Introduction About GLYCIPHAGE SR 500MG TABLET

Glyciphage SR 500mg Tablet is a popular medication used to help manage blood sugar levels in individuals with type 2 diabetes. It contains Metformin and is designed to release slowly, providing long-lasting effects. The SR (Sustained Release) formulation ensures consistent control over glucose levels throughout the day.

Glyciphage SR 500mg Tablet is best taken with food to reduce the risk of nausea and abdominal discomfort. For optimal results, take it consistently at the same time each day. Do not stop taking the medication unless advised by your doctor. Managing diabetes also heavily depends on your lifestyle, so it is crucial to follow the diet and exercise plan your doctor has prescribed while using this medication.

The most common side effects of this medicine include nausea, diarrhea, stomach upset, vomiting, flatulence, weakness, indigestion, headache, loss of appetite, changes in taste and metallic taste. Taking this medication alongside other antidiabetic drugs, alcohol, or skipping a meal may cause some people to experience hypoglycemia (low blood sugar levels). It is important to monitor your blood sugar levels regularly while taking this medication.

Before taking this medicine, inform your doctor if you have any kidney or liver or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function tests before starting management with it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects.

Uses Of GLYCIPHAGE SR 500MG TABLET

• Type 2 diabetes mellitus

Benefits of GLYCIPHAGE SR 500MG TABLET

1. Helps control blood sugar levels in Type 2 diabetes: It is primarily used to manage and regulate blood sugar in individuals with Type 2 diabetes, helping to keep glucose levels in check.
2. Contains Metformin as the active ingredient: The active ingredient, metformin, is a well-known medication that works by decreasing glucose production in the liver and improving insulin sensitivity.
3. Sustained release formula for long-lasting effects: The sustained release (SR) formulation ensures that the medication is released gradually over time, providing long-lasting effects throughout the day, which helps maintain stable blood sugar levels.
4. 500mg dosage per tablet: Each tablet contains 500mg of Metformin, making it suitable for individuals needing moderate blood sugar control.
5. Improves insulin sensitivity: By improving how the body responds to insulin, Glyciphage SR helps reduce insulin resistance, which is crucial for controlling Type 2 diabetes.
6. Reduces the risk of heart complications related to diabetes: It has been shown to help reduce the risk of heart-related issues in individuals with Type 2 diabetes, as diabetes increases the chance of cardiovascular complications.

How GLYCIPHAGE SR 500MG TABLET Works

Decreases Glucose Production in the Liver: Metformin works by reducing the amount of glucose produced by the liver. In type 2 diabetes, the liver often produces too much glucose, even when it is not needed. By reducing this production, Glyciphage SR helps keep blood sugar levels from rising too high.

Improves Insulin Sensitivity: Metformin helps the body's cells become more sensitive to insulin, which is the hormone that helps cells absorb glucose from the bloodstream. When insulin is more effective, it can lower blood sugar levels more efficiently.

Reduces Absorption of Sugar in the Intestines: Metformin also decreases the absorption of glucose from food in the intestines, meaning less sugar enters the bloodstream after eating.

These actions help lower blood sugar and improve insulin sensitivity, especially in individuals with type 2 diabetes.

How to use GLYCIPHAGE SR 500MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

How to Take Glyciphage SR 500mg?

• Typically, take once or twice daily with food to reduce gastrointestinal side effects such as nausea or upset stomach.
• Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
• Do not exceed 2 tablets per day unless specifically advised by your doctor.
• For best results, take the tablet at the same time each day.

Dosage recommendation for Adults and Children:

For Adults:

• Initial Dose: Typically, the starting dose is 500 mg once daily, taken with the evening meal to reduce gastrointestinal side effects.
• Increase Dose: If needed, the dose may be increased in increments of 500 mg weekly based on blood sugar levels and tolerance.
• Maximum Dose: The maximum recommended dose is generally 2000-2500 mg/day, divided into 2-3 doses, depending on the individual’s needs and physician’s advice.

