Introduction About CYCLOVAL EYE DROPS

CYCLOVAL EYE DROPS contains Cyclopentolate which belongs to the group of medicines called Mydriatic agents. It is used to dilate the pupil of the eye and to paralyse the lens temporarily for performing an eye examination or for preparing the eye for an operation. It is also used to manage uveitis (inflammation of middle layer of the eye tissues) and iritis (inflammation of coloured ring around the pupil of the eye).

CYCLOVAL EYE DROPS is not recommended for use in patients with glaucoma and paralysis of the intestine. CYCLOVAL EYE DROPS should be used with caution in patients with heart diseases (such as heart attack, heart failure or angina), enlarged prostate in men, history of ataxia and inflamed or red eyes. CYCLOVAL EYE DROPS is not recommended for use in pregnant and breastfeeding women, unless advised by your doctor.    

CYCLOVAL EYE DROPS is not recommended for use in new-born babies (less than 28 days old) unless recommended by the doctor and in children with brain damage, particularly if they may have fits and it is not recommended for use in elderly patients with high pressure inside the eye.

The most common side effects of using CYCLOVAL EYE DROPS are eye irritation, stinging sensation, fever, confusion, facial flushing, decreased movement of the gastrointestinal tract or slower transit of food and constipation. Consult your doctor if any of the side effect gets worsen or bothers you.

Uses Of CYCLOVAL EYE DROPS

• Dilates the pupil of the eye and to paralyse the lens temporarily (for performing an eye examination or for preparing the eye for an operation)
• Manage certain types of eye inflammation (uveitis and iritis)

How CYCLOVAL EYE DROPS Works

CYCLOVAL EYE DROPS works by blocking the action of acetylcholine to produce relaxation of the sphincter muscle of the iris resulting in dilation of the pupil (mydriasis) and manages the eye from accommodating for near vision (cycloplegia). Therefore, helpful in performing eye examination or eye operation.  

How to use CYCLOVAL EYE DROPS

Use CYCLOVAL EYE DROPS as advised by your physician. It is for ophthalmic use only. Wash your hands before and after application. Tilt your head slightly backwards and instil a few drops of the medicine into the affected eye. Your doctor will decide the correct dose and duration for you depending upon your age and severity of the condition.

Side Effects Of CYCLOVAL EYE DROPS

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly (such as daily walk). Consult your doctor if the symptom does not improve.

Skin rash Or Itching

Avoid hot showers as it can irritate the skin further. Do not scratch the affected area. Use sunscreen and protective clothing when going outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area after consulting the doctor. If the symptom does not improve consult your doctor.

Warning & Precautions

Pregnancy

Monitoring required

CYCLOVAL EYE DROPS is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before using CYCLOVAL EYE DROPS.

Breastfeeding

Monitoring required

CYCLOVAL EYE DROPS is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before using CYCLOVAL EYE DROPS.

Driving and Using Machines

Use with Caution

CYCLOVAL EYE DROPS may cause sensitivity to light, difficulty in focusing and blurred vision therefore, do not drive or operate any machines while using CYCLOVAL EYE DROPS.

Allergy

Contraindicated

Do not use CYCLOVAL EYE DROPS if you are allergic to cyclopentolate or benzalkonium chloride or to any other ingredients of this medicine. Inform your doctor if you are sensitive to belladonna alkaloids (drugs such as atropine) before using CYCLOVAL EYE DROPS.

Heart Disease

Use with Caution

CYCLOVAL EYE DROPS should be used with caution in patients with heart disease (such as heart attack, heart failure or angina). Consult your doctor before using CYCLOVAL EYE DROPS.

Use In Pediatrics

Monitoring required

CYCLOVAL EYE DROPS is not recommended for use in new-born babies (less than 28 days old) unless recommended by the doctor and in children with brain damage, particularly if they may have fits. Consult doctor before administering CYCLOVAL EYE DROPS to your child.

Use In Geriatrics

Contraindicated

CYCLOVAL EYE DROPS is not recommended for use in elderly patients with high pressure inside the eye. Consult your doctor before using CYCLOVAL EYE DROPS.

