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Introduction About D DON TABLET
D DON TABLET contains Domperidone commonly used to manage in post-operative vomiting, drug-induced nausea and vomiting, vomiting due to radiation and anticancer drugs and in acute vomiting due to a variety of causes such as fever, gastritis, pancreatitis, uremia and hepatitis.
D DON TABLET is also indicated in various types of dyspepsia such as postprandial, that associated with peptic ulcer and also in reflux oesophagitis as well as gastritis. It works by blocking dopamine receptors and improving digestion.
D DON TABLET helps in relieving nausea and vomiting, improves digestion by enhancing stomach movement and also may help with bloating and discomfort.
Take D DON TABLET as directed by your doctor. Usually taken before meals. Do not exceed the prescribed dose.
Avoid using D DON TABLET if you have liver disease or a history of heart issues. Consult a doctor if pregnant or breastfeeding.
The possible side effects of D DON TABLET are dry mouth, dizziness and abdominal cramps. Consult your doctor if any of the above side effects worsen or persists for a longer duration.
Uses Of D DON TABLET
It is used to manage:
- post-operative vomiting
- drug-induced nausea and vomiting
- vomiting due to radiation and anticancer drugs
- acute vomiting due to a variety of causes such as fever, gastritis, pancreatitis, uremia and hepatitis
- various types of dyspepsia such as postprandial, that associated with peptic ulcer and also in reflux oesophagitis as well as gastritis
Benefits of D DON TABLET
1. Relieves nausea and vomiting:
- Effectively helps manage nausea and vomiting caused by indigestion, gastritis, motion sickness, and certain medications
- Works by blocking dopamine receptors in the brain, reducing the urge to vomit
2. Improves digestion by enhancing stomach movement:
- Stimulates gastric motility, helping food move smoothly through the stomach and intestines
- Beneficial for individuals suffering from acid reflux, delayed digestion, and sluggish bowel movements
3. May help with bloating and discomfort:
- Helps relieve gas, bloating, and feelings of fullness after meals
- Supports smooth digestion and stomach emptying, managing discomfort from indigestion
How D DON TABLET Works
1. How quickly does D DON TABLET work?
- D DON TABLET typically starts working within 30 to 60 minutes after ingestion
- It provides rapid relief from nausea, vomiting, and bloating by improving stomach movement and reducing discomfort
2. How effective is D DON TABLET for nausea and vomiting?
- D DON TABLET is clinically proven to be effective in managing nausea and vomiting caused by indigestion and acid reflux, gastritis and food poisoning, motion sickness and certain medications (e.g., chemotherapy, painkillers)
How to use D DON TABLET
D DON TABLET is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.
D DON TABLET dosage instructions:
- Take D DON TABLET as directed by your doctor. Usually taken before meals
- Children (weighing more than 35 kg): As prescribed by a doctor
- Maximum Dose: Do not exceed 30 mg per day unless advised by a healthcare provider
How to take D DON TABLET:
- Take 15 to 30 minutes before meals for better absorption
- Swallow the tablet whole with a glass of water, do not crush or chew
Can D DON TABLETbe taken on an empty stomach?
- D DON TABLET is best taken on an empty stomach, preferably 15 to 30 minutes before meals
- Better absorption - Taking it before meals allows the medication to work faster and more effectively
- Enhances stomach movement - Helps food pass through the digestive tract smoothly, reducing nausea and bloating
- Manages Vomiting - Taking it in advance helps control nausea before eating
How to take D DON TABLET for best results?
- Take it on an empty stomach - consume 15 to 30 minutes before meals for better absorption and faster relief
- Follow the prescribed dosage - usually one tablet (10mg), up to three times a day, or as directed by your doctor
- Swallow whole with water - do not crush or chew the tablet, as this may affect its effectiveness
- Avoid alcohol and certain medications - alcohol and some drugs (like antifungals, antibiotics, or acid reducers) may interfere with its action
- Stay consistent - For chronic conditions like acid reflux or bloating, take it at the same time daily for optimal results
What if I forgot to take D DON TABLET
- Take the missed dose as soon as you remember
- If it is almost time for the next dose, skip the missed dose, do not double dose for the missed dose
Overdose
Symptoms of D DON TABLET Overdose:
- drowsiness or confusion
- irregular heartbeat (arrhythmia or palpitations)
- dizziness or fainting
- severe restlessness or agitation
- uncontrolled muscle movements (twitching or tremors)
What to do in case of an overdose?
