Introduction About ESILOC IV INJECTION

ESILOC IV INJECTION contains Esomeprazole which belongs to the group of medicines called Proton pump inhibitors. It is used for the management of Gastroesophageal reflux disease (GERD) and heartburn in adults and children. In adults, ESILOC IV INJECTION also helps in managing ulcers in the stomach or upper part of the gut (intestine) caused by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) medicines and helps in the management of rebleeding following therapeutic endoscopic procedures done for acute bleeding stomach (gastric) or intestinal (duodenal) ulcers.

GERD is a disease where acid from the stomach escapes into the tube which connects your throat to your stomach (esophagus) causing pain, inflammation. ESILOC IV INJECTION should be given in caution in patients with severe kidney and liver failure. Before receiving ESILOC IV INJECTION inform your doctor if you have or ever had a skin reaction after taking medicine to manage acidity or had history of allergic reaction to Esomeprazole or to any other proton pump inhibitor medicines (Ex. pantoprazole, lansoprazole, rabeprazole, omeprazole).

ESILOC IV INJECTION should be given only if considered clearly necessary by your doctor in pregnant women. It is not recommended in breast-feeding women. It is not recommended for use in children aged less than 1 year. Consult your doctor before receiving the medicine. The most common side effects of receiving ESILOC IV INJECTION are headache, diarrhoea, stomach pain, constipation, flatulence, nausea and vomiting. Contact your physician if any of the symptoms worsens with time.

Uses Of ESILOC IV INJECTION

It is used to:

• manage Gastroesophageal reflux disease (GERD)
• manage Stomach ulcers caused by NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
• prevent rebleeding following therapeutic endoscopic procedures done for acute bleeding stomach (gastric) or intestinal (duodenal) ulcers

How ESILOC IV INJECTION Works

ESILOC IV INJECTION belongs to proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of enzymes in the stomach cell. Hence it reduces gastric acidity by blocking the final step in acid production and helps in relief of acid related indigestion and heartburn.

How to use ESILOC IV INJECTION

ESILOC IV INJECTION is usually injected into a vein by your doctor or nurse. Your doctor will administer the correct dose for you depending upon your age, body weight and disease condition.

Side Effects Of ESILOC IV INJECTION

How To Manage Side Effects

Diarrhea

Drink plenty of liquids such as water, fruit juices or electrolytes to avoid loss of water (dehydration) in your body. Consult your doctor if the symptom persists for long time.

Headache

Rest and relax. Frequently hydrate yourself by drinking plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if needed. Do not consume too much of alcohol. Consult your doctor if symptom worsens.

Nausea And Vomiting

Try to take ESILOC IV INJECTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food.

Warning & Precautions

Pregnancy

Monitoring required

ESILOC IV INJECTION should be given in caution during pregnancy only if necessary. Consult your doctor before receiving ESILOC IV INJECTION.

Breastfeeding

Contraindicated

ESILOC IV INJECTION is generally not recommended for use in breast feeding women as it is unclear whether it passes through the breast milk. Consult your doctor before receiving ESILOC IV INJECTION.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools, machines if you experience dizziness and blurred vision after receiving ESILOC IV INJECTION. Consult your doctor before receiving the medicine.

Alcohol

Consult your doctor

Avoid or limit the consumption of alcohol while receiving ESILOC IV INJECTION because it might increase the amount of acid in your stomach than normal which can irritate your stomach lining and worsen your symptoms.

Kidney

Use with Caution

ESILOC IV INJECTION should be given in caution in patients with severe kidney problems. Consult your doctor receiving ESILOC IV INJECTION.

Liver

Use with Caution

ESILOC IV INJECTION should be given in caution in patients with severe liver problems. Consult your doctor receiving ESILOC IV INJECTION.

Allergy

Contraindicated

Do not receive ESILOC IV INJECTION if you are allergic to Esomeprazole or to any other ingredients of this medicine.

Use In Pediatrics

Contraindicated

ESILOC IV INJECTION is not recommended for use in children aged less than 1 year of age. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving ESILOC IV INJECTION.

Use In Geriatrics

Use with Caution

ESILOC IV INJECTION should be used with caution in elderly patients (65 years and above). Consult your doctor before receiving ESILOC IV INJECTION.

