INTRODUCTION

DIZIRON 25MG contains Cinnarizine which belongs to the group of medicines called Antihistamines. It is used in adults and in adolescents (aged 12 years or above) to manage motion sickness (nausea caused due to motion/travelling), vertigo (a sense of spinning) and Meniere’s disease (a disorder of the inner ear that causes episodes of dizziness, vertigo and problems in hearing).

It can also be used to manage the symptoms caused due to poor blood circulation in the limbs (such as Raynaud’s phenomenon (narrowing of the capillaries of the skin), acrocyanosis (bluish discoloration of extremities), intermittent claudication (pain in legs while walking), painful muscle spasm, varicose veins, cold or numb fingers or toes) and in the brain (such as irritabilty, loss of memory, lack of concentration). It is also used as a prophylactic therapy for preventing migraine headaches.

DIZIRON 25MG may cause stomach discomfort in some individuals. To avoid this, try to take DIZIRON 25MG with or after meals. While undergoing therapy with DIZIRON 25MG, avoid consuming alcohol as it might make your feel more tired and dizzier.

Before taking DIZIRON 25MG inform your doctor if you have any liver or kidney problems. You must also inform your doctor before taking DIZIRON 25MG if you have parkinsonism or low blood pressure.

Talk to your doctor if you are concomitantly taking any other medicines that can depress your central nervous system (such as antidepressants or hypnotics). Do not take DIZIRON 25MG if you are pregnant or breastfeeding without consulting your doctor.

The most common side effects of taking DIZIRON 25MG are drowsiness, sleepiness and tiredness. Therefore, do not drive or operate any heavy tools or machines that requires complete concentration. Consult your doctor if any of these side effects worsen.

USES OF DIZIRON 25MG

It is used in adults and in adolescents (aged 12 years or above) to:

• Manage motion sickness (feeling nausea which is caused due to motion or travelling)
• Manage vertigo (spinning sensation) and other balance disorders such as Meniere’s disease
• Manage problems caused due to poor blood circulation in the limbs (such as Raynaud’s phenomenon, painful muscle spasm in the legs, varicose veins, coldness or numbness in the extremities)
• Manage problems caused due to poor blood circulation in the brain (such as irritabilty, loss of memory, lack of concentration)
• Prevent migraine headaches

HOW DIZIRON 25MG WORKS

DIZIRON 25MG is an antihistamine medicine with anti-motion sickness and vasodilating properties. It contains cinnarizine which is a Histamine (H1) receptor blocker. It reduces the unpleasant symptoms of motion sickness (such as nausea, dizziness, feeling sick or clampy) by blocking the release of certain chemicals (histamines) in the body that triggers an allergic response.

It also improves body balance by preventing the narrowing of blood vessels supplying the inner ear. It reduces the spasm of blood vessels and improves blood flow to the peripheral parts of the body. It also mediates the release of certain chemical messengers (dopamine and serotonin) in the brain that stabilizes the mental health.

DIRECTIONS FOR USE

Take DIZIRON 25MG as advised by your physician. Swallow DIZIRON 25MG with a glass of water. Do not cursh or chew the medicine.

Take DIZIRON 25MG preferably after meals to avoid unwanted gastrointestinal side effects. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF DIZIRON 25MG

HOW TO MANAGE SIDE EFFECTS

Drowsiness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling drowsy. Do not consume excessive alcohol, as it could aggravate your condition. Consult your doctor if your dizziness worsens.

Stomach pain:

Take DIZIRON 25MG with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Eat and drink slowly or try to have smaller and frequent meals. If the symptom does not improve, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking DIZIRON 25MG, inform your doctor if you are taking any of the following medicines such as:

• medicines used to decrease anxiety and to induce sleep (Ex. diazepam, lorazepam, alprazolam)
• medicines used to manage depression (Ex. fluoxetine, amitriptyline, imipramine, escitalopram, sertraline)

Overdosage:

If you or anyone else accidentally took more DIZIRON 25MG, consult your doctor immediately or visit the nearby hospital. Overdosage might cause symptoms such as alternations in consciousness, vomiting, seizures, tremor, bradykinesia or loss of muscle tone.

SYNOPSIS

MORE INFORMATION

• Keep DIZIRON 25MG out of reach of children
• Store DIZIRON 25MG at room temperature

FAQs ABOUT DIZIRON 25MG

How does DIZIRON 25MG works?

DIZIRON 25MG is an antihistamine medicine with anti-motion sickness and vasodilating properties. It reduces the unpleasant symptoms of motion sickness (such as nausea, dizziness, feeling sick or clampy) by blocking the release of certain chemicals (histamines) in the body that triggers an allergic response. It also improves body balance by preventing the narrowing of blood vessels supplying the inner ear. It reduces the spasm of blood vessels and improves blood flow to the peripheral parts of the body. It also mediates the release of certain chemical messengers (dopamine and serotonin) in the brain that stabilizes the mental health.

What is the best time to take DIZIRON 25MG?

Take DIZIRON 25MG as directed by your physician. It must be taken after meals to avoid unwanted gastointestinal disturbances. Your doctor will decide the correct dose, duration of therapy and time of administration for you depending upon your age, body weight and disease condition.

