MESACOL 1G SUPPOSITORIES is used to manage gut inflammation and pain associated with ulcerative colitis or ulcerative proctitis. It contains a medicine called Mesalamine (also known as Mesalazine) which when inserted into the rectum, slowly releases the medicine and acts locally to reduce the inflammation and help relieve or stop the pain.

Uses Of MESACOL 1G SUPPOSITORIES

It is used to provide relief from gut inflammation and pain associated with:

• Ulcerative colitis
• Ulcerative proctitis

How MESACOL 1G SUPPOSITORIES Works

Mesalamine suppository works by reducing inflammation in the lining of the rectum and lower intestine. It is an anti-inflammatory drug that inhibits the production of certain chemicals (prostaglandins and leukotrienes) in the colon, which are involved in causing inflammation, swelling, and tissue damage. By directly targeting the affected area, the suppository form provides localized relief from inflammation, reducing symptoms like rectal bleeding, pain, and diarrhea.

How to use MESACOL 1G SUPPOSITORIES

• Empty your bowels before administering MESACOL 1G SUPPOSITORIES
• Clean your hands thoroughly before and after handling the suppository.
• Lie down on your left side with your right knee bent toward your chest for easy insertion.
• Gently insert the pointed end of the suppository into the rectum about 1 inch deep, ensuring it is fully inserted.
• Stay in a lying position for a few minutes to allow the suppository to dissolve and start working.

Side Effects Of MESACOL 1G SUPPOSITORIES

Common side effects of MESACOL 1G SUPPOSITORIES:

• Diarrhoea
• Abdominal pain
• Nausea, vomiting
• Headache
• Skin rash
• Flatulence (passing wind)
• Rectal discomfort
• Irritation at the site of application

Stop using this medicine and inform your doctor immediately if you experience any of the following side effects such as:

• abdominal pain and cramps, fever, severe headache and rash
• bloody urine with pain in sides of the abdomen

Warning & Precautions

Pregnancy

Consult your doctor

There is only limited information regarding the use of mesalamine during pregnancy. Therefore, consult your doctor for advice before using mesalazine suppositories if you are pregnant or think you may be pregnant.

Breastfeeding

Consult your doctor

There is only limited information regarding the use of mesalamine during breastfeeding. Available studies indicate the risk of causing allergic reactions such as diarrhea in newborn babies. Therefore, do not take mesalazine suppositories without medical supervision.

Driving and Using Machines

Safe

This medicine is not known to affect the ability to drive and/or use machines.

Kidney

Consult your doctor

MESACOL 1G SUPPOSITORIES is not recommended for use in patients with severe kidney problems. It should be used with caution in patients suffering from mild to moderate kidney diseases.

Liver

Consult your doctor

This medicine is not recommended for use in patients with severe liver problems. It should be used with caution in patients suffering from mild to moderate liver diseases.

Allergy

Contraindicated

Talk to your doctor before using MESACOL 1G SUPPOSITORIES if you are allergic to Mesalamine (or mesalazine) or other salicylates (such as sulphasalazine).

Lungs

Use with Caution

This medicine should be used with caution in patients suffering from asthma.

Use In Pediatrics

Contraindicated

MESACOL 1G SUPPOSITORIES is not recommended for use in children aged below 18 years.

Interactions

A. Drug-Drug interactions:

• Azathioprine (used to minimise the risk of graft rejection)
• 6-mercaptopurine or thioguanine
• Anticoagulants (such as warfarin)

Synopsis

More Information

Ulcerative Colitis:

• Definition: Ulcerative colitis is a chronic inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the lining of the large intestine (colon) and rectum. The inflammation usually begins in the rectum and may extend into the colon.
• Symptoms:
  • Abdominal pain and cramping
  • Persistent diarrhea, often with blood or pus
  • Rectal bleeding
  • Urgent need to have a bowel movement
  • Fatigue
  • Weight loss
  • Fever in severe cases

Ulcerative Proctitis:

• Definition: Ulcerative Proctitis is the inflammation of the lining of the rectum, the lower part of the large intestine. It can be a localized form of ulcerative colitis affecting only the rectum.
• Symptoms:
  • Rectal pain or discomfort
  • A constant feeling of needing to pass stool (tenesmus)
  • Rectal bleeding
  • Mucus discharge from the rectum
  • Diarrhea or constipation

Both conditions involve inflammation of the bowel, but proctitis is specifically confined to the rectum, whereas ulcerative colitis can affect a larger portion of the colon.

Drug information:

FAQs About MESACOL 1G SUPPOSITORIES

References

1. Mesalazine Suppositories. EMC. UK. [Revised in January 2023]. [Accessed on 4th October 2024].  click here

2. Camber Pharma. Mesalamine Suppositories. Revised in March 2020. [Accessed on 4th October 2024]. click here

3. Mesalamine Rectal. MedlinePlus. National Library of Medicine. [Revised in January 2023]. [Accessed on 4th October 2024]. click here

User Feedback

Was this information helpful? Share it with your friends?

Relevant Natural Remedies:

Useful Diagnostic Tests

• Healthy Stomach Package

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 05 Oct 2024 | 10:42 AM(IST)