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Quality Checked ProductsIntroduction About DOTIN 75 TABLET
DOTIN 75 TABLET is used to manage depression and can also help reduce feelings of anxiety. It contains Dothiepin which belongs to the group of medicines called Antidepressants. DOTIN 75 TABLET works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood.
DOTIN 75 TABLET is not recommended for use in patients with heart problems, glaucoma, prostate problems and fits. Before taking DOTIN 75 TABLET inform your doctor if you have any liver or kidney problems. Avoid consumption of alcohol during management with DOTIN 75 TABLET as it can make the drowsiness worse. It is not recommended for pregnant and breastfeeding women.
DOTIN 75 TABLET is not recommended for use in neonates and children. The most common side effects are increased heart rate, blurred vision, dryness in the mouth. Consult with your doctor if any of the side effect worsens.
Uses Of DOTIN 75 TABLET
- DOTIN 75 TABLET is used to manage depression and can also help reduce feelings of anxiety
How DOTIN 75 TABLET Works
DOTIN 75 TABLET is a tricyclic antidepressant which works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood.
How to use DOTIN 75 TABLET
Take DOTIN 75 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of DOTIN 75 TABLET
Common
- dry mouth
- blurred vision
- changes in the heart beat or heart conduction
- constipation and difficulty in passing water
- increased appetite
- weight gain or weight loss
Stop taking DOTIN 75 TABLET and consult your doctor immediately, if you experience:
- yellowing of the skin or whites of the eyes (jaundice)
- hepatitis (damage to the liver causing dark urine, jaundice, nausea and fever)
- fever (high temperature, sweating, shivering)
- discomfort around the right lower rib cage
- changes in the blood including bone marrow (these will be found if you have blood tests)
- severe mood changes such as extreme excitability
- fits
How To Manage Side Effects
Dry Mouth
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedDOTIN 75 TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
ContraindicatedDOTIN 75 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or use machines if you feel drowsy after taking DOTIN 75 TABLET. Consult your doctor for advice.
Alcohol
Consult your doctorDOTIN 75 TABLET can make you feel drowsy. If you drink alcohol with this medicine this can make you feel more drowsy.
Kidney
Use with CautionDOTIN 75 TABLET should be used with caution if you have severe renal disease. Consult your doctor before taking DOTIN 75 TABLET.
Liver
ContraindicatedDOTIN 75 TABLET is not recommended for use if you have liver problems. Consult your doctor before taking DOTIN 75 TABLET.
Allergy
ContraindicatedDo not take DOTIN 75 TABLET if you are allergic or hypersensitive to Dothiepin or any other ingredients of this medicine.
Heart Disease
Consult your doctorDOTIN 75 TABLET is not recommended for use in patients with acute myocardial infarction. It should be used with caution in patients with other cardiac disease. Consult your doctor before taking DOTIN 75 TABLET.
Use In Pediatrics
ContraindicatedDOTIN 75 TABLET is not recommended for use in neonates and children. Consult your doctor before taking the medicine.
Others
DOTIN 75 TABLET is not recommended for use if you:
- have prostate disease
- have mania
- have narrow-angle glaucoma
- have epilepsy
Before taking DOTIN 75 TABLET inform your doctor if you:
- are going to the dentist or going to have surgery
- have diabetics
- are receiving electro-shock therapy (ECT)
- have a thyroid problem
- are difficulty in passing urine, or a tumour of the adrenal gland (a gland above the kidney)
- suffer from hyperthyroidism
- suffer from porphyria
Interactions
A. Drug-Drug Interactions:
- Mono-amine oxidase inhibitor (Ex. selegiline, rasagiline)
- Antihypertensive agent (Ex. betanidine, debrisoquine, guanethidine, clonidine)
- Antiarrhythmic agents (Ex. quinidine, amiodarone, felcainide, procainamide, propafenone or disopyramide)
- Hayfever/allergy medicines (Ex. terfenadine or astemizole)
- Sotalol, quinidine, cisapride, pentamidine isetionate, clonidine
- Anti-malarial (Ex. halofantrine)
- Antibiotics (Ex. rifampicin)
- Barbiturates (Ex. amylobarbital, methylphenidate)
- Opioid/narcotic analgesics (Ex. codeine, morphine, co-proxamol, codydramol, tramadol)
- Sympathomimetic agents (Ex. ephedrine, pseudoephedrine, adrenaline and noradrenaline)
- Antimuscarinics (Ex. pimozide, sertindole)
- H2 blockers (Ex. Cimetidine)
- Diuretics
- Calcium channel blockers (Ex. amlodipine, diltiazem, nifedipine, verapamil)
- Anticonvulsants (Ex. phenytoin, primidone, carbamazepine)
- Oestrogen-containing contraceptives
- Local anaesthetics
- Quinolone antibiotics (Ex. moxifloxacin)
- Attention-Deficit/Hyperactivity Disorder (Ex. atomoxetine)
- Coumarin or other anticoagulants (Ex. warfarin)
- Anti-viral agents (Ex. ritonavir)
Overdosage:
If you or anyone else accidentally take too much of DOTIN 75 TABLET, consult your doctor immediately or visit the nearby hospital if you experience any unusual reactions. Symptoms of overdose are convulsions, reduction in heart and lung function and life threatening heart rhythm disorders which may even occur after apparent recovery.
