INTRODUCTION

ESTRABET contains Estradiol which belongs to Estrogen derivative. It contains estrogen hormone (estradiol) which is absorbed through the skin into the bloodstream. It works by replacing estrogen that is produced by the body. This medicine is used after menopause to reduce moderate to severe hot flashes and manages moderate to severe menopausal changes in and around the vagina. It provides systemic estrogen therapy by releasing estradiol, the major estrogenic hormone secreted by the human ovary.  Endogenous estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics.

Estradiol is the primary estrogen secreted prior to menopause. ESTRABET is absorbed through the skin and enters into the bloodstream which helps to reduce certain symptom of menopause like hot flashes, vaginal dryness, burning, and irritation. Always use this medicine exactly as instructed by your doctor. Before using this medicine, tell your doctor if you have liver, kidney or heart problems and if you are pregnant or breastfeeding. It is not recommended for use in children. The common side effects are breast pain, headache and nausea and vomiting.

USES OF ESTRABET

• Reduces certain symptom of menopause like hot flashes, vaginal dryness, burning, and irritation

HOW ESTRABET WORKS

ESTRABET is a female hormone. It is absorbed through the skin and enters into the bloodstream which helps to reduce certain symptom of menopause like hot flashes, vaginal dryness, burning, and irritation.

DIRECTIONS FOR USE

Always use this medicine exactly as your doctor has directed you. It is for external use only.

SIDE EFFECTS OF ESTRABET

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Stomach cramps:

Place a warm bottle or heated bag on your abdomen. Soak in a warm bath. Drink plenty of clear fluids and water.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are using any other vaginal tablets or creams.

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ESTRABET

What is ESTRABET used for?

It is used to manage and prevent hot flushes in women after menopause.

When ESTRABET should not be used?

It is not recommended if you have unusual vaginal bleeding, liver problems, or bleeding disorder. Consult your doctor for advice before using.

What happens in menopause?

Menopause is defined as an absence of menstrual periods for 12 months, results in the reduction of circulating estrogen.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs: Estrogens, progestins and contraceptives. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 309.

2. Levin ER, Hammes SR.  Estrogens and Progestins. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page 1173-1175.

3. Masters SB. Hypothalmic & Pituitary Hormones. Basic and Clinical Pharmacology. 11th ed. New Delhi, India; 2009. Page - 701-702.

4. Briggs GG, Freeman RK. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 500-501.

5. Naunton, Mark, Al Hadithy, Asmar F. Y, Brouwers, Jacobus R. B. J, Archer, David F. Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women. Menopause: The journal of the North American menopause society. Aug 5, 2005;[Revised Oct 12, 2005] https://journals.lww.com/menopausejournal/Abstract/2006/13030/Estradiol_gel__review_of_the_pharmacology,.26.aspx

6. Ascend Therapeutics US, LLC. 1975; U.S. Food & Drug Administration; [Revised March 2014] [Accessed Nov 13 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021166s010lbl.pdf  

7. Unimed Pharmaceuticals, Inc; U.S. Food & Drug Administration; [Revised Feb 2004] [Accessed Nov 13 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21166_estrogel_lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Calcium
• Vitamin D test