Introduction About INMETH SUPPOSITORIES

INMETH SUPPOSITORIES contains Indomethacin which belongs to the group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAID). It is used to relieve pain caused by certain conditions like moderate to severe rheumatoid arthritis (inflammatory disorder affecting many joints, including hands and feet characterised by painful swelling), ankylosing spondylitis (pain and stiffness in backbone).

It also manages osteoarthritis (pain and swelling of joints), shoulder pain (bursitis and/or tendinitis), acute gouty arthritis (a form of arthritis characterised by severe pain, redness and tenderness in joints.)

Avoid alcohol consumption while using INMETH SUPPOSITORIES as it may increase the risk of ulcer and bleeding in the stomach. INMETH SUPPOSITORIES is not recommended for use in patients before or after heart bypass surgery, having a history of proctitis (anal inflammation), recent rectal bleeding or asthma. INMETH SUPPOSITORIES should be used with caution in patients with kidney, liver, heart failure problems, depression or other psychiatric disturbances, epilepsy, parkinsonism, high blood pressure, history of peptic ulcer disease and/or GI bleeding.

INMETH SUPPOSITORIES is not recommended for use in the 3rd trimester of pregnancy, safety data in the first two trimester has not been established yet. INMETH SUPPOSITORIES should be used with caution if you are breast-feeding. It is not suitable for use in children below 14years of age and should be used with caution in elderly patients. The most common side effect of this medicine is a mild headache. Contact your doctor if the symptom does not improve.

Uses Of INMETH SUPPOSITORIES

It is used to reduce pain caused by conditions such as:

• moderate to severe rheumatoid arthritis including acute flares of chronic disease
• moderate to severe ankylosing spondylitis and osteoarthritis
• shoulder pain (bursitis and/or tendinitis)
• acute gouty arthritis (severe pain, redness, and tenderness in joints)

How INMETH SUPPOSITORIES Works

INMETH SUPPOSITORIES works by managing the function of enzyme cyclooxygenase-1 and 2 which leads to the stopping of prostaglandins synthesis (chemical substances responsible for pain & inflammation) that results in reduced inflammatory reactions and relief from pain.

How to use INMETH SUPPOSITORIES

Always use INMETH SUPPOSITORIES as directed by your physician. It is for rectal use only and is not to be taken orally or through the vagina. Push the suppository into the rectum with your finger.

Lie down for a few minutes and avoid having a bowel movement for at least an hour. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Side Effects Of INMETH SUPPOSITORIES

How To Manage Side Effects

Headache:

Apply a hot or cold-water bag on your head. Try to rest in a quiet and dark room. Drink tea or coffee. Massage on the scalp or head with mild pressure. Consult your doctor for advice.

Warning & Precautions

Pregnancy

INMETH SUPPOSITORIES is not recommended for use in the 3rd trimester of pregnancy as it increases the risk of premature closure of the foetal ductus arteriosus.

Safety data in the first two trimesters has not been established yet. Consult your doctor for advice before using.

Breastfeeding

INMETH SUPPOSITORIES should be used with caution if you are breast-feeding as it may pass through the breast milk. Benefit and risk ratio will be assessed by your doctor. Consult your doctor for advice.

Driving and Using Machines

Do not drive or operate any machines while using INMETH SUPPOSITORIES as it may cause drowsiness, dizziness, lightheaded or less alert. Consult your doctor before using INMETH SUPPOSITORIES.

Alcohol

Avoid consumption of alcohol while using INMETH SUPPOSITORIES as it may increase the risk of ulcers and bleeding in the stomach.

Kidney

INMETH SUPPOSITORIES should be used with caution in patients having kidney problems. Consult your doctor for advice.

Liver

INMETH SUPPOSITORIES should be used with caution in patients having liver problems. Consult your doctor for advice.

Allergy

Do not use INMETH SUPPOSITORIES if you are allergic to Indomethacin or other similar NSAIDs (aspirin, ibuprofen) or any other ingredients of this medicine.

