Duralast is used to manage early ejaculation by balancing certain chemicals in the brain. It contains Dapoxetine which belongs to the group of medicines called Selective serotonin reuptake inhibitors. It delays ejaculation by blocking the reuptake of a neurotransmitter called serotonin between the nerve cells. This increases the activity of serotonin within the brain, which increases the time taken to release semen (ejaculate) and can improve control over ejaculation.

Uses Of DURALAST 30MG TABLET

• Used to manage early ejaculation in adult men

How DURALAST 30MG TABLET Works

Duralast Tablet delays ejaculation by blocking the reuptake of a neurotransmitter called serotonin between the nerve cells. This increases the activity of serotonin within the brain, which increases the time taken to release semen (ejaculate) and can improve control over ejaculation during sexual intercourse.

How to use DURALAST 30MG TABLET

• Take Duralast Tablet as advised by your physician
• It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Take this medicine at least 1–3 hours before anticipated sexual activity
• Your doctor will decide the suitable dose and duration of therapy for you, depending upon your age, body weight, and health condition

Side Effects Of DURALAST 30MG TABLET

Common Side effects of Duralast Tablet:

• dizziness
• headache
• irritation, restlessness, difficulty in concentration, tiredness
• sleep disturbances
• involuntary shaking, trembling
• blurred vision
• ringing in the ears
• nasal block
• indigestion, stomach pain, bloating, diarrhoea, constipation
• excessive sweating
• increased or decreased blood pressure
• abnormal heart rate
• feeling itchy or cold sweats
• abnormal taste, teeth grinding

Stop taking Duralast Tablet and contact your doctor immediately if you experience any of the following side effects:

• seizures
• fainting or light-headedness while standing
• mood changes
• self-harming thoughts

Warning & Precautions

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you experience dizziness, fainting, or blurred vision after taking Duralast Tablet.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking Duralast Tablet as it might make you feel dizzy or drowsy, which can affect your daily activities.

Kidney

Use with Caution

Duralast Tablet should be used with caution in patients with kidney diseases.

Liver

Contraindicated

Duralast Tablet is not recommended for use in patients with moderate to severe liver diseases.

Allergy

Contraindicated

Do not take Duralast 30 Tablet if you are allergic to Dapoxetine or any other ingredients of this medicine.

Heart Disease

Contraindicated

Duralast 30 Tablet is not recommended for use in patients with heart problems (such as a heart attack or abnormal heart rhythm).

Use In Pediatrics

Contraindicated

Duralast 30 Tablet should not be used in children and adolescents (below 18 years of age).

Use In Geriatrics

Use with Caution

Duralast 30 Tablet should be used with caution in elderly patients (aged above 65 years).

Interactions

A. Drug-Drug interactions:

• Selective serotonin reuptake inhibitors (SSRIs) (Ex. fluoxetine, sertraline, citalopram, escitalopram, amitriptyline, isocarboxazid, selegiline, nefazodone, and St. John’s wort)
• Antipsychotics (Ex. Thioridazine)
• Alkali metal (Ex. Lithium)
• Amino acid (Ex. Tryptophan)
• Selective serotonin receptor agonists (Ex. almotriptan, sumatriptan)
• NSAIDs (Ex. ibuprofen and aspirin)
• Opioid analgesics (Ex. Tramadol)
• Antibiotics (Ex. telithromycin, linezolid, erythromycin, clarithromycin)
• Anti-viral agents (Ex. ritonavir, saquinavir, nelfinavir, atazanavir, amprenavir, fosamprenavir)
• Antifungals (Ex. ketoconazole, itraconazole, fluconazole)
• Anticoagulants (Ex. Warfarin)
• Phosphodiesterase (PDE) inhibitors. (such as sildenafil, tadalafil, or vardenafil)
• Calcium-channel blockers (Ex. verapamil, diltiazem)
• Neurokinin-1 antagonist (Ex. Aprepitant)
• Opiate (narcotic) analgesics (Ex. morphine, pethidine)
• Benzodiazepines (Ex. clonazepam, alprazolam, midazolam)

B. Drug-Food interaction:

Avoid drinking grapefruit juice within 24 hours prior to taking Duralast 30 Tablet as it may increase the level of Duralast in the body.