For Children (age 10 and older):

• The typical starting dose for children (10 years and older) is 500 mg once a day.
• The dose can be gradually increased, depending on the child’s blood sugar levels and tolerability.
• Maximum Dose: For children, the maximum dose is usually 2000 mg per day, divided into 2-3 doses.

What if I forgot to take GLYCIPHAGE SR 500MG TABLET

• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose, do not double up to make up for a missed one.
• Set a reminder: To avoid forgetting doses, consider setting an alarm on your phone or using a medication reminder app.

Side Effects Of GLYCIPHAGE SR 500MG TABLET

Like all medicines, Glyciphage SR 500mg may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Glyciphage SR 500mg are:

• Nausea
• Diarrhea
• Stomach upset
• Vomiting
• Flatulence
• Weakness
• Indigestion
• Headache
• Loss of appetite
• Changes in taste
• Metallic taste

When to consult your doctor?

• Severe allergic reactions symptoms such as rash, itching, swelling (especially around the face/tongue/throat), dizziness, trouble breathing
• Lactic Acidosis symptoms such as weakness, fatigue, unusual muscle pain, difficulty breathing, stomach discomfort, nausea, vomiting, dizziness, or feeling cold
• Hypoglycemia (Low Blood Sugar) symptoms such as shakiness, sweating, dizziness, confusion, hunger, or fast heartbeat
• Gastrointestinal problems symptoms such as severe diarrhea or vomiting, severe abdominal pain

How To Manage Side Effects

Diarrhea

• Drink Fluids: Drink clear fluids such as water, broths, and oral rehydration solutions (ORS).
• Electrolytes: If you are losing a lot of fluids (for example, from frequent diarrhea), consider drinking an electrolyte solution to help replenish lost minerals like potassium and sodium.
• BRAT Diet: Try to take Bananas, Rice (white rice), Apple sauce and Toast (plain, without butter) to control diarrhoea management.
• Avoid Certain Foods: While recovering avoid the following food items such as fatty, greasy, or fried foods, spicy foods, dairy products (especially if you have a temporary lactose intolerance), caffeinated drinks and alcohol and artificial sweeteners like sorbitol.
• Over-the-Counter Medications: You can take over-the-counter anti-diarrheal medications such as loperamide, Bismuth subsalicylate if appropriate for you. Follow the recommended dosage.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Warning & Precautions

Pregnancy

Consult your doctor

There is limited information on the use of Glyciphage SR during pregnancy. Animal studies have shown minimal to no harm to the developing baby. It is important to consult your doctor before taking this medication.

Breastfeeding

Consult your doctor

There is limited information on the use of Glyciphage SR during breastfeeding. It is important to consult your doctor before taking this medication.

Driving and Using Machines

Use with Caution

Do not drive or operate machines if you experience signs of high/low blood sugar.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking Glyciphage SR since it can increase the risk of lactic acidosis.

Kidney

Consult your doctor

Glyciphage SR 500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Glyciphage SR 500mg Tablet may be needed. Glyciphage SR is not recommended for individuals with severe kidney disease. Regular monitoring of kidney function is recommended while taking this medication. Please consult your doctor before taking it.

Liver

Consult your doctor

Glyciphage SR 500mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Glyciphage SR may be needed. Glyciphage SR is not recommended for use in patients with severe liver disease. Please consult your doctor before taking it.

Allergy

Contraindicated

Do not take this medication if you are allergic to metformin and/or any other ingredients of this medicine.

Lungs

Contraindicated

Glyciphage SR 500mg is not recommended for use in patients with severe infection of lungs or respiratory tract. Please consult your doctor before taking it.

Heart Disease

Contraindicated

Glyciphage SR 500mg is not recommended for use in patients with acute heart problems or recently had a heart attack. Please consult your doctor before taking it.

Use In Pediatrics

Consult your doctor

Glyciphage SR 500mg Tablet is not recommended for children below 10 years of age due to insufficient safety and efficacy data. For adolescents aged 10 to 17 years, the dosage and duration of management should be determined by your pediatrician based on individual medical conditions and responses to the medication.