- Seek immediate medical attention – Call your doctor or visit the nearest hospital
- Do not induce vomiting unless instructed by a healthcare provider
- Monitor for serious symptoms like difficulty breathing or chest pain
- Take the medicine packaging with you to the hospital for reference
Side Effects Of D DON TABLET
Common:
- dry mouth
- dizziness
- abdominal cramps
When to consult a doctor?
- swelling of the hands, feet, ankle, face, lips and throat which may cause difficulty in swallowing or breathing
- itchy lumpy rash (hives), nettle rash (urticaria)
- uncontrolled movements, which include irregular movements of eyes, an unusual move of the tongue, abnormal posture (Ex. twisted neck, trembling and muscle stiffness)
- have a fast unusual heartbeat
- seizures
How To Manage Side Effects
Dizziness Or Drowsiness
- Take adequate sleep. Do not involve in rigorous activities
- Do not interfere with your sleep cycle
Dry Mouth
- Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva
- Sip water at regular intervals of time
- Do not use mouthwashes that contain alcohol because they can be drying
Stomach Pain
- Apply Heat: Use a warm compress or heating pad on your stomach to relax muscles
- Drink Herbal Teas: Ginger, peppermint, or chamomile tea can soothe digestion
- Gentle Massage: Lightly rub your abdomen in a circular motion to relieve tightness
Warning & Precautions
Pregnancy
Monitoring requiredPregnant women should use D DON TABLET only if necessary under medical supervision. It crosses the placenta, and while no major birth defects have been reported, studies on its safety in pregnancy are limited. Doctors may prescribe it only if the benefits outweigh the risks, particularly in cases of severe nausea and vomiting (morning sickness or hyperemesis gravidarum).
Breastfeeding
Monitoring requiredBreastfeeding mothers should discuss the risks with their doctor. If prescribed while breastfeeding, monitor the baby for any unusual symptoms and seek pediatric advice if needed. D DON TABLET passes into breast milk in small amounts, so caution is advised. It is sometimes prescribed to increase breast milk production (off-label use), but its safety for this purpose is debated. Potential risks for the baby may cause drowsiness, irritability, or digestive issues in infants, long-term effects on breastfed babies are not well studied.
Driving and Using Machines
Use with CautionD DON TABLET does not affect the ability to drive or use machines. Yet do not drive or operate any machines if you feel dizzy after taking the medicine.
Kidney
Use with CautionD DON TABLET should be taken with caution in patients with kidney problems such as kidney impairment or kidney failure.
Liver
Use with CautionD DON TABLET may be used with dose adjustments, as advised by a doctor in patients with mild to moderate liver disease. D DON TABLET is metabolized in the liver, and impaired liver function can lead to higher drug accumulation, increasing the risk of side effects in patients with severe liver disease (cirrhosis, hepatic impairment).
Allergy
ContraindicatedDo not take D DON TABLET if you are allergic to Domperidone or any other ingredients of this medicine.
Heart Disease
ContraindicatedD DON TABLET is not recommended in patients suffering from heart problems such as prolonged QT corrected interval or heart failure.
Use In Pediatrics
Consult your doctorD DON TABLET is not recommended for use in children and adolescents below 12 years of age or weighing less than 35 kgs. Consult with your child’s doctor before giving this medicine to your child.
Use In Geriatrics
Use with CautionD DON TABLET should be used with caution for use over 60 years of age, as this medicine may associated with an increased risk of heart rhythm disorder and cardiac arrest.
Who should not take [GBNKEYWORD
D DON TABLET is not recommended for use if you have:
- tumor in the pituitary gland (prolactinoma)
- history of blockage or tear in the intestine
- hypokalemia (low level of potassium)
- hyperkalemia (high level of potassium in the blood)
- hypomagnesemia (low level of magnesium in the blood)
- signs and symptoms of bleeding in the stomach or intestine (black tarry bowel motions or blood in your bowel motions)
Diet and Lifestyle Advice
Natural Remedies vs D DON TABLET - what works faster?
