INTRODUCTION

LARIAGO contains Chloroquine which belongs to a group of medicines called antimalarials and amebicides. It manages uncomplicated malaria caused by susceptible strains of P. falciparum, P.malariae, P. ovale and P.vivax, prophylaxis of malaria and extraintestinal amebiasis. Chloroquine phosphate is an antimalarial and amebicidal medicine. It does not prevent relapses in patients with vivax or ovale malaria because it is not effective against exoerythrocytic forms of the parasites.

Before taking LARIAGO inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. Your doctor will prescribe the right dose depends on your child’s age and body weight. The common side effects are nausea, diarrhea, headache, rash, itching and hair loss.

USES OF LARIAGO

• Manages Malaria and Extraintestinal amebiasis

HOW LARIAGO WORKS

Chloroquine acts by killing the organisms which causes malaria and amebiasis.

DIRECTIONS FOR USE

Always take LARIAGO as instructed by your doctor. Swallow the medicine whole and do not crush or chew. Do not exceed the recommended dose.

SIDE EFFECTS OF LARIAGO

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink plenty of fluids and ORS can be used to prevent dehydration.

Stomach pain:

Place a warm water bottle on your abdomen. Soak in a warm bath and drink plenty of clear fluids and water.

Headache:

Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller.

Nausea:

Take normal regular meals and do not eat spicy foods.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking,

• antacids and kaolin
• cimetidine (manages stomach ulcers)
• insulin (manages diabetes)
• arrhythmogenic medicines
• ampicillin
• cyclosporine
• mefloquine
• praziquantel
• tamoxifen

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT LARIAGO

Can I stop taking LARIAGO when my symptoms are relieved?

No, do not stop taking and complete the full course of management even if you feel better.

Can the use of LARIAGO cause diarrhea?

Yes. It may cause diarrhea, if you are experiencing severe diarrhea, consult your doctor for advice.

Is LARIAGO effective?

Yes, it is effective if used in the prescribed dose and frequency as instructed by your physician.

REFERENCES

1. KD Tripathi MD. Antimicrobial drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 786.

2. Vinetz JM, Clain J, Bounkeua V, et al. Chemotherapy of Malaria. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1402-405.

3. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 630.

4. PJ. Antiprotozoal Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 901-904.

5. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 248-249.

6. Rosa Elena Mejia Torres, Engels Ilich Banegas, Meisy Mendoza, Cesar Diaz, Sandra Tamara Mancero Bucheli, Gustavo A. Fontecha, Md Tauqeer Alam, Ira Goldman, Venkatachalam Udhayakumar, and Jose Orlinder Nicolas Zambrano. Efficacy of Chloroquine for the Management of Uncomplicated Plasmodium falciparum Malaria in Honduras. May 01, 2013; [Accessed on June 10, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752747/

7. Sanofi-aventis U.S. LLC. U.S. Food & Drug Administration. [Revised on 2017] [Accessed on June 10, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/006002s044lbl.pdf

8. Bayshore Pharmaceuticals LLC. [Revised on April 2020] [Accessed on June 10, 2021] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4543d87b-6a1a-4e08-9cdd-33b4909c2c21

9. West­ward Pharmaceutical Corp. U.S. Food & Drug Administration. [Revised on Oct 2009] [Accessed on June 10, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/083082s050lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Malarial Falciparum & Vivax Antigen
• Malaria Parasite Identification
• Peripheral Smear Examination
• Peripheral Smear for Malaria