Use In Geriatrics

Use with Caution

Glyciphage SR 500mg should be used with caution in elderly patients aged 65 years and above. Dosage adjustment and careful monitoring are required in such patients. Consult your doctor before taking it.

Other Warnings for GLYCIPHAGE SR 500MG TABLET

Before taking Glyciphage SR 500mg tablet, inform your doctor if you:

• are about to have any X-ray or scan
• are about a have a major surgery
• are in fasting

Who should not take [GBNKEYWORD

 Glyciphage SR 500mg tablet is not recommended for use if you:

• have severe, uncontrollable diabetes
• have lactic acidosis or ketoacidosis  
• are dehydrated  
• have any systemic infection  
• have shock or problems in blood circulation
• have breathing problems
• are an alcoholic

Safety Advice

• Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.
• Typically, take once or twice daily with food to reduce gastrointestinal side effects such as nausea or upset stomach.
• Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
• Do not exceed 2 tablets per day unless specifically advised by your doctor.
• For best results, take the tablet at the same time each day.
• Follow the prescribed diet and exercise plan along with taking this medication for best results.
• Alcohol can raise the risk of lactic acidosis, so it is recommended to limit or avoid alcohol consumption while taking Glyciphage SR 500mg.
• Drink enough water, as dehydration can raise the risk of side effects like lactic acidosis.
• Check your blood sugar levels regularly as your doctor suggests to ensure the medication is working. If you feel symptoms of low blood sugar, like dizziness, sweating, or shaking, contact your doctor immediately.
• Let your doctor know if you have kidney problems.
• Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women.
• Do not suddenly stop taking the medication without consulting your doctor, as this can lead to uncontrolled blood sugar levels.
• Your doctor may advise you to temporarily stop taking Glyciphage SR before surgery, certain imaging procedures with contrast agents, or if you are seriously ill. Be sure to follow your doctor's instructions during these situations.
• This medicine has a lower risk of weight gain and low blood sugar compared to other diabetes medications.
• Let your doctor know about any other medications or supplements you are taking, as some drugs may interact with Glyciphage SR, particularly those that impact kidney function or blood sugar levels.

Diet and Lifestyle Advice

A. What are some meals planning tips for managing blood sugar in diabetes, and which foods might help or interfere with Glyciphage SR's effectiveness?

Foods that Impact Glyciphage SR Effectiveness:

Glyciphage SR works by reducing glucose production in the liver and improving insulin sensitivity. However, certain foods and dietary habits can impact its absorption or effectiveness:

1. Alcohol: Can cause a drop in blood sugar, leading to hypoglycemia when combined with Glyciphage SR, especially if consumed in large quantities.
2. High-Fat Meals: These may delay gastric emptying and slow the absorption of Glyciphage SR, reducing its effectiveness.
3. Sugary Foods: Overloading on sugars may increase blood sugar levels, making it harder for the medication to maintain balance.
4. Large Meals: Extremely large meals can lead to insulin resistance, which could overwhelm the medication’s ability to regulate blood sugar.

Additional Tips:

• Consistency in meal timing and portion control is key to effective diabetes management.
• Monitor blood sugar regularly to understand how different foods interact with your medication and adjust accordingly.
• Pair fiber-rich foods with meals to help slow the absorption of glucose.

By following a balanced diet and being mindful of the foods that can either help or hinder the effectiveness of Glyciphage SR, managing blood sugar levels becomes more achievable.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Glyciphage SR 500mg:

1. Insulin and Insulin Secretagogues (e.g., sulfonylureas)

• Interaction: When metformin is used in combination with insulin or other medications that stimulate insulin release, the risk of hypoglycemia (low blood sugar) can increase.
• Effect: This can lead to symptoms such as shaking, sweating, confusion, or dizziness.
• Management: Regular monitoring of blood glucose levels is essential. The dosage of insulin or sulfonylureas may need adjustment to prevent hypoglycemia.

