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Introduction About DICLOSAID F TABLET
DICLOSAID F TABLET is a combination of Diclofenac and Famotidine which belongs to the group of medicines called Non-steroidal Anti-inflammatory Drugs and H2-Receptor Antagonists respectively. It is used to relieve pain and inflammation in conditions affecting the joints (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis), muscles (back, shoulder) and tendons (tendonitis, tenosynovitis and bursitis) by reducing the risk of stomach ulcer (due to the use of pain killer).
DICLOSAID F TABLET is not recommended for use in patients having kidney, heart or liver failure, gastric or duodenal ulcers, bleeding in the digestive tract, cerebrovascular diseases and blood circulation problems.
DICLOSAID F TABLET should be taken with caution in patients with lung diseases, ulcerative colitis, crohn’s disease, porphyria, bleeding disorders, diabetes, systemic lupus erythematosus, planned for surgery of the stomach or intestine, history of blood clots, high blood pressure, raised cholesterol or triglycerides, the possibility of a malignant tumor in the stomach or history of a smoking habit.
DICLOSAID F TABLET should not be taken by pregnant and breastfeeding women including children and adolescents (aged 18 years or below). DICLOSAID F TABLET should be used with caution in elderly patients (65 years and above).
The most common side-effects of taking DICLOSAID F TABLET are stomach pain, heartburn, nausea, vomiting, indigestion, loss of appetite, flatulence, diarrhea and constipation. Talk to your doctor if any of the side effects worsen.
Uses Of DICLOSAID F TABLET
- Relieves pain and inflammation by reducing the risk of stomach ulcers
How DICLOSAID F TABLET Works
In DICLOSAID F TABLET, diclofenac effectively reduces pain, swelling and redness by blocking the inflammatory and pain pathways. Famotidine reduces the amount of acid produced in the stomach by blocking certain receptors called H2 receptors which produce stomach acid. Thus, it manages the occurrence of symptoms of stomach ulcers such as upper abdominal pain, heartburn and/or indigestion.
How to use DICLOSAID F TABLET
Take DICLOSAID F TABLET as advised by your physician. Swallow DICLOSAID F TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of DICLOSAID F TABLET for you depending upon your age, body weight and disease condition.
Side Effects Of DICLOSAID F TABLET
Common
- stomach pain, heartburn
- nausea, vomiting
- indigestion, flatulence
- loss of appetite
- headache, dizziness
- vertigo (sensation of feeling off balance)
- skin rash or spots
- constipation, diarrhea
Uncommon
- fast or irregular heartbeat
- chest pain
- heart disorders including heart attack or breathlessness
- tiredness
- dry mouth
- changes in taste
- severe itching
Rare
- stomach ulcers or bleeding, gastritis
- vomiting
- diarrhea with blood or bleeding from the back passage
- black, tarry faeces or stools
- drowsiness
- signs of fluid retention such as swollen ankles
- signs of asthma such as wheezing, breathlessness, coughing, and a tightness across the chest
Stop taking DICLOSAID F TABLET and inform your doctor immediately if you experience any of the following side-effects:
- signs of myocardial infarction or heart attack such as sudden and chest crushing
- signs of heart failure such as breathlessness, difficulty in breathing while lying down, swelling of legs or feet
- signs of stroke such as sudden weakness or numbness in the face, arm or leg especially on one side of the body, sudden loss of vision or disturbance in vision, sudden difficulty in speaking or ability to understand speech, sudden migraine like headaches
- signs of bleeding in stomach or intestines such as blood in vomit or black, tarry feaces
- signs of allergic reactions such as skin rash, itching, bruising, painful red areas, peeling, or blistering, swollen face, lips, hands or fingers
- signs of bronchospasm such as wheezing or shortness of breath
- signs of jaundice such as yellowing of skin or whites of the eyes
- persistent sore throat
- high temperature
- unexpected change in the amount of urine or appearance
- mild cramping and tenderness of the abdomen followed by rectal bleeding or bloody diarrhea
- signs of stevens johnson syndrome and toxic epidermal necrolysis such as severe blistering of the skin, eyes, mouth and genitals
- signs of kounis syndrome (serious allergic reaction) such as chest pain
- signs of interstitial pneumonia (lung disorder) such as shortness of breath or dry cough due to inflammation of the lungs
- signs of angioneurotic oedema such as swelling of the deeper layers of the skin caused by a build-up of fluid
How To Manage Side Effects
Nausea or Vomiting:
Try to take DICLOSAID F TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if your symptom does not improve.
