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Introduction About DOFASMA A TABLET
DOFASMA A TABLET is used to manage asthma and chronic obstructive pulmonary disorder. It is a combination of Ambroxol and doxophylline, which belong to the group of medicines called Mucolytics and bronchodilators, respectively. It stimulates the production of a substance that lowers surface tension, which keeps the air sacs in the lungs from collapsing after exhalation. It also inhibits certain enzymes in the body called phosphodiesterase, which in turn increases the substance that leads to muscle relaxation, leading to dilation of the constricted airway tract. It also acts as an anti-inflammatory agent to reduce inflammation. This combined action makes breathing easier.
Limit the consumption of beverages and foods containing caffeine while taking DOFASMA A TABLET, as it may increase the risk of side effects. DOFASMA A TABLET is not recommended for use in patients with acute myocardial infarction and low blood pressure. If you are pregnant or breast-feeding, consult your doctor for advice before taking DOFASMA A TABLET.
DOFASMA A TABLET is not recommended for use in children (under 6 years of age), and it should be used with caution in elderly patients. Consult your doctor before taking it. The most common side effects of taking DOFASMA A TABLET are taste changes, nausea, and numbness in the throat and mouth. Consult your doctor if any of the symptoms worsen.
Uses Of DOFASMA A TABLET
To manage:
- Asthma
- Chronic obstructive pulmonary disorder (COPD)
How DOFASMA A TABLET Works
DOFASMA A TABLET helps to manage asthma and chronic obstructive pulmonary disorder, where ambroxol stimulates the production of a substance that lowers surface tension, which keeps the air sacs in the lungs from collapsing after exhalation. Doxophylline inhibits certain enzymes in the body called phosphodiesterase, which in turn increases the substance that leads to muscle relaxation, leading to dilation of the constricted airway tract. It also acts as an anti-inflammatory agent to reduce inflammation. This combined action makes breathing easier.
How to use DOFASMA A TABLET
Take DOFASMA A TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration will be decided by your doctor for you depending upon your age, body weight, and disease condition.
Side Effects Of DOFASMA A TABLET
Common
- Changes in taste sensation
- Numbness in the mouth and throat
- Nausea
Uncommon
- Vomiting
- Diarrhoea
- Indigestion
- Stomach pain
- Dry mouth
Rare
- Increased blood sugar
- Skin rash and itchiness
Stop taking DOFASMA A TABLET and contact your doctor immediately if you experience any of the following side effects:
- Allergic symptoms (skin itchiness, rashes, difficulty breathing, or eye swelling)
- Skin rash, including lesions on the mucous membranes of the mouth, throat, nose, eyes, and reproductive organs
- Severe nausea, vomiting, stomach pain, headache, irritability, insomnia, increased heart rate, skipped heartbeat, and fast breathing
How To Manage Side Effects
Dry Mouth
Sip water and other sugar-free liquids regularly. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea persists.
Stomach Pain
Avoid spicy or fatty foods, caffeine, or alcohol that may exacerbate symptoms. Eat a bland diet consisting of easily digestible foods like rice, bananas, applesauce, and toast. Applying a heating pad or taking a warm bath can also help soothe abdominal muscles and alleviate discomfort. Drink plenty of fluids to stay hydrated but avoid excessive consumption to prevent further irritation. If stomach pain persists, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedDOFASMA A TABLET is generally not recommended for use in pregnant women as the medicine can cross the placental barrier. Consult your doctor for advice before taking it.
Breastfeeding
ContraindicatedDOFASMA A TABLET is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor for advice before taking it.
Driving and Using Machines
SafeDOFASMA A TABLET does not affect the alertness of the patient and therefore does not interfere with the ability to drive and use machines.
Kidney
Use with CautionDOFASMA A TABLET should be taken with caution in patients with impaired kidney function. Consult your doctor before taking DOFASMA A TABLET.
Liver
Use with CautionDOFASMA A TABLET should be taken with caution in patients with severe liver disease. Consult your doctor before taking DOFASMA A TABLET.