Does DIZIRON 25MG stops dizziness?

Yes. DIZIRON 25MG is an antivertigo medicine with anti-motion sickness and vasodilating properties. It helps to reduce dizziness, vertigo, and other balance disorders. It corrects dizziness by improving the blood supply to the inner ear that controls hearing, balance and posture.

What are the side effects of DIZIRON 25MG?

The most common side effects of taking DIZIRON 25MG are drowsiness, sleepiness, and tiredness. Therefore, do not drive or operate any heavy tools or machines that requires complete concentration. It may also cause nausea and weight gain. Consult your doctor if any of these side effects worsen.

Will DIZIRON 25MG helps for ear buzzing?

Yes. DIZIRON 25MG is an antivertigo medicine with anti-motion sickness and vasodilating properties. It helps to reduce tinnitus (ringing sound in the ear), vertigo and other balance disorders. It corrects ear buzzing by improving the blood supply to the inner ear that controls hearing, balance and posture.

Can DIZIRON 25MG be used for long-term?

No. Take DIZIRON 25MG only for the stipulated duration prescribed by the doctor. Taking DIZIRON 25MG for a prolonged period than prescribed by the doctor may cause unwanted side effects such as parkinsonism (rigidity, tremor and abnormal muscle movements). However, elderly patients may use it to control vertigo under proper medical suprevision.

Can DIZIRON 25MG cause weight gain?

Yes. Weight gain is one of the common side effects of taking DIZIRON 25MG. It is because cinnarizine may stimulate your appetite and make you eat more. If this side effect bothers you, contact your doctor.

Who should not take DIZIRON 25MG?

DIZIRON 25MG should not be used in patients who are allergic to cinnarizine. It should be used with caution in patients with Parkinson’s disease or low blood pressure. Talk to your doctor if you have any sugar intolerance or any liver or kidney problems before taking DIZIRON 25MG. DIZIRON 25MG is not recommended for use in pregnant or breastfeeding women and in children aged below 12 years.

Is DIZIRON 25MG good for headache?

Yes. DIZIRON 25MG is an antivertigo medicine with anti-motion sickness and vasodilating properties. It helps to reduce vascular headache or migraine by improving blood flow to the brain.

Can DIZIRON 25MG cause parkinsonism?

DIZIRON 25MG acts by correcting your body balance, posture, and movements. Therefore, long term use or overuse may precipitate extrapyramidal symptoms such as tremor or rigidity. This is particularly evident in elderly patients and in patients with parkinsonism, and so caution should be exercised when used among such population.

Can DIZIRON 25MG make me feel sleepy?

Yes, DIZIRON 25MG can make your feel sleepy or drowsy. Do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.

How long should I take DIZIRON 25MG?

You need to take DIZIRON 25MG as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition

Can I stop taking DIZIRON 25MG without consulting your doctor?

No, you should not stop taking DIZIRON 25MG without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using DIZIRON 25MG, consult your doctor for advice. Your doctor would reduce the dose gradually before discontinuation of therapy.

Can I take DIZIRON 25MG after having a meal?

Yes, DIZIRON 25MG should be taken after having a meal because if [GBNKEYOWRD] if taken in an empty stomach, it may cause stomach discomfort.

What are the medicines that I should avoid while taking DIZIRON 25MG?

Avoid concomitant use of other CNS depressants which can reduce anxiety and induce sleep (such as alprazolam, clonazepam, midazolam), anti-epileptics (Ex. phenytoin, carbamazepine) and tricyclic antidepressants (such as amitriptyline, imipramine) while taking DIZIRON 25MG as it can lead to unwanted side effects.

Will taking a higher dose of DIZIRON 25MG be more effective?

No, taking a higher dose of DIZIRON 25MG will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What to do if I forget to take a dose of DIZIRON 25MG?

If you forget to take a dose of DIZIRON 25MG, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of DIZIRON 25MG to compensate a missed dose, as it could lead to toxicity.

REFERENCES

1. K.D. Tripathi. Antiemetic, Prokinetic and Digestant Drugs. Gastrointestinal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 663.

2. Milind Vasant Kirtane, Anita Bhandari, Prashant Narang and Ravi Santani. Cinnarizine: A Contemporary Review. NIH National Library of Medicine, National center for biotechnology information. November 2019. [Accessed on 16th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841794/

3. Johnson and Johnson Ltd. Health Product Regulatory Authority. [Revised in November 2019] [Accessed on 16th August 2022] http://www.hpra.ie/img/uploaded/swedocuments/311b29d1-75be-4d1e-8d70-dcbe034c2f03.pdf

4. Aspin Pharma (Pvt) Ltd. Stugeron Tablets/Stugeron Forte Capsules. [Accessed on 16th August 2022]. https://aspin.com.pk/wp-content/uploads/2020/02/Stugeron-PIL.pdf

5. Leephal Ventures Pvt. Ltd. Nausea and Vomiting. Vertigon and Cinzan Dt. [Accessed on 16th August 2022]. https://www.leehpl.com/nausea-and-vomiting.html#cinzan-dt