Gonablok 50mg Capsule 10'S
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Introduction About GONABLOK 50MG CAPSULE
GONABLOK 50MG CAPSULE contains Danazol which belongs to the group of medicines called Androgens. It is used to manage endometriosis, severe cyclical mastalgia (breast pain associated with hormonal variations), breast cysts, dysfunctional uterine bleeding (bleeding from vagina other than that of menstrual cycle), symptomatic gynecomastia, preoperative thinning of endometrium and hereditary angioneurotic edema (painless swelling under the skin).
Endometriosis is defined as an illness where some of the tissues that line the womb are found elsewhere in the body. Gynecomastia refers to an increase in the amount of breast gland tissue in males, due to an imbalance of hormones estrogen and testosterone.
Prior to the management, your doctor may want you to take several blood tests to understand your existing condition.
Avoid consumption of alcohol during management with GONABLOK 50MG CAPSULE, as it may cause nausea or breathlessness.
Before taking GONABLOK 50MG CAPSULE, inform your doctor if you have hormonal cancer, blood clots, heart, liver or kidney problems or porphyria.
GONABLOK 50MG CAPSULE is not recommended for use among pregnant or breastfeeding women, therefore consult your doctor before taking it.
Safety and effectiveness of GONABLOK 50MG CAPSULE in paediatric and elderly patients have not been established.
The most common side effects of taking GONABLOK 50MG CAPSULE are weight gain, bloating, nausea, vomiting, lethargy and headache. Consult your doctor if any of the side effects worsen.
Uses Of GONABLOK 50MG CAPSULE
Manage:
- endometriosis
- severe cyclical mastalgia
- breast cysts
- dysfunctional uterine bleeding
- symptomatic gynecomastia
- preoperative thinning of endometrium
- hereditary angioneurotic edema
How GONABLOK 50MG CAPSULE Works
GONABLOK 50MG CAPSULE works by suppressing the secretion of gonadotropins (a group hormones that stimulate the activity of the gonads) in both men and women, leading to inhibition of testicular/ovarian function. In addition, it suppresses gonadal function directly by inhibiting the enzymes involved in steroid hormone synthesis.
How to use GONABLOK 50MG CAPSULE
Take GONABLOK 50MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking GONABLOK 50MG CAPSULE unless your doctor advice you to stop.
Side Effects Of GONABLOK 50MG CAPSULE
Common
- weight gain
- bloating
- nausea, vomiting
- gastroenteritis
- joint pain, muscle spasm
- lethargy
- headache
- depression
Rare
Stop taking GONABLOK 50MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction (rash, difficulty swallowing or breathing, swelling of your lips, face, throat or tongue)
- signs of heart attack (pain or tightness in the chest, jaw or arm)
- severe headache and vomiting
- clitoris becomes larger
- blurred vision, problems with eyesight, difficulty wearing contact lenses
- liver problems that may cause the eyes or skin to go yellow (jaundice)
- pain in the liver or liver failure may cause a swollen abdomen, mental disorientation and confusion
- pain when moving arms or legs (this may be due to a blood clot)
- feeling weak together with numb arms or legs which you may not be able to move (stroke)
- bruising more easily, getting more infections than usual (signs of a blood problem)
How To Manage Side Effects
Headache:
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Nausea:
Take GONABLOK 50MG CAPSULE with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptom does not improve.
Vomiting:
Get adequate rest. Drink sufficient amount of fluids, especially water. Have small sips if you feel sick. Eat when you feel hungry. Do not take any medicine for vomiting without asking your doctor. Consult your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
GONABLOK 50MG CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
GONABLOK 50MG CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
GONABLOK 50MG CAPSULE has no or negligible influence on the ability to drive and use machines.
Alcohol
Avoid consumption of alcohol while taking GONABLOK 50MG CAPSULE as it can cause nausea or breathlessness.
Kidney
GONABLOK 50MG CAPSULE is not recommended for use in patients with impaired kidney function. Consult your doctor before taking GONABLOK 50MG CAPSULE.
Liver
GONABLOK 50MG CAPSULE is not recommended for use in patients with impaired liver function. Consult your doctor before taking GONABLOK 50MG CAPSULE.
Allergy
Do not take GONABLOK 50MG CAPSULE if you are allergic to Danazol or any other ingredients of this medicine.
Heart Disease
GONABLOK 50MG CAPSULE is not recommended for use in patients with impaired heart function. It should be used with caution in patients with high blood pressure or heart disease. Consult your doctor before taking GONABLOK 50MG CAPSULE.