Interactions

A. Drug-Drug interactions:

Before using CYCLOVAL EYE DROPS, inform your doctor if you are using or taking any of the following medicines:

• ophthalmic cholinesterase inhibitors Ex. physostigmine, pilocarpine, carbachol (medicines used for glaucoma)
• antihistamines such as fexofenadine, cetirizine (used to manage allergy symptoms)
• amantadine (medicine used for parkinson’s disease and influenza A infection)
• anti-psychotics (used to manage schizophrenia and bipolar disorder) such as butyrophenones (Ex. haloperidol) and phenothiazine (Ex. chlorpromazine, fluphenazine)
• tricyclic anti-depressants (used to manage depression) such as amitriptyline, lofepramine and trimipramine

Overdosage:

If you or anyone else accidentally use too much of CYCLOVAL EYE DROPS, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are increased intraocular pressure, reduced GI motility, decreased salivary, sweat glands, bronchial, pharynx, and nasal secretions, behavioural disturbances, high fever, increased heart rate, high blood pressure, vasodilation and urinary retention.   

Synopsis

More Information

• Keep CYCLOVAL EYE DROPS out of reach of children
• Store below 25°C

FAQs About CYCLOVAL EYE DROPS

Q: What is CYCLOVAL EYE DROPS used for?

A: CYCLOVAL EYE DROPS is used to dilate the pupil of the eye and to paralyse the lens temporarily for performing an eye examination or for preparing the eye for an operation. It is also used to manage uveitis (inflammation of middle layer of the eye tissues) and iritis (inflammation of coloured ring around the pupil of the eye).

Q: Can I use CYCLOVAL EYE DROPS during pregnancy?

A: CYCLOVAL EYE DROPS is not recommended for use in pregnant women unless clearly advised by your doctor. Consult your doctor before using CYCLOVAL EYE DROPS if you are pregnant or planning to get pregnant.

Q: Can CYCLOVAL EYE DROPS be used in children?

A: CYCLOVAL EYE DROPS is not recommended for use in new-born babies (less than 28 days old) unless recommended by the doctor and in children with brain damage, particularly if they may have fits. Consult doctor before administering CYCLOVAL EYE DROPS to your child.

Q: How does CYCLOVAL EYE DROPS work?

A: CYCLOVAL EYE DROPS works by blocking the action of acetylcholine to produce relaxation of the sphincter muscle of the iris resulting in dilation of the pupil (mydriasis) and manages the eye from accommodating for near vision (cycloplegia). Therefore, helpful in performing eye examination or eye operation.   

Q: Can I wear contact lenses while using CYCLOVAL EYE DROPS?

A: No, remove the contact lens before instilling CYCLOVAL EYE DROPS into the eye and re-insert after 15 minutes of using the medicine, as it may cause discolouration of the lenses. Consult your doctor before using CYCLOVAL EYE DROPS.

References

1. KD. Tripathi. Drugs acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 118.

2. Laurence L. Brunton, John S. Lazo, Keith L. Parker. Ocular Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. Page- 1724.

3. Johns Hopkins University. Optimal Method for Mydriasis in Cataract Surgery. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2019] [Accessed on 1st August 2022] https://clinicaltrials.gov/ct2/show/NCT02909140

4. Kalpana Babu and Padmamalini Mahendrada. Medical Management of Uveitis – Current Trends. NIH National Library of Medicine, National center for biotechnology information. PMC Pubmed Central. June 2013. [Accessed on 1st August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744780/

5. Holopack Verpackungstechnik GmbH. Health Products Regulatory Authority (HPRA).  [Revised in March 2022] [Accessed on 1st August 2022] https://www.hpra.ie/img/uploaded/swedocuments/11d99839-c800-49fc-91a0-750d5788e318.pdf

6. Holopack Verpackungstechnik GmbH. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 1st August 2022] https://www.medicines.org.uk/emc/files/pil.1724.pdf

7. Laboratoire Chauvin. Health Products Regulatory Authority (HPRA). [Revised in June 2022] [Accessed on 1st August 2022] https://www.hpra.ie/img/uploaded/swedocuments/129246b2-08ee-417f-bdf7-860712764776.pdf

8. Bausch and Lomb Incorporated. Cyclopentolate. [Revised in June 2021] [Accessed on 1st August 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ad85b220-6003-4a78-b900-5195ceaf0fd5

Useful Diagnostic Tests

• Tonometric examination