Allergy
ContraindicatedDo not take DOFASMA A TABLET if you are allergic to Ambroxol, Bromhexine, Doxophylline, or other xanthine derivatives (such as methylxanthine).
Lungs
Use with CautionDOFASMA A TABLET should be taken with caution in patients with existing lung conditions such as chronic obstructive lung disorder, severe uncontrolled asthma, pneumonia, or bronchial motor activity disorder, along with excessive mucous secretion (risk of a mucous plug). Consult your doctor before taking DOFASMA A TABLET.
Heart Disease
Consult your doctorDOFASMA A TABLET is not recommended for use in patients with acute myocardial infarction (blockage of blood flow to the heart muscle) and low blood pressure. It should be taken with caution in patients with heart disease, high blood pressure, pulmonary heart disease, congestive heart failure (the heart muscle doesn't pump blood sufficiently), and severe hypoxemia (low levels of oxygen in the blood). Consult your doctor before taking DOFASMA A TABLET.
Use In Pediatrics
ContraindicatedDOFASMA A TABLET is generally not recommended for use in children (under 6 years of age). Consult the child's doctor for advice.
Use In Geriatrics
Use with CautionDOFASMA A TABLET should be used with caution with elderly patients. Consult your doctor before taking DOFASMA A TABLET.
Others
Before taking DOFASMA A TABLET, inform your doctor if you have:
- Hyperthyroidism
- Peptic ulcers or predilection for the development of peptic ulcers
- Concomitant infections
- Low immune system due to other health conditions (Ex. HIV infection)
Interactions
A. Drug-Drug interactions:
- Antibiotics (Ex. erythromycin, troleandomycin, lincomycin, and clindamycin)
- Anti-gout (Ex. allopurinol)
- H2 receptor antagonist (Ex. cimetidine)
- Beta-blockers (Ex. propranolol)
- Influenza vaccine
- Anticonvulsant (Ex. phenytoin)
- Antineoplastic (Ex. melphalan, busulfan, methotrexate)
B. Drug-food interaction:
Avoid consuming beverages and foods containing caffeine while taking DOFASMA A TABLET, as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally takes too much DOFASMA A TABLET, consult your physician immediately or visit the nearby hospital. Symptoms of overdosage are severe cardiac arrhythmias (irregular heart rhythm) and tonic-clonic seizures.
Synopsis
| Drug | : | Ambroxol, Doxophylline |
| Pharmacological Category | : | Aromatic amines, Methylxanthines |
| Therapeutic Indication | : | Asthma & COPD |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep DOFASMA A TABLET out of reach of children
- Store at room temperature
FAQs About DOFASMA A TABLET
Q: What is DOFASMA A TABLET used for?
A: DOFASMA A TABLET is used to manage asthma (a condition in which the airways become narrow, swell, and produce extra mucus, which leads to breathing difficulties, chest pain, severe dry cough, and increased heartbeat) and chronic obstructive pulmonary disorder (a lung disorder in which the flow of air to the lungs is obstructed, which leads to shortness of breath, dry cough with phlegm, wheezing, fatigue, and weight loss).
Q: What are the side effects of DOFASMA A TABLET?
A: The most common side effects of taking DOFASMA A TABLET are changes in taste sensation, nausea, and numbness in the throat or mouth. Consult your doctor if any of the symptoms worsen.
Q: How does DOFASMA A TABLET work?
A: GBNKEYWORD] helps to manage asthma and chronic obstructive pulmonary disorder, where ambroxol stimulates the production of a substance that lowers surface tension, which keeps the air sacs in the lungs from collapsing after exhalation. Doxophylline inhibits certain enzymes in the body called phosphodiesterase, which in turn increases the substance that leads to muscle relaxation, leading to dilation of the constricted airway tract. It also acts as an anti-inflammatory agent to reduce inflammation. This combined action makes breathing easier.
Q: What should I avoid while taking DOFASMA A TABLET?
A: Avoid consuming beverages and foods containing caffeine while taking DOFASMA A TABLET, as it may increase the risk of side effects. Also, avoid smoking or using tobacco products, as it may worsen the condition of the patient by reducing lung function.
