Inlyta 1mg Tablet 14'S
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Introduction About INLYTA 1MG TABLET
INLYTA 1MG TABLET contains Axitinib which belongs to the group of medicines called Kinase inhibitors. It manages advanced kidney tumour in adults, when another medicine (called sunitinib or a cytokine) is no longer stopping disease from progressing.
INLYTA 1MG TABLET works by reducing the blood supply to the cancer cells and slows down the growth of cancer. Avoid consumption of grapefruit during treatment with INLYTA 1MG TABLET.
Before taking INLYTA 1MG TABLET, inform your doctor if you have high blood pressure, have had a recent problem with blood clots in your veins and arteries including stroke, heart attack, embolism, or thrombosis, thyroid gland problems, bleeding problems, aneurysm, liver problem or have an operation or an unhealed wound.
INLYTA 1MG TABLET is generally not recommended for use in pregnant or breastfeeding women and in children (aged below 18 years) unless advised by the doctor.
The most common side effects of taking INLYTA 1MG TABLETare diarrhoea, nausea or vomiting, stomach ache, indigestion, soreness of the mouth, tongue or throat, and constipation. Consult your doctor if any of the side effects worsen.
Uses Of INLYTA 1MG TABLET
- It manages advanced kidney cancer in adults
How INLYTA 1MG TABLET Works
INLYTA 1MG TABLET targets and inhibits specific enzymes (kinases) involved in the formation of new blood vessels (angiogenesis) that cancer cells need to grow. By blocking these enzymes, it helps to starve the cancer of nutrients and slows its progression.
How to use INLYTA 1MG TABLET
Take INLYTA 1MG TABLETas advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of INLYTA 1MG TABLET
Common
- High blood pressure
- Diarrhoea, nausea or vomiting, stomachache, indigestion, soreness of the mouth, tongue or throat, constipation
- Shortness of breath, cough, hoarseness
- Lack of energy, feeling weak or tired
- Redness and swelling of the palms of the hands or soles of the feet (hand-foot syndrome), skin rash, dryness of the skin
- Joint pain, pain in hands or feet
- Loss of appetite
- Weight loss
- Headache, taste disturbance or loss of taste
- Dehydration
- Kidney problems
- Flatulence (wind), haemorrhoids, bleeding from gums, bleeding from the rectum, a burning or stinging sensation in the mouth
- Muscle pain
- Nose bleeding
- Skin itching, redness of the skin, hair loss
- Ringing/sound in the ears (tinnitus)
- Swelling of the abdomen, legs, or ankles, protruding neck veins, excessive tiredness, shortness of breath (signs of heart failure events)
- Fistula
- Dizziness
- Inflammation of the gall bladder
Stop taking INLYTA 1MG TABLETand contact your doctor immediately if you experience any of the following side effects:
- Heart failure events (excessive tiredness, swelling of the abdomen, legs, or ankles, shortness of breath, or protruding neck veins)
- Blood clots in your veins and arteries (types of blood vessels), including stroke, heart attack, embolism, or thrombosis (symptoms such as chest pain or pressure; pain in your arms, back, neck or jaw; shortness of breath; numbness or weakness on one side of your body; trouble talking; headache; vision changes or dizziness.)
- Bleeding (symptoms of black tarry stools, coughing up of blood or bloody sputum, or change in your mental status)
- Hole in the stomach or intestine or formation of fistula
- Severe increase in blood pressure (hypertensive crisis), severe headache, or severe chest pain.
- Reversible swelling of the (symptoms such as headache, confusion, seizures (fits), or changes in vision with or without high blood pressure)
How To Manage Side Effects
Constipation
Eat more fruits, vegetables, whole grains, and legumes. Fiber adds bulk to the stool and helps it move through the digestive tract. Aim for a daily intake of 25-30 grams of fiber.
Diarrhea
Drink plenty of fluids such as water, oral rehydration solutions (ORS), or clear broths to prevent dehydration. Avoid caffeinated, alcoholic, and sugary drinks, as they can worsen dehydration.
Nausea And Vomiting
Try to take INLYTA 1MG TABLETwith or just after a meal or a snack. Stick to simple meals. Avoid eating oily, fried or spicy foods. Consult your doctor if the symptom does not improve.
Skin rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom does not improve.
Stomach Pain
Use a heating pad or a warm water bottle on your abdomen to help relax muscles and reduce pain. Drink clear fluids like water or herbal teas (such as ginger or peppermint) to stay hydrated and soothe your stomach.
Warning & Precautions
Pregnancy
ContraindicatedINLYTA 1MG TABLET is not recommended for use in pregnant women or if you are planning to have a baby as it can harm the unborn child. Use a reliable method of contraception and up to 1 week after the last dose of INLYTA 1MG TABLET, to prevent pregnancy.
Breastfeeding
ContraindicatedINLYTA 1MG TABLET is not recommended for use in breastfeeding. If you are breast-feeding, your doctor should discuss with you whether to discontinue breast-feeding or discontinue INLYTA 1MG TABLET.
