Introduction About KOMBIGLYZE XR 5/500MG TABLET

KOMBIGLYZE XR 5/500MG TABLET is a combination of Metformin and Saxagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to manage type II diabetes mellitus when diet, exercise and management with other conventional medicines does not result in adequate sugar control. It is used as an adjunct therapy along with proper diet and exercise to achieve better results.    

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.

Take KOMBIGLYZE XR 5/500MG TABLET preferably with meals. During therapy with KOMBIGLYZE XR 5/500MG TABLET, your doctor might regularly monitor your blood sugar levels and kidney function to avoid the risk of unwanted side effects.  

Before taking KOMBIGLYZE XR 5/500MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have problems in blood circulation or are severely dehydrated due to excessive vomiting or diarrhea recently.

KOMBIGLYZE XR 5/500MG TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with alcoholism and in patients with severe systemic infections.

Do not take KOMBIGLYZE XR 5/500MG TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking KOMBIGLYZE XR 5/500MG TABLET are nausea, diarrhea, stomach pain, constipation, loss of appetite and metallic taste. Consult your doctor if any of these side effects trouble you.

Uses Of KOMBIGLYZE XR 5/500MG TABLET

• Manage type II diabetes mellitus

How KOMBIGLYZE XR 5/500MG TABLET Works

KOMBIGLYZE XR 5/500MG TABLET is an antidiabetic medicine. It contains two medicines namely metformin and Saxagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduces its absoprtion in the body.

Saxagliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, KOMBIGLYZE XR 5/500MG TABLET controls blood sugar levels and improve glycemic control in patients with type II diabetes.

How to use KOMBIGLYZE XR 5/500MG TABLET

Take KOMBIGLYZE XR 5/500MG TABLET preferably with or after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking KOMBIGLYZE XR 5/500MG TABLET unless your doctor advice you to stop.

Side Effects Of KOMBIGLYZE XR 5/500MG TABLET

How To Manage Side Effects

Constipation

Taking KOMBIGLYZE XR 5/500MG TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Nausea And Vomiting

Take KOMBIGLYZE XR 5/500MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your condition worsens.

Warning & Precautions

Pregnancy

Contraindicated

KOMBIGLYZE XR 5/500MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

KOMBIGLYZE XR 5/500MG TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

KOMBIGLYZE XR 5/500MG TABLET has no influence on your ability to drive or handle heavy tools or machines. However, do not drive or operate any machines if your ability is affected by KOMBIGLYZE XR 5/500MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking KOMBIGLYZE XR 5/500MG TABLET as it may increase the risk of unwanted side effects.

Kidney

Contraindicated

KOMBIGLYZE XR 5/500MG TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.

Liver

Contraindicated

KOMBIGLYZE XR 5/500MG TABLET is not recommended for use in patients with liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take KOMBIGLYZE XR 5/500MG TABLET if you are allergic to Metformin or Saxagliptin.

Heart Disease

Contraindicated

KOMBIGLYZE XR 5/500MG TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure, recent heart attack, arrythmia, prolonged QT interval). Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

KOMBIGLYZE XR 5/500MG TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

KOMBIGLYZE XR 5/500MG TABLET should be used with caution among the elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking KOMBIGLYZE XR 5/500MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to manage diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
• medicines used to manage asthma (Ex. salbutamol or terbutaline)
• corticosteroids (used to manage pain and inflammation) Ex. hydrocortisone, prednisolone
• diuretics (used to reduce edema and to manage hypertension) Ex. furosemide, hydrochlorothiazide
• medicines used to manage pain and inflammation (such as ibuprofen and celecoxib)
• medicines used to manage high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
• cimetidine (a medicine used to manage stomach ulcer)
• diltiazem, verapamil (medicines used to manage heart problems)
• rifampicin (a medicine used to manage tuberculosis)
• ketoconazole (a medicine used to manage fungal infections)
• medicines used to control epilepsy (such as carbamazepine, phenytoin, phenobarbital)

Overdosage:

If you or anyone else accidentally took more KOMBIGLYZE XR 5/500MG TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep KOMBIGLYZE XR 5/500MG TABLET out of the sight and reach of children
• Store KOMBIGLYZE XR 5/500MG TABLET below 30°C

FAQs About KOMBIGLYZE XR 5/500MG TABLET

Q: What is KOMBIGLYZE XR 5/500MG TABLET used for?

