Introduction About MASTIFEN SYRUP

MASTIFEN SYRUP contains Ketotifen which belongs to the group of medicines called Antihistamines. It is used in prophylactic management of bronchial asthma and allergic conditions such as rhinitis (inflammation of the inside of the nose caused by an allergen like pollen, dust).

Bronchial asthma is a condition in which the airways narrow and swell, producing extra mucus. This can cause difficulty in breathing, trigger cough, wheezing and shortness of breath. Avoid consumption of alcohol during management with MASTIFEN SYRUP. It is not recommended for use in patients having epilepsy.

Before taking MASTIFEN SYRUP, inform your doctor if you are intolerant to certain sugars, have a history of epilepsy, diabetes. It is generally not recommended for use in pregnant and breastfeeding women. The most common side effects are agitation, irritability, inability to sleep and nervousness.

Uses Of MASTIFEN SYRUP

To prevent:

• bronchial asthma
• rhinitis

How MASTIFEN SYRUP Works

MASTIFEN SYRUP works by blocking histamine (a substance in the body that causes allergic symptoms) and stops the release of mediators from cells involved in hypersensitivity reaction.

How to use MASTIFEN SYRUP

Take MASTIFEN SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of MASTIFEN SYRUP

Warning & Precautions

Pregnancy

MASTIFEN SYRUP is not recommended for use in pregnant women or women planning to have a baby. Consult your doctor before taking it.

Breastfeeding

MASTIFEN SYRUP is not recommended for use in breastfeeding women as it may pass in the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Do not drive or use machines while taking MASTIFEN SYRUP as you may feel drowsy and your reactions may be slower than usual.

Alcohol

Do not drink alcohol while taking MASTIFEN SYRUP.

Allergy

Do not take MASTIFEN SYRUP if you are allergic to Ketotifen or any other ingredients of this medicine

Interactions

A. Drug - Drug interactions:

Before taking MASTIFEN SYRUP, inform your doctor if you are taking any of the following medicine:

• oral medicines for diabetes (Ex. biguanides, metformin)
• for asthma (Ex. budesonide, beclomethasone)
• to manage sleeplessness, anxiety, depression (Ex. diazepam, lorazepam)
• antihistamines to manage allergic reactions (Ex. brompheniramine, azelastine)
• anticoagulants (Ex. warfarin)

Overdosage:

If you or anyone else accidentally takes too much of MASTIFEN SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are blurred vision, confusion, convulsions, disorientation, dizziness, drowsiness (severe), faintness or lightheadedness when getting up from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, hyperexcitability, loss of consciousness, palpitations, sweating, unusual tiredness or weakness.

Synopsis

More Information

• Keep MASTIFEN SYRUP out of reach of children
• Do not store above 25°C

FAQs About MASTIFEN SYRUP

What is MASTIFEN SYRUP used for?

MASTIFEN SYRUP is used in the prophylactic management of bronchial asthma and allergic conditions such as rhinitis (inflammation of the inside of the nose caused by an allergen like pollen or dust).

How does MASTIFEN SYRUP work?

MASTIFEN SYRUP works by blocking histamine (a substance in the body that causes allergic symptoms) and stops the release of mediators from cells involved in hypersensitivity reaction.

Can I take medicine for diabetes while taking MASTIFEN SYRUP?

Thrombocytopenia may occur in patients taking MASTIFEN SYRUP at the same time as oral antidiabetic drugs (biguanides). Simultaneous administration of these drugs should therefore be avoided.

Can MASTIFEN SYRUP cause weight gain in asthma patients?

Yes, MASTIFEN SYRUP can cause an increase in appetite and hence weight gain. Consult your doctor before taking it for more information on this medicine.

Can MASTIFEN SYRUP affect my sleep cycle?

Yes, it may cause some people to become excited, irritable, or nervous or to have trouble sleeping. These are symptoms of central nervous system stimulation and are especially likely to occur in children.

References

1. Goodman Gilmans. Ocular Pharmacology. The Pharmacological Basis of Therapeutics. Twelfth Edition. 2011. Page –1789.

2. Ketotifen. NIH. National Library of medicine. National center for biotechnology information. Pubchem. December 2022. [Accessed on 23rd May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Ketotifen

3. S M Grant , K L Goa, A Fitton, E M Sorkin. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. NIH. National Library of medicine. National center for biotechnology information. Pubmed.gov. September 1990. [Accessed on 23rd May 2022] https://pubmed.ncbi.nlm.nih.gov/2226222/

4. Delpharm Orleans. Health Products Regulatory Authority (HPRA) [Accessed on 23rd May 2022] https://www.hpra.ie/img/uploaded/swedocuments/6fcc7356-bde1-496a-9ae0-070836b5e690.pdf

5. Ketotifen. Mayoclinic. [Revised in November 2022] [Accessed on 23rd May 2022] https://www.mayoclinic.org/drugs-supplements/ketotifen-oral-route/side-effects/drg-20064435

6. Ketotifen fumarate. CDSCO. [Accessed on 23rd May 2022] https://cdscoonline.gov.in/CDSCO/Drugs

Useful Diagnostic Tests

• Spirometry
• Allergy blood test