as:
- dantrolene (a medicine used to manage muscle spasms)
- medicines used to manage graft rejection and to suppress immune functions (such as tacrolimus, sirolimus, temsirolimus, everlimus, cyclosporine)
- St. John’s wort (an herbal medicine used to manage depression)
- medicines used to manage bacterial infection (such as fusidic acid, erythromycin, clarithromycin, telithromycin)
- medicines used to manage fungal infection (such as ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
- rifampicin (a medicine used to manage tuberculosis infection)
- other medicines used to reduce blood cholesterol levels (such as gemfibrozil, simvastatin, fenofibrate, colestipol or ezetimibe)
- medicines used to manage heart problems (Ex. diltiazem, digoxin, verapamil, amiodarone)
- medicines used to manage viral infections such as HIV or Hepatitis C (Ex. letermovir, ritonavir, lopinavir, atazanavir, indinavir, darunavir, the combination of tipranavir/ritonavir, telaprevir, boceprevir and the combination of elbasvir/grazoprevir, ledipasvir/sofosbuvir)
- warfarin (a medicine used to manage blood clots)
- oral contraceptives (used to manage pregnancy) Ex. levonorgestrel
- stiripentol (a medicine used to control epilepsy)
- medicines used to manage stomach ulcers (such as cimetidine)
- antacids (used to neutralize stomach acid and to reduce heartburn) Ex. aluminium hydroxide or magnesium hydroxide
- phenazone (a medicine used for pain relief)
- colchicine (a medicine used to manage gout)
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking MODLIP AM TABLET, as it could severely reduce your blood pressure and may make you feel faint, dizzy or drowsy.
Overdosage:
If you or anyone else accidentally took more MODLIP AM TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin, and shortness of breath.
Synopsis
| Drug | : | S(-)Amlodipine, Atorvastatin |
| Pharmacological Category | : | Calcium Channel Blockers, HMG-CoA reductase inhibitors |
| Therapeutic Indication | : | Hypertension, Hyperlipidaemia |
| Dosage Forms | : | Tablet |
More Information
- Keep MODLIP AM TABLET out of reach of children
- Store MODLIP AM TABLET at room temperature
FAQs About MODLIP AM TABLET
Q: What are the uses of MODLIP AM TABLET?
A: MODLIP AM TABLET is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke, angina and other heart problems.
Q: Can the use of MODLIP AM TABLET cause diabetes?
A: Yes. MODLIP AM TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking this medicine if you are diabetic, obese or have hypertension. Your doctor will closely monitor your blood sugar levels while undergoing therapy with MODLIP AM TABLET to avoid any unwanted side effects.
Q: What is the best time to take MODLIP AM TABLET?
A: Take MODLIP AM TABLET as advised by your physician. Your doctor will decide the best time for you to take MODLIP AM TABLET. Try to take this medicine at the same time each day. It can be taken with or without food.
Q: What are the side effects of taking MODLIP AM TABLET?
A: The most common side effects of taking MODLIP AM TABLET are swelling of ankles or other body parts, headache, dizziness, sleepiness, tiredness, constipation, muscle cramps, throat pain, neck pain, joint pain and back pain. Contact your doctor if any of these side effects trouble you.
Q: Can I consume alcohol along with MODLIP AM TABLET?
A: MODLIP AM TABLET should be used with caution in patients who consume large amounts of alcohol. It is advisable to avoid alcohol consumption while taking this medicine to achieve maximum benefits.
Q: Can the use of MODLIP AM TABLET make me feel more tired?
A: Yes. The use of MODLIP AM TABLET can make you feel more tired, because it acts by reducing the supply of energy to the muscles present in your body. However, you may also feel tired due to other reasons such as severe liver damage. Consult your doctor if you experience excessive tiredness with muscle pain.
Q: Who should not take MODLIP AM TABLET?
A: MODLIP AM TABLET is not recommended for use in patients with severe liver damage. It is also not suitable for use in patients having muscle problems and in women in who are pregnant or breastfeeding. Before taking MODLIP AM TABLET inform your doctor if you have diabetes or any kidney or heart problems. Do not take this medicine if you are undergoing therapy with antibiotics such as fusidic acid.
Q: What are the dietary restrictions that I need to follow while taking MODLIP AM TABLET?
