Introduction About ILAWIN DSR CAPSULE

ILAWIN DSR CAPSULE contains Domperidone and Ilaprazole which belongs to the group of medicines called Antiemetics and Proton pump inhibitors respectively. It is used in the management of gastro-esophageal reflux disease (GERD), peptic ulcer (a sore on the lining of your stomach, small intestine or esophagus), nausea and vomiting.

Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the tube connecting mouth and stomach (esophagus). This acid reflux can irritate the lining of esophagus. The symptoms include heartburn, chest pain, difficulty swallowing, sensation of a lump in your throat.

Before taking ILAWIN DSR CAPSULE inform your doctor if you have heart, pituitary gland, kidney, liver problems, HIV/AIDS, bloody stools, blockage of intestine, problems with potassium/magnesium levels in blood. Avoid consumption of alcohol while taking ILAWIN DSR CAPSULE.

Inform your doctor if you are pregnant or planning to have a baby. ILAWIN DSR CAPSULE is not recommended for use in breastfeeding women. It is not recommended for use in children and adolescents below 12 years of age. The most common side effects of taking ILAWIN DSR CAPSULE is dry mouth. Consult your doctor if symptom does not show improvement.

Uses Of ILAWIN DSR CAPSULE

It is used to manage:

• Gastro-Esophageal Reflux Disease (GERD)
• peptic ulcer
• nausea and vomiting

How ILAWIN DSR CAPSULE Works

ILAWIN DSR CAPSULE works by reducing excess stomach acid production and managing the reflux of stomach acid into the food pipe in which Domperidone antagonizes the inhibitory effect of dopamine, resulting in stimulation of gastric muscle contraction which increases the gastric motility. And Ilaprazole works by suppressing gastric acid secretion through inhibition of the enzyme (H+/K+-ATPase) at the secretory surfaces of gastric parietal cells (responsible for gastric acid secretion).

How to use ILAWIN DSR CAPSULE

Take ILAWIN DSR CAPSULE as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.

Side Effects Of ILAWIN DSR CAPSULE

Warning & Precautions

Pregnancy

Consult your doctor

Safety and effectiveness of ILAWIN DSR CAPSULE in pregnant women has not been established yet so consult your doctor before taking it.

Breastfeeding

Contraindicated

ILAWIN DSR CAPSULE is not recommended for use in breastfeeding women as small amount may excreted in the breast milk and can affect the heart of the baby. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

ILAWIN DSR CAPSULE does not affect your ability to drive or use machines. Consult your doctor for advice.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ILAWIN DSR CAPSULE. Consult your doctor for advice.

Kidney

Use with Caution

ILAWIN DSR CAPSULE should be used with caution in patients with liver disease. Dose will be adjusted by your doctor and kidney function will be monitored regularly. Consult your doctor before taking.

Liver

Consult your doctor

ILAWIN DSR CAPSULE is not recommended for use in patients with moderate to severe liver disease. ILAWIN DSR CAPSULE should be used with caution in patients with liver disease. Consult your doctor before taking.

Allergy

Contraindicated

Do not take ILAWIN DSR CAPSULE if you are allergic to Domperidone or Ilaprazole or any other ingredients of this medicine.

Heart Disease

Contraindicated

ILAWIN DSR CAPSULE is not recommended for use in patients with prolonged QT corrected interval and heart failure. Consult your doctor before taking.

Use In Pediatrics

Contraindicated

ILAWIN DSR CAPSULE is not recommended for use in children and adolescents below 12 years of age. Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug interactions:

Before taking ILAWIN DSR CAPSULE, inform your doctor if you are taking any of the following medicines:

• azoles for fungal infections (Ex. ketoconazole, fluconazole or voriconazole)
• medicines used for bacterial infections (Ex. telithromycin, moxifloxacin, pentamidine, erythromycin, clarithromycin)  
• heart problems or high blood pressure (Ex. sotalol, diltiazem, verapamil, amiodarone, dronedarone, quinidine, disopyramide, dofetilide)
• used for psychoses (Ex. haloperidol, pimozide, sertindole)
• used for depression (Ex. citalopram, escitalopram)
• used for gastro-intestinal disorders (Ex. cisapride, dolasetron, prucalopride)
• medicines used for allergy (Ex. mequitazine, mizolastine)
• medicines used for malaria (halofantrine)
• medicines used for AIDS/HIV (protease inhibitors, zidovudine)
• medicine used for cancer (Ex. toremifene, vandetanib, vincamine)
• other medicines (Ex. bepridil, diphemanil, methadone)

Overdosage:

If you or anyone else accidentally took too much of ILAWIN DSR CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sleepy, confused, uncontrolled movements (eye movements, unusual tongue movements or abnormal posture).

