Introduction About GLOBRIGHT CREAM

GLOBRIGHT CREAM is a combination of Hydroquinone, Tretinoin, Mometasone furoate which belongs to the group of medicines called Depigmenting agents, Retinoids and Corticosteroids respectively. It is used in adults for the management of moderate to severe melasma (dark spots on the skin) in association with sun-avoidance measures, like using sunscreens and wearing protective clothing. Melasma is one of the most frequently acquired hyperpigmentation (excess melanin production) disorders with symptoms such as symmetrical brown patches on sun exposed areas mainly on face.

It is advised to avoid exposure to sun during management with GLOBRIGHT CREAM for better results. While going out apply sunscreens and wear full covering protective clothes. Before using GLOBRIGHT CREAM inform your doctor if you have any liver, kidney, lung or heart diseases.

Safety and efficacy of GLOBRIGHT CREAM is not established in pregnant women and in children below 12 years of age. Ask for your doctor’s advice before using. GLOBRIGHT CREAM should be used with caution in breastfeeding women. The most common side effects of using GLOBRIGHT CREAM are mild burning, stinging, redness and dryness. Consult your doctor if any of the symptoms worsen or doesn’t improve.

Uses Of GLOBRIGHT CREAM

It is used in adults to

• Manages moderate to severe melasma (dark spots on the skin)

How GLOBRIGHT CREAM Works

GLOBRIGHT CREAM helps in managing melasma where Hydroquinone is a skin bleaching agent that blocks enzyme tyrosinase which is responsible for the production of melanin that cause pigmentation. Thus, it helps for fading of dark spots in skin. Tretinoin helps to recover the damage to the skin caused by sun exposure (photodamage) by thickening skin layer and loss of keratinized cells.it helps to rejuvenate the skin. Mometasone furoate blocks prostaglandin synthesis and reduces redness, swelling and itching caused by tretinoin and other skin infections.

How to use GLOBRIGHT CREAM

Apply GLOBRIGHT CREAM as advised by your physician. It is for external use only. Wash your hands before and after applying GLOBRIGHT CREAM. Wash your face with a mild soap and dry properly. Apply GLOBRIGHT CREAM at night and gently massage it in until it is absorbed. Avoid contact with your eyes, nose, mouth, mucous membrane. Avoid exposure to sunlight while using this medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of GLOBRIGHT CREAM

How To Manage Side Effects

Application Site Reactions

Apply cool compress or wet cloth over affected area. Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin and apply calamine lotion as a coolant. Contact doctor if it is not subsiding.

Dry Skin

Drink plenty of water, milk, honey and stay hydrated. Apply sunflower oil, coconut oil ,aloe vera or petroleum jelly to moisturize skin. Contact doctor if it doesn’t improve.

Warning & Precautions

Pregnancy

Consult your doctor

The safety and efficacy of GLOBRIGHT CREAM is not being established in pregnant women. Consult with your doctor before using.

Breastfeeding

Use with Caution

GLOBRIGHT CREAM should be used with caution in breast feeding women. Consult with your doctor before using.

Allergy

Contraindicated

Do not use GLOBRIGHT CREAM if you are allergic to Hydroquinone, Tretinoin, Mometasone or any other constituents of this medicine. Consult your doctor before using.

Use In Pediatrics

Consult your doctor

The safety and efficacy of GLOBRIGHT CREAM is not being established in children below 12 years of age. Consult with your child’s doctor before using it for your child.

Use In Geriatrics

Consult your doctor

There is no information on the use of GLOBRIGHT CREAM in elderly patients. Consult your doctor before using GLOBRIGHT CREAM.

Interactions

A. Drug-Drug interactions:

Before using GLOBRIGHT CREAM, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine.

Overdosage:

If you or anyone else accidentally ingests or apply too much of GLOBRIGHT CREAM, consult your doctor immediately.

Synopsis

More Information

FAQs About GLOBRIGHT CREAM

Q: What is GLOBRIGHT CREAM used for?

A: GLOBRIGHT CREAM is used in adults for the management of moderate to severe melasma (dark spots on the skin) in association with sun-avoidance measures, like using sunscreens and wearing protective clothing. Consult doctor before using.

Q: How to use GLOBRIGHT CREAM?

A: Apply GLOBRIGHT CREAM as advised by your physician. It is for external use only. Wash your hands before and after applying GLOBRIGHT CREAM. Wash your face with a mild soap and dry properly and gently massage the medicine until it is absorbed. Avoid contact with your eyes, nose, mouth, mucous membrane. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q: Can I use GLOBRIGHT CREAM to manage wounds?

A: GLOBRIGHT CREAM is not recommended to use on wounds and ulcerated skin . Consult doctor before using GLOBRIGHT CREAM.

Q: Do I need to take any precaution while using GLOBRIGHT CREAM?

A: It is advised to reduce exposure to sun during management with GLOBRIGHT CREAM for better results. While going out apply sunscreens and wear full covering protective clothes. Exposure to sunlight or ultra-violet light will cause repigmentation of lightened skin. Do not apply GLOBRIGHT CREAM to broken skin.

Q: What is the best time to use GLOBRIGHT CREAM?

A: It is advised to use GLOBRIGHT CREAM before bedtime. This will reduce the chances of exposure of the managed skin to sun. However, ask for your doctor’s advice before using.

References

1. KD Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 952, 953, 955.

2. Kiran V Godse. Triple combination of hydroquinone, tretinoin and mometasone furoate with glycolic acid peels in melasma. NIH National Library of Medicine, National Centre for Biotechnology. Pubmed Central. Jan 2009. [Accessed on 15th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800888/

3. Kowichi Jimbow, HirokoObata, Madhu A.Pathak, Thomas B.Fitzpatrick. Mechanism of depigmentation by hydroquinone. Journal of investigative dermatology. Science Direct. January 2016. [Accessed on 15th September 2022] https://www.sciencedirect.com/science/article/pii/S0022202X15442642

4. Torrent Pharmaceuticals Ltd. Aurochem Laboratorie. Lookbrite (Hydroquinone + Tretinoin + Mometasone) [Accessed on 15th September 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2476.pdf

5. Torque pharma. No Scars (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.torquepharma.com/no-scars-cream/

6. Leeford Healthcare. Ultrabrite Cream (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.leeford.in/product/1346/ultrabrite-cream-15-g

7. Leeford Healthcare. Elosone HT Forte (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.leeford.in/product/1459/elosone-ht-fort