Q: What happens if I forget to take a dose of DOFASMA A TABLET?
A: You should take DOFASMA A TABLET immediately when you remember. If it is time for your next dose, skip the missed dose and follow your regular dose schedule. Do not double the dose to make up for your missed dose.
Q: Is DOFASMA A TABLET safe to use in patients with lung diseases?
A: DOFASMA A TABLET should be used with caution in patients with existing lung conditions such as chronic obstructive lung disorder, severe uncontrolled asthma, pneumonia, or bronchial motor activity disorder, along with excessive mucous secretion (risk of a mucous plug). Consult your doctor before taking it.
Q: How do I take DOFASMA A TABLET?
A: Take DOFASMA A TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration will be decided by your doctor for you depending upon your age, body weight, and disease condition.
Q: Is DOFASMA A TABLET safe during pregnancy?
A: DOFASMA A TABLET is generally not recommended for use in pregnant women as the medicine can cross the placental barrier. Consult your doctor for advice before taking it.
Q: Can I use DOFASMA A TABLET with children?
A: DOFASMA A TABLET is generally not recommended for use in children (under 6 years of age). Consult the child's doctor for advice.
Q: What precautions must be taken while using DOFASMA A TABLET?
A: DOFASMA A TABLET should be taken with caution in patients with impaired kidney function, severe liver disease, existing lung conditions such as chronic obstructive lung disorder, severe uncontrolled asthma, pneumonia, or bronchial motor activity disorder along with excessive mucous secretion (risk of a mucous plug), heart disease, high blood pressure, pulmonary heart disease, congestive heart failure (heart muscle doesn't pump blood sufficiently), and severe hypoxemia (low levels of oxygen in the blood), or have hyperthyroidism, peptic ulcer, concomitant infections, or a low immune system due to other health conditions (Ex. HIV infection). Consult your doctor before taking DOFASMA A TABLET.
Q: Who should not take DOFASMA A TABLET?
A: Do not take DOFASMA A TABLET if you are allergic to Ambroxol, Bromhexine, Doxophylline, or other xanthine derivatives (such as methylxanthine) or if you have acute myocardial infarction (blockage of blood flow to the heart muscle) and low blood pressure.
References
1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 218-219, 227.
2. Ahmad Kantar, Ludger Klimek, Dorotheea Cazan, Annette Sperl, Ulrike Sent, and Margarida Mesquita. An overview of the efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with a special regard to children. Journal of Multidisciplinary Respiratory Medicine. March 2020. [Accessed on 7th June 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137760/
3. Paola Rogliani, Luigino Calzetta, Josuel Ora, Mario Cazzola, and Maria Gabriella Matera. Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis. Journal of Multidisciplinary Respiratory Medicine. August 2019. [Accessed on 7th June 2024] https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0189-0
4. Mario Cazzola, Maria Gabriella Matera. The effect of doxofylline in asthma and COPD. Journal of Respiratory Medicine. April 2020. [Accessed on 7th June 2024] https://www.resmedjournal.com/article/S0954-6111(20)30044-5/fulltext
5. Vibcare Pharma Pvt. Ltd. Vibodoxo AM (Doxofylline and Ambroxol). [Accessed on 7th June 2024] https://vibcare.co.in/doxofylline-ambroxol/#!/SIDEEFFECTS
6. Pharmaceutical Society of Singapore. Ambroxol Tablets. hsa.gov. [Revised in April 2017] [Accessed on 7th June 2024] https://www.hsa.gov.sg/docs/default-source/announcements/prescription-only-medicines-(pom)/ambroxol-pil-26-04-2017.pdf
7. Abc Farmaceutici. Ansimar (Doxofylline Tablets). [Revised in March 2011] [Accessed on 7th June 2024] https://www.abcfarmaceutici.it/uploads/news/40_file3_en.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Total IGE
- Wheeze/Rhinitis Comprehensive Panel Adult
- Basic Allergy Package
- Absolute Eosinophil Count, Blood
- Culture Sputum (Aerobic)
- Allergy Comprehensive Profile
- Allergy Post Screening Profile
Author Details
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