A: KOMBIGLYZE XR 5/500MG TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with Type II diabetes mellitus.

Q: How and when to take KOMBIGLYZE XR 5/500MG TABLET?  

A: Take KOMBIGLYZE XR 5/500MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take KOMBIGLYZE XR 5/500MG TABLET?

A: You need to take KOMBIGLYZE XR 5/500MG TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take KOMBIGLYZE XR 5/500MG TABLET?

A: KOMBIGLYZE XR 5/500MG TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of KOMBIGLYZE XR 5/500MG TABLET?

A: If you forgot to take a dose of KOMBIGLYZE XR 5/500MG TABLET, take it as soon as you remember. However, if it is time for the next dose of KOMBIGLYZE XR 5/500MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of KOMBIGLYZE XR 5/500MG TABLET to compensate the missed ones.

Q: What are the most common side effects of taking KOMBIGLYZE XR 5/500MG TABLET?

A: The most common side effects of taking KOMBIGLYZE XR 5/500MG TABLET are nausea, diarrhea, stomach pain, constipation, loss of appetite and metallic taste. Consult your doctor if any of these side effects trouble you.

Q: Can I stop taking KOMBIGLYZE XR 5/500MG TABLET without consulting your doctor?

A: No. You should not stop taking KOMBIGLYZE XR 5/500MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using KOMBIGLYZE XR 5/500MG TABLET, consult your doctor for advice.

Q: Will taking a higher dose of KOMBIGLYZE XR 5/500MG TABLET be more effective?

A: No, taking a higher dose of KOMBIGLYZE XR 5/500MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking KOMBIGLYZE XR 5/500MG TABLET?

A: Before taking KOMBIGLYZE XR 5/500MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Do not take KOMBIGLYZE XR 5/500MG TABLET without consulting your doctor if you are pregnant or breastfeeding.

Q: Can I take medication for high blood pressure along with KOMBIGLYZE XR 5/500MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking KOMBIGLYZE XR 5/500MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with KOMBIGLYZE XR 5/500MG TABLET as they have known interactions with KOMBIGLYZE XR 5/500MG TABLET.

Q: Can KOMBIGLYZE XR 5/500MG TABLET be taken with insulin?

A: Co-administration of KOMBIGLYZE XR 5/500MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.

Q: Can KOMBIGLYZE XR 5/500MG TABLET be used in pregnant women?

A: KOMBIGLYZE XR 5/500MG TABLET should not be used in pregnant women unless recommended by the physician. Therefore, consult your doctor for advice.

Q: How to take KOMBIGLYZE XR 5/500MG TABLET?

A: You must take KOMBIGLYZE XR 5/500MG TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

Q: How much KOMBIGLYZE XR 5/500MG TABLET should I take?

A: KOMBIGLYZE XR 5/500MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Q: Can KOMBIGLYZE XR 5/500MG TABLET cause constipation?

A: KOMBIGLYZE XR 5/500MG TABLET may cause constipation in some individuals. To manage this side effect, eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly. Contact your doctor if this side effect bothers you.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.

2. Molly G. Minze, Mary S. Klein, and Brian T. Terrell. Saxagliptin and Metformin in Fixed Combination for the Treatment of Type 2 Diabetes in Adults. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2013. [Accessed on 20th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284079/

3. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 20th December 2022] https://www.medicines.org.uk/emc/files/pil.7608.pdf

4. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 20th December 2022] https://www.medicines.org.uk/emc/files/pil.11951.pdf

5. Central Drugs Standard Control Organization. Metformin (ER )1000mg/500mg +Saxagliptin 2.5 mg/5mg Tablets. September 2011. [Accessed on 20th December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf

Useful Diagnostic Tests

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 18 Oct 2023 | 05:05 PM(IST)