Introduction About METPURE XL 50MG TABLET

METPURE XL 50MG TABLET contains Metoprolol which belongs to the group of medicines called Antihypertensives.  It is used in adults to manage essential hypertension (persistently high blood pressure, that can show symptoms like headache, sweating, fast heartbeat or throbbing sensation).

METPURE XL 50MG TABLET is not recommended for use in patients with certain heart diseases and should be used with caution in patients having liver diseases. METPURE XL 50MG TABLET should be used with caution in pregnant and breast-feeding woman.

Safety and effectiveness of METPURE XL 50MG TABLET in children (less than 6 years of age) have not been established so, consult your child’s doctor for advice. METPURE XL 50MG TABLET should be used with caution in elderly patients.

The most common side effects of taking METPURE XL 50MG TABLET are tiredness, dizziness, depression, diarrhea, shortness of breath, slow heartbeat and rash. Consult your doctor if any of the symptoms are not improving.

Uses Of METPURE XL 50MG TABLET

• Manage essential hypertension in adults

How METPURE XL 50MG TABLET Works

METPURE XL 50MG TABLET effectively lowers blood pressure by reducing the effect of stress hormones on the heart due to physical and mental exertion, resulting in reduced pulse rate.

How to use METPURE XL 50MG TABLET

Take METPURE XL 50MG TABLET as advised by your physician. Swallow this medicine with water, do not crush or chew it. Correct dosage and duration of medicine to be taken will be prescribed by your doctor depending upon your age, body weight and disease condition. Do not stop taking METPURE XL 50MG TABLET unless your doctor advises you to stop.

Side Effects Of METPURE XL 50MG TABLET

How To Manage Side Effects

Dizziness:

When you start taking METPURE XL 50MG TABLET, you may feel dizzy. If this happens, resting or lying down for some time can help. This is caused by your blood pressure decreasing. It should get better as you continue to take the medicine. If symptom persists, contact your doctor.

Skin rash:

Try to avoid hot showers because it may cause skin irritation. Avoid frequent contact and rubbing over the affected area. Use sunscreen and protective clothing when outdoors. If symptom persists, contact your doctor.

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If symptom persists, contact your doctor.

Warning & Precautions

Pregnancy

METPURE XL 50MG TABLET should be used with caution in pregnant women. Consult your doctor for advice.

Breastfeeding

METPURE XL 50MG TABLET should be used with caution in breastfeeding woman. Consult your doctor for advice.

Liver

METPURE XL 50MG TABLET should be used with caution in patients having liver impairment. Consult your doctor for advice.

Allergy

METPURE XL 50MG TABLET is not recommended for use if you are allergic to S-Metoprolol, other beta blockers like propranolol, atenolol or any of the other ingredients of this medicine.

Lungs

METPURE XL 50MG TABLET is not recommended for use in patients having bronchospastic diseases (tightening of airways). Consult your doctor for advice.

Heart Disease

METPURE XL 50MG TABLET is not recommended for use in patients with second- or third-degree heart block, decompensated heart failure, heart rhythm disorder (sinus bradycardia and sick sinus syndrome), cardiogenic shock, severe peripheral arterial circulatory disorder, acute myocardial infarction. Consult your doctor for advice.

Interactions

A. Drug - Drug interactions:

Before taking METPURE XL 50MG TABLET, inform your doctor if you are taking any of the following medicines:

• medicines used to manage high blood pressure and heart problems (Ex. reserpine, quinidine, propafene, diltiazem, verapamil, clonidine, digoxin)
• certain medicines used to manage depression (Ex. selegiline, phenelzine, fluoxetine, paroxetine)

Overdosage:

If you or anyone else accidentally take too much of METPURE XL 50MG TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of overdose are severely low blood pressure, breathing problems, nausea or vomiting.

Synopsis

More Information

• Keep METPURE XL 50MG TABLET out of reach of children
• Store below 30°C

FAQs About METPURE XL 50MG TABLET

Can METPURE XL 50MG TABLET cause diarrhea?

Yes. Diarrhea is a common side effect of METPURE XL 50MG TABLET. Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If you experience persistent diarrhea, consult your doctor.

Can I take METPURE XL 50MG TABLET before having a surgery?

Inform the medical staff about METPURE XL 50MG TABLET before having a surgery. This is because you can get low blood pressure (hypotension) if you are given certain anaesthetics (medicine used to cause insensitivity to pain) while you are taking METPURE XL 50MG TABLET.

Can METPURE XL 50MG TABLET be given to children?

Safety and effectiveness of METPURE XL 50MG TABLET in children have not been established. Consult your child’s doctor for advice. The doctor will determine a proper dose or select a suitable alternative management for your child.  

What if I forget to take a dose of METPURE XL 50MG TABLET?

If you forget to take a dose of METPURE XL 50MG TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for a forgotten dose.

Is METPURE XL 50MG TABLET safe in pregnant women?

METPURE XL 50MG TABLET should be used with caution in pregnant women. If you are pregnant, think you may be pregnant or are planning for a baby, consult your doctor before taking it.

References

1. KD. Tripathi. Drugs Acting in ANS. Essentials of medical pharmacology. Eighth edition. 2019. Page – 163.

2. Dasbiswas, Arup, Suresh Shinde and Debasri Dasbiswas. S-metoprolol: the 2008 clinical review. Europe PMC. April 2008. [Accessed on 30th July 2022]. https://europepmc.org/article/med/18828349

3. Mohan, Jagdish C., et al. Rediscovering Chirality-Role of S-Metoprolol in Cardiovascular Disease Management. Europe PMC. June 2017. [Accessed on 30th July 2022]. https://europepmc.org/article/med/28782316

4. Zuventus healthcare limited. KIMET-XL 12.5/25/50 TAB (S-metoprolol). [Accessed on 30th July 2022]. http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=183

5. Aralez Pharmaceuticals US Inc. metoprolol succinate. Dailymed.com. [Revised in July 2022] [Accessed on 30th July 2022]. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=991fe00b-498b-400e-9e5b-921cb07d9b2c#:~:text=TOPROL%2DXL%2C%20metoprolol%20succinate%2C,(1.1)

6. Central Drugs Standard Control Organization (CDSCO). [Accessed on 30th July 2022]. https://cdscoonline.gov.in/CDSCO/Drugs

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• ECG