Speed of action: Which is faster?
- D DON TABLET starts working within 30 to 60 minutes after ingestion. It blocks dopamine receptors in the brain, helping relieve nausea and vomiting quickly
- Natural remedies may take longer to show effects as they work by soothing the digestive system gradually. However, some remedies like ginger or peppermint may provide mild relief within 30 to 60 minutes
| Remedy | Time to Work | Best for |
| D DON TABLET | 30-60 minutes | Nausea, vomiting, bloating |
| Ginger | 30-60 minutes | Mild nausea, morning sickness |
| Peppermint tea | 30-90 minutes | Bloating, indigestion |
| Fennel seeds | 1-2 hours | Gas, bloating |
| Hydration (warm water, electrolyte drinks) | 30 minutes | Dehydration-related nausea |
Foods to eat when taking D DON TABLET:
- Rice, oatmeal, toast, boiled potatoes
- Lean meats, eggs, tofu, lentils
- Ginger & herbal teas
- Bananas & apples
- Yogurt & probiotics
Foods to avoid when taking D DON TABLET:
- Spicy & oily foods
- Caffeinated drinks (coffee, tea, energy drinks)
- Carbonated beverages
- High-fat & processed foods
- Dairy (if lactose intolerant)
Lifestyle changes for better digestion:
- Chew food slowly to improve digestion and prevent bloating
- Avoid overeating - opt for small, frequent meals instead of large portions
- Take a short walk after meals (10-15 minutes) to aid digestion
- Drink warm water throughout the day to support digestion
- Sleep on your left side to reduce acid reflux
- Avoid lying down immediately after meals and wait for at least 2-3 hours
Natural ways to reduce nausea - Do they work?
Effective Natural Remedies for Nausea - For mild nausea, these remedies can be effective
- Ginger
- Peppermint
- Lemon & citrus scents
- Acupressure (P6 Pressure Point)
- Stay hydrated
Drug - Drug interaction
Medications to Avoid: Can I take D DON TABLET with other medications?
| Medication type | Can you take it with D DON TABLET? | Possible interaction/precaution |
| Antacids (e.g., Pantoprazole, Omeprazole) | Yes | Take it 30 mins before the antacid for best results |
| Antibiotics (e.g., Clarithromycin, Erythromycin) | No | May increase it side effects like heart rhythm issues |
| Antifungals (e.g., Ketoconazole, Itraconazole) | No | Increases the risk of severe side effects |
| Painkillers (e.g., Paracetamol, Ibuprofen) | Yes | Generally safe, but avoid excessive NSAIDs to manage stomach irritation |
| Blood Pressure Medications (e.g., Amlodipine, Metoprolol) | Caution | May increase dizziness, monitor blood pressure |
| Diabetes Medications (e.g., Metformin, Insulin) | Yes | Safe, but watch for changes in blood sugar levels |
| Antidepressants (e.g., SSRIs, Tricyclics) | Caution | Some may interact, increasing the risk of heart issues. Consult a doctor |
| Blood Thinners (e.g., Warfarin, Aspirin) | Caution | May increase the risk of bleeding, consult a doctor |
| Hormonal Pills (e.g., Birth Control, HRT) | Yes | No known significant interactions |
| Seizure Medications (e.g., Carbamazepine, Phenytoin) | Caution | May reduce D DON TABLET effectiveness. Consult your doctor. |
Drug - Food interaction
Potential Food Interactions:
| Food type | Can you take it? | Possible Interaction/Precaution |
| Spicy & oily foods | Avoid | May worsen nausea, acid reflux, and bloating |
| Caffeine (coffee, tea, energy drinks) | Limit | Can reduce its effectiveness and cause restlessness |
| Citrus fruits (oranges, lemons, grapefruit) | Caution | May increase stomach acid, potentially irritating the stomach |
| Dairy products (milk, cheese, yogurt) | Yes (if tolerated) | Safe for most, but avoid if lactose intolerant as it may cause bloating |
| High-fiber foods (whole grains, beans, lentils) | Yes | Supports digestion but should be consumed in moderation to avoid bloating |
| Fermented foods (pickles) | Yes | Can support gut health, but excessive intake may increase acidity |
| Sugary & processed foods (candy, sodas, fast food) | Avoid | Can worsen bloating and slow digestion |
Synopsis
| Drug | : | Domperidone |
| Pharmacological Category | : | Dopamine antagonists |
| Therapeutic Indication | : | Nausea and Vomiting |
| Dosage Forms | : | Tablets, Capsules, Dispersible tablets, Rapitab, Suspension, Oral Suspension, Syrup, Oral Drops, Drops |
More Information
D DON TABLET vs other anti-nausea medications – which one works best?