2. Corticosteroids (e.g., prednisone)

• Interaction: Corticosteroids can increase blood glucose levels by reducing the effectiveness of insulin.
• Effect: Elevated blood glucose (hyperglycemia) may occur.
• Management: Close monitoring of blood sugar levels during corticosteroid therapy. You may need to adjust the dosage of metformin or use additional insulin for blood sugar control.

3. Diuretics (e.g., furosemide)

• Interaction: Diuretics can lead to dehydration and electrolyte imbalances, potentially increasing the risk of lactic acidosis (a rare but serious side effect of metformin).
• Effect: Dehydration, low blood pressure, and kidney problems.
• Management: Adequate hydration is necessary while using both drugs. Kidney function should be monitored regularly.

4. Angiotensin-Converting Enzyme (ACE) Inhibitors (e.g., enalapril)

• Interaction: ACE inhibitors may enhance the glucose-lowering effect of metformin, increasing the risk of hypoglycemia.
• Effect: Low blood sugar (hypoglycemia).
• Management: Monitor blood glucose levels closely, particularly when starting or increasing the dose of an ACE inhibitor.

5. Alcohol

• Interaction: Alcohol increases the risk of lactic acidosis, a rare but severe side effect of metformin, and can also enhance the hypoglycemic effects of metformin.
• Effect: Lactic acidosis (muscle pain, breathing problems, abdominal pain, dizziness, and fatigue), hypoglycemia.
• Management: Avoid excessive alcohol intake while on metformin. Ensure adequate hydration and avoid alcohol during times of illness or fasting.

6. Contrast Media (e.g., iodinated contrast used in imaging tests)

• Interaction: Iodinated contrast agents can impair kidney function, increasing the risk of lactic acidosis when combined with metformin.
• Effect: Acute kidney injury, increased risk of lactic acidosis.
• Management: Discontinue metformin 48 hours before and after administration of iodinated contrast media and check kidney function before resuming metformin.

7. Beta-Blockers (e.g., atenolol)

• Interaction: Beta-blockers can mask the symptoms of hypoglycemia (such as trembling and tachycardia) and also can potentially alter insulin sensitivity.
• Effect: Unnoticed hypoglycemia.
• Management: Monitor blood glucose levels more frequently. Patients should be educated about the potential absence of hypoglycemia symptoms while on beta-blockers.

8. Cimetidine

• Interaction: Cimetidine may increase metformin plasma levels, potentially raising the risk of metformin-related side effects such as lactic acidosis.
• Effect: Increased risk of side effects from metformin, such as gastrointestinal issues.
• Management: Monitor for signs of lactic acidosis, and dose adjustments may be necessary.

9. Certain Antifungals (e.g., fluconazole)

• Interaction: Fluconazole and other antifungal drugs can increase the blood levels of metformin, raising the risk of side effects.
• Effect: Increased risk of lactic acidosis.
• Management: Monitor kidney function and blood glucose closely. Adjust metformin dosage if necessary.

Drug - Food interaction

1. Alcohol:

• Avoid excessive alcohol consumption when taking Glyciphage SR. Alcohol can increase the risk of lactic acidosis (a rare but serious side effect of metformin) and may lower blood sugar levels, which can be dangerous if not monitored. If you drink alcohol, do so in moderation, and always ensure your blood sugar levels are stable.

2. High-Carbohydrate Meals:

• Be cautious with very high-carb meals or meals that are rich in sugars, especially if you have difficulty managing your blood sugar levels. While Glyciphage SR helps regulate blood sugar, consuming large amounts of carbohydrates can still cause blood sugar spikes. It is important to follow a balanced diet with controlled portions of carbohydrates, lean proteins, and healthy fats.

3.Large Meals or Skipping Meals:

• Avoid eating large meals or skipping meals as this can affect blood sugar control. Skipping meals can lead to low blood sugar (hypoglycemia), and large meals may cause blood sugar to rise too quickly. It is ideal to eat regular, balanced meals throughout the day to maintain stable blood glucose levels.

4.Caffeine:

• Caffeine (from coffee, tea, or energy drinks) can sometimes interfere with blood sugar control. If you consume a lot of caffeine, it might cause mild spikes in blood sugar. It is a good idea to monitor your glucose levels more closely if you drink caffeinated beverages.

