Eslizen 600mg Tablet 10'S
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Introduction About ESLIZEN
ESLIZEN contains Eslicarbazepine which belongs to the group of medicines called Antiepileptics. It is used to manage epilepsy and as an adjunctive therapy in adults with partial-onset seizures with or without secondary generalisation. Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behaviour, sensations and sometimes loss of awareness.
ESLIZEN is not recommended for use in patients allergic to Eslicarbazepine or who have heart rhythm disorders such as second- or third-degree heart block, severe liver or kidney disease. Before taking ESLIZEN, inform your doctor if you had a history of seizures, have pacemaker (device to control heartbeat) and blood problems such as anaemia. ESLIZEN should be used with caution in pregnant women only if it is clearly necessary and it is not recommended for use in breastfeeding women.
This medicine is not recommended for use in children (below 6 years) and can be used with caution in children and adolescents (from 6 to 18 years) after consulting the doctor. The most common side effects of taking ESLIZEN are dizziness, sleepiness, sensation of being unsteady, floating, nausea, vomiting, headache and diarrhoea. Consult your doctor if any of the above side effects worsens.
Uses Of ESLIZEN
- Used to manage epilepsy
How ESLIZEN Works
ESLIZEN works by stabilizing hyperexcited nerve cells in brain by blocking the voltage gated sodium channels that reduces repetitive abnormal nerve cell activity in brain which results in managing the occurrence of epilepsy or seizures.
How to use ESLIZEN
Take ESLIZEN as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition. Do not stop taking ESLIZEN unless your doctor advice you to stop.
Side Effects Of ESLIZEN
Common
- dizziness
- sleepiness
- nausea
- vomiting
- headache
- diarrhoea
- double or blurred vision
- difficulty in concentration
- tiredness
- feeling low in energy
- shaking
- skin rashes
- decreased appetite
- troubled sleep
- ataxia (difficulty in movement coordination)
Uncommon
- signs of allergic reactions such as sneezing, itchy, runny or blocked nose, watering eye
- constipation
- seizures
- cold intolerance, low body temperature, large tongue, thin and brittle fingernails, or hair
- yellowing of the skin or the whites of your eyes, nausea or vomiting, loss of appetite, stomach pain, dark urine (liver problems)
- high blood pressure
- low blood pressure
- dehydration
- abnormal eye movements, fuzzy vision, or red eye
- suffering falls, clumsiness
- poor memory or forgetfulness
- crying, feeling depressed, nervous, confused, poor interest or emotion
- inability to speak, write or understand
- agitation
- attention-deficit or hyperactivity disorder (a neurobehavioral disorder of childhood)
- irritability
- mood swings or hallucinations
- nose bleeding
- chest pain
- tingling or numbness sensation felt in any part of your body
- migraine (severe headache)
- burning sensation
- abnormal senses of touch, smell
- hearing difficulty, ringing in the ears
- swelling in legs and arms
- abdominal disturbances such as heartburn, stomach upset, pain, bloating
- dry mouth
- dark stools
- swollen gums or toothache
- sweating
- dry skin, itching and skin changes such as red skin
- hair loss
- signs of urinary tract infection such as strong, persistent urge to urinate, burning sensation while urinating
- weight loss
- muscle pain and weakness
- signs of bone metabolism disorder such as aching pain, increased bone fractures, weakened muscles
- flushing
- pain in limbs, cold limbs
- slow or irregular heartbeat
- sedation
- signs of neurological movement disorder (condition marked by twisting, repetitive movements or abnormal postures) such as tremor, pain, cramping
- anxiety
Rare
- self-harming thoughts
- signs of pancytopenia (low blood count of red cell, white cells, and platelets) such as weakness, dizziness, trouble breathing, fast heartbeat and fever
- signs of agranulocytosis (deficiency of immune cells) such as fever, chills, weakness, sore throat, bleeding gums, and bone pain
Stop taking and consult your doctor immediately if you experience:
- rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue (signs of an allergic reaction)
How To Manage Side Effects
Constipation
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.
Diarrhea
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult your doctor and inform them if the symptom gets worse.
Dizziness Or Drowsiness
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsened.
Headache
Consume lots of water and take rest. Do not skip meals. Do not strain your eyes for long durations, such as watching screen. Avoid taking alcohol. Consult your doctor if the condition persists for long or gets worsened.
Nausea And Vomiting
Try to take ESLIZEN with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor and inform if symptom gets worse.
Warning & Precautions
Pregnancy
Use with CautionESLIZEN should be used with caution in pregnant women only if it is clearly necessary. Consult your doctor before taking.
Breastfeeding
ContraindicatedESLIZEN is not recommended for use in breastfeeding women as it passes into the breast milk. Consult your doctor before taking.
Driving and Using Machines
Consult your doctorDo not drive or operate any machinery if you feel dizzy, drowsy and vision disturbances after taking ESLIZEN.
Kidney
ContraindicatedESLIZEN is not recommended for use in patients with severe kidney disease. It should be used with caution in patient with mild kidney disease. Consult your doctor before taking.
