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Introduction About LCIN INFUSION
LCIN INFUSION contains Levofloxacin, which belongs to the group of medicines called Antibiotics. LCIN INFUSION is used to manage infections of the lungs (including ventilator-associated pneumonia), urinary tract (including kidney and bladder), prostate gland, skin, and soft tissue (including muscles) in affected individuals.
It is also used to reduce the chances of getting anthrax (pulmonary disease) or worsening of the disease after getting exposed to anthrax-causing bacteria.
LCIN INFUSION is not recommended for use in patients allergic to levofloxacin and/or other quinolone antibiotics (such as moxifloxacin, ciprofloxacin, and ofloxacin). It is also not recommended for use in patients suffering from epilepsy (seizure) and/or tendinitis (inflammation/irritation of the tendon).
Before receiving LCIN INFUSION, inform your doctor if you have/had brain damage (due to stroke/other brain injury), diabetes, myasthenia gravis (long-term neuromuscular junction disease), aneurysm (a condition that occurs due to bulge/enlargement of large blood vessels), organ transplantation, mental health problems, heart problems (such as very slow heart rhythm, weak heart, myocardial infarction), kidney problems, and/or liver problems.
LCIN INFUSION is not recommended for use during pregnancy or in women planning for pregnancy. It is also not recommended for use in breastfeeding women.
LCIN INFUSION is not recommended for use in children and adolescents (aged below 18 years). The medicine can be used with caution in elderly patients (aged above 60 years) after consulting the doctor.
The most common side effects after receiving LCIN INFUSION are sleeping problems, headache, dizziness, nausea, vomiting, diarrhea, and/or reactions at the site of injection. Consult your doctor if any of these symptoms worsen.
Uses Of LCIN INFUSION
- Manage infections of the lungs (including ventilator-associated pneumonia), urinary tract (including kidney and bladder), prostate gland, skin, and soft tissue (including muscles) in affected individuals.
- Reduces the risk of getting anthrax (pulmonary disease) or worsening of the disease after getting exposed to anthrax-causing bacteria
How LCIN INFUSION Works
LCIN INFUSION works by inhibiting DNA gyrase (an enzyme responsible for DNA synthesis) in bacteria, which results in the destruction of bacterial cell structure, thus managing the occurrence of bacterial infection in affected individuals.
How to use LCIN INFUSION
LCIN INFUSION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the exact dose and duration of management for you depending upon your age, body weight, and disease condition.
Side Effects Of LCIN INFUSION
Common
- sleeping problems, headache
- dizziness, nausea, vomiting, diarrhea
- reactions at injection site, inflammation of vein
Uncommon
- candidiasis (a fungal infection)
- anxiety, confusion, nervousness, sleepiness, trembling, and spinning sensation
- shortness of breath
- altered taste, loss of appetite, stomach upset, indigestion, stomach-ache, flatulence, constipation
- itching, skin rash, red itchy welts, hyperhidrosis (increased sweating)
- joint and muscle pain
- general weakness
Rare
- bruising and bleeding due to low blood platelet count
- signs of hypersensitivity reaction (immune-mediated reaction) such as skin rash, red itchy welts, fever, swelling, and/or shortness of breath
- signs of low blood sugar such as shakiness, sweating, headache, hunger, and/or nausea
- tingling sensation in hands and feet
- hearing impairment (tinnitus), blurred vision
- fever, racing heartbeat, low blood pressure, muscle weakness
- interstitial nephritis (allergic kidney reaction associated with altered kidney function and occasional kidney failure)
- sharply demarcated, erythematous patches with/without blisters
- memory impairment
Stop receiving LCIN INFUSION and consult your doctor immediately in case you experience:
- signs of allergic reaction such as rash, swallowing/breathing problems, swelling of lips/face/throat/tongue
- signs of severe bowel problems such as watery diarrhea, stomach cramps, fever
- pain/inflammation of tendons/ligaments
- fits
- change in psychotic reactions such as hallucinations, paranoia
- feeling depressed, mental problems, agitation, abnormal dreams/nightmares
- serious disturbance in mental abilities causing confused thinking and reduced awareness of the environment
- signs of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) such as widespread rash, high fever, liver enzyme elevations, white blood cell abnormalities, and/or enlarged lymph nodes
- signs of SIADH (syndrome associated with impaired water excretion and low levels of sodium) such as nausea, vomiting, cramps, and/or irritability
- lowered blood sugar levels leading to coma (especially in diabetic patients)
- signs of neuropathy (nerve damage) such as burning, tingling, pain, and/or numbness
- serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (associated with signs such as reddish macules/circular patches with central blisters on the trunk, skin peeling, ulcers of the mouth/throat/nose/genitals/eyes preceded by fever and flu-like symptoms)
- signs of liver problems such as loss of appetite, skin and eyes becoming yellow in colour, dark-coloured urine, itching, and/or abdomen
- suicidal thoughts/actions
- impaired eyesight/other eye disturbances
- signs of aortic aneurysm (a large bulge in the aortic artery) and dissection (a tear in the inner layer of the aortic artery), such as sudden, severe pain in your abdomen, chest, or back
- rapid onset of shortness of breath (especially when you lie down flat in your bed), swelling of ankles, feet, and abdomen, and/or new onset of heart palpitations
How To Manage Side Effects
Diarrhea
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult your doctor if diarrhea gets worse.
