Introduction About LONOPIN 300MG PEN

LONOPIN 300MG PEN contains Enoxaparin which belongs to the group of medicines called Anticoagulants. It is used to manage blood clot formation in the body.

LONOPIN 300MG PEN works by stopping the blood clots formation. It also manages the existing blood clots from growing bigger in size. Due to this property, it is highly used as a prophylactic therapy for managing blood clot formation during risky conditions that involves clot formation such as before or after a surgery, during dialysis or after a heart attack or a severe chest pain (angina).

It can also be used to reduce the risk of blood clot formation caused due to prolong period of immobility or due to cancer therapy.

Before receiving LONOPIN 300MG PEN inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have diabetes, high blood pressure or a history of stomach ulcer.

LONOPIN 300MG PEN is not recommended for use in patients who are bleeding heavily or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding. It is also not suitable for use in patients scheduled for spinal anesthesia or lumbar puncture.

Inform your doctor before receiving LONOPIN 300MG PEN if you are pregnant or breastfeeding. The most common side effects of receiving LONOPIN 300MG PEN are injection site reactions (such as pain or irritation), skin rashes, low platelet count, bleeding or bruising and headache. Consult your doctor if any of these side effect worsens.

Uses Of LONOPIN 300MG PEN

• Manage and manages blood clots in the body

How LONOPIN 300MG PEN Works

LONOPIN 300MG PEN is an anticoagulant medicine. It inactivates certain proteins (such as coagulation factor II a and X a) in the blood that causes blood clotting. This reduces the chances of blood clot formation within the body which therefore manages blockage of blood vessels.

How to use LONOPIN 300MG PEN

LONOPIN 300MG PEN will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously).

It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Side Effects Of LONOPIN 300MG PEN

How To Manage Side Effects

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Injection site reactions:

Place an ice pack on the affected area. Do not frequently move the injection site. Consult your doctor if the symptom did not improve.

Warning & Precautions

Pregnancy

LONOPIN 300MG PEN should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.

Breastfeeding

LONOPIN 300MG PEN should be used with caution in breastfeeding women. Therefore, consult your doctor before receiving it.

Driving and Using Machines

LONOPIN 300MG PEN does not affect your ability to drive or operate machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by LONOPIN 300MG PEN.

Alcohol

Avoid consumption of alcohol before receiving LONOPIN 300MG PEN.

Kidney

LONOPIN 300MG PEN should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.

Liver

LONOPIN 300MG PEN should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.

Allergy

Talk to your doctor before receiving LONOPIN 300MG PEN if you are allergic to Enoxaparin or to any other low molecular weight heparins (such as nadroparin, tinzaparin or dalteparin).

Heart Disease

LONOPIN 300MG PEN should be used with caution in patients fitted with heart valves and in patients with heart problems (such as heart infections or high blood pressure). Therefore, consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving LONOPIN 300MG PEN, inform your doctor if you are taking any of the following medicines:

• warfarin (a medicine used for blood thinning)
• other medicines used to stop blood clots from forming (Ex. aspirin, clopidogrel, dipyridamole)
• dextran injection (used to replace blood)
• medicines used to relieve pain and swelling (Ex. ibuprofen, diclofenac, ketorolac, tromethamine)
• medicines used to manage asthma, rheumatoid arthritis, and other conditions (Ex. prednisolone, dexamethasone)
• medicines that increase blood potassium levels (Ex. spironolactone, triamterene, amiloride)
• sulfinpyrazone (used to manage gout)

Overdosage:

LONOPIN 300MG PEN will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

More Information

• Keep LONOPIN 300MG PEN out of reach of children
• Store LONOPIN 300MG PEN at room temperature

FAQs About LONOPIN 300MG PEN

What is the use of LONOPIN 300MG PEN?

LONOPIN 300MG PEN is an anticoagulant used to manage blood clots in the body. It works by stopping the blood clots formation and manages the existing blood clots from growing bigger in size.

How LONOPIN 300MG PEN works?

LONOPIN 300MG PEN is an anticoagulant medicine. It inactivates certain proteins (such as coagulation factor II a and X a) in the blood that causes blood clotting. This reduces the chances of blood clot formation within the body which therefore manages blockage of blood vessels.

How LONOPIN 300MG PEN is administered?

LONOPIN 300MG PEN will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.

What precautions must be followed while receiving LONOPIN 300MG PEN?

Before receiving LONOPIN 300MG PEN inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have diabetes, high blood pressure or a history of stomach ulcer. LONOPIN 300MG PEN is not recommended for use in patients who are bleeding heavily or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding. It is also not suitable for use in patients scheduled for spinal anesthesia or lumbar puncture. Inform your doctor before receiving LONOPIN 300MG PEN if you are pregnant or breastfeeding.