5.Fiber-Rich Foods:

• Foods high in fiber, such as whole grains, fruits, vegetables, and legumes, can help improve blood sugar control by slowing the absorption of glucose. Including these in your diet is beneficial when managing type 2 diabetes.

Synopsis

More Information

A. Why Choose Glyciphage SR 500mg Tablet?

1. Effective Blood Sugar Control: Glyciphage SR helps to reduce blood sugar levels by improving insulin sensitivity and reducing the amount of sugar released by the liver. This makes it an effective choice for managing Type 2 diabetes.
2. Sustained Release Formula: The SR (Sustained Release) formulation ensures that the medication is absorbed slowly, providing more stable blood sugar control over an extended period. This can reduce the risk of sudden spikes or drops in blood sugar levels.
3. Fewer Side Effects: The sustained release nature of the tablet tends to cause fewer gastrointestinal side effects (such as nausea or diarrhea) compared to immediate-release forms of metformin.
4. Convenient Dosing: Glyciphage SR typically requires once or twice a day dosing, making it easier for patients to adhere to their medication regimen.
5. Weight Neutral or Weight Loss: Unlike some diabetes medications that can cause weight gain, metformin is generally considered weight-neutral or even helps with modest weight loss, making it a suitable choice for overweight patients with Type 2 diabetes.
6. Cardiovascular Benefits: Some studies suggest that metformin may offer cardiovascular benefits, which is important since people with Type 2 diabetes are at a higher risk for heart disease.

B. How does the sustained-release (SR) formulation of Metformin help maintain long-term blood sugar control by releasing the active ingredient slowly and steadily?

Continuous Action: The SR formulation ensures that Metformin is released slowly, which helps to maintain more stable blood glucose levels throughout the day, rather than experiencing rapid drops and spikes in blood sugar.

Improved Compliance: Because SR formulations often require fewer doses (typically once or twice a day), they can improve patient adherence to their medication regimen. This consistency in dosing promotes better long-term blood sugar management.

Reduced Side Effects: Slow release of the medication can also reduce the gastrointestinal side effects, such as nausea or stomach upset, that are often associated with immediate-release Metformin. This makes it easier for patients to continue their treatment over a long period.

Better Blood Sugar Control: By providing a more sustained release of Metformin, the SR formulation helps to regulate glucose production in the liver and improves insulin sensitivity in muscle cells, contributing to better overall blood sugar control.

C.Product Comparision

 1. Glyciphage SR Vs Glucophage

Key Benefits of Glyciphage SR:

• Sustained-release mechanism reduces the chance of large blood sugar spikes and dips.
• Fewer gastrointestinal side effects like nausea or diarrhea, commonly experienced with immediate-release formulations like Glucophage.
• Once- or twice-daily dosing improves patient adherence.

Both medications effectively control blood sugar, but Glyciphage SR offers advantages in terms of patient comfort and convenience due to its slower absorption and reduced frequency of administration.

2. Glyciphage SR Vs Januvia

Key Benefits of Glyciphage SR:

1. Sustained-Release Mechanism: Helps in providing a more consistent release of metformin, leading to fewer blood sugar fluctuations throughout the day. This is particularly beneficial for managing blood glucose levels more steadily.
2. Gastrointestinal Side Effects: The gradual release minimizes the gastrointestinal side effects typically seen with immediate-release metformin.
3. Convenience: Can be taken once or twice daily, depending on individual needs.

Key Benefits of Januvia:

1. Targeted Action: Specifically boosts insulin release when needed, reducing blood sugar without the risk of hypoglycemia in patients with type 2 diabetes.
2. Weight Neutrality: Generally, does not cause weight gain, a common concern for many people with diabetes.
3. Once Daily Dosing: Easy to take, typically just once per day.

Both medications are effective in managing type 2 diabetes, but their mechanisms of action and benefits vary depending on individual needs.