| Medication | Best for | How it works | Time to work | Common side effects | Prescription required? |
| D DON TABLET (Domperidone) | Nausea, bloating, acid reflux, gastroparesis | Blocks dopamine receptors in the gut, speeds up stomach emptying | 30-60 minutes | Dry mouth, dizziness, heart rhythm issues (rare) | Yes |
| Ondansetron | Chemotherapy-induced nausea, post-surgery nausea, pregnancy nausea | Blocks serotonin in the brain and gut | 30 minutes | Constipation, headache, dizziness | Yes |
| Metoclopramide | Gastroparesis, migraine-related nausea, GERD | Increases stomach motility, blocks dopamine | 30-60 minutes | Fatigue, restlessness, involuntary muscle movements (long-term use risk) | Yes |
| Meclizine | Motion sickness, vertigo-related nausea | Blocks histamine receptors in the brain | 1-2 hours | Drowsiness, dry mouth | No (otc) |
| Promethazine | Severe nausea, motion sickness, post-surgery nausea | Blocks dopamine and histamine receptors | 20-30 minutes | Drowsiness, dizziness, dry mouth | Yes |
| Ginger Supplements | Mild nausea, pregnancy nausea, motion sickness | Natural anti-inflammatory, aids digestion | 30-60 minutes | Mild heartburn (rare) | No (otc) |
What to do if you experience side effects? (Quick tips):
| Side effect | What to do? |
| Dry mouth | Drink plenty of water, chew sugar-free gum, or suck on ice chips |
| Dizziness | Avoid sudden movements, stand up slowly, and stay hydrated |
| Headache | Rest in a quiet place, drink water, and take a mild pain reliever if needed |
| Bloating/Gas | Eat light meals, avoid carbonated drinks, and try herbal teas (e.g., peppermint, ginger) |
| Diarrhea | Stay hydrated, avoid greasy/spicy foods, and eat plain foods like bananas and rice |
| Fatigue | Get enough rest, reduce caffeine intake, and avoid heavy activities |
Gastrointestinal Disorders:
Nausea & Vomiting: D DON TABLET is commonly prescribed for nausea, vomiting, and gastric motility disorders.
Common causes of Nausea & Vomiting:
- Indigestion & acid reflux (GERD)
- Gastric infections (food poisoning, stomach flu)
- Pregnancy (morning sickness)
- Motion sickness & vertigo
- Side effects of medications (antibiotics, painkillers, chemotherapy)
Treatment options:
- D DON TABLET: Works by blocking dopamine receptors in the gut, promoting faster stomach emptying, and managing nausea
- Ondansetron: Used for severe nausea (e.g., chemotherapy, post-surgery)
- Natural remedies: Ginger, peppermint tea, acupressure on the wrist (P6 point)
Gastric Motility Disorders: These conditions affect how food moves through the digestive tract, often causing bloating, nausea, and delayed gastric emptying.
Common conditions:
- Gastroparesis (Delayed stomach emptying)
- Functional Dyspepsia (Chronic indigestion)
- IBS (Irritable Bowel Syndrome) with slow digestion
Role of D DON TABLET in management
- Speeds up stomach emptying, reducing bloating & nausea
- Improves gut movement, managing food from sitting in the stomach too long
- Enhances digestion, making it useful for acid reflux & bloating
FAQs About D DON TABLET
Q: What is D DON TABLET used for?
