Introduction About DEPOPRED INJECTION

DEPOPRED INJECTION is used to manage various adrenal gland problems, including adrenal insufficiency, congenital adrenal hyperplasia, and nonsuppurative thyroiditis. It is also effective in managing autoimmune and inflammatory conditions affecting different parts of the body, such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, psoriasis, optic neuritis, uveitis, asthma, and certain blood disorders like leukemia. Additionally, it helps manage inflammatory bowel diseases like Crohn's disease and ulcerative colitis, as well as tuberculous meningitis in the brain.

This medication is also prescribed for managing severe allergic reactions, including drug-induced hypersensitivity, atopic dermatitis, allergic conjunctivitis, and allergic rhinitis. It can prevent graft rejection after organ transplantation and support kidney health by reducing protein loss in the urine or increasing urine output in conditions like nephrotic syndrome.

Before receiving DEPOPRED INJECTION inform your doctor if you any viral infections, or any liver, kidney or heart problems. You must also inform your doctor if you have hypertension, diabetes, thyroid deficiency, glaucoma, skin problem, gut inflammation, muscle problems, osteoporosis, any types of tumors or cancer in the body, depression or any other forms of mental illness.

DEPOPRED INJECTION is not recommended for use in patients with severe fungal infections, brain swelling due to malaria, or brain injury or stroke. It should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. Avoid drinking grapefruit juice or eating grapefruit while receiving DEPOPRED INJECTION as it may lead to unwanted side effects.

The most common side effects of receiving DEPOPRED INJECTION are high blood pressure, swelling of body parts, muscle cramps or weakness, skin thinning, feeling sad or depressed and slowed growth in children. Consult your doctor if any of these side effect worsens.

You must also inform your doctor if you experience severe depression with suicidal thoughts or severe stomach pain with blood-stained stools or vomit after receiving it.

• adrenal insufficiency and its associated conditions
• bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
• skin and collagen disorders (Ex. severe erythema multiforme)
• eye problems (Ex. optic neuritis, uveitis or iritis)
• respiratory tract diseases (Ex. asthma, tuberculosis)
• blood cancer (leukemia), lymph cancer (lymphoma)
• problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
• brain problems (Ex. tuberculous meningitis)
• drug induced hypersensitivity reactions
• allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis)

It can also:

• prevent graft rejection following organ transplantation
• reduce flare-ups of multiple sclerosis and other stressful conditions
• improve urine output or reduce protein loss in urine among patients having nephrotic syndrome

It also reduces the release of certain chemicals (prostaglandins) in the body that causes pain, swelling and inflammation. It manages graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.

Common Side Effects of DEPOPRED INJECTION:

• high blood pressure (causing headache, or a general feeling of being unwell)
• swelling of body parts
• muscle cramps, weakness or wasting
• cataract, blurred vision
• slowed growth in children
• moon shaped face (Cushingoid facies)
• feeling sad, mood changes, mania, anxiety
• problems in sleeping
• difficulty in thinking, confusion, loss of memory, hallucinations
• fear or frightening thoughts
• acne, poor wound healing
• skin thinning

Contact your doctor immediately if you experience any of the following side effects while undergoing therapy with DEPOPRED INJECTION:

• signs of allergic reaction (such as skin rash, itching, blistering and peeling of the skin, swelling of the face, lips, mouth, throat which may lead to breathing difficulties)
• signs of bleeding in the gut (such as stomach pain which radiates until your back, bleeding from the anus, black or blood-stained stools, blood in vomit)
• increased infections causing fever or a general feeling of being unwell
• signs of flare up of a previous tuberculosis infection (such as coughing blood or pain in the chest)
• signs of pancreatitis (inflammation of pancreas causing severe stomach pain and vomiting)
• signs of blood clot in lungs (such as sharp chest pain, shortness of breath, coughing up blood)
• signs of increased pressure within the skull (such as severe headaches with vomiting, lack of energy and drowsiness) usually occurs once therapy is stopped
• thrombophlebitis (blood clots in vein supplying the legs causing leg pain, swelling, redness and tenderness)
• feeling depressed, suicidal thoughts
• blurred vision or other visual disturbances

Before receiving DEPOPRED INJECTION, inform your doctor if you are taking any of the following medicines such as:

• acetazolamide (a medicine used to manage glaucoma or edema)
• aminoglutethimide or cyclophosphamide (used for managing cancer)
• anticoagulants (used for blood thinning) such as acenocoumarol, phenindione and warfarin
• anti-cholinergic medicines used to manage myasthenia gravis (such as distigmine and neostigmine)
• antibacterials (Ex. isoniazid, erythromycin, clarithromycin and troleandomycin)
• anti diabetics (Ex. metformin, glipizide)
• aprepitant or fosaprepitant (antiemitics)
• non-steroidal anti-inflammatory medicines (used for fever and pain relief) such as aspirin, ibuprofen
• antiepileptics (such as carbamazepine, phenytoin and primidone)
• carbenoxolone and cimetidine (antiulcer agents)
• ciclosporin, tacrolimus (immunosuppressants)
• Cardiovascular agents (such as digoxin, diltiazem or mibefradil)
• oral contraceptives (birth control pills) Ex. ethinylestridiol and norethisterone
• medicines used to manage HIV infection (such as ritonavir, indinavir, cobicistat)
• Antifungals (such as ketoconazole, amphotericin B, itraconazole)
• muscle relaxants (Ex. pancuronium or vecuronium)
• diuretics (used to manage edema and hypertension) Ex. furosemide, chlorothiazide, hydrochlorothiazide
• medicines used to manage asthma (such as aminophylline, salmeterol, formoterol)
• rifampicin and rifabutin (Antituberculosis)
• live vaccines

B. Drug - Food interaction:

Avoid drinking grapefruit juice or eating grapefruit while undergoing therapy with DEPOPRED INJECTION as it may lead to unwanted side effects.

Overdosage:

DEPOPRED INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.