Introduction About D FAX 100 TABLET

D FAX 100 TABLET contains Desvenlafaxine which belongs to the group of medicines called Antidepressants. It is used in adults to manage major depressive disorder. Major depressive disorder (also known as clinical depression) is a mental health disorder characterized by persistant depressed mood, lack of interest, feeling of guilt, sleep disturbances or sucidial thoughts for a prolonged period (more than 2 weeks) that causes significant impairment in performing day-to-day activities.

Take D FAX 100 TABLET for the stipulated duartion mentioned by your doctor. Although, you might feel improvement in your condition after 2 weeks of therapy with D FAX 100 TABLET, it may take several weeks for D FAX 100 TABLET to deliver complete benefits. Therefore, continue to take D FAX 100 TABLET for the stipulated duration recommended by your doctor even if you feel better during the midway of the therapy.

Before taking D FAX 100 TABLET, inform your doctor if you have high blood fat levels or any liver, kidney or heart problems. You must also inform your doctor if you have or have a family history of bipolar disorder, mania or epilepsy. Do not take D FAX 100 TABLET if you are pregnant or breastfeeding without consulting your doctor.

Talk to your doctor if you are currently taking other antidepressant medicines (such as monoamine oxidase inhibitors (Ex. isocarboxazid, phenelzine and tranylcypromine)) while taking D FAX 100 TABLET. You must also inform your doctor if you have taken any antidepressant (especially monoamine oxidase inhibitor) within the last 14 days.

D FAX 100 TABLET may make you feel dizzy or sleepy. Therefore, do not drive or operate any heavy tools or machines that requires complete concentration.

Other side effects might include decreased sex drive, increased sweating, constipation, and dry mouth. Consult your doctor if any of these side effects worsen. Also, inform your doctor immediately if you experience any worsening or depression, unusual behaviour or have suicidal thoughts after taking D FAX 100 TABLET.

Uses Of D FAX 100 TABLET

• Manage major depressive disorder (depression) in adults

How D FAX 100 TABLET Works

D FAX 100 TABLET is a potent antidepressant drug. It contains a medicine called desvenlafaxine which is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It acts by increasing the levels of certain chemicals (serotonin and norepinephrine) within the brain that elevates your mood and stabilizes mental health. As a result, it makes you feel active and energetic.

How to use D FAX 100 TABLET

Take D FAX 100 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.

D FAX 100 TABLET can be taken with or without food. Your doctor will decide the correct dose and duration of theray for you depending upon your age, body weight and disease condition.

Continue to take D FAX 100 TABLET for the stipulated duration recommended by your doctor even if you feel better during the midway of the therapy.

Side Effects Of D FAX 100 TABLET

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.

Nausea And Vomiting

Take D FAX 100 TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.

Warning & Precautions

Pregnancy

Contraindicated

D FAX 100 TABLET is generally not recommended for use in pregnant women. If you become pregnant while undergoing therapy with D FAX 100 TABLET, inform your doctor immediately.

Breastfeeding

Contraindicated

D FAX 100 TABLET is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking D FAX 100 TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking D FAX 100 TABLET.

Kidney

Use with Caution

D FAX 100 TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

Use with Caution

D FAX 100 TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take D FAX 100 TABLET if you are allergic to Desvenlafaxine or Venlafaxine.

Heart Disease

Use with Caution

D FAX 100 TABLET should be used with caution in patients with heart diseases (such as high blood pressure). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking D FAX 100 TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to manage depression such as monoamine oxidase inhibitors (Ex. moclobemide, isocarboxazid, phenelzine and tranylcypromine), tricyclic antidepressants (Ex. amitriptyline, nortriptyline), lithium, fluoxetine, sertraline, citalopram, escitalopram etc.
• linezolid (an antibiotic used to manage bacterial infection)
• intravenous methylene blue (used to manage abnormal methemoglobin levels in blood)
• medicines used to manage migraine headaches (such as sumatriptan, zolmitriptan)
• fentanyl (an opioid analgesic used for pain relief)
• tramadol (used for pain relief)
• tryptophan (an aminoacid used for maintaing mental health)
• buspirone (a medicine used to reduce anxiety)
• amphetamines (used as CNS stimulants) Ex. dexamphetamine and lisdexamphetamine
• dextromethorphan (a cough medicine)
• methadone (a medicine used to manage pain or drug addiction)
• pentazocaine (an anesthetic used to cause numbness before surgeries)
• St. John’s Wort (a herbal medicine used to manage depression)
• medicines that can affect blood clotting (such as aspirin or warfarin)
• non-steroidal anti-inflammatory drugs (used for pain relief) Ex. paracetamol, ibuprofen, diclofenac
• medicines used to manage mood and anxiety (such as barbiturates (Ex. phenobarbital), benzodiazepines (Ex. diazepam, clonazepam, alprazolam))
• medicines used to manage psychotic disorders (Ex. chlorpromazine, prochlorperazine, trihexiphenidyl)

Overdosage:

If you or anyone else accidentally consumed more D FAX 100 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include headache, nausea, vomiting, dizziness, feeling agitated, constipation, diarrhea, dry mouth, numbness of body parts and fast heart rate.

Synopsis

More Information

• Keep D FAX 100 TABLET out of reach of children
• Store D FAX 100 TABLET at room temperature

FAQs About D FAX 100 TABLET

Q: What is the use of D FAX 100 TABLET?

A: D FAX 100 TABLET is an antidepressant medicine used to manage depression in adults.

Q: How long does it take for D FAX 100 TABLET to work?

A: It may take several weeks for D FAX 100 TABLET to heal your condition. Therefore, continue to take D FAX 100 TABLET for the stipulated duration recommended by your doctor without any interruption.

Q: Is D FAX 100 TABLET a strong antidepressant?

