Mexate 10mg Tablet 4'S

4 Tablet(s) in a Strip Mkt: Cadila Healthcare Ltd (Zydus) Country of Origin: India
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MRP ₹49.77
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Mexate 10mg Tablet 4'S ₹40.81
MRP ₹49.77
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Introduction About MEXATE 10MG TABLET

MEXATE 10MG TABLET contains Methotrexate, which belongs to the group of medicines called Antimetabolites. MEXATE 10MG TABLET is used to manage active rheumatoid arthritis in adults, which is a form of severe arthritis occurring due to unknown reasons (idiopathic) and old age and is non-responsive to conventional painkillers (such as Non-Steroidal Anti Inflammatory Drugs Ex. Aceclofenac).

MEXATE 10MG TABLET is also used to manage its polyarthritic forms (characterized by the involvement of five or more joints), which are severe, active, and idiopathic in nature and affect young people (Juvenile Idiopathic Arthritis, JIA).

MEXATE 10MG TABLET is also used to manage psoriasis and relapsed (reoccurred) and refractory (unaffected by other conventional managements) Non-Hodgkin’s lymphoma, which is a type of cancer of the lymphatic system.

Psoriasis is a skin condition characterized by itchy scales that is not responsive to conventional managements such as phototherapy and retinoids.

Before taking MEXATE 10MG TABLET, it is recommended to inform the doctor about your medical and family history, including the list of medicines (prescription, non-prescription medicines, and herbal medicines) that are being taken.

Also, MEXATE 10MG TABLET is not recommended to be taken by pregnant and nursing women, women planning pregnancy, those who drink huge amounts of alcohol, or patients suffering from liver and kidney impairment.

MEXATE 10MG TABLET is not recommended in children for the management of psoriasis and rheumatoid arthritis. However, MEXATE 10MG TABLET can be used with caution in children to manage polyarticular juvenile idiopathic arthritis, which is characterized by the involvement of five or more joints that are of severe, active, juvenile, and idiopathic character. Consult the doctor before taking MEXATE 10MG TABLET.

In addition, caution must be exercised by patients suffering from lung disorders, blood disorders, and gastric disorders before taking MEXATE 10MG TABLET.

Care must be taken to avoid taking products containing caffeine, such as black tea, coffee, and cold drinks, while taking MEXATE 10MG TABLET.

The common side effects seen after taking MEXATE 10MG TABLET are headache, nausea, vomiting, dizziness, and altered levels of blood cells. Consult a doctor if any of the above side effects worsen after taking MEXATE 10MG TABLET.

Side Effects Of MEXATE 10MG TABLET

Rare

Stop taking MEXATE 10MG TABLET and consult your doctor immediately if you experience any of the following:

  • formation of scar tissue in the lungs (pulmonary fibrosis), development of pneumonia indicated by shortness of breath along with thick mucus
  • severe allergic reactions characterized by tightness in the chest, swelling of the face, throat, and hands, along with difficulty breathing
  • severe toxic reactions of the skin resulting in the formation of vesicles, as seen in Stevens-Johnson Syndrome, toxic epidermal necrolysis (Lyell’s syndrome)
  • decreased white blood cells, characterized by fever and general deterioration of the body, along with an increased level of local infections
  • painful urination
  • kidney damage
  • inflammation and/or damage to the liver is characterized by yellowing of the skin and eyes along with fever, itchy skin, and a swollen or tender stomach
  • ulcer and/or bleeding in the stomach, characterized by black tar-like stools, vomiting blood, and stomach pain
  • formation of blood clots characterized by cramps, swelling in the legs, redness, breathlessness, and chest pain
  • decreased formation of urine
  • fever, chills, shivering along with a rapid heartbeat, breathing
  • presence of blood in the urine
  • fits (convulsions)
  • spitting or coughing blood
  • disorders of the brain, such as encephalopathy
  • easy tendency to bleed and bruise, persistent bleeding
  • loss of coordination
  • loss of the ability to speak and/or understand speech
  • weakness and inability to move one side of the body or the whole body
  • miscarriage and/or damage to the fetus (in women)

Warning & Precautions

Interactions

A. Drug-Drug Interactions:

Before taking MEXATE 10MG TABLET, inform your doctor if you are taking any of the following medicines:

  • medicines used to manage bacterial infections (Ex. amoxicillin, ciprofloxacin)
  • medicines used to increase urine excretion (Ex. frusemide)
  • medicines used to manage increased sugar levels (Ex. metformin)
  • medicines used to manage fits (Ex. phenytoin)
  • medicines used to manage increased cholesterol levels (Ex. cholestyramine)
  • medicines used to manage gout (Ex. probenecid)
  • medicines to manage reduced folic acid levels (Ex. folic acid preparations)
  • medicines used to manage severe heartburn or ulcers (Ex. omeprazole)
  • other medicines used to manage rheumatoid arthritis (Ex. leflunomide)
  • medicines that can be harmful to the liver (Ex. sulfasalazine)
  • medicines used in the management of cancer (Ex. doxorubicin, cisplatin, and mercaptopurine)
  • medicines used to manage pain (Ex. ibuprofen, naproxen, diclofenac)
  • other medicines used to manage rheumatoid arthritis and psoriasis (Ex. leflunomide, phenylbutazone, or amidopyrine)
  • medicines used to manage asthma (Ex. theophylline)
  • medicines used in organ transplantation (Ex. cyclosporin, azathioprine)
  • medicines used to induce sleep (Ex. phenobarbitone)
  • medicines used to induce calmness and relieve anxiety (Ex. diazepam)
  • medicines used for oral contraception (Ex. estrogen)
  • medicines used to manage skin conditions (Ex. retinoids)
  • medicines used to manage malaria (Ex. pyrimethamine)
  • medicines that contain live vaccines (Ex. MMR vaccine)
  • medicines used for general anesthesia and pain relief (Ex. nitrous oxide)
  • medicines used to manage heart problems (Ex. amiodarone)
  • medicines used to manage heart failure (Ex. digoxin)
  • medicines used for the management of various inflammatory conditions like skin diseases and allergic reactions (Ex. hydrocortisone)

B. Drug-Food interactions:

It is recommended to avoid the consumption of drinks containing caffeine, such as black tea, coffee, and soft drinks, along with MEXATE 10MG TABLET, to manage dehydration.

