Introduction About GLUCRETA L 5/10 TABLET

GLUCRETA L 5/10 TABLET is a combination of Dapagliflozin and Linagliptin, which belongs to the group of medicines called Antidiabetic agents. It is used for the management of patients with type 2 diabetes mellitus who are inadequately controlled on metformin monotherapy.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.

Before starting management with GLUCRETA L 5/10 TABLET, your doctor will assess your volume status and kidney function by conducting a blood test. GLUCRETA L 5/10 TABLET should be used with caution in patients with liver disease, heart failure, and low blood pressure. Consult your doctor before taking it.

Inform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby. GLUCRETA L 5/10 TABLET is not recommended for use by breastfeeding women as it is not known whether it may pass through breast milk. Consult your doctor for advice.

The most common side effects of taking GLUCRETA L 5/10 TABLET are hypoglycemia, vulvovaginitis, balanitis and related genital infections, urinary tract infections, dizziness, rash, and back pain. Consult your doctor if any of the side effects worsen.

Uses Of GLUCRETA L 5/10 TABLET

To manage type II diabetes mellitus

How GLUCRETA L 5/10 TABLET Works

GLUCRETA L 5/10 TABLET effectively controls blood glucose levels, where dapagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and managing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body.

Linagliptin works by inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme (a protein that helps to degrade incretin hormones) and thus increasing the concentrations of incretin hormones, stimulating the release of insulin in a glucose-dependent manner, decreasing the levels of glucagon, and reducing glucose production in the liver.

How to use GLUCRETA L 5/10 TABLET

Take GLUCRETA L 5/10 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Side Effects Of GLUCRETA L 5/10 TABLET

How To Manage Side Effects

Constipation

Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Dry Mouth

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candy to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the dry mouth gets worse.

Hypoglycemia

Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.

Skin rash Or Itching

Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.

Warning & Precautions

Pregnancy

Consult your doctor

Inform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby.

Breastfeeding

Contraindicated

GLUCRETA L 5/10 TABLET is not recommended for use by breastfeeding women as it is not known whether it may pass through breast milk. Consult your doctor for advice.

Driving and Using Machines

Use with Caution

Do not drive or operate any machinery if you feel dizzy after taking GLUCRETA L 5/10 TABLET.

Alcohol

Consult your doctor

Avoid excessive consumption of alcohol while taking GLUCRETA L 5/10 TABLET, as it may increase the risk of lactic acidosis.

Kidney

Consult your doctor

GLUCRETA L 5/10 TABLET is not recommended for use if you have severe kidney disease or are on dialysis. Inform your doctor before taking GLUCRETA L 5/10 TABLET if you have urinary tract infections or moderate kidney disease.

Liver

Use with Caution

GLUCRETA L 5/10 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.

Allergy

Contraindicated

GLUCRETA L 5/10 TABLET is not recommended for use if you are allergic to dapagliflozin, linagliptin, or any of the other ingredients of this medicine.

Heart Disease

Use with Caution

GLUCRETA L 5/10 TABLET should be used with caution in patients with heart failure or low blood pressure. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

GLUCRETA L 5/10 TABLET is not recommended for use in children or adults under 18 years of age. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

GLUCRETA L 5/10 TABLET should be used with caution with elderly patients. Consult your doctor before taking it.

Interactions

A. Drug-drug interactions:

Before taking GLUCRETA L 5/10 TABLET, inform your doctor if you are taking any of the following medicines, such as:

• insulin or a sulphonyl urea, Ex. glimepiride or glipizide (other medicines used to manage diabetes mellitus)
• diuretics (medicines that increase urine production) (Ex. furosemide, chlorothiazide)
• rifampin (a medicine used in the management of tuberculosis)
• digoxin (a medicine used in the management of heart failure)
• topiramate or other carbonic anhydrase inhibitors (Ex. zonisamide, acetazolamide, or dichlorphenamide) (medicines used in the management of fits and glaucoma)
• ranolazine (a medicine used to manage angina)
• vandetanib (a medicine used to manage thyroid cancer)
• dolutegravir (a medicine used to manage HIV infection)
• cimetidine (a medicine used to manage stomach problems)
• corticosteroid (generally used to manage inflammation) (Ex. beclomethasone dipropionate)

Overdosage:

If you or anyone else accidentally took more GLUCRETA L 5/10 TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

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FAQs About GLUCRETA L 5/10 TABLET

Q: What are the side effects of GLUCRETA L 5/10 TABLET?

A: The most common side effects of taking GLUCRETA L 5/10 TABLET are hypoglycemia, vulvovaginitis, balanitis and related genital infections, urinary tract infection, dysuria, polyuria, dizziness, rash, and back pain. Consult your doctor if any of the side effects worsen.

Q: How does GLUCRETA L 5/10 TABLET work?

A: GLUCRETA L 5/10 TABLET effectively controls blood glucose levels, where dapagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and managing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body. Linagliptin works by inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme (a protein that helps to degrade incretin hormones) and thus increasing the concentrations of incretin hormones, stimulating the release of insulin in a glucose-dependent manner, decreasing the levels of glucagon, and reducing glucose production in the liver.

Q: Is GLUCRETA L 5/10 TABLET safe during pregnancy?

A: There is no information on the use of GLUCRETA L 5/10 TABLET during pregnancy. Inform your doctor if you are pregnant or planning to be pregnant before taking it.

Q: What precautions must be taken while using GLUCRETA L 5/10 TABLET?

A: GLUCRETA L 5/10 TABLET should be used with caution in patients with liver disease, urinary tract infections or moderate kidney disease, heart failure or low blood pressure, genital fungal infections, type 1 diabetes, a condition called diabetic ketoacidosis, a disease of the pancreas, a headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, a fast heartbeat, sweating, and feeling jittery, a stuffy or runny nose and a sore throat, or have diabetic skin lesions. Consult your doctor before taking GLUCRETA L 5/10 TABLET.

Q: What if I forget to take GLUCRETA L 5/10 TABLET?

A: If you miss a dose of GLUCRETA L 5/10 TABLET, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Q: Is GLUCRETA L 5/10 TABLET safe for kidneys?

A: GLUCRETA L 5/10 TABLET is not recommended for use if you have severe kidney disease or are on dialysis. Inform your doctor before taking GLUCRETA L 5/10 TABLET if you have urinary tract infections or moderate kidney disease.

Q: What is GLUCRETA L 5/10 TABLET used for?

A: GLUCRETA L 5/10 TABLET is used for the management of patients with type 2 diabetes mellitus who are inadequately controlled on metformin alone.

Q: What should I avoid while taking GLUCRETA L 5/10 TABLET?

A: Avoid excessive consumption of alcohol while taking GLUCRETA L 5/10 TABLET, as it may increase the risk of lactic acidosis.

Q: Who should avoid taking GLUCRETA L 5/10 TABLET?

A: GLUCRETA L 5/10 TABLET is not recommended for use if you have severe kidney disease or are on dialysis, allergic to dapagliflozin, or linagliptin.

Q: Can GLUCRETA L 5/10 TABLET be used in kids?

A: GLUCRETA L 5/10 TABLET is not recommended for use in children or adults under 18 years of age. Consult your doctor before taking it.