Introduction About CYCLOBION 1% OPHTHALMIC SOLUTION

CYCLOBION 1% OPHTHALMIC SOLUTION contains Cyclopentolate which belongs to the group of medicines called Mydriatic agents. It is used to dilate the pupil of the eye and to paralyse the lens temporarily for performing an eye examination or for preparing the eye for an operation. It is also used to manage uveitis (inflammation of middle layer of the eye tissues) and iritis (inflammation of coloured ring around the pupil of the eye).

CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in patients with glaucoma and paralysis of the intestine. CYCLOBION 1% OPHTHALMIC SOLUTION should be used with caution in patients with heart diseases (such as heart attack, heart failure or angina), enlarged prostate in men, history of ataxia and inflamed or red eyes. CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in pregnant and breastfeeding women, unless advised by your doctor.    

CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in new-born babies (less than 28 days old) unless recommended by the doctor and in children with brain damage, particularly if they may have fits and it is not recommended for use in elderly patients with high pressure inside the eye.

The most common side effects of using CYCLOBION 1% OPHTHALMIC SOLUTION are eye irritation, stinging sensation, fever, confusion, facial flushing, decreased movement of the gastrointestinal tract or slower transit of food and constipation. Consult your doctor if any of the side effect gets worsen or bothers you.

Uses Of CYCLOBION 1% OPHTHALMIC SOLUTION

• Dilates the pupil of the eye and to paralyse the lens temporarily (for performing an eye examination or for preparing the eye for an operation)
• Manage certain types of eye inflammation (uveitis and iritis)

How CYCLOBION 1% OPHTHALMIC SOLUTION Works

CYCLOBION 1% OPHTHALMIC SOLUTION works by blocking the action of acetylcholine to produce relaxation of the sphincter muscle of the iris resulting in dilation of the pupil (mydriasis) and manages the eye from accommodating for near vision (cycloplegia). Therefore, helpful in performing eye examination or eye operation.  

How to use CYCLOBION 1% OPHTHALMIC SOLUTION

Use CYCLOBION 1% OPHTHALMIC SOLUTION as advised by your physician. It is for ophthalmic use only. Wash your hands before and after application. Tilt your head slightly backwards and instil a few drops of the medicine into the affected eye. Your doctor will decide the correct dose and duration for you depending upon your age and severity of the condition.

Side Effects Of CYCLOBION 1% OPHTHALMIC SOLUTION

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly (such as daily walk). Consult your doctor if the symptom does not improve.

Skin rash Or Itching

Avoid hot showers as it can irritate the skin further. Do not scratch the affected area. Use sunscreen and protective clothing when going outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area after consulting the doctor. If the symptom does not improve consult your doctor.

Warning & Precautions

Pregnancy

Monitoring required

CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before using CYCLOBION 1% OPHTHALMIC SOLUTION.

Breastfeeding

Monitoring required

CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before using CYCLOBION 1% OPHTHALMIC SOLUTION.

Driving and Using Machines

Use with Caution

CYCLOBION 1% OPHTHALMIC SOLUTION may cause sensitivity to light, difficulty in focusing and blurred vision therefore, do not drive or operate any machines while using CYCLOBION 1% OPHTHALMIC SOLUTION.

Allergy

Contraindicated

Do not use CYCLOBION 1% OPHTHALMIC SOLUTION if you are allergic to cyclopentolate or benzalkonium chloride or to any other ingredients of this medicine. Inform your doctor if you are sensitive to belladonna alkaloids (drugs such as atropine) before using CYCLOBION 1% OPHTHALMIC SOLUTION.

Heart Disease

Use with Caution

CYCLOBION 1% OPHTHALMIC SOLUTION should be used with caution in patients with heart disease (such as heart attack, heart failure or angina). Consult your doctor before using CYCLOBION 1% OPHTHALMIC SOLUTION.

Use In Pediatrics

Monitoring required

CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in new-born babies (less than 28 days old) unless recommended by the doctor and in children with brain damage, particularly if they may have fits. Consult doctor before administering CYCLOBION 1% OPHTHALMIC SOLUTION to your child.

Use In Geriatrics

Contraindicated

CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in elderly patients with high pressure inside the eye. Consult your doctor before using CYCLOBION 1% OPHTHALMIC SOLUTION.