Constipation:
Eat plenty of fiber rich foods such as vegetables, fresh fruits, cereals and drink plenty of water. Exercise more regularly. Consult your doctor if your symptom does not improve.
Diarrhea:
Drink lot of fluids such as water, squash or fruit juice to keep yourself hydrated. Do not take any medicine on your own for managing diarrhea without consulting your doctor. Consult your doctor if your symptom does not improve.
Indigestion:
Try to have smaller and more frequent meals while taking DICLOSAID F TABLET. Eat and drink slowly. Try to reduce consumption of tea, coffee and cola. Avoid smoking and don’t have rich, spicy or fatty foods. Consult your doctor if the symptom does not improve.
Dizziness:
Try to rest and relax. Avoid driving or operating any tools or machines while you are feeling dizzy. Avoid alcohol as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
DICLOSAID F TABLET is not recommended for use during the last three months of pregnancy since it may affect the baby’s circulation. It should be used with caution in the first 6 months of pregnancy only if considered clearly necessary. Consult your doctor before taking DICLOSAID F TABLET.
Breastfeeding
DICLOSAID F TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking DICLOSAID F TABLET.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy, tired, sleepy, have headache or eyesight problems after taking DICLOSAID F TABLET. Consult your doctor before taking DICLOSAID F TABLET.
Alcohol
Avoid consumption of alcohol while taking DICLOSAID F TABLET since it may increase the risk of gastrointestinal bleeding.
Kidney
DICLOSAID F TABLET is not recommended for use in patients with kidney failure. It should be used with caution in patients with kidney problems. Consult your doctor before taking DICLOSAID F TABLET.
Liver
DICLOSAID F TABLET is not recommended for use in patients with liver failure. It should be used with caution in patients with liver problems. Consult your doctor before taking DICLOSAID F TABLET.
Allergy
Do not take DICLOSAID F TABLET if you are allergic to Diclofenac or Famotidine.
Lungs
DICLOSAID F TABLET should be used with caution in patients with lung problems such as asthma, infections of the respiratory tract or chronic pulmonary disease. Consult your doctor before taking DICLOSAID F TABLET.
Heart Disease
DICLOSAID F TABLET is not recommended for use in patients with heart disease such as heart failure, heart attack, blockages of blood vessels to the heart or who had undergone operation to clear or bypass blockages. Consult your doctor before taking DICLOSAID F TABLET.
Others
DICLOSAID F TABLET is not recommended for use if you:
- have gastric or duodenal ulcer
- have signs of bleeding in the digestive tract such as blood in vomit, bleeding when emptying bowels, black or feces in blood
- have signs of bowel or stomach problems after taking non-steroidal anti-inflammatory drugs (NSAIDs)
- have cerebrovascular diseases such as stroke, mini-stoke
- have peripheral arterial disease
Before taking DICLOSAID F TABLET tell your doctor if you:
- have stomach or bowel disorders such as ulcerative colitis, Crohn’s disease
- have porphyria (type of red blood cell disorder)
- have blood or bleeding disorders
- have diabetes
- have swelling of the nasal mucosa, seasonal allergic rhinitis
- have chest pain
- have blood clots
- have high blood pressure, raised cholesterol or triglyceride levels
- have systemic lupus erythematosus (condition where immune system attacks its own tissues)
- have a planned for a surgery of stomach or intestine
- have a habit of smoking
- have possibility of a malignant tumor growth in the stomach
Use in Pediatrics:
DICLOSAID F TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use in Geriatrics:
DICLOSAID F TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking DICLOSAID F TABLET.
