Introduction About ISONORM SR 30MG TABLET

ISONORM SR 30MG TABLET contains Isosorbide Mononitrate which belongs to the group of medicines called Nitrate vasodilators. It is used to manage chronic angina pectoris and it is not recommended for use in sudden or acute angina. Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone.        

ISONORM SR 30MG TABLET is not recommended for use in patients suffering from lung disease that result in low levels of oxygen in the body (hypoxemia) or cardiac conditions such as low blood volume, low blood pressure, and thickened cardiac muscles (cardiac myopathy) or shock (vascular collapse). Before taking ISONORM SR 30MG TABLET, inform your doctor if you have a history of liver or kidney diseases, glaucoma, thyroid problems, or if you suffer from low body temperature.      

Your doctor may advise you to follow lifestyle changes such as diet changes (taking foods low in fat, salt or sugar) and do regular mild exercises to achieve better results during management with this medicine. It is not recommended for use in children and should be used with caution in elderly patients.  

ISONORM SR 30MG TABLET should be used with caution in pregnant and breast-feeding women, so consult your doctor before taking it. The common side effects of taking ISONORM SR 30MG TABLET are headache, tiredness, dizziness, nausea, decreased blood pressure (hypotension) and rapid heartbeat (palpitations). Consult your doctor if any of the above side effects worsen.

Uses Of ISONORM SR 30MG TABLET

• Manage Angina Pectoris (chest pain)

How ISONORM SR 30MG TABLET Works

ISONORM SR 30MG TABLET helps to relax the blood vessels and muscles of the heart, which causes the space inside the blood vessels to widen. This helps to ease the flow of blood in the blood vessels of the heart and provides relief from the pain associated with blockage of vessels as seen in angina.

How to use ISONORM SR 30MG TABLET

Take ISONORM SR 30MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ISONORM SR 30MG TABLET for you depending upon your age, body weight and disease condition.

Side Effects Of ISONORM SR 30MG TABLET

How To Manage Side Effects

Dizziness Or Drowsiness

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets worse.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Take ISONORM SR 30MG TABLET with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Tiredness

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise (mild walking) and follow regular sleep schedule. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Monitoring required

ISONORM SR 30MG TABLET should be used with caution in pregnant women and who are planning for pregnancy unless considered clearly considered necessary. Consult your doctor before taking ISONORM SR 30MG TABLET.  

Breastfeeding

Use with Caution

ISONORM SR 30MG TABLET should be used with caution in breast-feeding women due to lack of safety data. Consult your doctor before taking ISONORM SR 30MG TABLET.  

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking ISONORM SR 30MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ISONORM SR 30MG TABLET because it might increase the risk of dizziness and sometimes fainting also.

Kidney

Contraindicated

ISONORM SR 30MG TABLET is not recommended for use if you had or have or suspect of having disorders of the kidney. Consult your doctor before taking ISONORM SR 30MG TABLET.

Liver

Contraindicated

ISONORM SR 30MG TABLET is not recommended for use if you had or have or suspect of having disorders of the liver. Consult your doctor before taking ISONORM SR 30MG TABLET.

Allergy

Contraindicated

Do not take ISONORM SR 30MG TABLET if you are allergic to isosorbide mononitrate or other nitrates (such as isosorbide dinitrate).

Lungs

Contraindicated

ISONORM SR 30MG TABLET is not recommended for use in patients having lung disease resulting in low levels of oxygen in the body (hypoxaemia). Consult your doctor before taking it.

Heart Disease

Contraindicated

ISONORM SR 30MG TABLET is not recommended for use in patients with sudden anginal attack, low blood volume, low blood pressure, thickened cardiac muscles (cardiac myopathy), hardened heart valves (stenosis), compression of the heart due to fluid around it (cardiac tamponade) and vascular collapse (shock). Consult your doctor before taking ISONORM SR 30MG TABLET.

Use In Pediatrics

Contraindicated

ISONORM SR 30MG TABLET is not recommended for use in children. Consult child’s doctor for advice.

