Introduction About LACOTIDE SYRUP

LACOTIDE SYRUP contains Lacosamide which belongs to the group of medicines called Antiepileptics. It is used to manage a certain type of epilepsy characterised by the occurrence of partial onset seizure with or without secondary generalisation.

In this type of epilepsy, fits first affect only one side of your brain. However, these may then spread to larger areas on both sides of your brain. It may be used on its own or with other antiepileptic medicines.

Epilepsy is a neurological disorder of the central nervous system in which the brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.

Before taking LACOTIDE SYRUP, inform your doctor if you have or ever had a certain type of heartbeat problem called second or third-degree AV block.

LACOTIDE SYRUP is not recommended to use among women who are pregnant or breastfeeding. Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking.

The most common side effects of taking LACOTIDE SYRUP are headache, feeling dizzy or sick, nausea and double vision. Contact your doctor if any of the above symptoms worsen.

Uses Of LACOTIDE SYRUP

• Used as an adjunctive management of partial onset seizures in patients above 17 years of age

How LACOTIDE SYRUP Works

LACOTIDE SYRUP works slowly by inactivating the sodium gated channels, which decreases the abnormal and excessive activity of the nerve cells in the brain and controls seizures or fits.

How to use LACOTIDE SYRUP

Take LACOTIDE SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of LACOTIDE SYRUP

How To Manage Side Effects

Nausea or Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.

Diarrhea:

Drink a lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Constipation:

Eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly.

Warning & Precautions

Pregnancy

LACOTIDE SYRUP is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.

Breastfeeding

LACOTIDE SYRUP is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking it.

Driving and Using Machines

Do not drive or operate any machines if you feel dizzy or blurred vision after taking LACOTIDE SYRUP.

Alcohol

Avoid consumption of alcohol while taking LACOTIDE SYRUP. Consult your doctor for advice.

Kidney

LACOTIDE SYRUP should be used with caution in patients with kidney problems. Consult your doctor before taking it.

Liver

LACOTIDE SYRUP should be used with caution in patients with liver problems. Consult your doctor before taking it.

Allergy

Do not take LACOTIDE SYRUP if you are allergic to Lacosamide or any of the other ingredients of the medicine.

Heart Disease

LACOTIDE SYRUP is not recommended for use in patients with second or third-degree AV block and LACOTIDE SYRUP should be used with caution in patients with heart disease like AV block, atrial fibrillation, atrial flutter, heart failure, heart attack. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking LACOTIDE SYRUP, inform your doctor if you are taking any of the following medicine:

• medicines used to manage heart problems
• medicines used to manage epilepsy or pain (Ex. carbamazepine, lamotrigine or pregabalin)
• medicines used for fungal infections (Ex. fluconazole, itraconazole or ketoconazole)
• medicine used to manage HIV (Ex. ritonavir)
• medicines used to manage bacterial infections (Ex. clarithromycin or rifampicin)
• herbal medicine used to manage mild anxiety and depression (Ex. St. John’s wort)

Overdosage:

If you or anyone else accidentally takes too much of LACOTIDE SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea, vomiting, fits (seizures), heartbeat problems such as a slow, fast or irregular heartbeat or a fall in blood pressure with rapid heartbeat and sweating.

Synopsis

More Information

• Keep LACOTIDE SYRUP out of reach of children
• Store at a temperature not exceeding 30°C

FAQs About LACOTIDE SYRUP

What are the symptoms of overdose of LACOTIDE SYRUP?

Symptoms of overdose of LACOTIDE SYRUP are dizziness, nausea, vomiting, fits (seizures), heartbeat problems such as a slow, fast or irregular heartbeat. Consult your doctor immediately if you experience these unusual reactions.

How to take LACOTIDE SYRUP?

Take LACOTIDE SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Is it safe to use LACOTIDE SYRUP in patients with kidney problems?

LACOTIDE SYRUP should be used with caution in patients with kidney problems. Consult your doctor before taking it.

How do LACOTIDE SYRUP work?

LACOTIDE SYRUP works slowly by inactivating the sodium gated channels, which decreases the abnormal and excessive activity of the nerve cells in the brain and controls seizures or fits.

Is it safe to take LACOTIDE SYRUP during pregnancy?

LACOTIDE SYRUP is generally not recommended to use in pregnant women unless clearly considered necessary. Consult your doctor before taking it.

What are the common side effects of LACOTIDE SYRUP?

The common side effects of LACOTIDE SYRUP are headache, feeling dizzy or sick (nausea) and double vision (diplopia). Consult your doctor for advice.

References

1. Misty D. Smith, Cameron S. Metcalf and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 303-326.

2. Liyan Hou, Bingjie Peng, Defu Zhang, Jingjing Yang, Ying Wang, Li Tong, Sheng Li, Qingshan Wang1 and Jie Zhao. Clinical Efficacy and Safety of Lacosamide as an Adjunctive Treatment in Adults With Refractory Epilepsy. Frontiers in neurology. December 2021. [Accessed on 21st May] https://www.frontiersin.org/articles/10.3389/fneur.2021.712717/full

3. Jon Allard, William Henley, Brendan Mclean, Sunil Ram, Manny Bagary, Rohit Shankar. Lacosamide in the general population and in people with intellectual disability: Similar responses? European Journal of Epilepsy. March 2020. [Accessed on 21st May] https://www.seizure-journal.com/article/S1059-1311(20)30054-6/fulltext

4. G. L. Krauss. Lacosamide for the treatment of epilepsy. Taylor and Francis online. June 2011. [Accessed on 21st May] https://www.tandfonline.com/doi/full/10.3109/07853890.2011.603700

5. Torrent pharmaceutical LTD. [Revised in April 2021] [Accessed on 21st May] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2867.pdf