Introduction About MASTIFEN TABLET

MASTIFEN TABLET contains Ketotifen which belongs to the group of medicines called Antihistamines. It is used in prophylactic management of bronchial asthma and allergic conditions such as rhinitis (inflammation of the inside of the nose caused by an allergen like pollen, dust).

Bronchial asthma is a condition in which the airways narrow and swell, producing extra mucus. This can cause difficulty in breathing, trigger cough, wheezing and shortness of breath. Avoid consumption of alcohol during management with MASTIFEN TABLET. It is not recommended for use in patients having epilepsy.

Before taking MASTIFEN TABLET, inform your doctor if you are intolerant to certain sugars, have a history of epilepsy or diabetes. It is generally not recommended for use in pregnant and breastfeeding women. The most common side effects are agitation, irritability, inability to sleep and nervousness.

Uses Of MASTIFEN TABLET

To prevent:

• Bronchial asthma
• Rhinitis

How MASTIFEN TABLET Works

MASTIFEN TABLET works by blocking histamine (a substance in the body that causes allergic symptoms) and stops the release of mediators from cells involved in hypersensitivity reaction.

How to use MASTIFEN TABLET

Take MASTIFEN TABLET as advised by your physician.

For Tablet, Capsule: Swallow MASTIFEN TABLET with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse MASTIFEN TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Side Effects Of MASTIFEN TABLET

Warning & Precautions

Pregnancy

MASTIFEN TABLET is not recommended for use in pregnant women or women planning to have a baby. Consult your doctor before taking it.

Breastfeeding

MASTIFEN TABLET is not recommended for use in breastfeeding women as it may pass in the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Do not drive or use machines while taking MASTIFEN TABLET as you may feel drowsy and your reactions may be slower than usual.

Alcohol

Do not drink alcohol while taking MASTIFEN TABLET.

Allergy

Do not take MASTIFEN TABLET if you are allergic to Ketotifen or any other ingredients of this medicine.

Interactions

A. Drug - Drug interactions:

Before taking MASTIFEN TABLET, inform your doctor if you are taking any of the following medicine:

• oral medicines for diabetes (Ex. biguanides)
• for asthma (Ex. budesonide, beclomethasone)
• to manage sleeplessness, anxiety, depression (Ex. diazepam, lorazepam)
• antihistamines to manage allergic reactions (Ex. brompheniramine, azelastine)
• anticoagulants (Ex. warfarin)

Overdosage:

If you or anyone else accidentally take too much of MASTIFEN TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are blurred vision, confusion, convulsions, disorientation, dizziness, drowsiness (severe), faintness or lightheadedness when getting up from a lying or sitting position, fast, pounding or irregular heartbeat or pulse, hyperexcitability, loss of consciousness, palpitations, sweating, unusual tiredness or weakness.

Synopsis

More Information

• Keep MASTIFEN TABLET out of reach of children
• Do not store above 25°C

FAQs About MASTIFEN TABLET

What is MASTIFEN TABLET used for?

MASTIFEN TABLET is used in the prophylactic management of bronchial asthma and allergic conditions such as rhinitis (inflammation of the inside of the nose caused by an allergen like pollen or dust).

How does MASTIFEN TABLET work?

MASTIFEN TABLET works by blocking histamine (a substance in the body that causes allergic symptoms) and stops the release of mediators from cells involved in hypersensitivity reaction.

Can I take medicine for diabetes while taking MASTIFEN TABLET?

Thrombocytopenia may occur in patients taking MASTIFEN TABLET at the same time as oral antidiabetic drugs(biguanides). Simultaneous administration of these drugs should therefore be avoided.

Can MASTIFEN TABLET cause weight gain in asthma patients?

Yes, MASTIFEN TABLET can cause an increase in appetite and hence weight gain. Consult your doctor before taking it for more information on this medicine.

Can MASTIFEN TABLET affect my sleep cycle?

Yes, it may cause some people to become excited, irritable or nervous or to have trouble sleeping. These are symptoms of central nervous system stimulation and are especially likely to occur in children.

References

1. Goodman Gilmans. Ocular Pharmacology. The Pharmacological Basis of Therapeutics. Twelfth Edition. 2011. Page –1789.

2. Ketotifen. NIH. National library of medicine. National center for biotechnology information. Pubchem. December 2022. [Accessed on 23rd May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Ketotifen

3. S M Grant , K L Goa, A Fitton, E M Sorkin. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in asthma and allergic disorders. NIH. National library of medicine. National center for biotechnology information. Pubmed.gov. September 1990. [Accessed on 23rd May 2022] https://pubmed.ncbi.nlm.nih.gov/2226222/

4. Mipharm S.p.A. Health Products Regulatory Authority (HPRA) [Accessed on 23rd May 2022]. https://www.hpra.ie/img/uploaded/swedocuments/86ee3e8a-67c2-43bf-95bf-dda1afbebf7b.pdf

5. Ketotifen. Mayoclinic. [Revised in November 2022] [Accessed on 23rd May 2022] https://www.mayoclinic.org/drugs-supplements/ketotifen-oral-route/side-effects/drg-20064435

6. Ketotifen fumarate. CDSCO. [Accessed on 23rd May 2022] https://cdscoonline.gov.in/CDSCO/Drugs

Useful Diagnostic Tests

• Spirometry
• Allergy blood test