Introduction About DUPROST 0.5MG CAPSULE

DUPROST 0.5MG CAPSULE contains Dutasteride which belongs to the group of medicines called 5-Alpha reductase inhibitors. It is used to manage the signs and symptoms of benign prostatic hyperplasia (BPH) among adult men.

BPH (also known enlarged prostate) is a non-cancerous growth of the prostate gland caused due to increased production of a stress hormone called dihydrotestosterone (DHT) in aging men. Symptoms of BPH includes urinary problems such as difficulty in passing urine, urinary incontinence (unintentional passing of urine), frequent urination at night, sexual dysfunction, or painful ejaculation.

DUPROST 0.5MG CAPSULE is highly used in combination with other medicines (such as tamsulosin or silodosin) to achieve better results. During management with DUPROST 0.5MG CAPSULE, your doctor will regularly monitor your serum PSA levels (prostate specific antigen) to rule out risk of unwanted side effects.

Before taking DUPROST 0.5MG CAPSULE inform your doctor if you any liver or kidney problems. Women who are pregnant or think they may be pregnant should not come in contact with DUPROST 0.5MG CAPSULE as it may cause serious harm to the growing fetus.

Men taking DUPROST 0.5MG CAPSULE should use condom to manage seminal exposure of DUPROST 0.5MG CAPSULE to their partners who are in childbearing age group.

They must also avoid donating their blood while on therapy with DUPROST 0.5MG CAPSULE and until at least 6 months after stopping the therapy to manage the exposure of dutasteride to a pregnant female transfusion recipient.

The most common side effects of taking DUPROST 0.5MG CAPSULE are low sex drive, impotence, difficulty in reaching orgasm, low sperm count and problems in ejaculation. Consult your doctor if any of these side effects trouble you.

Uses Of DUPROST 0.5MG CAPSULE

It is used in adult men to manage the signs and symptoms of:

• benign prostatic hyperplasia (enlarged prostate)

How DUPROST 0.5MG CAPSULE Works

DUPROST 0.5MG CAPSULE is a 5-alpha reductase inhibitor. It blocks the activity of certain enzymes (Type II 5α-reductase) in the body that is responsible for converting normal male hormones (testosterone) into stress hormones (dihydrotestosterone) which causes abnormal prostate enlargement. As a result, it shrinks the size of an enlarged prostate and reduces the signs and symptoms of BPH.

How to use DUPROST 0.5MG CAPSULE

Take DUPROST 0.5MG CAPSULE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. DUPROST 0.5MG CAPSULE can be taken with or without meals.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking DUPROST 0.5MG CAPSULE without consulting your doctor.

Side Effects Of DUPROST 0.5MG CAPSULE

How To Manage Side Effects

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Warning & Precautions

Pregnancy

DUPROST 0.5MG CAPSULE is not intended for use in women. Also, women who are pregnant or can become pregnant should not handle the broken/leaked medicine or be exposed to the semen of men taking DUPROST 0.5MG CAPSULE, as it may cause serious abnormalities in the growing baby. Contact your doctor for advice if a pregnant woman gets accidentally exposed to DUPROST 0.5MG CAPSULE.

Breastfeeding

DUPROST 0.5MG CAPSULE is not intended for use in women.

Driving and Using Machines

DUPROST 0.5MG CAPSULE is unlikely to affect your ability for driving or handling heavy tools or machines.

Alcohol

Avoid consumption of alcohol while taking DUPROST 0.5MG CAPSULE as it may make you dizzier.

Kidney

DUPROST 0.5MG CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

DUPROST 0.5MG CAPSULE is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with any other liver problems. Therefore, consult your doctor before taking it.

Allergy

Do not take DUPROST 0.5MG CAPSULE if you are allergic to dutasteride or to any other 5-alpha reductase inhibitors (such as finasteride).

Interactions

A. Drug-Drug interactions:

Before taking DUPROST 0.5MG CAPSULE, inform your doctor if you are taking any of the following medicines such as:

• medicines used to manage heart problems (Ex. verapamil or diltiazem)
• medicines used to manage HIV infection (Ex. ritonavir or indinavir)
• medicines used to manage fungal infections (Ex. itraconazole or ketoconazole)
• nefazodone (a medicine used to manage depression)
• other medicines used in the management of enlarged prostate such as alpha blockers (Ex. prazosin, terazosin and doxazosin)

Overdosage:

If you or anyone else accidentally took more DUPROST 0.5MG CAPSULE, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep DUPROST 0.5MG CAPSULE out of reach of children
• Store DUPROST 0.5MG CAPSULE at room temperature

FAQs About DUPROST 0.5MG CAPSULE

What is the use of DUPROST 0.5MG CAPSULE?

DUPROST 0.5MG CAPSULE is used to manage the signs and symptoms of benign prostatic hyperplasia (BPH) in adult men. It helps in the shrinkage of an enlarged prostate and reduce the unpleasant symptoms associated with BPH.

Can DUPROST 0.5MG CAPSULE helps to urinate easily?

DUPROST 0.5MG CAPSULE shrinks the size of an abnormally enlarged prostate which obstructs urine flow in patients with BPH. As a result, it improves urine flow and reduces pain or discomfort while passing urine.

Can DUPROST 0.5MG CAPSULE help to dissolve kidney stones?