D. What are some exercise tips to help enhance the effects of Glyciphage SR in managing blood sugar levels?

Regular physical activity is a great complement to Glyciphage SR in managing blood sugar levels. Exercise helps improve insulin sensitivity, allowing your body to use glucose more effectively. Here are some exercise tips to maximize the effects:

1. Aim for Consistency: Engage in at least 30 minutes of moderate exercise most days of the week. Whether it is brisk walking, cycling, or swimming, consistency is key in maintaining stable blood sugar levels.
2. Incorporate Strength Training: Include weightlifting or resistance exercises twice a week. This type of exercise increases muscle mass, which can improve glucose uptake and storage.
3. Stay Active Throughout the Day: If you’re sitting for long periods, take short breaks to walk around. Simple activities like standing or light stretching can boost circulation and metabolism.
4. Prioritize Cardio: Aerobic exercises like jogging, dancing, or even hiking can enhance cardiovascular health and help regulate blood sugar levels.
5. Monitor Your Blood Sugar: Be mindful of how your body responds to different types of exercise. Checking your blood sugar before and after physical activity can help you understand your personal patterns and adjust accordingly.
6. Hydrate and Fuel Properly: Drink plenty of water and eat a balanced meal or snack with carbohydrates and protein before exercise to sustain energy levels and prevent blood sugar spikes or crashes.

Incorporating regular exercise into your routine alongside Glyciphage SR can greatly improve your blood sugar control and overall health.

FAQs About GLYCIPHAGE SR 500MG TABLET

Q: What is Glyciphage SR 500mg Tablet used for?

A: Glyciphage SR 500mg Tablet is commonly prescribed for managing Type 2 diabetes mellitus. It helps control blood sugar levels by improving the body's response to insulin and reducing glucose production in the liver.

Q: How does Glyciphage SR 500mg Tablet work?

A: Glyciphage SR 500mg Tablet, containing Metformin, works by improving insulin sensitivity, reducing the amount of sugar produced by the liver, and increasing the uptake of glucose in the muscles, which ultimately lowers blood sugar levels.

Q: What are the common side effects of Glyciphage SR 500mg Tablet?

A: Common side effects of Glyciphage SR 500mg Tablet include nausea, diarrhea, stomach upset, and a metallic taste in the mouth. These side effects are usually mild and may go away with time.

Q: Can I take Glyciphage SR 500mg Tablet on an empty stomach?

A: It is generally recommended to take Glyciphage SR 500mg Tablet with food to reduce the risk of gastrointestinal issues such as nausea and stomach upset.

Q: How long does it take for Glyciphage SR 500mg Tablet to lower blood sugar levels?

A: Glyciphage SR 500mg Tablet usually starts working within a few hours, but it may take several weeks to see the full effect of blood sugar control. Consistent use as prescribed by your doctor is essential for optimal results.

Q: Can Glyciphage SR 500mg Tablet be taken with other diabetes medications?

A: Yes, Glyciphage SR 500mg Tablet can often be used alongside other diabetes medications, including insulin or blood pressure medications.,etc, but only under a doctor’s supervision. Combining medications may enhance blood sugar control.

Q: What should I do if I miss a dose of Glyciphage SR 500mg Tablet?

A: If you miss a dose of Glyciphage SR 500mg Tablet, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses to make up for a missed dose.

Q: Are there any precautions before taking Glyciphage SR 500mg Tablet?

A: Before taking Glyciphage SR 500mg Tablet, inform your doctor if you have any kidney or liver problems, a history of lactic acidosis, or if you are pregnant or breastfeeding. Regular monitoring of kidney function is important while on this medication.

Q: Can Glyciphage SR 500mg Tablet cause weight gain?

A: Unlike some other diabetes medications, Glyciphage SR 500mg Tablet is not associated with weight gain. In fact, it may help with modest weight loss in some individuals due to its effect on insulin sensitivity.

Q: How should Glyciphage SR 500mg Tablet be stored?

A: Store Glyciphage SR 500mg Tablet in a cool, dry place, away from moisture and direct sunlight. Keep it out of reach of children, and never use expired medications.