Lungs

INMETH SUPPOSITORIES is not recommended for use in patients with asthma. Consult your doctor for advice.

Heart Disease

INMETH SUPPOSITORIES is not recommended for use in patients before and after heart bypass surgery.

It should be used with caution in patients with high blood pressure or heart failure. Consult your doctor for advice.

Interactions

A. Drug - Drug interactions:

Before using INMETH SUPPOSITORIES, inform your doctor if you are taking any of the following medicines:

• medicines used for blood thinning (Ex. warfarin)
• antiplatelet agents (Ex. aspirin)
• pemetrexed, methotrexate (to manage cancer)
• other non-steroidal anti-inflammatory drugs (such as aspirin, or diflunisal)
• medicines used to manage high blood pressure such as beta blockers (Ex. atenolol), ACE inhibitors (Ex. lisinopril), angiotensin II receptor antagonists (Ex. valsartan), hydralazine or nifedipine, cardiac glycosides (used to manage heart failure) Ex. digoxin
• medicines used to manage depression, such as selective serotonin reuptake inhibitors (Ex. fluoxetine)
• lithium (medicine used to manage some mental health problems)
• medicines used to increase urine output (Ex. furosemide, triamterene)
• cyclosporin (medicine used to manage graft rejection after transplant)
• probenecid (a medicine used to manage gout)

Overdosage:

If you or anyone else accidentally uses too much of INMETH SUPPOSITORIES, consult your doctor immediately or visit the nearby hospital. Signs and symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and stomach pain.

Synopsis

More Information

• Keep out of reach of children
• Store in a dry place below 30°C

FAQs About INMETH SUPPOSITORIES

What is INMETH SUPPOSITORIES used for?

It is used to relieve pain caused by certain conditions like rheumatoid arthritis, ankylosing spondylitis (pain and stiffness in backbone), osteoarthritis (pain and swelling of joints), shoulder pain.

How to use INMETH SUPPOSITORIES?

Always use this medicine as directed by your physician. It is for rectal use only and not to be taken orally or through vagina. Push the suppository into the rectum with your finger. Lie down for a few minutes and avoid having a bowel movement for at least an hour. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

Can INMETH SUPPOSITORIES be used during pregnancy?

INMETH SUPPOSITORIES is not recommended for use in the 3rd trimester of pregnancy as it increases the risk of premature closure of the foetal ductus arteriosus. Safety data in the first two trimesters has not been established yet. Consult your doctor for advice before using.

How does INMETH SUPPOSITORIES work?

INMETH SUPPOSITORIES works by managing the function of enzyme cyclooxygenase-1 and 2 which leads to the stopping of prostaglandins synthesis (chemical substances responsible for pain & inflammation) that results in reduced inflammatory reactions and relief from pain.

Can INMETH SUPPOSITORIES cause dizziness?

Yes, do not drive or operate any machines while taking INMETH SUPPOSITORIES as it may cause drowsiness, dizziness, tiredness, or vision problems. Consult your doctor before taking INMETH SUPPOSITORIES.

References

1. KD. Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Eighth edition. 2013. Page – 219-220.

2. Akul Munjal; Abdallah E. Allam. Indomethacin. National Library of Medicine, National center for biotechnology information. Star Pearls. September 2022. [Accessed on 15th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK555936/

3. L. P. J. Holt and C. F. Hawkins. Indomethacin: Studies of Absorption and of the Use of Indomethacin Suppositories. National Library of Medicine, National center for biotechnology information. Pubmed central. May 1965. [Accessed on 15th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2165800/

4. Iroko Pharmaceuticals, LLC. U.S. Food & Drug Administration. [Revised in May 2016] [Accessed on 15th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/017814s041s042lbl.pdf

5. Indomethacin (rectal). Mayoclinic. [Revised in November 2021] [Accessed on 15th June 2022] https://www.mayoclinic.org/drugs-supplements/indomethacin-rectal-route/side-effects/drg-20069803?p=1#:~:text=Some%20possible%20warning%20signs%20of,gain%2C%20vomiting%20of%20blood%20or