Is LONOPIN 300MG PEN safe?

LONOPIN 300MG PEN is considered safe at the doses administered by the physician. However, consult your doctor if you experience any unusual side effects

What are the common side effects of receiving LONOPIN 300MG PEN?

The most common side effects of receiving LONOPIN 300MG PEN are injection site reactions (such as pain or irritation), skin rashes, low platelet count, bleeding or bruising and headache. Consult your doctor if any of these side effect worsens.

Can the use of LONOPIN 300MG PEN make me bleed more?

As LONOPIN 300MG PEN is a blood thinning medicine, it makes your blood thin and flowy which might increase the risk of excessive bleeding. To avoid this, your doctor will carefully evaluate your condition and prescribe a suitable dose for you. As a precaution, you must also inform your doctor if you have or recently had any surgery or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding.

Can LONOPIN 300MG PEN be used during heart attack?

LONOPIN 300MG PEN can be used to manage blood clots in patients who suffered a heart attack. However, consult your doctor before taking it.

Who should not receive LONOPIN 300MG PEN?

LONOPIN 300MG PEN is not recommended for use in patients who are bleeding heavily or have any pre-existing conditions (such as stomach ulcer or stroke) that can increase the risk of internal bleeding. It is also not suitable for use in patients scheduled for spinal anaesthesia or lumbar puncture.

Can I stop receiving LONOPIN 300MG PEN once my symptoms subside?

Do not stop taking LONOPIN 300MG PEN without consulting your doctor. You need to receive LONOPIN 300MG PEN for the duration recommended by your doctor to achieve complete management of blood clot formation within your body.

Is LONOPIN 300MG PEN heparin?

Yes. LONOPIN 300MG PEN contains a medicine called enoxaparin which is a low molecular weight heparin.

Can I use LONOPIN 300MG PEN during pregnancy?

LONOPIN 300MG PEN should be used with caution in pregnant women especially those with a mechanical heart valve. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before receiving LONOPIN 300MG PEN.

Can LONOPIN 300MG PEN be used in children?

The safety and effectiveness of LONOPIN 300MG PEN have not been established in children and adolescents (aged below 18 years). Your doctor will decide about administering LONOPIN 300MG PEN to your child after evaluating the risks and benefits of the therapy.

Can LONOPIN 300MG PEN be given IV?

LONOPIN 300MG PEN will be given to you only by a physician or a nurse under the skin (subcutaneously). It can also be given into your vein (intravenously) during surgeries or after heart attack. Your doctor will decide the appropriate route of administration for you depending upon your medical condition.

Can LONOPIN 300MG PEN cause thrombocytopenia?

LONOPIN 300MG PEN can lower your blood platelet count (thrombocytopenia), making you bruise more easily than usual. Consult your doctor if you experience any unusual bruising.

References

1. KD. Tripathi. Drugs affected coagulation, bleeding and thrombosis. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 619.

2. Takeo Nomura, Mika Takahashi, Kazunori Iwasaki, Tomoya Oribe, Mayuka Shinohara, Yuko Fukuda, Shinsuke Mizoguchi, Fuminori Sato, Hiromitsu Mimata. Efficacy and Safety of Enoxaparin for Preventing Venous Thromboembolic Events following Urologic Laparoscopic Surgery. International Scholarly Research Notices. April 2013. [Accessed on 28th October 2022] https://www.hindawi.com/journals/isrn/2013/415918/

3. Health-Med spólka z ograniczona odpowiedzialnoscia spólka jawna. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 28th October 2022] https://www.medicines.org.uk/emc/files/pil.782.pdf

4. Sanofi-aventis U.S. LLC. Enoxaparin. [Revised in April 2022] [Accessed on 28th October 2022] https://products.sanofi.us/lovenox/lovenox.pdf

5. Bharat Serums and Vaccines Limited. Lonopin. Enoxaparin Injection. IP. 20mg/40mg/60mg. [Revised in November 2018]. [Accessed on 28th October 2022] https://bsvgroup.com/assets/pdf/products/Re-LONOPIN-20-40-60mg-Common-Pack-Insert-for-Domestic-(Zen-Pharma-LL)-03-12-18-App.pdf

6. Central Drugs Standard Control Organization. Enoxaparin Sodium Injection (Addl. Indication). [Revised in August 2009]. Sodium Enoxaparin (LMWH) [Revised in March 1992]. Enoxaparin Sodium Inj. [Revised in March 2000]. [Accessed on 28th October 2022] https://cdscoonline.gov.in/CDSCO/Drugs