Q: Can I drink alcohol while taking Glyciphage SR 500mg Tablet?

A: Moderate alcohol consumption is generally safe while taking Glyciphage SR 500mg Tablet, but excessive alcohol intake can increase the risk of lactic acidosis, a rare but serious side effect. Consult your doctor about alcohol consumption.

Q: Is Glyciphage SR 500mg Tablet suitable for long-term use?

A: Yes, Glyciphage SR 500mg Tablet is typically used for long-term management of Type 2 diabetes. Regular check-ups and monitoring are necessary to ensure the medication is effective and that no adverse effects occur.

Q: Is nausea a side effect of Glyciphage SR 500mg Tablet?

A: Yes, nausea can be a side effect of Glyciphage SR (Metformin). It is more common when starting the medication, but usually improves as your body adjusts.

Q: Can Glyciphage SR 500mg Tablet cause diarrhea?

A: Yes, diarrhea is a known side effect of Glyciphage SR. It often occurs when the medication is first started, but tends to subside after a few days or weeks. Taking the medication with food may help reduce this side effect.

Q: Is Glyciphage SR 500mg Tablet safe during pregnancy?

A: There is limited information on the use of Glyciphage SR during pregnancy. Animal studies have shown minimal to no harm to the developing baby. It is important to consult your doctor before taking this medication.

Q: Are there any contraindications for using Glyciphage SR 500mg Tablet?

A: Yes, Glyciphage SR should not be used in individuals with severe kidney disease, liver disease, or metabolic acidosis, including diabetic ketoacidosis. It is also contraindicated in individuals with hypersensitivity to metformin.

Q: Can I take Glyciphage SR 500mg Tablet with insulin?

A: Yes, Glyciphage SR can be taken with insulin. In fact, they are often used together to manage blood sugar levels in patients with type 2 diabetes. However, the dose of insulin may need to be adjusted.

Q: Are there any known food interactions with Glyciphage SR 500mg Tablet?

A: There are no significant food interactions with Glyciphage SR. However, it is recommended to take it with food to minimize gastrointestinal side effects like nausea or diarrhea.

Q: Can Glyciphage SR 500mg Tablet be used for type 1 diabetes?

A: No, Glyciphage SR (Metformin) is typically used for type 2 diabetes and is not recommended for type 1 diabetes. Insulin is the primary management for type 1 diabetes.

Q: Is it safe to drive after taking Glyciphage SR 500mg Tablet?

A: Glyciphage SR generally does not cause drowsiness or impair your ability to drive. However, if you experience dizziness or low blood sugar, you should avoid driving.

Q: How soon will I see results after starting Glyciphage SR?

A: You may begin to see improvements in blood sugar control within 1–2 weeks after starting Glyciphage SR, though it may take longer to see significant changes.

Q: Can Glyciphage SR be used by elderly patients?

A: Yes, elderly patients can use Glyciphage SR, but they may be more susceptible to side effects, particularly kidney-related issues. Dosage adjustments may be necessary, and renal function should be monitored.

Q: How to manage type 2 diabetes with medication?

A: Managing type 2 diabetes with medication involves taking prescribed medications like Glyciphage SR, maintaining a healthy diet, regular exercise, and monitoring blood sugar levels. It may also involve weight management and regular checkups with your healthcare provider.

Q: What are the most effective methods for managing blood sugar levels while using Glyciphage SR?

A: To control blood sugar with Glyciphage SR, follow a balanced diet with controlled carbohydrate intake, exercise regularly, monitor blood glucose levels, and take the medication as prescribed.

Q: Does Glyciphage SR help with insulin resistance?

A: Yes, Glyciphage SR (Metformin) helps reduce insulin resistance by improving the body's sensitivity to insulin, which is particularly helpful for patients with type 2 diabetes.

Q: How to monitor blood sugar levels while on Glyciphage SR?

A: Blood sugar should be monitored regularly, ideally before meals and at bedtime, using a blood glucose meter. Regular check-ups with your healthcare provider to assess overall diabetes management are also important.

