Introduction About GLIMESTAR PM2 TABLET

Glimestar PM2 Tablet is commonly used as part of a comprehensive routine for managing blood sugar levels in adults. It combines Glimepiride, Pioglitazone and Metformin, each working in different ways to support body's glucose control. It is typically taken under guidance as part of a balanced diet and physical activity regimen.

Take Glimestar PM2 Tablet exactly as advised by your healthcare provider usually once daily with food. 

Inform your doctor if you have any liver, kidney or heart problems, eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution.

Glimestar PM2 Tablet is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.

Avoid smoking and consumption of alcohol while taking the medicine as it may aggravate the existing condition. The most common side effects usually seen are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of the above side effects worsen or persists for a longer duration.

Key Composition

• Glimepiride
• Pioglitazone
• Metformin

Uses Of GLIMESTAR PM2 TABLET

• Used to manage Type II diabetes mellitus

How GLIMESTAR PM2 TABLET Works

How does Glimestar PM2 work in the body?

Glimestar PM2 stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism) making our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood. This reduces blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absorption in the body.

Where does Glimestar PM2 Act – Liver, Muscle, or Pancreas?

Each component targets a different organ system:

1. Glimepiride – Pancreas

• How it works: Supports the pancreas in releasing insulin naturally
• Where it acts: Primarily on the beta cells of the pancreas
• When it is active: Especially useful around meal times, as it encourages a timely insulin response

2. Metformin – Liver and Muscles

• How it works: Reduces the liver glucose output and improves the body’s use of insulin
• Where it acts: Mainly in the liver (reducing glucose production) and muscle tissues (enhancing glucose uptake)
• Bonus effect: May also help reduce appetite and improve digestion in some individuals

3. Pioglitazone – Fat Cells and Muscles

• How it works: Improves insulin sensitivity so the body can use its own insulin more effectively
• Where it acts: Mostly in muscle, fat, and liver cells
• Additional support: Helps the body respond better to insulin already present, even if it is in lower amounts

Why is a triple combination used?

When the body needs multi-organ support, especially in cases of long-standing or poorly managed blood sugar conditions, doctors may recommend a combination like Glimestar PM2. Each component addresses a different biological resistance point, helping improve balance without relying too heavily on any single mechanism.

How to use GLIMESTAR PM2 TABLET

How to take Glimestar PM2 Tablet

• Glimestar PM2 is generally taken once daily as advised by a healthcare professional

Should Glimestar PM2 be taken with food?

• Yes. It is commonly recommended to take Glimestar PM2 with or just before meals to support digestive comfort and avoid sudden drops in blood sugar levels
• Eating around the same time daily can also help maintain steady glucose balance

When is the best time to take Glimestar PM2?

Glimestar PM2 is often taken once daily with the first major meal, typically breakfast. However, the timing may vary depending on your doctor's direction and overall treatment plan.

Dosage Instructions for Glimestar PM2

• The dosage is tailored to individual needs, typically 1 tablet daily
• The exact dose depends on several factors, including:
  • Blood sugar patterns
  • Response to other medications
  • Weight and dietary habits

 Safe usage tips for Glimestar PM2

• Keep a snack handy, especially if you are active, to counter any potential drop in energy
• Maintain proper hydration throughout the day
• Avoid skipping meals after taking your dose
• Monitor your glucose levels regularly as advised

What if I forgot to take GLIMESTAR PM2 TABLET

If you miss a dose:

• Take it as soon as you remember, preferably with food
• Skip the missed dose if it is close to your next scheduled dose, never double-dose
• Resume your regular schedule the next day

Overdose

Taking more of Glimestar PM2 Tablet, can cause signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). Consume any sugary food immediately. If the symptom worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

Side Effects Of GLIMESTAR PM2 TABLET

Commonly reported experiences after taking Glimestar PM2:

• hypoglycemia (low blood sugar levels)
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• joint pain, back pain, muscle pain

When to speak to a healthcare provider:

• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat)
• symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, unusual tiredness)
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (nausea or vomiting, stomach pain, yellowing of the skin or the whites of the eyes)

Warning & Precautions

Pregnancy

Consult your doctor

Human data is limited and not conclusive to determine the safety of Glimestar PM2 Tablet during pregnancy. Reproductive toxicity has been observed at high doses in animal models.

Breastfeeding

Consult your doctor

Glimestar PM2 Tablet may be excreted in small amounts in breast milk, potential to cause low blood sugar in the infant. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding.

Driving and Using Machines

Use with Caution

If your ability is affected by Glimestar PM2 Tablet, avoid driving or operating any heavy tools or machines.

Alcohol

Consult your doctor

Consumption of alcohol while taking Glimestar PM2 Tablet, may increase the risk of unwanted side effects. So it is better to avoid alcohol consumption.

Kidney

Consult your doctor

Glimestar PM2 Tablet is not recommended for use in patients with severe kidney problems as it may increase the risk of lactic acid build-up. It should be used with caution in patients with other kidney problems. Kidney function should be assessed before starting and monitored regularly while using this medicine. Dosage may need to be adjusted or stopped.

Liver

Consult your doctor

Glimestar PM2 Tablet is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Liver enzymes may need regular monitoring.

Allergy

Contraindicated

Do not take Glimestar PM2 Tablet if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other ingredients of this medicine.

