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LARIAGO SUSPENSION contains Chloroquine which belongs to a group of medicines called antimalarials. It is used to manage, prevent and suppress malaria and acts on the malarial parasite in the blood stream. Chloroquine phosphate is in a class of drugs called antimalarials which works by killing the organisms that cause malaria. The mechanism of chloroquine is to inhibit the formation of hemozoin (Hz) from the heme released by the digestion of hemoglobin (Hb). This free heme then lyses membranes and leads to parasite death.
Before taking LARIAGO SUSPENSION inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. Your physician will give the right dose depends on your child’s age and body weight. The common side effects are diarrhea, headache, rash, itching and hair loss.
USES OF LARIAGO SUSPENSION
- Manages Malaria
HOW LARIAGO SUSPENSION WORKS
Chloroquine acts on the malarial parasite in the blood stream which kills the parasite and stops the infection from spreading.
DIRECTIONS FOR USE
Always take LARIAGO SUSPENSION as instructed by your doctor. Shake well before use. Do not exceed the recommended dose.
SIDE EFFECTS OF LARIAGO SUSPENSION
SERIOUS
- red and lumpy skin rash
- swollen eyelids, face, lips, mouth and tongue
- breathing difficulty or swallowing
- fits (convulsions)
COMMON
- feeling sick or being sick
- diarrhoea
- headache
- tingling, burning, sensitive skin, muscle weakness, cramps and balance problems
- hair loss
- darkening of the nails and mucus membranes
- unable to sleep (insomnia)
- blurred vision
- depression
RARE
- loss of eyesight (long term)
- anxious or confusion
- yellow colour of the skin or eyes (jaundice)
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink plenty of fluids and ORS can be used to prevent dehydration.
Headache:
Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller.
Feeling sick or Being sick:
Take normal regular meals and do not eat spicy foods.
WARNING & PRECAUTIONS
PREGNANCY
LARIAGO SUSPENSION should be used with caution in pregnant women only if clearly needed. Consult your doctor for advice.
BREASTFEEDING
LARIAGO SUSPENSION should be used with caution during breastfeeding. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or handle any machines while taking this medicine, since it may cause blurred or double vision.
KIDNEY
LARIAGO SUSPENSION should be used with caution in patients with active kidney diseases. Consult your doctor for advice.
LIVER
LARIAGO SUSPENSION should be used with caution in patients with active liver diseases. Consult your doctor for advice.
ALLERGY
Tell your physician if you are allergic (hypersensitive) to Chloroquine.
HEART DISEASE
LARIAGO SUSPENSION should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your physician, if you have or had,
- blood disorders (porphyria)
- epilepsy or diseases of the nervous system
- psoriasis
- severe disease of the digestive system
- favism
INTERACTIONS
Tell your doctor if you are taking,
- amiodarone (used to control heart rate)
- praziquantel (manages infections of the bowel and bladder caused by parasites)
- ciclosporin (used by transplant patients)
- anti-convulsant medicines (manages epilepsy)
- digoxin (used to manage heart problems)
- moxifloxacin and droperidol
- mefloquine (manages malaria)
- ciprofloxacin (manages infection)
- cimetidine, omeprazole (manages excess stomach acid)
- pyrimethamine (manages protozoal infections)
- kaolin (used for diarrhoea)
- antacid medicines (manages indigestion)
SYNOPSIS
| Drug | : | Chloroquine |
| Pharmacological Category | : | Antimalarials and Amebicides |
| Therapeutic Indication | : | Manages Malaria |
| Dosage Forms | : | Tablet, Injection, Oral suspension |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT LARIAGO SUSPENSION
Can I stop taking LARIAGO SUSPENSION when my symptoms are relieved?
No, do not stop taking and complete the full course of management even if you feel better.
Can the use of LARIAGO SUSPENSION cause diarrhea?
Yes. It may cause diarrhea, if you are experiencing severe diarrhea, consult your doctor for advice.
Is LARIAGO SUSPENSION effective?
Yes, it is effective if used in the prescribed dose and frequency as instructed by your physician.
REFERENCES
1. KD Tripathi MD. Antimicrobial drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 786.
2. Vinetz JM, Clain J, Bounkeua V, et al. Chemotherapy of Malaria. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1402-1405.
3. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 630.
4. PJ. Antiprotozoal Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 901-904.
5. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 248-249.
6. H. Van Doorne, N. F. Wieringa, E. H. Bosch & R. De Meijer. The suitability of some preservatives in chloroquine phosphate syrup. Aug, 1988. [Accessed on June 12, 2021] https://link.springer.com/article/10.1007/BF01959426
7. Wallace Manufacturing Chemists Ltd., Laleham Health and Beauty Ltd. [Revised on Sep, 2015] [Accessed on June 12, 2021] https://www.medicines.org.uk/emc/files/pil.2306.pdf
USEFUL DIAGNOSTIC TESTS
- Malarial Falciparum & Vivax Antigen
- Malaria Parasite Identification
- Peripheral Smear Examination
- Peripheral Smear for Malaria
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