Use In Geriatrics

Use with Caution

ISONORM SR 30MG TABLET should be used with caution in elderly patients. Your doctor may adjust the dose of ISONORM SR 30MG TABLET due to increased risk of side effects in elderly individuals. Consult your doctor before taking it

Interactions

A. Drug-Drug Interactions

Before taking ISONORM SR 30MG TABLET, inform your doctor if you are taking any of the following medicines:

• medicines used to manage male impotency (Ex. sildenafil, tadalafil)
• medicines to manage high blood pressure such as calcium channel blockers (Ex. verapamil)

Overdosage:
If you or anyone else accidentally take too much of ISONORM SR 30MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are pulsating/throbbing headache, reddening of the skin along with an increase in the temperature, blurred vision, rapid drop in blood pressure and fainting.

Synopsis

More Information

• Keep ISONORM SR 30MG TABLET out of reach of children.
• Store at room temperature  

FAQs About ISONORM SR 30MG TABLET

Q: What is ISONORM SR 30MG TABLET used for?

A: ISONORM SR 30MG TABLET is used to manage chronic angina pectoris (chest pain) and it is not recommended for use in sudden or acute angina. Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone.      

Q: Can ISONORM SR 30MG TABLET be used in elderly patients?

A: Yes, ISONORM SR 30MG TABLET should be used with caution in elderly patients. Your doctor may adjust the dose of ISONORM SR 30MG TABLET due to increased risk of side effects in elderly individuals. Consult your doctor before taking it

Q: Is ISONORM SR 30MG TABLET safe to use during pregnancy?

A: ISONORM SR 30MG TABLET should be used with caution in pregnant women and who are planning for pregnancy unless considered clearly considered necessary. Consult your doctor before taking ISONORM SR 30MG TABLET if you are pregnant or planning to get pregnant

Q: Can ISONORM SR 30MG TABLET be used in patients with heart disease?

A: ISONORM SR 30MG TABLET is not recommended for use in patients with sudden anginal attack, low blood volume, low blood pressure, thickened cardiac muscles (cardiac myopathy), hardened heart valves (stenosis), compression of the heart due to fluid around it (cardiac tamponade) and vascular collapse (shock). Consult your doctor before taking ISONORM SR 30MG TABLET.

Q: What are the common side effects of ISONORM SR 30MG TABLET?

A: The common side effects of taking ISONORM SR 30MG TABLET are headache, tiredness, dizziness, nausea, decreased blood pressure (hypotension) and rapid heartbeat (palpitations). Consult your doctor if any of the side effect worsen or bothers you.

References

1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page 539-588

2. Gunasekara, N.S. and Noble, S., 1999. Isosorbide 5-Mononitrate, Drugs. [Revised in October 2012] [Accessed on 20th July 2022] https://link.springer.com/article/10.2165/00003495-199957020-00016

3. Walker, J.M., Curry, P.V.L., Bailey, A.E. and Steare, S.E., 1996. A comparison of nifedipine once daily (Adalat LA), isosorbide mononitrate once daily, and isosorbide dinitrate twice daily in patients with chronic stable angina. International journal of cardiology. [Accessed on 20th July 2022] https://www.sciencedirect.com/science/article/abs/pii/0167527395025316

4. Kremers Urban Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised in July 2014] [Accessed on 20th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/075155Orig1s034lbl.pdf

5. McDermott Laboratories Limited trading as Gerard Laboratories. Health Products Regulatory Authority (HPRA). [Accessed on 20th July 2022] https://www.hpra.ie/img/uploaded/swedocuments/eaf73f71-5d63-415f-be5e-d37e58d92ccf.pdf

Useful Diagnostic Tests

• Electrocardiogram (ECG)
• Chest x-ray
• Chest CT
• Coronary CT angiography
• Cardiac MRI
• Coronary angiography
• Echocardiogram

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 04 Mar 2023 | 06:25 PM(IST)