Heart Disease

Consult your doctor

Risk of weight gain or swelling (edema) may increase, which could worsen underlying heart conditions so it is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Blood pressure and signs of congestive heart function should be monitored during regular follow-ups.

Use In Pediatrics

Contraindicated

Glimestar PM2 Tablet is not advisable for use in children and in adolescents (aged below 18 years).  

Use In Geriatrics

Use with Caution

Glimestar PM2 Tablet should be used with caution in elderly patients (aged above 65 years). Lower doses may be considered due to metabolism changes. In kidney or liver conditions: Careful evaluation is required to reduce the risk of adverse effects.

Other Warnings for GLIMESTAR PM2 TABLET

Before taking Glimestar PM2 Tablet, inform your doctor if you:

• are recovering from any injury, operation, infections or from any form of stress
• have edema (swelling of body parts)
• previously had stroke
• have anemia  
• have any bone problems or at risk of developing bone fractures
• are a premenopausal woman
• have thyroid problems

Who should not take [GBNKEYWORD

If you:

• have type I diabetes mellitus (insulin dependent diabetes)
• have lactic acidosis (build-up of lactic acid in the body)
• have diabetic ketoacidosis
• have bladder cancer
• pass bloody urine

Diet and Lifestyle Advice

Making mindful adjustments to your daily habits and food choices can support the role of Glimestar PM2 in your long-term routine.

1. Balanced Meal Planning

2. Meal Timing & Portion Control

• Aim to eat small, regular meals to avoid sugar dips or spikes
• Never skip meals
• Drinking enough plain water (8–10 glasses/day) helps the kidneys process metformin safely

• Avoid sugary drinks, fruit juices, or flavored sodas, which can spike sugar levels unexpectedly
• Limit caffeine and alcohol, especially if you notice fluctuations in energy or focus

3. Physical Activity: Consistency Over Intensity

• Include 30–45 minutes of moderate movement like walking, yoga, or cycling, at least 5 days a week
• Start slow and build up - consistency helps insulin sensitivity and energy management
• Avoid heavy workouts on an empty stomach or right after medicine intake to manage sugar lows.

4. Sleep & Stress Management

• Aim for 7–8 hours of restful sleep to support hormonal balance
• Mindfulness techniques like deep breathing, journaling, or light reading may help reduce stress-induced sugar fluctuations
• Avoid screen time right before bed as it may interfere with both sleep and sugar rhythms

5. Lifestyle monitoring tools (Optional for Users)

• Keep a simple glucose diary to note down timings, meals, and how you feel
• Use apps or physical journals to track exercise, sleep, and hydration
• Discuss your notes with your healthcare provider during checkups

Glimestar PM2 Tablet vs Other Commonly Prescribed Combination Tablets

Drug - Drug interaction

1. Medicines that may influence sugar levels

Some medicines can either enhance or reduce the glucose-lowering effects of Glimestar PM2.

2. Antibiotics and Antifungals

3. Other Antidiabetic Agents

Using Glimestar PM2 along with other glucose-lowering agents such as insulin, GLP-1 analogs, or SGLT2 inhibitors may lead to a compounded effect, increasing the chance of hypoglycemia. Always consult your doctor before combining.

4. Central Nervous System (CNS) acting medicines

Some medications that act on the brain can alter appetite or sugar metabolism:

Synopsis

More Information

What to expect while using Glimestar PM2 Tablet?

• Users may initially experience changes in energy levels, appetite, or digestive rhythm as the body adjusts
• Mild gastric sensitivity, such as a metallic taste or bloating, is sometimes noted due to the metformin component
• Consistency with meals and timing is important to avoid unexpected dips in sugar levels
• Your healthcare provider may ask for periodic lab tests to check kidney, liver, and glucose control markers

Did You Know? Facts About Glimestar PM2 Tablet

1. Meal Timing Matters

Taking Glimestar PM2 just before or with a meal may support better balance. Skipping meals while on such medications may lead to unwanted energy dips.

2. Not All Sugar Lows Are the Same

Beta-blockers, often prescribed for heart conditions, can mask the usual signs of low sugar (like fast heartbeat), which is why monitoring is so essential with Glimestar PM2.

3. Lab Monitoring Helps Tailor Doses

Did you know that routine tests like HbA1c, liver function, kidney profile, and eye check-ups are part of long-term safety when on glucose-modifying combinations.

4. Movement Enhances Effectiveness

Mild activity like walking after meals can complement how Glimestar PM2 supports your routine. Even 10–15 minutes of regular movement can align well with medicine timing.

FAQs About GLIMESTAR PM2 TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 277.

2. Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim and In Joo Kim. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2019. [Accessed on 12th June 2025] 

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 12th June 2025] 

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 12th June 2025] 

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 12th June 2025] 

6. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 12th June 2025] 

7. Cipla Ltd. TRIEXER ER Tablets (Glimepiride + Pioglitazone hydrochloride + Metformin hydrochloride). Ciplamed. [Revised in September 2020] [Accessed on 12th June 2025] 

8. Central Drugs Standard Control Organization. FDC of Glimepiride (1mg/2mg) + Pioglitazone (15mg) + Metformin (500mg E.R) Tablet. August 2005. [Accessed on 12th June 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 12 Jun 2025 | 01:02 PM(IST)