Introduction About LIFOTONIN TABLET

LIFOTONIN TABLET contains Melatonin which belongs to the group of medicines called Hormones. It is used to manage jetlag in adults. Jet-lag can be recognized by sleep disturbances, daytime tiredness, fatigue, mild mental impairment, irritability and digestive system disturbances experienced after flying.           

Avoid smoking as it may reduce the effect of this medicine and alcohol consumption while taking LIFOTONIN TABLET as it can impair sleep and potentially worsen certain symptoms of jetlag (Ex. headache, morning fatigue and concentration).            

LIFOTONIN TABLET should be used with caution in patients with impaired liver or kidney function, epilepsy, autoimmune disease (where the body is attacked by its own immune system), diabetes or impaired glucose tolerance. Consult your doctor before taking it.     

LIFOTONIN TABLET is not recommended for use in pregnant women and women of childbearing potential must use effective contraception. LIFOTONIN TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.     

LIFOTONIN TABLET is not recommended for use in children and adolescents under 18 years of age. LIFOTONIN TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.    

The most common side effects of taking LIFOTONIN TABLET are headache and drowsiness. Consult your doctor if any of the side effect worsens or persist for a long period of time. 

Uses Of LIFOTONIN TABLET

• Manage jet-lag in adults

How LIFOTONIN TABLET Works

LIFOTONIN TABLET helps to restore the normal day-and-night rhythm by synchronizing the body’s biological day-and-night rhythm as disturbances in biological rhythm may cause sleep disturbances, daytime tiredness, fatigue, mild mental impairment, irritability and other symptoms. Thus LIFOTONIN TABLET helps to restore the normal day-and-night rhythm and reduce the symptoms.

How to use LIFOTONIN TABLET

Take LIFOTONIN TABLET as advised by your doctor. Swallow the whole medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of the medicine depending upon your age, body weight and disease condition.

Side Effects Of LIFOTONIN TABLET

How To Manage Side Effects

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any machines if you feel drowsiness. Avoid alcohol consumption as it aggravates drowsiness. Consult your doctor if the symptom does not improve.

Dry Mouth

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Skin rash Or Itching

Avoid hot showers because hot water can irritate the skin further. Do not rub or scratch the affected area. Use sunscreen and protective clothing when going outdoor. Regularly use moisturizers to soothe and hydrate the affected area. If the symptom still persists, consult your doctor.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, inform your doctor.

Warning & Precautions

Pregnancy

Contraindicated

LIFOTONIN TABLET is not recommended for use in pregnant women and women of childbearing potential must use effective contraception. Consult your doctor before taking it.

Breastfeeding

Contraindicated

LIFOTONIN TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel drowsiness and decreased alertness for several hours after taking LIFOTONIN TABLET.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking LIFOTONIN TABLET as it can impair sleep and potentially worsen certain symptoms of jetlag (Ex. headache, morning fatigue and concentration).

Kidney

Use with Caution

LIFOTONIN TABLET should be used with caution in patients with impaired kidney function. Consult your doctor before taking it.

Liver

Use with Caution

LIFOTONIN TABLET should be used with caution in patients with impaired liver function. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take LIFOTONIN TABLET if you are allergic to melatonin or other ingredients of this medicine.

Use In Pediatrics

Contraindicated

LIFOTONIN TABLET is not recommended for use in children and adolescents under 18 years of age. Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

LIFOTONIN TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking LIFOTONIN TABLET.

Interactions

A. Drug-Drug Interactions:

Before taking LIFOTONIN TABLET inform your doctor if you are taking any of following medicines:

• fluvoxamine (used to manage of depression and obsessive-compulsive disorder)
• psoralens (used for managing skin disorders like psoriasis)
• cimetidine (used to manage stomach problems such as ulcers)
• estrogens (used as contraceptives or hormone replacement preparations)
• quinolones, rifampicin (used to manage bacterial infections)
• carbamazepine (used to manage epilepsy)
• benzodiazepines and non-benzodiazepine hypnotics (medicines that induce sleep, Ex. midazolam, temazepam, zaleplon, zolpidem and zopiclone)
• warfarin (used to manage or manage blood clots)

B. Drug-Food Interactions:

Food should not be consumed 2 hours before or 2 hours after taking LIFOTONIN TABLET.

Overdosage:

If you or anyone else accidentally take too much of LIFOTONIN TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage includes drowsiness, headache, dizziness and nausea.

Synopsis

More Information

• Keep LIFOTONIN TABLET out of reach of children
• Do not store LIFOTONIN TABLET above 25°C

FAQs About LIFOTONIN TABLET

Q: What is LIFOTONIN TABLET used for?

A: LIFOTONIN TABLET is used to manage jetlag in adults. Jet-lag can be recognized by sleep disturbances, daytime tiredness, fatigue, mild mental impairment, irritability and digestive system disturbances experienced after flying. Consult your doctor before taking it.

Q: Is LIFOTONIN TABLET safe in pregnant women?  

A: LIFOTONIN TABLET is not recommended for use in pregnant women and women of childbearing potential must use effective contraception. Consult your doctor for advice before taking it.

Q: Can I drink alcohol while taking LIFOTONIN TABLET?

A: Avoid alcohol consumption while taking LIFOTONIN TABLET as it can impair sleep and potentially worsen certain symptoms of jetlag (Ex. headache, morning fatigue and concentration).

Q: How does LIFOTONIN TABLET work?

A: LIFOTONIN TABLET helps to restore the normal day-and-night rhythm by synchronizing the body’s biological day-and-night rhythm as disturbances in biological rhythm may cause sleep disturbances, daytime tiredness, fatigue, mild mental impairment, irritability and other symptoms. Thus LIFOTONIN TABLET helps to restore the normal day-and-night rhythm and reduce the symptoms.

Q: What are the common side effects of LIFOTONIN TABLET?

A: The most common side effects of taking LIFOTONIN TABLET are headache and drowsiness. Consult your doctor if any of the side effects worsen or persist for a long period of time. 

References

1. K.D. Tripathi. Drugs acting on Central Nervous System. Essentials of Medical Pharmacology. 7th edition. 2013. Page 409

2. Rosemary A. Savage, Nowera Zafar, Sandesh Yohannan, John-Mark M. Miller. Melatonin. National Institute of Health. NLM. National Centre for Biotechnology Information. Stat pearls. August 2021. [Accessed on 21st July 2022] https://www.ncbi.nlm.nih.gov/books/NBK534823/

3. Sylvie Tordjman. Sylvie Chokron. Richard Delorme. Annaelle Charrier. Eric Bellissant. Nemat Jaafari. Claire Fougerou. Melantoin. Pharmacology, functions and therapeutic benefits. Current Neuropharmacology. April 2017. [Accessed on 21st July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405617/

4. Rafarm SA. Electronic Medicines Compendium (EMC).  [Revised in August 2021] [Accessed on 21st Jul 2022] https://www.medicines.org.uk/emc/files/pil.10405.pdf

5. Rafarm SA. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 21st July 2022] https://www.medicines.org.uk/emc/files/pil.11967.pdf

Useful Diagnostic Tests

• Polysomnography