Q: What are normal blood sugar levels for someone on Glyciphage SR?

A: The target blood sugar levels for someone on Glyciphage SR may vary, but generally, fasting blood glucose should be between 80-130 mg/dL, and post-meal levels should be below 180 mg/dL.

Q: How does Glyciphage SR affect blood sugar readings?

A: Glyciphage SR helps lower blood sugar by improving insulin sensitivity, reducing glucose production in the liver, and enhancing glucose uptake by muscles. This can lead to improved blood sugar readings.

Q: What is the best diet while taking Glyciphage SR?

A: A balanced diet high in fiber, with controlled portions of carbohydrates and healthy fats, is best. Foods such as whole grains, vegetables, lean proteins, and healthy fats can help maintain stable blood sugar levels.

Q: What are some exercise and lifestyle tips for managing diabetes while using Glyciphage SR?

A: Regular exercise (e.g., walking, swimming, cycling) helps improve insulin sensitivity. A healthy diet, maintaining a healthy weight, and stress management are also important components of diabetes management.

Q: Which foods should be avoided while taking Glyciphage SR 500mg Tablet?

A: Avoid foods with high sugar content, processed foods, and excessive amounts of unhealthy fats. These can spike blood sugar levels and counteract the effects of Glyciphage SR.

Q: What drugs interact with Glyciphage SR 500mg?

A: Drugs that may interact with Glyciphage SR include diuretics, corticosteroids, blood pressure medications, and certain antibiotics. Always inform your healthcare provider about all medications you are taking.

Q: Is Glyciphage SR safe for people with kidney disease?

A: Glyciphage SR should be used cautiously in people with kidney disease. It can lead to serious side effects like lactic acidosis in those with impaired kidney function, so dosage adjustments or alternative medications may be necessary.

Q: How does Glyciphage SR affect kidney function?

A: Glyciphage SR can affect kidney function, particularly in people with pre-existing kidney disease. It is important to monitor kidney function regularly while taking this medication.

Q: What precautions should be taken if you have kidney problems and take Glyciphage SR?

A: If you have kidney problems, your doctor may need to adjust your dose or suggest alternative management. It is crucial to monitor kidney function through regular blood tests.

Q: What are the alternatives to Glyciphage SR 500mg for diabetes?

A: Alternatives to Glyciphage SR include other oral medications like sulfonylureas, DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors. Insulin therapy may also be considered.

Q: Can Glyciphage SR 500mg cause weight loss?

A: Yes, Glyciphage SR can cause modest weight loss, as it helps lower blood sugar levels and improve insulin sensitivity. However, it is not primarily prescribed for weight loss.

Q: Does Glyciphage SR help with managing obesity in diabetes?

A: Glyciphage SR may help manage weight in patients with type 2 diabetes by improving insulin sensitivity and reducing appetite, but it is not a primary treatment for obesity.

Q: Can Glyciphage SR reduce diabetic neuropathy?

A: Glyciphage SR does not directly reduce diabetic neuropathy, but by improving blood sugar control, it can reduce the risk of complications like nerve damage.

Q: How does Glyciphage SR help with cardiovascular health in diabetes?

A: By improving insulin sensitivity and lowering blood glucose levels, Glyciphage SR may reduce the risk of cardiovascular issues associated with diabetes.

Q: Can I use herbal supplements with Glyciphage SR?

A: You should consult with your doctor before using herbal supplements alongside Glyciphage SR, as some supplements may interact with the medication and affect blood sugar control.

Q: Why Choose Netmeds for Your Glyciphage SR 500mg Purchase?

A: Netmeds is a trusted online pharmacy offering genuine medications, timely delivery, and competitive prices. It also provides the convenience of purchasing medication from the comfort of your home with access to expert healthcare guidance.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.

2. Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 12th Feb 2025]  

3. Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 12th Feb 2025]  

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 12th Feb 2025]  

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 12th Feb 2025]  

6. Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 12th Feb 2025]  

7. Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 12th Feb 2025]  

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 13 Feb 2025 | 03:03 PM(IST)