Interactions
A. Drug – Drug Interactions:
Before taking DICLOSAID F TABLET inform to your doctor, if you are taking any of these medicines:
- medicines to manage diabetes (Ex. glimepiride, gliclazide, glyburide)
- anticoagulants (medicines used to manage blood clots) Ex. warfarin, rivaroxaban
- diuretics (medicine used to manage high blood pressure) such as chlorothiazide, chlorthalidone, hydrochlorothiazide
- medicines used to manage mental problems Ex. lithium
- medicines used to manage inflammatory diseases or cancer Ex. methotrexate
- medicines used to manage some inflammatory disease and manage organ rejection after transplants Ex. ciclosporin, tacrolimus
- medicines used to manage or manage urinary tract infections Ex. trimethoprim
- medicine used for managing bacterial infections such as quinolone (Ex. ciprofloxacin, gemifloxacin, levofloxacin)
- other non-steroidal anti-inflammatory drugs or cox 2 inhibitors Ex. aspirin, ibuprofen
- medicines used to terminate pregnancy ex. mifepristone
- medicines used to manage heart problems or high blood pressure such as beta blockers (Ex. atenolol, bisoprolol, carvedilol) or Angiotensin-converting enzyme (ACE) inhibitors (Ex. benazepril, captopril, enalapril)
- medicine used to manage heart problems such as cardiac glycosides (Ex. digoxin)
- medicines used to manage depression such as selective serotonin reuptake inhibitors Ex. fluoxetine, fluvoxamine
- antifungals (medicine used to manage fungal infections) Ex. ketoconazole, itraconazole, voriconazole
- phenytoin (used to manage seizures)
- cholestyramine/clostipetol (medicines used to lower cholesterol levels)
- prednisolone, betamethasone (used to manage inflammatory condition)
- probenecid (used to manage gout)
- antacids (medicines used to manage indigestion) Ex. Aluminium hydroxide, magnesium carbonate
- medicines used to manage recurrence of ulcers Ex. sucralfate
- medicines used to manage high blood phosphate levels in patients of dialysis Ex. calcium carbonate
- medicines used in the management of HIV infection (Ex. atazanavir)
Overdosage:
If you or anyone else accidentally take too much of DICLOSAID F TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of DICLOSAID F TABLET includes headache, nausea, vomiting, abdominal pain, stomach or intestinal bleeding, excitation, disorientation, drowsiness, dizziness, fainting, ringing in ears, or occasionally convulsions (seizures, uncontrolled fits).
Synopsis
| Drug | : | Diclofenac, Famotidine |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drugs (NSAID), H2 Receptor Antagonist |
| Therapeutic Indication | : | Manages pain and inflammation by reducing the risk of stomach ulcer |
| Dosage Forms | : | Tablet |
More Information
- Keep DICLOSAID F TABLET out of reach of children
- Store DICLOSAID F TABLET at room temperature
FAQs About DICLOSAID F TABLET
Is DICLOSAID F TABLET safe in pregnant and breast-feeding women?
DICLOSAID F TABLET is not recommended for use during the last three months of pregnancy since it may affect the baby’s circulation. It should be used with caution in the first 6 months of pregnancy only if advised by the doctor. Consult your doctor before taking DICLOSAID F TABLET.
Is DICLOSAID F TABLET safe to use in elderly patients?
DICLOSAID F TABLET should be used with caution in elderly patients (aged 65 years and above). Your doctor will decide the correct dose and duration of the management with DICLOSAID F TABLET for you depending upon vital organ function and other disease condition. Consult your doctor before taking DICLOSAID F TABLET.
Can I stop taking DICLOSAID F TABLET on my own?
It is important that you keep taking DICLOSAID F TABLET for as long as your doctor has told you to take. Try not to stop the medicine on your own. If you have any further questions on the use of DICLOSAID F TABLET, consult your doctor.
Can DICLOSAID F TABLET be used in patients with kidney problems?
DICLOSAID F TABLET is not recommended for use in patients with kidney failure. It should be used with caution in patients with kidney problems. Your doctor may monitor your kidney function before and during management with this medicine to manage the risk of any unusual effects. Consult your doctor before taking DICLOSAID F TABLET.
What are the common side effects of DICLOSAID F TABLET?
The common side effects of taking DICLOSAID F TABLET are stomach pain, heartburn, nausea, vomiting, indigestion, flatulence, loss of appetite, headache, dizziness, skin rash or spots, constipation and diarrhea. Consult your doctor if any of the side effects worsen during or after management with DICLOSAID F TABLET.
References
1. K.D. Tripathi. Autacoids and Related Drugs & Gastrointestinal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 204 & 650.
2. J. Suryakumar, T. Chakrapani & D. R. Krishna. Famotidine Affects the Pharmacokinetics of Diclofenac Sodium. October 2012 [Accessed on 3rd June 2022] https://link.springer.com/article/10.1007/BF03258382
3. Tong J Gan. Diclofenac: an update on its mechanism of action and safety profile. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. July 2010 [Accessed on 3rd June 2022] https://pubmed.ncbi.nlm.nih.gov/20470236/
4. G J Morgan Jr, J Kaine, R DeLapp, R Palmer. Treatment of elderly patients with nabumetone or diclofenac: gastrointestinal safety profile. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 2001 [Accessed on 3rd June 2022] https://pubmed.ncbi.nlm.nih.gov/11276273/
5. Famotidine. NIH National Library of Medicine, National center for biotechnology information. PubChem. [Revised in June 2022] [Accessed on 3rd June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Famotidine
6. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.2661.pdf
7. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.2660.pdf
Useful Diagnostic Tests
- Liver function test
- Kidney function test
Author Details
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