Overdosage:

If you or someone else accidentally takes too much MEXATE 10MG TABLET, it is recommended to consult your doctor immediately. Symptoms of overdosage with MEXATE 10MG TABLET are an easy tendency to bruise or bleed, nausea, vomiting, and unusual weakness, along with the development of mouth sores and ulcers.

Synopsis

Drug :   Methotrexate
Pharmacological Category :   Anti-metabolites
Therapeutic Indication :   Rheumatoid Arthritis, Psoriasis, Cancer        
Dosage Forms :   Injection, Gel, Capsule, Tablet                                    

FAQs About MEXATE 10MG TABLET

Q: What is MEXATE 10MG TABLET used for?

A: MEXATE 10MG TABLET is used to manage active rheumatoid arthritis in adults, which is a form of severe arthritis occurring due to unknown reasons (idiopathic) and old age and is non-responsive to conventional painkillers (such as non-steroidal anti-inflammatory drugs, Ex. Aceclofenac). MEXATE 10MG TABLET is also used to manage the polyarthritic forms (characterized by the involvement of five or more joints), which are severe, active, and idiopathic in nature and affect young people (Juvenile Idiopathic Arthritis, JIA).

Q: Can I take MEXATE 10MG TABLET in pregnancy?

A: MEXATE 10MG TABLET is not recommended for use in pregnant women and/or in women who are planning pregnancy because it can be harmful for the fetus (a growing baby in the womb). Consult your doctor before taking MEXATE 10MG TABLET.

Q: Can I take MEXATE 10MG TABLET if I’m breastfeeding a baby?

A: MEXATE 10MG TABLET is not recommended for nursing mothers due to a lack of safety data. Consult your doctor before taking MEXATE 10MG TABLET.

Q: Can MEXATE 10MG TABLET be taken by children?

A: MEXATE 10MG TABLET is not recommended in children for the management of psoriasis and rheumatoid arthritis. However, MEXATE 10MG TABLET can be used with caution in children to manage polyarticular juvenile idiopathic arthritis. Your doctor will prescribe the right dose depending on your child’s age, body weight, and health condition. Consult your doctor for advice before taking MEXATE 10MG TABLET.

Q: Can MEXATE 10MG TABLET be used by the elderly?

A: MEXATE 10MG TABLET is recommended to be administered with caution and in a lower dosage to elders due to diminished function of the liver and kidneys and reduced folate levels in the blood in old age. Also, it is recommended to closely monitor the elderly, taking MEXATE 10MG TABLET for the identification of possible side effects. Consult the doctor before taking MEXATE 10MG TABLET.

Q: Is there any specific food to avoid while taking MEXATE 10MG TABLET?

A: It is recommended to avoid the consumption of drinks containing caffeine, such as black tea, coffee, and soft drinks, along with MEXATE 10MG TABLET, to manage dehydration.

References

1. KD. Tripathi. Antirheumatoid and Antigout Drugs, Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 210, 857.

2. Brown, P.M., Pratt, A.G. and Isaacs, J.D., 2016. Mechanism of action of Methotrexate in Rheumatoid Arthritis and the search for biomarkers.  Nature Reviews Rheumatology. [Published on 27th October 2016] [Accessed on 3rd February 2024] https://www.nature.com/articles/nrrheum.2016.175

3. Orion Corporation. Electronic Medicines Compendium (EMC) U.K [Revised in August 2023] [Accessed on 3rd February 2024] https://www.medicines.org.uk/emc/files/pil.1376.pdf

4. Cipla. Methotrexate. [Revised on 13th April 2020] [Accessed on 3rd February 2024] https://www.cipla.com/sites/default/files/Methotrexate%202.5%20mg%20%E2%80%93%20Patient%20Card%20-%20Risk%20Minimisation%20Information%20for%20Patients.pdf

5. Accord Healthcare Inc. U.S.A. [Revised in December 2021] [Accessed on 3rd February 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=874c7f43-a3be-4236-89cc-24c44e3c5813&type=display#section-9

6. Teva Women's Health, Inc. [Revised in April 2021] [Accessed on 3rd February 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e942f8db-510f-44d6-acb5-b822196f5e8c&type=display#section-9

7. Pfizer Healthcare Ireland. [Revised in September 2020] [Accessed on 3rd February 2024] http://www.hpra.ie/img/uploaded/swedocuments/Licence_PA0822-206-005_23092020105544.pdf

8. Pfizer Australia Pty Ltd. [Revised in August 2021] [Accessed on 3rd February 2024] https://www.nps.org.au/assets/medicines/152212ff-3721-4bba-b3cc-a53300ff0e7d.pdf

9. Imutaj. Taj Pharma. [Accessed on 3rd February 2024] https://tajpharma.in/portfolio-item/methotrexate-tablets-ip-5mg-imutaj-taj-pharma/

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    Methotrexate 10 mg
    Hsn Code
    30049042
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