Introduction About HISTOLIN PLUS SYRUP

HISTOLIN PLUS SYRUP is a combination of Ammonium Chloride, Diphenhydramine, Menthol, and Sodium Citrate which belongs to the group of medicines called Cough and Cold preparations. It is used to relieve allergy indications such as colds, hay fever, sneezing, coughing, itching, watery red eyes, runny and blocked nose.

HISTOLIN PLUS SYRUP is not recommended for use in patients with porphyria, persistent chronic cough (cough occurs with smoking, asthma, emphysema, or when the cough is accompanied by excessive secretions), epilepsy, glaucoma, and difficult urination. HISTOLIN PLUS SYRUP should be used with caution in patients with lung, heart, or liver diseases.

HISTOLIN PLUS SYRUP is not recommended for use among women who are pregnant and breastfeeding unless considered clearly necessary. Contact your doctor before taking. HISTOLIN PLUS SYRUP is not recommended for use in new born or premature infants and in children under 6 years of age. Contact your doctor before taking.

HISTOLIN PLUS SYRUP should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking. The most common side effects of taking HISTOLIN PLUS SYRUP are slight dry mouth, dizziness, headache, nausea, vomiting, and gastrointestinal discomfort. Contact your physician in case of worsening of the above symptoms.

Uses Of HISTOLIN PLUS SYRUP

It is used to relieve allergy symptoms such as:

• cold
• hay fever
• sneezing
• coughing
• itching
• watery red eyes
• runny or blocked nose

How HISTOLIN PLUS SYRUP Works

HISTOLIN PLUS SYRUP helps to manage cough, where Ammonium chloride is an expectorant that works by decreasing the stickiness of airway secretions and helps in their removal from the airways. Diphenhydramine is an antihistaminic that relieves allergy symptoms like watery eyes, sneezing, and a runny nose. Menthol is a demulcent and soothing agent that helps to give the sensation of breathing easier and reduces cough by acting on the cold receptors present in the nose and throat. Sodium Citrate belongs to Mucolytic, thins and loosens phlegm in the nose, trachea and lungs helps to make coughing easier.

How to use HISTOLIN PLUS SYRUP

Take HISTOLIN PLUS SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Side Effects Of HISTOLIN PLUS SYRUP

How To Manage Side Effects

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid operating any machines or driving while you are feeling dizzy. Do not consume alcohol, as it increases dizziness. Contact your doctor if dizziness or drowsiness did not improve.

Nausea And Vomiting

Take this medicine with, or just after food. Eat simple meals and avoid oily or spicy foods. Contact your doctor if the nausea or vomiting did not improve.

Warning & Precautions

Pregnancy

Monitoring required

HISTOLIN PLUS SYRUP is not recommended for use in pregnancy unless considered clearly necessary. Contact your doctor before taking.

Breastfeeding

Use with Caution

HISTOLIN PLUS SYRUP should be used with caution in breastfeeding women as it is not known whether it may pass through breast milk. Contact your doctor before taking.

Driving and Using Machines

Use with Caution

Do not drive or operate machines if you feel drowsiness after taking HISTOLIN PLUS SYRUP.

Alcohol

Contraindicated

Avoid alcohol consumption while taking HISTOLIN PLUS SYRUP as it may lead to unwanted effects.

Liver

Use with Caution

HISTOLIN PLUS SYRUP should be used with caution in patients with liver dysfunction. Contact your doctor before taking.

Allergy

Contraindicated

Do not use HISTOLIN PLUS SYRUP if you are allergic to Ammonium Chloride, Diphenhydramine, Menthol, Sodium Citrate, or any other ingredients of the medicine.

Lungs

Use with Caution

HISTOLIN PLUS SYRUP should be used with caution in patients with lung diseases. Contact your doctor before taking.

Heart Disease

Use with Caution

HISTOLIN PLUS SYRUP should be used with caution in patients with heart rhythm problems. Contact your doctor before taking.

Use In Pediatrics

Consult your doctor

HISTOLIN PLUS SYRUP is not recommended to use in new born and premature infants and in children below 6 years of age and it should be used with caution in children above 6 years of age. Contact your doctor before taking.

Use In Geriatrics

Use with Caution

HISTOLIN PLUS SYRUP should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.

Interactions

A. Drug-Drug interactions:

Before taking HISTOLIN PLUS SYRUP, inform your physician if you are taking any of the following medicine:

• monoamine oxidase (MAO) inhibitors Ex. estazolam, zolpidem (medicines used as sedatives and hypnotics)
• diazepam, alprazolam (medicines used as tranquilizers)
• ephedrine (medicine used to manage nasal congestion, diabetic swelling, and other conditions)

Overdosage:

If you or anyone else accidentally takes too much of HISTOLIN PLUS SYRUP, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep HISTOLIN PLUS SYRUP out of the sight and reach of children
• Store HISTOLIN PLUS SYRUP below 25°C

FAQs About HISTOLIN PLUS SYRUP

Q: For what conditions HISTOLIN PLUS SYRUP is used?

A: HISTOLIN PLUS SYRUP used to relieve allergy symptoms such as colds, hay fever, sneezing, coughing, itching, watery red eyes, and runny or blocked nose.

Q: Can I use HISTOLIN PLUS SYRUP in children?

A: HISTOLIN PLUS SYRUP is not recommended to use in new born and premature infants and in children below 6 years of age and it should be used with caution in children above 6 years of age. Contact your doctor before taking.

Q: Does HISTOLIN PLUS SYRUP cause dizziness?

A: Yes. HISTOLIN PLUS SYRUP may cause dizziness. Avoid operating any machines or driving while you are feeling dizzy. Do not consume alcohol, as it increases dizziness. Contact your doctor if the dizziness did not improve.

Q: Is it safe to use HISTOLIN PLUS SYRUP in pregnant and breastfeeding women?

A; HISTOLIN PLUS SYRUP is not recommended for use among women who are pregnant and breastfeeding unless considered clearly necessary. Contact your doctor before taking.

Q: When to seek medical emergency?

A: Stop taking HISTOLIN PLUS SYRUP and contact your physician immediately if you experience spontaneous bruising or bleeding (which may be signs of a blood disorder) and accidentally take too much of HISTOLIN PLUS SYRUP.

References

1. K.D. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 218, 220, 221.

2. Peter V. Dicpinigaitis, Sean Dhar, Amber Johnson, Yvonne Gayle, John Brew, and Wilson Caparros-Wanderley. Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection. International Journal of Clinical Pharmacy. February 2015. [Accessed on 22nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409637/

3. Wellona Pharma. Family cough medicines. [Accessed on 22nd August 2022] https://wellonapharma.com/product/finished/diphenhydramine-ammonium-chloride-sodium-citrate-and-menthol-syrup

4. DM Pharma. Darcet Syrup. [Accessed on 22nd August 2022] http://dmpharma.co.in/DARCET%20Syrup.html

5. MIMS. Sunex syrup. [Accessed on 22nd August 2022] https://www.mims.com/malaysia/drug/info/sunex?type=full

6. Dailymed.com. Silphen syrup. [Revised in August 2020] [Accessed on 22nd August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d18e22f2-8cda-4862-b437-e83648a5108a

7. Laleham Health and Beauty Limited. Unicough Oral Solution. [Revised in September 2015] [Accessed on 22nd August 2022] https://www.boots.com/wcsstore/ExtendedSitesCatalogAssetStore/Product_PatientLeaflets/A00000545-10210894.P-10210894_-_Unicough_-_PIL.pdf

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 15 Feb 2023 | 04:28 PM(IST)