Interactions

A. Drug-Drug interactions:

Before using CYCLOBION 1% OPHTHALMIC SOLUTION, inform your doctor if you are using or taking any of the following medicines:

• ophthalmic cholinesterase inhibitors Ex. physostigmine, pilocarpine, carbachol (medicines used for glaucoma)
• antihistamines such as fexofenadine, cetirizine (used to manage allergy symptoms)
• amantadine (medicine used for parkinson’s disease and influenza A infection)
• anti-psychotics (used to manage schizophrenia and bipolar disorder) such as butyrophenones (Ex. haloperidol) and phenothiazine (Ex. chlorpromazine, fluphenazine)
• tricyclic anti-depressants (used to manage depression) such as amitriptyline, lofepramine and trimipramine

Overdosage:

If you or anyone else accidentally use too much of CYCLOBION 1% OPHTHALMIC SOLUTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are increased intraocular pressure, reduced GI motility, decreased salivary, sweat glands, bronchial, pharynx, and nasal secretions, behavioural disturbances, high fever, increased heart rate, high blood pressure, vasodilation and urinary retention.   

Synopsis

More Information

• Keep CYCLOBION 1% OPHTHALMIC SOLUTION out of reach of children
• Store below 25°C

FAQs About CYCLOBION 1% OPHTHALMIC SOLUTION

Q: What is CYCLOBION 1% OPHTHALMIC SOLUTION used for?

A: CYCLOBION 1% OPHTHALMIC SOLUTION is used to dilate the pupil of the eye and to paralyse the lens temporarily for performing an eye examination or for preparing the eye for an operation. It is also used to manage uveitis (inflammation of middle layer of the eye tissues) and iritis (inflammation of coloured ring around the pupil of the eye).

Q: Can I use CYCLOBION 1% OPHTHALMIC SOLUTION during pregnancy?

A: CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in pregnant women unless clearly advised by your doctor. Consult your doctor before using CYCLOBION 1% OPHTHALMIC SOLUTION if you are pregnant or planning to get pregnant.

Q: Can CYCLOBION 1% OPHTHALMIC SOLUTION be used in children?

A: CYCLOBION 1% OPHTHALMIC SOLUTION is not recommended for use in new-born babies (less than 28 days old) unless recommended by the doctor and in children with brain damage, particularly if they may have fits. Consult doctor before administering CYCLOBION 1% OPHTHALMIC SOLUTION to your child.

Q: How does CYCLOBION 1% OPHTHALMIC SOLUTION work?

A: CYCLOBION 1% OPHTHALMIC SOLUTION works by blocking the action of acetylcholine to produce relaxation of the sphincter muscle of the iris resulting in dilation of the pupil (mydriasis) and manages the eye from accommodating for near vision (cycloplegia). Therefore, helpful in performing eye examination or eye operation.   

Q: Can I wear contact lenses while using CYCLOBION 1% OPHTHALMIC SOLUTION?

A: No, remove the contact lens before instilling CYCLOBION 1% OPHTHALMIC SOLUTION into the eye and re-insert after 15 minutes of using the medicine, as it may cause discolouration of the lenses. Consult your doctor before using CYCLOBION 1% OPHTHALMIC SOLUTION.

References

1. KD. Tripathi. Drugs acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 118.

2. Laurence L. Brunton, John S. Lazo, Keith L. Parker. Ocular Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. Page- 1724.

3. Johns Hopkins University. Optimal Method for Mydriasis in Cataract Surgery. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2019] [Accessed on 1st August 2022] https://clinicaltrials.gov/ct2/show/NCT02909140

4. Kalpana Babu and Padmamalini Mahendrada. Medical Management of Uveitis – Current Trends. NIH National Library of Medicine, National center for biotechnology information. PMC Pubmed Central. June 2013. [Accessed on 1st August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744780/

5. Holopack Verpackungstechnik GmbH. Health Products Regulatory Authority (HPRA).  [Revised in March 2022] [Accessed on 1st August 2022] https://www.hpra.ie/img/uploaded/swedocuments/11d99839-c800-49fc-91a0-750d5788e318.pdf

6. Holopack Verpackungstechnik GmbH. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 1st August 2022] https://www.medicines.org.uk/emc/files/pil.1724.pdf

7. Laboratoire Chauvin. Health Products Regulatory Authority (HPRA). [Revised in June 2022] [Accessed on 1st August 2022] https://www.hpra.ie/img/uploaded/swedocuments/129246b2-08ee-417f-bdf7-860712764776.pdf

8. Bausch and Lomb Incorporated. Cyclopentolate. [Revised in June 2021] [Accessed on 1st August 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ad85b220-6003-4a78-b900-5195ceaf0fd5

Useful Diagnostic Tests

• Tonometric examination