Interactions

A. Drug-Drug interactions:

Before receiving ESILOC IV INJECTION, inform your doctor if you are receiving any of these following medicines:

• medicines used to manage HIV infection (Ex. nelfinavir, atazanavir)
• corticosteroids (Ex. hydrocortisone, cortisone, prednisone and prednisolone)
• medicines used to manage blood clots (Ex. clopidogrel, warfarin)
• anti-fungal medicines (Ex. ketoconazole, itraconazole or voriconazole)
• medicine used to manage cancer (Ex. erlotinib)
• anti-depressants used to manage depression (Ex. citalopram, imipramine, clomipramine or St. John’s wort (Hypericum perforatum)
• medicines used to manage anxiety, relax muscles (Ex. diazepam)
• medicine used to manage fits (Ex. phenytoin)
• medicines used to manage intermittent pain in your legs while walking caused by an insufficient blood supply (Ex. cilostazol)
• medicines used for indigestion and heartburn (Ex. cisapride)
• digoxin (medicine used for heart problems)
• methotrexate (a chemotherapy medicine used in high doses to manage cancer)
• immunosuppressants for organ transplantation (Ex. tacrolimus)
• medicines used for management of tuberculosis (Ex. rifampicin)

Overdosage:

ESILOC IV INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

More Information

• Keep ESILOC IV INJECTION out of reach of children
• Store at room temperature

FAQs About ESILOC IV INJECTION

Q: Can ESILOC IV INJECTION used to manage heartburn?

A: Yes. ESILOC IV INJECTION contains Esomeprazole used to manage symptoms of stomach acid reflux such as heartburn, indigestion in adults and children above 1 year of age. Consult your doctor regarding the symptoms before receiving it.

Q: Can I take an antacid along while receiving ESILOC IV INJECTION?

A: Yes. It is safe to receive ESILOC IV INJECTION with antacids as there is no known interaction. However, consult your doctor before taking antacid after receiving ESILOC IV INJECTION.

Q: Can I drive after receiving ESILOC IV INJECTION?

A: It is advisable not drive as you may experience dizziness and blurred vision after receiving ESILOC IV INJECTION. Consult your doctor before receiving the medicine.

Q: Can ESILOC IV INJECTION be given to children?

A: ESILOC IV INJECTION is not recommended for use in children aged less than 1 year for the management of GERD. The dose may be adjusted based on age and body weight. Consult your doctor before receiving ESILOC IV INJECTION. 

Q: Can ESILOC IV INJECTION be given to pregnant women?

A: ESILOC IV INJECTION should be given in pregnant women only if considered clearly necessary by your doctor. If you think you may be pregnant or planning to become pregnant, consult your doctor for advice before receiving ESILOC IV INJECTION.

Q: Does ESILOC IV INJECTION cause headache? 

A: Yes, headache is one of the most common side effects of receiving ESILOC IV INJECTION. In case if you are experiencing a headache after receiving ESILOC IV INJECTION, try to rest and relax. Keep drinking plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if needed. Do not consume too much of alcohol. Consult your doctor if headache persists for a long time.

References

1. KD Tripathi. Drugs for Peptic Ulcer and G.E.R.D. Essentials of Medical Pharmacology. seventh edition. 2013. Page – 649, 653, 657.

2. Franke, Andreas, Caroline Hepp, Hermann Harder, Christoph Beglinger, and Manfred V. Singer. Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers. Scandinavian journal of gastroenterology. NIH National Library of Medicines, National Library of Medicine. 2008. [Accessed on 4th October 2022] https://pubmed.ncbi.nlm.nih.gov/18924018/

3. AstraZeneca Pharmaceuticals LP. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 4th October 2022] https://www.medicines.org.uk/emc/files/pil.43.pdf

4. Laboratorios NORMON, S.A. R. Esomeprazole. [Revised in September 2018] [Accessed on 4th October 2022] https://cdn.accord healthcare.com/ie/public/pil/bbba3599_esomeprazole_40_mg_powder_for_solution_for_infusion_pil_ie_02.pdf

5. Safarimex. Health Products Regulatory Authority [Revised in March 2017] [Accessed on 4th October 2022] https://www.hpra.ie/img/uploaded/swedocuments/2191053.PA1852_002_001.b829a905-b910-49b9-b19b-ebc6c1c72f32.000001PIL.170608.pdf

6. AstraZeneca Pharmaceuticals LP. U.S. Food & Drug Administration. [Revised in September 2012] [Accessed on 4th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021689s026lbl.pdf

Useful Diagnostic Tests

• Complete Blood Count

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 09 Feb 2023 | 12:00 AM(IST)