No. DUPROST 0.5MG CAPSULE is only used to manage benign prostatic hyperplasia. It cannot dissolve kidney stones. However, consult your doctor before taking it.

Can the use of DUPROST 0.5MG CAPSULE reduce hair fall?

DUPROST 0.5MG CAPSULE is intended to manage benign prostatic hyperplasia. It is not recommended for use in reducing hair fall. However, consult your doctor before taking it.

Can the use of DUPROST 0.5MG CAPSULE affect my sexual life?

DUPROST 0.5MG CAPSULE may cause problems in sperm release (ejaculation) or decrease in sex drive. These side effects are usually temporary and disappears once therapy has been stopped. However, consult your doctor if they trouble you.

Can the use of DUPROST 0.5MG CAPSULE cause prostate cancer?

DUPROST 0.5MG CAPSULE may increase the risk of prostate cancer over prolonged use. Therefore, take DUPROST 0.5MG CAPSULE only as advised by your physician. During management with DUPROST 0.5MG CAPSULE, your doctor will regularly monitor your serum PSA levels (prostate specific antigen) to rule out risk of unwanted side effects.

I wish to father a child. Can I use DUPROST 0.5MG CAPSULE?

Before taking DUPROST 0.5MG CAPSULE, inform your doctor if you are planning to have a baby, because it can be found in the semen of men taking it. Both pregnant women and women of child-bearing potential must not be exposed to this medicine either through direct handling or through semen, because it may harm to the unborn baby. Men taking DUPROST 0.5MG CAPSULE should use condom during sexual intercourse to manage seminal exposure of DUPROST 0.5MG CAPSULE to their partners. They must also avoid donating their blood while on therapy with DUPROST 0.5MG CAPSULE and until at least 6 months after stopping the therapy to manage the exposure of dutasteride to a pregnant female transfusion recipient.

Can DUPROST 0.5MG CAPSULE cause infertility?

DUPROST 0.5MG CAPSULE does not make you infertile. However, it can reduce sex drive or can cause few problems in ejaculation. These side effects are usually temporary and disappears once therapy is stopped. However, consult your doctor if they trouble you. Also, take DUPROST 0.5MG CAPSULE only for the stipulated duration mentioned by your doctor to avoid the risk of side effects.

Can the use of DUPROST 0.5MG CAPSULE make me feel dizzy?

DUPROST 0.5MG CAPSULE may make you feel dizzy or faint especially while changing position. Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Who should not take DUPROST 0.5MG CAPSULE?

Do not take DUPROST 0.5MG CAPSULE if you have prostate cancer. It is not recommended for use in children and adolescents aged below 18 years. It should be used with caution in elderly patients. Women who are pregnant or think they may be pregnant should not come in contact with DUPROST 0.5MG CAPSULE as it may cause serious harm to the growing fetus. Before taking DUPROST 0.5MG CAPSULE inform your doctor if you any liver or kidney problems.

What is the best time to take DUPROST 0.5MG CAPSULE?

Take DUPROST 0.5MG CAPSULE regularly at the same time each day. It can be taken in the morning or at night with or without meals as instructed by your doctor.

What are the side effects of DUPROST 0.5MG CAPSULE?

The most common side effects of taking DUPROST 0.5MG CAPSULE are low sex drive, impotence, difficulty in reaching orgasm, low sperm count and problems in ejaculation. Consult your doctor if any of these side effects trouble you.

How long will it take for DUPROST 0.5MG CAPSULE to show the results?

It may take around 4 weeks for DUPROST 0.5MG CAPSULE to show results. However, this period may vary from patient-to-patient depending upon their disease condition. Therefore, continue to take this medicine as advised by your doctor.

What to do if I forgot to take a dose of DUPROST 0.5MG CAPSULE?

If you have missed a dose of DUPROST 0.5MG CAPSULE, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and take the next one regularly. Do not take a double dose of DUPROST 0.5MG CAPSULE to compensate the missed ones.

Can I stop taking DUPROST 0.5MG CAPSULE once my symptoms subside?

Do not stop taking DUPROST 0.5MG CAPSULE without consulting your doctor. Make sure to take this medicine for the stipulated duration recommended by your doctor to achieve maximum results.

References

1. KD Tripathi. Hormones and related drugs: Androgens and Drugs for Erectile Dysfunction. Essentials of Medical Pharmacology. 7th edition. 2013. Page - 303.

2. Roehrborn CG, Marks LS, Fenter T, Freedman S, Tuttle J, Gittleman M, Morrill B, Wolford ET. Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia. Urology. April 2004. [Accessed on 6th December 2022] https://www.goldjournal.net/article/S0090-4295(04)00068-8/fulltext

3. Cyndea Pharma S.L.Galenicum Health S.L. Accord Healthcare Limited. Pharmadox Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised in October 2019] [Accessed on 6th December 2022] https://www.medicines.org.uk/emc/files/pil.8917.pdf

4. GlaxoSmithKline Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised in June 2011] [Accessed on 6th December 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021319s023s025lbl.pdf

Useful Diagnostic Tests

• Prostate-specific antigen (PSA) blood test
• Prostate magnetic resonance imaging (MRI)
• Urine flow study
• Digital rectal examination
• Cystoscopy