A: D DON TABLET is used to manage in post-operative vomiting, drug-induced nausea and vomiting, vomiting due to radiation and anticancer drugs and in acute vomiting due to a variety of causes such as fever, gastritis, pancreatitis, uremia and hepatitis.
Q: How long does D DON TABLET stay in the system?
A: D DON TABLET have half-life approximately 7-9 hours in healthy adults. Typically takes around 35-45 hours (5 half-lives) for the drug to be fully cleared from the system.
Q: Can I take D DON TABLET for acid reflux?
A:D DON TABLET is mainly used for nausea, but it may provide some relief for acid reflux symptoms. If acid reflux is due to slow stomach emptying (gastroparesis), it can improve digestion by increasing stomach motility.
Q: When reflux is associated with nausea and bloating, does D DON TABLET can provide relief?
A: Yes, D DON TABLET can help when reflux is accompanied by nausea, bloating, and slow stomach emptying (gastroparesis).
Q: Is D DON TABLET safe for long-term use?
A:Prolonged use of D DON TABLET should be monitored by a doctor to manage potential side effects.
Q: Can Children take D DON TABLET?
A:Consult a pediatrician before giving D DON TABLET to children.
Q: How long can I take D DON TABLET?
A: It is recommended that D DON TABLET be taken for the shortest period and at the lowest dose. This is because D DON TABLET can cause an irregular heartbeat when taken for a longer period or at a high dose.
Q: Can I take D DON TABLET with antibiotics?
A: Use of D DON TABLET with antibiotics like erythromycin, levofloxacin, and some antifungals is not recommended as this can cause interaction.
Q: Does D DON TABLET increase milk secretion?
A: Yes, D DON TABLET may increase milk secretion also known as galactorrhoea. This is an uncommon side effect of using D DON TABLET. Talk to your doctor if you are experiencing this side effect while taking this medicine.
Q: Does D DON TABLET cause Heart problems?
A: D DON TABLET may be associated with an increased risk of heart problems (like an irregular heartbeat) and heart attacks. The risk also increases when it is given together with other medicines.
Q: Does D DON TABLET cause dry mouth?
A: Yes. it can cause dry mouth. A dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying.
Q: What is the best time to take D DON TABLET?
A: It is recommended to take D DON TABLET before meals. If taken after meals, absorption of the medicine is somewhat delayed. Patients should try to take each dose of it at a scheduled time to avoid missing a dose.
Q: Is D DON TABLET safe during pregnancy?
A: D DON TABLET is classified as Pregnancy Category C, there is limited human research, and it should only be used if the benefits outweigh potential risks. It crosses the placenta, but no significant birth defects have been reported in studies.
Q: Can I take D DON TABLET with antacids?
A: Yes. But take D DON TABLET before meals (at least 30 minutes before food) or take antacids after meals, if needed, but at least 1-2 hours apart from it.
References
- KD Tripathi. Antiemetics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page - 414.
- Rhew K, Han N, Oh JM. Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. August 2019. [Accessed on 14th June 2025]
- NIH National Library of Medicine, National Centre for Biotechnology Information. Pubchem. Domperidone. [Accessed on 14th June 2025]
- Savio C Reddymasu, Irfan Soykan, Richard W McCallum. Domperidone: review of pharmacology and clinical applications in gastroenterology. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. September 2007. [Accessed on 14th June 2025]
- S.C. Zentiva S.A. Electronic Medicines Compendium (emc). [Revised in April 2021] [Accessed on 14th June 2025]
- Torrent Pharmaceuticals Ltd. Domstal DT (Domperidone). [Revised in February 2022]. [Accessed on 14th June 2025]
- Torrent Pharmaceuticals Ltd. Domstal (Domperidone). [Revised in April 2022]. [Accessed on 14th June 2025]
- Torrent Pharmaceuticals Ltd. Domstal OD (Domperidone). [Accessed on 14th June 2025]
- Janssen-Cilag (New Zealand) Ltd. Medsafe. [Revised in November 2020]. [Accessed on 14th June 2025]
- Morepen Laboratories Ltd. DOM DT 20mg, DOM DT 5mg [Accessed on 14th June 2025]
Author Details
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