Others
GONABLOK 50MG CAPSULE is not recommended for use if you:
- ever had blood clots (thrombosis)
- have porphyria (a rare inherited illness which affects your metabolism)
- have a type of cancer which is influenced by hormones
- have unusual vaginal bleeding which is unchecked by a doctor
Before taking GONABLOK 50MG CAPSULE, inform your doctor if you:
- have an illness which could be worsened by fluid retention
- have diabetes (high blood sugar levels)
- have epilepsy (fits)
- have polycythaemia (an illness in which the blood gets thicker)
- get migraines
- have cancer or possible breast cancer
- are about to have any procedure
Use in paediatrics:
Safety and effectiveness of GONABLOK 50MG CAPSULE in children has not been established.
Use in geriatrics:
Safety and effectiveness of GONABLOK 50MG CAPSULE in elderly patients (aged above 65 years) has not been established.
Interactions
A. Drug-Drug interactions:
Before taking GONABLOK 50MG CAPSULE, inform your doctor if you are taking any of the following medicines:
- steroids (used in oral contraception and hormone replacement therapy) Ex. testosterone, estrogen, progesterone
- medicines used to lower blood cholesterol levels (Ex. simvastatin, atorvastatin)
- medicines used to manage fits (Ex. phenytoin, carbamazepine)
- medicines used to thin the blood (Ex. warfarin, clopidogrel)
- anaesthetics (used to manage pain during procedures) Ex. midazolam, propofol
- medicines used to stop the rejection of organs after a transplant (Ex. ciclosporin and tacrolimus)
- alpha calcidol (used for vitamin D deficiency and illness where there is lack of calcium in the blood)
- medicines used to lower blood sugar levels (Ex. metformin, glyburide)
- medicines used to manage high blood pressure (Ex. atenolol, diltiazem)
- medicines used to manage migraine (Ex. sumatriptan, rizatriptan)
Overdosage:
If you or anyone else accidentally take too much of GONABLOK 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Danazol |
| Pharmacological Category | : | Androgens |
| Therapeutic Indication | : | Hormonal issues |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep GONABLOK 50MG CAPSULE out of reach of children
- Store at room temperature
FAQs About GONABLOK 50MG CAPSULE
Can I become pregnant while taking GONABLOK 50MG CAPSULE?
It is important that you do not become pregnant while taking GONABLOK 50MG CAPSULE. Start taking the medicine on the first day of your period and use reliable contraception (such as an intra uterine device or barrier method in conjunction with contraceptive foam or jelly). The contraceptive pill should not be used until your management with GONABLOK 50MG CAPSULE is finished.
What if I forget to take a dose of GONABLOK 50MG CAPSULE?
If you forget to take a dose of GONABLOK 50MG CAPSULE, take it as soon as you remember and then continue your management as usual. Do not take the medicine twice to make up for the forgotten dose.
Can I stop taking GONABLOK 50MG CAPSULE on my own?
Do not stop taking GONABLOK 50MG CAPSULE just because you feel better. Keep taking the medicine until your doctor tells you to do so. If you stop taking it randomly on your own, your illness may get worse.
Does GONABLOK 50MG CAPSULE cause weight gain?
Yes, GONABLOK 50MG CAPSULE causes androgenic side effects like weight gain. Consult your doctor in case of any concerns. Do not take any other medicine without informing your doctor.
Does GONABLOK 50MG CAPSULE cause menopause?
GONABLOK 50MG CAPSULE is an androgen and can thus exert the adverse effects of androgens too, but since it inhibits Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) secretion, it can also elicit menopausal-like symptoms. Consult your doctor for advice.
Should I be concerned if I am about to take any test while taking GONABLOK 50MG CAPSULE?
If you are going to have any blood test, it is important to tell your doctor you are taking GONABLOK 50MG CAPSULE. Taking GONABLOK 50MG CAPSULE may affect the results of some blood tests like testosterone levels, liver and thyroid function, fats, sugars and protein levels in your blood. Your doctor may take regular blood tests to check your liver function and your blood levels.
References
1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 301.
2. J.K. Aronson. Danazol. Medical Pharmacology and Therapeutics (Fifth Edition). ScienceDirect. 2016. [Accessed on 3rd May 2022] https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/danazol#:~:text=Danazol%20is%20a%20weak%20androgen,also%20elicit%20menopausal%2Dlike%20symptoms.
3. Assistance Publique - Hopitaux de Paris. Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy (ANDROTELO). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in October 2018] [Accessed on 3rd May 2022] https://clinicaltrials.gov/ct2/show/NCT03710356
4. Cipla Ltd. Danogen Capsules (Danazol). Ciplamed. [Revised in June 2021] [Accessed on 3rd May 2022] https://www.ciplamed.com/content/danogen-capsule
5. Ros Wood. Danazol. Endometriosis.org. [Accessed on 3rd May 2022] https://endometriosis.org/treatments/danazol/
Useful Diagnostic Tests
- Pelvic exam
- Ultrasound
- Magnetic resonance imaging (MRI)
- Mammography
Author Details
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