A: While taking MODLIP AM TABLET, follow a low-cholesterol diet as instructed by your doctor and avoid excessive alcohol intake. Avoid eating oil rich or deep-fried foods. Limit your sugar intake by avoid eating biscuits, cakes, soft drinks, or pastries. Stick to a simple nutritious diet. Avoid consumption of grapefruit while taking MODLIP AM TABLET as it may reduce its effectiveness.
Q: What should I do if I forget to take a dose of MODLIP AM TABLET?
A: If you forget to take a dose of MODLIP AM TABLET, take it as soon as you remember. However, if it is time to take the next dose of MODLIP AM TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of MODLIP AM TABLET to compensate the missed dose, as it could lead to toxicity.
Q: Can I stop taking MODLIP AM TABLET once my symptom subsides?
A: Do not stop taking this medicine without consulting your doctor, as it could once again increase your blood pressure and cholesterol levels once again. MODLIP AM TABLET can only control your hypertension and blood cholesterol levels and cannot manage them completely, therefore, it is important to take this medicine until your doctor advises you to stop.
Q: Can I take MODLIP AM TABLET if I am diabetic?
A: MODLIP AM TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking MODLIP AM TABLET if you are diabetic, obese or have hypertension
Q: Does MODLIP AM TABLET cause muscle pain?
A: MODLIP AM TABLET may cause a rare but serious side effect of unexplained muscle pain or weakness called rhabdomyolysis. Therefore, consult your doctor if you experience any signs of muscle problems after taking MODLIP AM TABLET. Also, talk to your doctor before taking MODLIP AM TABLET if you already have weak muscles or have a family history of any muscle disorders.
Q: How MODLIP AM TABLET controls cholesterol levels in the body?
A: MODLIP AM TABLET is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.
Q: How long should I take MODLIP AM TABLET to manage high cholesterol?
A: You should take MODLIP AM TABLET as long as your doctor advises you to take. Because MODLIP AM TABLET will only help you in managing your blood pressure and cholesterol levels and cannot completely manage them. If you stop using MODLIP AM TABLET, your symptoms may raise once again.
Q: Can MODLIP AM TABLET be taken by pregnant or breast-feeding women?
A: MODLIP AM TABLET is not recommended for use in pregnant or breast-feeding women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. However, if you accidentally become pregnant while taking this medicine, stop taking it and consult your doctor immediately.
Q: Can I take MODLIP AM TABLET daily?
A: Take MODLIP AM TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take MODLIP AM TABLET every day or not.
Q: Can MODLIP AM TABLET cause ankle swelling?
A: MODLIP AM TABLET may cause edema or swelling of ankles in few patients. If you experience ankle swelling, keep your legs on a table or slightly elevated from the ground level. If this symptom bothers you, contact your doctor.
Q: Can the use of MODLIP AM TABLET affect the liver?
A: Yes. MODLIP AM TABLET may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Can MODLIP AM TABLET cause erectile dysfunction?
A: MODLIP AM TABLET may cause problems in erection in few individuals. Consult your doctor if it bothers you.
References
1. KD Tripathi. Antianginal and Other Anti-ischaemic Drugs. Antihypertensive Drugs. Insulin, Hypolipidemic Drugs and Plasma Expanders. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 549, 562 & 637.
2. Devabhaktuni, Madhuri, and Sripal Bangalore. Fixed combination of amlodipine and atorvastatin in cardiovascular risk management: patient perspectives. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2009. [Accessed on 4th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686256/
3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.3478.pdf
4. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.13960.pdf
5. Sun Pharmaceutical Industries. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.4339.pdf
6. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.11753.pdf
7. Pfizer labs. CADUET® (amlodipine besylate and atorvastatin calcium) tablets, for oral use. U.S. Food and drug Administration [Revised in March 2015] [Accessed on 20th May] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021540s036lbl.pdf
8. Torrent Pharmaceuticals Ltd. Modlip-AM. [Revised in January 2022]. [Accessed on 4th January 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1755.pdf
9. Central Drugs Standard Control Organization. S(-) Amlodipine Besylate eq. to S(-) Amlodipine-2.5mg+Atorvastatin cal eq. to Atorvastatin 10mg tablet. February 2004. [Accessed on 4th January 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Kidney function tests
- CBC
- Lipid Profile
- Liver Function Test
- Echocardiography
Author Details
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