Driving and Using Machines
Use with CautionDo not drive or use machines while taking INLYTA 1MG TABLETas you may feel tired or dizziness.
Liver
Use with CautionINLYTA 1MG TABLET should be used with caution in patients with liver problems. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take INLYTA 1MG TABLET if you are allergic to Axitinib.
Heart Disease
Use with CautionINLYTA 1MG TABLET should be used with caution in patients with heart problems (stroke, heart attack, embolism, or thrombosis) and high blood pressure. Consult your doctor before taking INLYTA 1MG TABLET.
Use In Pediatrics
ContraindicatedINLYTA 1MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.
Others
Before taking INLYTA 1MG TABLET, inform your doctor if you:
- have had a recent problem with blood clots
- have thyroid gland problems
- have bleeding problems
- have aneurysm
- have an operation or an unhealed wound
- Are lactose intolerant
Interactions
A. Drug-Drug interactions:
Before taking INLYTA 1MG TABLET, inform your doctor if you are taking any of the following medicines:
- Antifungals (Ex. ketoconazole or itraconazole)
- Antibacterials (Ex. clarithromycin, erythromycin or telithromycin)
- Anti-HIV agents (Ex. atazanavir, indinavir, nelfinavir, ritonavir or saquinavir)
- Antidepressants (Ex. Nefazodone, St. John’s wort)
- Antituberculosis (Ex. rifampicin, rifabutin or rifapentine)
- Steroids (Ex. Dexamethasone)
- Anti-epileptics (Ex. phenytoin, carbamazepine or phenobarbital)
- Antiasthma (Ex. Theophylline)
B. Drug-Food interactions:
Do not take INLYTA 1MG TABLET with grapefruit or grapefruit juice, as it may increase the chance of side effects.
Overdosage:
If you or anyone else accidentally take too much of INLYTA 1MG TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Axitinib |
| Pharmacological Category | : | Kinase inhibitors |
| Therapeutic Indication | : | Advance kidney tumour |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep INLYTA 1MG TABLETout of reach of children
- Store at room temperature
FAQs About INLYTA 1MG TABLET
Q: What is INLYTA 1MG TABLET?
A: INLYTA 1MG TABLET is a targeted therapy drug used primarily to manage advanced renal cell carcinoma (RCC), a type of kidney cancer. It works by inhibiting the growth of blood vessels that supply cancers, thereby slowing down the growth and spread of cancer cells.
Q: How does INLYTA 1MG TABLET work?
A: INLYTA 1MG TABLET is a tyrosine kinase inhibitor (TKI). It targets and inhibits specific enzymes (kinases) involved in the formation of new blood vessels (angiogenesis) that cancer cells need to grow. By blocking these enzymes, it helps to starve the cancer cells for nutrients and slows its progression.
Q: How is INLYTA 1MG TABLET administered?
A: INLYTA 1MG TABLET is usually taken orally in the form of tablets. The dosage and schedule will be determined by your healthcare provider based on your specific condition and response to treatment. It is typically taken twice daily.
Q: What are the common side effects of INLYTA 1MG TABLET?
A: The most common side effects of taking INLYTA 1MG TABLETare diarrhoea, nausea or vomiting, stomach ache, indigestion, soreness of the mouth, tongue or throat, and constipation. Consult your doctor if any of the side effects worsen.
Q: What are the serious side effects?
A: Serious side effects may include severe high blood pressure, heart problems, liver problems. bleeding issues and gastrointestinal perforation.
Q: How should INLYTA 1MG TABLET be taken?
A: Take INLYTA 1MG TABLETas advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q: What should I do if I miss a dose?
A: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up on doses to make up for a missed one. Contact your healthcare provider for specific instructions.
Q: Are there any interactions with other medications?
A: INLYTA 1MG TABLET can interact with other medications, including certain antibiotics, antifungals, and medications used for high blood pressure. Inform your healthcare provider about all the medications, supplements, and herbs you are taking.
Q: Who should not take INLYTA 1MG TABLET?
A: INLYTA 1MG TABLET should not be taken by individuals who are allergic to it or any of its ingredients. Additionally, it may not be suitable for people with certain health conditions, so discuss your medical history with your healthcare provider.
Q: What should I do in case of an emergency?
A: Seek immediate medical help if you experience severe side effects or symptoms such as chest pain, severe headache, vision changes, or signs of bleeding, seek immediate medical attention.
References
1. KD Tripathi MD. Anticancer and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page:195-199.
2.Audrey Bellesoeur, Edith Carton, Jerome Alexandre, Francois Goldwasser, and Olivier Huillard. Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2021. [Accessed on 22nd August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317158/
3.Pfizer Manufacturing Deutschland GmbH. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 22nd August 2024] https://www.medicines.org.uk/emc/product/7948/pil#gref
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