Dizziness Or Drowsiness
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult your doctor if the dizziness worsens.
Headache
If LCIN INFUSION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking LCIN INFUSION. If it lasts more than a week or is severe, inform your doctor.
Nausea And Vomiting
Receive LCIN INFUSION with or just after a meal. Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks, and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor if the nausea and vomiting worsen.
Warning & Precautions
Pregnancy
ContraindicatedLCIN INFUSION is not recommended for use during pregnancy or in women planning for pregnancy. Consult your doctor before taking LCIN INFUSION.
Breastfeeding
ContraindicatedLCIN INFUSION is not recommended for use in breastfeeding women. Consult your doctor before taking LCIN INFUSION.
Driving and Using Machines
Use with CautionDo not drive or operate machines if you feel dizzy, sleepy, spinning sensation, and/or changes in eyesight after receiving LCIN INFUSION.
Kidney
Use with CautionLCIN INFUSION should be used with caution in patients with kidney problems such as impaired renal function. Consult your doctor before receiving the medicine.
Liver
Use with CautionLCIN INFUSION should be used with caution in patients with liver problems. Consult your doctor before receiving the medicine.
Allergy
ContraindicatedDo not receive LCIN INFUSION if you are allergic to levofloxacin, other quinolone antibiotics (such as moxifloxacin, ciprofloxacin, or ofloxacin), and/or any other ingredients of this medicine.
Heart Disease
Use with CautionLCIN INFUSION should be used with caution in patients with heart problems such as prolonged QT interval, very slow heart rhythm, weak heart, myocardial infarction, heart valve regurgitation, aortic aneurysm/dissection, endocarditis, and congenital heart valve disease. Consult your doctor before receiving the medicine.
Use In Pediatrics
ContraindicatedLCIN INFUSION is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before receiving the medicine.
Use In Geriatrics
Use with CautionLCIN INFUSION should be taken with caution in elderly patients (aged above 60 years). Consult your doctor before receiving the medicine.
Others
LCIN INFUSION is not recommended for use if you:
- have/ever had epilepsy (seizure)
- have/ever had tendinitis (inflammation/irritation of tendon) after management with quinolone antibiotics
Before receiving LCIN INFUSION, inform your doctor if you:
- have had damage to your brain due to a stroke or other brain injury
- are suffering from glucose-6-phosphate dehydrogenase deficiency (a genetic disorder of red blood cells)
- have ever had mental health problems
- are diabetic
- suffer from myasthenia gravis (long-term neuromuscular junction disease)
- have a history of aneurysm (bulge or enlargement of a large blood vessel)
- suffer from connective tissue disorders such as Marfan syndrome, vascular Ehlers-Danlos syndrome, Turner syndrome, and Sjogren’s syndrome
- suffer from vascular disorders such as Takayasu arteritis, giant cell arteritis, Behçet´s disease, high blood pressure or known atherosclerosis, rheumatoid arthritis
- have ever developed a severe skin rash/peeling, blistering, and/or mouth sores after taking the medicine
- have a salt imbalance in the blood
- are suffering from peripheral neuropathy (a type of nerve problem)
- have received an organ transplant
Interactions
A. Drug-Drug interactions:
Before receiving LCIN INFUSION, inform your doctor if you are receiving any of the following medicine:
- corticosteroids (medicines used to reduce inflammation and suppress the immune system) Ex. cortisone, hydrocortisone
- other quinolone antibiotics (medicines used to manage bacterial infections) Ex. moxifloxacin, ciprofloxacin, or ofloxacin
- vitamin K antagonists (medicines used to thin blood) Ex. warfarin
- theophylline (used for breathing problems)
- non-steroidal anti-inflammatory drugs (medicines used for pain and inflammation) Ex. aspirin, ibuprofen, fenbufen, ketoprofen, indomethacin
- ciclosporin (used to manage rejection of transplanted organs)
- antiarrhythmics (medicine used for abnormal heart rhythm) Ex. quinidine, hydroquinidine, disopyramide, sotalol, dofetilide, ibutilide, amiodarone
- tricyclic antidepressants (medicines used to manage depression) Ex. amitriptyline, imipramine
- antipsychotics (medicines used to manage bipolar disorder and schizophrenia) Ex. olanzapine, risperidone, clozapine
- erythromycin, clarithromycin, azithromycin (medicines used to manage bacterial infections)
- probenecid (a medicine used for management of gout)
- cimetidine (used for ulcers and heartburn)
Overdosage:
LCIN INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of overdose are seizures, confusion, dizziness, being less conscious, tremors, and/or heart problems (associated with signs such as uneven heartbeats and nausea).