Liver
ContraindicatedESLIZEN is not recommended for use in patients with severe liver disease. It should be used with caution in patients with mild to moderate liver disease. Consult your doctor before taking.
Allergy
ContraindicatedESLIZEN is not recommended for use if you are allergic to Eslicarbazepine or to any other ingredients of this medicine.
Heart Disease
ContraindicatedESLIZEN is not recommended for use in patients with heart diseases such as heart rhythm disorder (second- or third-degree heart block). It should be used with caution in patients with heart failure or heart attack. Consult your doctor before taking the medicine.
Use In Pediatrics
ContraindicatedESLIZEN is not recommended for use in children (below 6 years). It should be used with caution in children and adolescents (from 6 to 18 years of age). Your doctor will prescribe the right dose depending on your child’s age, body weight and disease condition. Consult your doctor before taking.
Use In Geriatrics
Use with CautionESLIZEN should be used with caution in elderly patients (above 65 years). Consult your doctor before taking.
Others
Before taking ESLIZEN, inform the doctor if you:
- suffer from seizures causing widespread electric discharge that involved both sides of the brain
- have blood problems such as anaemia, bleeding disorders like haemophilia
- have pacemaker (device to control heartbeat) problems
Interactions
A. Drug-Drug Interactions:
Before taking ESLIZEN, inform your doctor if you are taking any of the following medicine:
- carbamazepine, oxcarbazepine, phenytoin, phenobarbital (used to manage seizures)
- hormonal contraceptives such as contraceptive pill (estrogen and progestin)
- simvastatin, rosuvastatin (used to lower blood cholesterol levels)
- warfarin (used to manage blood clots)
- amitriptyline (used to manage depression)
- diuretics (used to manage high blood pressure and reduce sodium level in blood such as chlorthalidone, hydrochlorothiazide, metolazone
- medicines used to manage heart diseases such as beta blockers (Ex. propranolol), antiarrhythmics (Ex. amiodarone, verapamil)
Overdosage:
If you or anyone else accidently takes too much of ESLIZEN, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are unsteady walking and muscle weakness on one side of the body.
Synopsis
| Drug | : | Eslicarbazepine |
| Pharmacological Category | : | Anti-epileptic drugs |
| Therapeutic Indication | : | Epilepsy |
| Dosage Forms | : | Tablet |
More Information
- Keep ESLIZEN out of reach of children
- Store at room temperature
FAQs About ESLIZEN
Q: What is ESLIZEN used for?
A: ESLIZEN is used to manage epilepsy and as an adjunctive therapy in adults with partial-onset seizures with or without secondary generalisation.
Q: What are the side effects of ESLIZEN?
A: The most common side effects of taking ESLIZEN are dizziness, sleepiness, sensation of being unsteady, spinning, or floating, nausea, vomiting, headache, and diarrhoea. Consult your doctor before taking.
Q: What if I forget to take ESLIZEN?
A: If you forget to take ESLIZEN, take it as early as you remember and carry on as usual. Do not take a double dose to make up for a forgotten dose.
Q: When can I stop taking ESLIZEN?
A: Do not stop taking ESLIZEN suddenly. If you do so, you might suffer more seizures. Your doctor will decide your duration of taking this medicine. Let your doctor decide when to stop your management with ESLIZEN. The dose will be given prescribed according to your health condition.
Q: What if I accidently take more ESLIZEN than I should?
If you or anyone else accidently takes too much of ESLIZEN, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are unsteady walking and muscle weakness on one side of the body.
Q: Can cardiac patients take ESLIZEN?
A: ESLIZEN is not recommended for use in patients with heart diseases such as heart rhythm disorder (second- or third-degree heart block). It should be used with caution in patients with heart failure or heart attack. Consult your doctor before taking the medicine.
References
1. Gerald G. Briggs, Roger K. Freeman, Craig V Towers, Alicia B Forinash. Drugs in Pregnancy and Lactation. Eleventh edition. 2017. Page 1727-1730.
2. Graciana L. Galiana, Angela C. Gauthier, Richard H. Mattson. Eslicarbazepine Acetate: A New Improvement on a Classic Drug Family for the Treatment of Partial-Onset Seizures. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. September 2017. [Assessed 21st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629137/
3. Eugen Trinka, Elinor Ben-Menachem, Pedro A Kowacs Christian Elger, Birgit Keller, Kurt Löffler, José Francisco Rocha, Patrício Soares-da-Silva. Efficacy and safety of eslicarbazepine acetate versus controlled-release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double-blind, randomized, parallel-group, multicenter study. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. Febraury 2018. [Assessed 21st June 2022] https://pubmed.ncbi.nlm.nih.gov/29369348/
4. G.L. Pharma GmbH. Electronic Medicines Compendium (EMC). [Revised in April 2020] [Assessed 21st June 2022] https://www.medicines.org.uk/emc/files/pil.13077.pdf
5. Sunovion Pharmaceuticals Canada Inc. Eslicarbazepine acetate. [Revised in July 2019] [Assessed 21st June 2022] https://www.sunovion.ca/monographs/aptiom.pdf
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