INTRODUCTION

LARIAGO contains Chloroquine which belongs to a group of medicines called antimalarials and amebicides. It manages malaria, amebiasis and other conditions which act by preventing the growth of parasites in the red blood cells. Chloroquine phosphate is an antimalarial and amebicidal medicine. It does not prevent relapses in patients with vivax or ovale malaria because it is not effective against exoerythrocytic forms of the parasites.

Before receiving LARIAGO inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. Your doctor will administer the right dose depends on your child’s age and body weight. The common side effects are vomiting, weakness, stomach pain, diarrhea, loss of appetite and nausea.

USES OF LARIAGO

• Manages Malaria and amebiasis

HOW LARIAGO WORKS

Chloroquine acts by killing the organisms which causes malaria and amebiasis. It works by preventing the growth of parasites in the red blood cells.

DIRECTIONS FOR USE

LARIAGO will be administered by your physician or nurse. Your doctor will administer the right dose depending on your condition.

SIDE EFFECTS OF LARIAGO

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink plenty of fluids and ORS can be used to prevent dehydration.

Stomach pain:

Place a warm water bottle on your abdomen. Soak in a warm bath and drink plenty of clear fluids and water.

Headache:

Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller.

Nausea:

Take normal regular meals and do not eat spicy foods.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, sweet foods.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking, or have recently taken any other medicines, including medicines obtained without a prescription or vitamins and herbal supplements.

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT LARIAGO

Can LARIAGO be used during breastfeeding?

It should be used with caution during breastfeeding. Consult your doctor for advice.

Does LARIAGO cause nausea?

It may cause nausea in some individuals, if this persists for a long time then consult your doctor for advice.

Is LARIAGO safe?

Yes, it is safe if prescribed by your physician. However, tell your doctor if you have any liver, kidney or heart diseases.

REFERENCES

1. KD Tripathi MD. Antimicrobial drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 786.

2. Vinetz JM, Clain J, Bounkeua V, et al. Chemotherapy of Malaria. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page: 1402-1405.

3. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 630.

4. PJ. Antiprotozoal Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 901-904.

5. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 248-249.

6. Rosa Elena Mejia Torres, Engels Ilich Banegas, Meisy Mendoza, Cesar Diaz, Sandra Tamara Mancero Bucheli, Gustavo A. Fontecha, Md Tauqeer Alam, Ira Goldman, Venkatachalam Udhayakumar, and Jose Orlinder Nicolas Zambrano. Efficacy of Chloroquine for the Management of Uncomplicated Plasmodium falciparum Malaria in Honduras. May 01, 2013; [Accessed on June 10, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752747/

7. L. A. Salako, A. F. Aderounmu, and O. Walker. Influence of route of administration on the pharmacokinetics of chloroquine and desethylchloroquine. 1987. [Accessed on June 10, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490847/

USEFUL DIAGNOSTIC TESTS

• Malarial Falciparum & Vivax Antigen
• Malaria Parasite Identification
• Peripheral Smear Examination
• Peripheral Smear for Malaria