Synopsis
| Drug | : | Dothiepin |
| Pharmacological Category | : | Tricyclic Antidepressants |
| Therapeutic Indication | : | Depression, Anxiety |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep DOTIN 75 TABLET out of reach of children
- Store DOTIN 75 TABLET at room temperature
FAQs About DOTIN 75 TABLET
Q: What is DOTIN 75 TABLET and why is it given?
A: DOTIN 75 TABLET is used to manage depression and can also help reduce feelings of anxiety. It contains Dothiepin which belongs to the group of medicines called Antidepressants.
Q: Can I stop taking DOTIN 75 TABLET on my own?
A: You should not stop taking the medicine, suddenly on your own without the advice of your doctor. Your doctor may gradually withdraw the dose in case of stopping the medicine. If you stop taking DOTIN 75 TABLET suddenly you may experience some withdrawal symptoms like irritability, insomnia and excessive perspiration (sweating).
Q: Is DOTIN 75 TABLET safe to use in pregnant and breast-feeding women?
A: No. DOTIN 75 TABLET is not recommended for pregnant and breastfeeding women. Consult your doctor before taking DOTIN 75 TABLET if you are pregnant or planning to get pregnant or breast-feeding your child.
Q: Can I drive or operate heavy machines after taking DOTIN 75 TABLET?
A: No. It may cause drowsiness. Therefore, it is not advisable to drive or use machineries and tools until you feel normal again. Consult your doctor for advice before taking DOTIN 75 TABLET.
Q: Can I buy DOTIN 75 TABLET online?
A: If you wish to buy DOTIN 75 TABLET in Netmeds, you need a prescription from a Registered Medical Practitioner. Netmeds has made buying online medicines easier for consumers and is one of India's leading Online Pharmacy.
Q: What if I forget to take DOTIN 75 TABLET?
A: If you miss a dose of DOTIN 75 TABLET, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Q: What is depression and anxiety?
A: Depression (major depressive disorder) is a common and serious mental disorder that negatively affects how you feel, think, act, and perceive the world. Anxiety is an emotion characterized by feelings of tension, worried thoughts, and physical changes like increased blood pressure.
Q: Is DOTIN 75 TABLET habit forming?
A: No. It is not a habit-forming medicine. However, it can cause side-effects especially when you stop taking it suddenly. Consult your doctor for advice.
Q: Is DOTIN 75 TABLET good for sleep?
A: It is a tricyclic antidepressant, is licensed for the management of depression, particularly where sedation is required. Although often prescribed to aid sleep, it disrupts REM sleep and there is no evidence that it has sleep-promoting effects.
Q: Is DOTIN 75 TABLET safe?
A: It may increase the risk of cardiovascular toxicity (cardiac arrhythmias, conduction disorders, cardiac failure and circulatory collapse) and severe hypotension. Consult your doctor before taking the medicine.
References
1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page-459.
2. T Nakagawa, K Ukai, S Kubo. Antidepressive effects of the stereoisomer cis-dosulepin hydrochloride. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1993. [Accessed on May 31st, 2024] https://pubmed.ncbi.nlm.nih.gov/8447840/
3. P Zusky, T C Manschreck, C Blanchard, J Rosenbaum, C Elliot, P Lou. Dothiepin hydrochloride: treatment efficacy and safety. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 1986. [Accessed on May 31st, 2024] https://pubmed.ncbi.nlm.nih.gov/3531188/
4. Dosulepin. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on May 31st, 2024] https://pubchem.ncbi.nlm.nih.gov/compound/Dosulepin#section=Mechanism-of-Action
5. Teva Pharmaceuticals Works Pvt Ltd. Dosulepin. [Revised in March 2021] [Accessed on May 31st, 2024] https://products.tevauk.com/mediafile/id/50662.pd
6. Arlak pharma. [Accessed on May 31st, 2024] https://www.arlakbiotech.com/product/ethip-50-tab/
7. Taj Generics. [Accessed on May 31st, 2024] https://tajgenerics.com/portfolio-item/dosulepin-tablets-50mg/
8. Tasmed. [Accessed on May 31st, 2024] https://tasmedlab.com/allproduct/dotin/
9. Strides Pharma UK Limited. [Revised on August, 2023] [Accessed on May 31st, 2024] https://www.medicines.org.uk/emc/files/pil.14342.pdf
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