Synopsis

More Information

• Keep ILAWIN DSR CAPSULE out of reach of children
• Do not store above 25°C

FAQs About ILAWIN DSR CAPSULE

Q: What is ILAWIN DSR CAPSULE used for?

A: ILAWIN DSR CAPSULE is used in the management of gastro-esophageal reflux disease (GERD), peptic ulcer (a sore on the lining of your stomach, small intestine or esophagus), nausea and vomiting.

Q: Can ILAWIN DSR CAPSULE be used in breastfeeding women?

A: ILAWIN DSR CAPSULE is not recommended for use in breastfeeding women as small amount is excreted in the breast milk and can affect the heart of the baby. Consult your doctor before taking it.

Q: Can ILAWIN DSR CAPSULE be used in children?

A: ILAWIN DSR CAPSULE is not recommended for use in children and adolescents below 12 years of age. Consult your doctor before taking this medicine.

Q: What if I accidentally take more of ILAWIN DSR CAPSULE?

A: If you or anyone else accidentally take too much of ILAWIN DSR CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sleepy, confused, uncontrolled movements (eye movements, unusual tongue movements or abnormal posture).

Q: How does ILAWIN DSR CAPSULE work?

A: ILAWIN DSR CAPSULE works by reducing excess stomach acid production and managing the reflux of stomach acid into the food pipe in which Domperidone antagonizes the inhibitory effect of dopamine, resulting in stimulation of gastric muscle contraction which increases the gastric motility. And Ilaprazole works by suppressing gastric acid secretion through inhibition of the enzyme (H+/K+-ATPase) at the secretory surfaces of gastric parietal cells (responsible for gastric acid secretion).

References

1. KD Tripathi. Antiemetic, Prokinetic and Digestant Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 715-716.

2. T Takahashi, S Kurosawa, J W Wiley, C Owyang. Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs. [Accessed on 20th July 2022] https://pubmed.ncbi.nlm.nih.gov/1860634/#:~:text=The%20DA2%2Dreceptor%20antagonist%20domperidone,the%20gastrokinetic%20effect%20of%20domperidone.

3. Xi-Qing Ji, Jun-Feng Du, Gang Chen, Guang Chen, and Bo Yu. Efficacy of ilaprazole in the treatment of duodenal ulcers: A meta-analysis. [Accessed on 20th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009550/

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 20th July 2022] https://www.medicines.org.uk/emc/files/pil.556.pdf

5. Janssen Pharmaceutica N.V. Health Products Regulatory Authority (HPRA). [Revised in February 2015] [Accessed on 20th July 2022] http://www.hpra.ie/img/uploaded/swedocuments/2155094.PA0823_051_004.28b5f597-4412-4a58-9c10-6e20449d4fd6.000001ProductLeaflet30mg.150312.pdf

6. Livzon. Ilaprazole. [Accessed on 20th July 2022] https://en.livzon.com.cn/product/8.html

7. Ilaprazole. Pubchem. [Revised in July 2022] [Accessed on 20th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Ilaprazole

8. Ilaprazole. NIH. [Accessed on 20th July 2022] https://drugs.ncats.io/drug/776Q6XX45J

9. Domperidone+Ilaprazole. Mayoclinic. [Revised on May 2020] [Accessed on 20th July 2022] https://www.mayoclinic.org/diseases-conditions/gerd/symptoms-causes/syc 20361940#:~:text=Gastroesophageal%20reflux%20disease%20(GERD)%20occurs,reflux%20from%20time%20to%20time.