Introduction About GLUCOBAY M 25MG TABLET

GLUCOBAY M 25MG TABLET is used to manage type 2 diabetes mellitus in patients who have not sufficiently responded to either diet and exercise alone or after a combination of diet and exercise with other single oral antidiabetic medicines. It is a combination of Acarbose and Metformin which belongs to the group of medicines called Antidiabetic agents.

GLUCOBAY M 25MG TABLET is not recommended for patients with ulcerative colitis or Crohn’s disease, severe liver disorders, kidney diseases, hernias, intestinal diseases, gastric diseases, type-1 diabetes, nausea, vomiting, diarrhoea, weight loss, dehydration, severe infections in the lungs or kidney, acute or chronic metabolic acidosis, diabetic ketoacidosis, acute heart failure, or heart attack. Inform your doctor before any x-ray or scanning and if there are any pre-planned surgeries.

If you are a pregnant or a breastfeeding women, consult your doctor before taking the medicine. It is not recommended in children less than 16 years of age. The common side effects are flatulence, diarrhoea, stomach pain, upset stomach, loss of appetite, and changes in taste. Consult your doctor if any of your symptoms get worse or persist.

Uses Of GLUCOBAY M 25MG TABLET

• Used to manage type 2 diabetes mellitus

How GLUCOBAY M 25MG TABLET Works

GLUCOBAY M 25MG TABLET contains Acarbose and Metformin. Acarbose works by inhibiting the action of enzymes involved in the digestion of carbohydrates and sugars, thereby delaying the digestion of carbohydrates complex (sugars) and lowering blood sugar levels. Metformin reduces the amount of sugar that the liver releases into the blood and gives a better response to insulin. This is the major action responsible for lowering blood glucose levels.  

How to use GLUCOBAY M 25MG TABLET

• Take GLUCOBAY M 25MG TABLET as directed by your physician
• Swallow the medicine with a glass of water, and do not crush or chew the medicine
• It is better to take the medicine with food to avoid stomach disorders and take this medicine at the same time every day
• Your doctor will decide the correct dose of the medicine for you depending upon your condition

Side Effects Of GLUCOBAY M 25MG TABLET

Common side effects of GLUCOBAY M 25MG TABLET:

• digestive problems
• diarrhoea
• loss of appetite
• changes in taste
• flatulence
• rumbling in the stomach
• feeling of fullness (bloating)

Stop taking this medicine and contact your doctor immediately if you experience any of the following side effects:

• accumulation of lactic acid in the blood (lactic acidosis)
• weakness, tiredness, muscle pain, trouble breathing, stomach pain, nausea
  and vomiting, diarrhoea chillness in arms and legs, dizziness or light-headed, irregular
  heartbeat
• tiredness, loss of appetite, weight loss, yellowing of the skin or eyes
• fatigue, headache, muscle cramps and weakness

Warning & Precautions

Pregnancy

Consult your doctor

If you are a pregnant or planning for a pregnancy, consult your doctor before taking the medicine.

Breastfeeding

Consult your doctor

If you are a breastfeeding women, consult your doctor before taking the medicine.

Driving and Using Machines

Use with Caution

Do not drive or handle heavy machines if you experience side effects like feeling dizzy, drowsy, or tired, or if you have blurred vision while taking the medicine.

Alcohol

Contraindicated

Consumption of alcohol is not recommended during management with the medicine.

Kidney

Consult your doctor

GLUCOBAY M 25MG TABLET is not recommended for use in patients with severe kidney impairment or kidney infections and should be used with caution in patients with mild to moderate kidney disease.  

Liver

Consult your doctor

GLUCOBAY M 25MG TABLET is not recommended in patients with severe liver problems or liver infections and should be used with caution in patients with mild to moderate liver disease.  

Allergy

Contraindicated

Talk to your doctor if you are allergic to Acarbose or Metformin or any other ingredients of this medicine.

Lungs

Consult your doctor

There is no proper information regarding the use of this medicine in patients with lung diseases. It should be used with caution in patients with lung diseases.  

Heart Disease

Contraindicated

GLUCOBAY M 25MG TABLET is not recommended for patients with acute heart failure or heart attack.  

Use In Pediatrics

Contraindicated

GLUCOBAY M 25MG TABLET is not recommended for use in children (below 18 years of age).

Use In Geriatrics

Use with Caution

GLUCOBAY M 25MG TABLET should be used with caution in elderly people.  

Interactions

A. Drug-Drug interactions:

Before GLUCOBAY M 25MG TABLET, inform your doctor if you are taking any of the following medicines:

• Diuretics (Ex. furosemide)
• NSAID and COX-2-inhibitors (Ex. ibuprofen, celecoxib)
• ACE inhibitors and angiotensin II receptor antagonists (Ex. enalapril, ramipril, valsartan, losartan, verapamil)
• Bronchodilators (Ex. salbutamol, terbutaline)
• corticosteroids (Ex. prednisolone)
• Antibiotics (Ex. neomycin, vancomycin trimethoprim)
• H2 blockers (Ex. cimetidine)
• Anti-viral agents (Ex. Dolutegravir)
• Anti-anginals (Ex. ranolazine, acetazolamide)
• Cardiac glycosides (Ex. digoxin)
• Anti-cancer agents (Ex. crizotinib, olaparib)
• Anti-fungal (Ex. isavuconazole)
• Anti-diabetics (Ex. insulin and rosiglitazone)
• Birth control pills (Ex. estragon, progesterone)
• Sympathomimetics (Ex. phenylpropanolamine)
• Hormones (Ex. thyroxine)
• Anticonvulsants (Ex. phenytoin, topiramate, zonisamide)
• Bile acid sequestrants (Ex. nicotinic acid, colestyramine)
• Anti-TB agents (Ex. isoniazid, rifampicin)
• Opiate (narcotic) analgesics (Ex. Morphine)
• Class 1A anti-arrhythmics (Ex. procainamide, quinidine, and quinine)
• Anticoagulants (Ex. warfarin)
• Intestinal absorbents (Ex. charcoal)
• Digestive enzymes (Ex. amylase and lipase)
• X-rays (Ex. iodine)

B. Interaction with food or drink:

• Foods containing cane sugar should be avoided as it may cause stomach discomfort and diarrhoea

Overdosage:

If you or anyone else accidentally took too much of GLUCOBAY M 25MG TABLET, consult your doctor immediately. Symptoms of overdose include stomach discomfort, nausea, vomiting drowsiness, weakness, dizziness, malaise, headache, and flatulence. Lactic acidosis and hypoglycaemia have also been reported.

Synopsis

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References

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 274 - 276.

2. Liu, Z., Zhao, X., Sun, W, Wang, Y., Liu, S., & Kang, L. (2017). Metformin combined with acarbose vs. single medicine in the treatment of type 2 diabetes: A meta-analysis. NCBI; PMC US National Library of Medicine, National Institute of Health. [Revised on April 2017] [Accessed on 16th April 2022] click here

3. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised on June 2020] [Accessed on 16th April 2022] click here

4. Valeant Canada LP. [Revised on June 2012] [Accessed on 16th April 2022] click here

5. Bristol-Myers Squibb Company. [Revised on May 2018] [Accessed on 16th April 2022] click here

6. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised on August 2016] [Accessed on 16th April 2022] click here

7. Bayer healthcare pharmaceuticals. U.S. Food & Drug Administration. [Revised on March 2011] [Accessed on 16th April 2022] click here

User Feedback

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 21 Nov 2024 | 10:15 AM(IST)