Synopsis
| Drug | : | Levofloxacin |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections and reduce the risk of anthrax occurrence |
| Dosage Forms | : | Tablet, Syrup, Oral Suspension, Oral Solution, Injection, Infusion, Eye Drops, Ear Drops |
More Information
Storage
- Keep LCIN INFUSION out of reach of children
- Do not Store LCIN INFUSION above 25°C
FAQs About LCIN INFUSION
Q: What is LCIN INFUSION used for?
A: LCIN INFUSION is used to manage infections of the lungs (including ventilator-associated pneumonia), urinary tract (including kidney and bladder), prostate gland, skin, and soft tissue (including muscles) in affected individuals. It is also used to reduce the chances of getting anthrax (pulmonary disease) or worsening of the disease after getting exposed to anthrax-causing bacteria.
Q: What are the side effects of LCIN INFUSION?
A: The most common side effects after receiving LCIN INFUSION are sleeping problems, headache, dizziness, nausea, vomiting, diarrhea, and/or reactions at the site of injection. Consult your doctor if any of these symptoms worsen.
Q: What happens if you receive more LCIN INFUSION than the required dose?
A: LCIN INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of overdose are seizures, confusion, dizziness, being less conscious, tremors, and/or heart problems (associated with signs such as uneven heartbeats and nausea).
Q: How LCIN INFUSION works?
A: LCIN INFUSION works by inhibiting DNA gyrase (an enzyme responsible for DNA synthesis) in bacteria, which results in the destruction of bacterial cell structure, thus managing the occurrence of bacterial infection in affected individuals.
Q: How will LCIN INFUSION be administered?
A: LCIN INFUSION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the exact dose and duration of management for you depending upon your age, body weight, and disease condition.
Q: Is LCIN INFUSION safe for kidneys?
A: LCIN INFUSION should be used with caution in patients with kidney problems such as impaired renal function. Consult your doctor before receiving the medicine.
Q: Who should not use LCIN INFUSION?
A: LCIN INFUSION is not recommended for use if you have/ever had epilepsy (seizure), tendinitis (inflammation/irritation of tendon) after management with quinolone antibiotics, or if you are allergic to levofloxacin or other quinolone antibiotics (such as moxifloxacin, ciprofloxacin, or ofloxacin).
Q: Can LCIN INFUSION be used during pregnancy?
A: LCIN INFUSION is not recommended for use during pregnancy or in women planning for pregnancy. Consult your doctor before taking LCIN INFUSION.
Q: Is LCIN INFUSION safe for kids?
A: LCIN INFUSION is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before receiving the medicine.
Q: Can LCIN INFUSION manage UTIs?
A: Yes, LCIN INFUSION is used to manage infections of the urinary tract (including the kidney and bladder) and other infections in affected individuals. Consult your doctor for advice.
References
1. KD Tripathi. Sulfonamides, Cotrimoxazole, and Quinolones. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 713.
2. Vivek Podder, Nazia M. Sadiq. Levofloxacin. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. September 2022. [Accessed on 8th August 2024] https://www.ncbi.nlm.nih.gov/books/NBK545180/
3. Maco Productions SAS Rue Lorthois. Health Products Regulatory Authority (HPRA). [Revised in April 2016] [Accessed on 8th August 2024] https://www.hpra.ie/img/uploaded/swedocuments/PIL-2177692-26052016093632-635998521932940000.pdf
4. Medimark Biotech. VELOXIN. [Accessed on 8th August 2024] http://www.medimarkbiotech.com/products/anti-biotic-injectable/
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Culture & Sensitivity, Blood
- Liver Function Test (LFT)
- Kidney Function Test (KFT)
- Serum Electrolytes/ Electrolytes Profile
- Full Body Health Checkup Advanced
- Healthy Midlife Checkup
- Full Body Checkup - Gold
- Full Body Checkup – Silver
Author Details
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