A: Yes. D FAX 100 TABLET is a strong antidepressant that effectively controls signs of depression. It works by increasing the levels of certain chemicals (serotonin and noreipherine) within the brain that stabilizes mental health.

Q: What is the best time to take D FAX 100 TABLET?

A: Take D FAX 100 TABLET approximately at the same time each day. You can take D FAX 100 TABLET either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.

Q: What is the difference between Venlafaxine and Desvenlafaxine?

A: Both Venlafaxine and Desvenlafaxine are selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used to manage depression. Desvenlafaxine is the primary active metabolite of venlafaxine. Following administration, it reaches the site of action with limited bioconversions. Whereas venlafaxine following administration must get converted into desvenlafaxine before providing necessary effects.

Q: Can D FAX 100 TABLET be used to reduce anxiety?

A: D FAX 100 TABLET is a prescription medicine used to manage depression. It has been shown to reduce anxiety. However, there are no proper evidence to prove that. If you wish to control anxiety using D FAX 100 TABLET, speak with your doctor for advice.

Q: How does D FAX 100 TABLET works?

A: D FAX 100 TABLET is a potent antidepressant drug. It acts by increasing the levels of certain chemicals (serotonin and norepinephrine) within the brain that elevates your mood and stabilizes mental health. As a result, it makes you feel active and energetic.

Q: Can I take D FAX 100 TABLET in the mornings?

A: Take D FAX 100 TABLET approximately at the same time each day. You can take D FAX 100 TABLET either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.

Q: Can D FAX 100 TABLET cause weight gain?

A: Yes. Weight gain is one of the common side effects of taking D FAX 100 TABLET. If this side effect bothers you, contact your doctor.

Q: Will D FAX 100 TABLET reduce my sex drive?

A: Yes. D FAX 100 TABLET may affect your sexual life. It may decrease sex drive or causing problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.

Q: Will the use of D FAX 100 TABLET make you feel sleepy or tired?

A: Yes, D FAX 100 TABLET can make your feel sleepy, drowsy, or tired. Do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.

Q: What precautions must be followed while taking D FAX 100 TABLET?

A: Before taking D FAX 100 TABLET, inform your doctor if you have high blood fat levels or any liver, kidney or heart problems. You must also inform your doctor if you have or have a family history of bipolar disorder, mania or epilepsy. Do not take D FAX 100 TABLET if you are pregnant or breastfeeding without consulting your doctor. Avoid taking other antidepressant medicines concomittantly while taking D FAX 100 TABLET without consulting your doctor. Take D FAX 100 TABLET for the stipulated duration recommended by your doctor to achieve better results. Contact your doctor immediately if you experience any worsening or depression, unusual behaviour or have suicidal thoughts or behaviour after taking D FAX 100 TABLET.

Q: Can D FAX 100 TABLET be used in children?

A: D FAX 100 TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.

Q: What to do if I forget to take a dose of D FAX 100 TABLET?

A: If you forget to take a dose of D FAX 100 TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of D FAX 100 TABLET to compensate a missed dose, as it could lead to toxicity.

Q: Will taking a higher dose of D FAX 100 TABLET than the prescribed one be beneficial?

A: No, taking a higher dose of D FAX 100 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: Can I stop taking D FAX 100 TABLET once my symptoms subside?

A; No. Do not stop taking D FAX 100 TABLET without consulting your doctor even if you feel better during the mid-way of the therapy. You may feel better after 2 weeks of therapy with D FAX 100 TABLET, but it might take several weeks for you to experience complete benefits. Also, sudden discontinuation of therapy may cause withdrawal symptoms such as headache, dizziness, nausea, irritability, lack of sleep, diarrhea, anxiety, abnormal dreams, fatigue and increased sweating.

Q: Can D FAX 100 TABLET be taken daily?

A: Yes. D FAX 100 TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.

References

1. Barbara G Wells, Joseph T. DiPiro, Terry L. Schwinghammer and Cecily V. DiPiro. Major Depressive Disorder. Pharmacotherapy Handbook. Nineth Edition. Page – 715 & 718.

2. Harrison’s Manual of Medicine. Psychiatric Medication. 18th Edition. Page – 1327.

3. Raheel Naseeruddin, Alan Rosani and Raman Marwaha. Desvenlafaxine. NIH. National Library of Medicine. National Center of Biotechnology Information. StatPearls. [Revised in July 2022]. [Accessed on 30th August 2022]. https://www.ncbi.nlm.nih.gov/books/NBK534829/#:~:text=Desvenlafaxine%20is%20an%20antidepressant%20that,treat%20hot%20flashes%20during%20menopause.

4. Michael R. Liebowitz and Karen A. Tourian. Efficacy, Safety, and Tolerability of Desvenlafaxine 50 mg/d for the Treatment of Major Depressive Disorder: A Systematic Review of Clinical Trials. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC PubMed Central. 2010. [Accessed on 30th August 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947544/

5. Pfizer Ltd. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 30th August 2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021992s030lbl.pdf

6. Pfizer Ltd. MEDICATION GUIDE PRISTIQ® (pris-TEEK) (desvenlafaxine) extended-release tablets. [Revised in January 2022] [Accessed on 30th August 2022]. https://labeling.pfizer.com/ShowLabeling.aspx?id=14010

7. Pfizer Ltd. PACKAGE INSERT PRISTIQ® (desvenlafaxine) Extended-Release Tablets. [Revised in September 2021] [Accessed on 30th August 2022]. https://labeling.pfizer.com/ShowLabeling.aspx?id=12155

8. Pfizer Australia Pty Ltd. PRISTIQ®. Healthlinks.Net.AU. [Revised in March 2022] [Accessed on 30th August 2022]. http://secure.healthlinks.net.au/content/pf/retriever.cfm?product=pfcprist11212