Overdosage:

If you or anyone else accidentally took more of Duralast, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

Disease description:

Premature ejaculation (PE) is when ejaculation happens sooner than a man or his partner would like during sex, within a defined period of time, usually less than 2 to 3 minutes. Occasional PE is also known as rapid ejaculation, premature climax or early ejaculation. It is considered the most common sexual disorder in the male population.

FAQs About DURALAST 30MG TABLET

Q: When is the best time to take Duralast?

A: Take Duralast at least 1–3 hours before anticipated sexual activity.

Q: How long can duralast make you last?

A: Studies tell, after three months of men taking 30 mg dose of dapoxetine took an average 2.78 minutes to ejaculate after penetration.

Q: Does duralast cure premature ejaculation permanently?

A: There is no permanent cure for premature ejaculation (PE), but there are treatments that can help. Some treatments include medications, counselling and techniques.

Q: Is duralast safe for heart?

A: No. Duralast is not recommended for use in patients with heart problems (such as a heart attack or abnormal heart rhythm).

Q: Is duralast safe for the kidneys?

A: Duralast should be used with caution in patients with kidney diseases.

Q: Are dapoxetine and Viagra the same?

A: No. Viagra enhances blood flow to the penis, which helps in achieving and sustaining an erection. Dapoxetine helps to delay ejaculation by increasing serotonin levels in the brain, which improves control over the timing of ejaculation.

Q: Can you take Duralast and Viagra together?

A: Consult your doctor before taking Duralast and Viagra together, as they may lower your blood pressure, especially when standing up.

Q: Can I take duralast daily?

A: Duralast should only be used if you are diagnosed with premature ejaculation. It is not intended for regular daily use.

Q: Who should not take duralast?

A: Duralast is not recommended if you are allergic to it, men who are below 18 years or above 65 years. It is not intended for use in women. Avoid consuming alcohol as it might cause increased dizziness.

Q: What is the maximum effect of dapoxetine?

A: The mean half life of dapoxetine after a single dose was estimated using modelling as 1.3–1.5 hours.

Q: Can I take tadalafil and dapoxetine together?

A: No. Viagra enhances blood flow to the penis, which helps in achieving and sustaining an erection. Dapoxetine helps to delay ejaculation by increasing serotonin levels in the brain, which improves control over the timing of ejaculation.

Q: How should I take dapoxetine for best results?

A: Take dapoxetine exactly as instructed by your doctor. Drink a full glass of water at the same time as you take a tablet.

Q: When is dapoxetine most effective?

A: Dapoxetine is available at 2 different strengths such as 30 mg and 60 mg. The recommended starting dose for all men is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity.

Q: What age is dapoxetine for?

A: Dapoxetine is used for premature ejaculation (PE) in men between 18 to 64 years old.

Q: How many minutes does dapoxetine make you last?

A: Men taking a 30 mg dose of dapoxetine took an average 2.78 minutes to ejaculate after penetration, those on a 60 mg dose took 3.32 minutes.

Q: Why do some men release quickly?

A: Men release quickly due to premature ejaculation, nervousness of being with a new partner, anxiousness of having sex again after a long period of abstinence, lack of confidence, guilt, being overly excited or stimulated or other reasons.

References

1. K.D. Tripathi MD. Antidepressant and antianxiety drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 461-462.

2. Chris G. McMahon. Efficacy of Dapoxetine in the Treatment of Premature Ejaculation: Clinical insights: Reproductive health. [Revised in August 2021] [Accessed on 27th March 2024] click here

3. A. Menarini Farmaceutica Internazionale. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 27th March 2024] click here

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Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 14 Oct 2024 | 10:45 AM(IST)