CTD O 12.5/20mg Tablet 10'S
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Introduction About CTD O 12.5/20MG TABLET
CTD O 12.5/20MG TABLET is a combination of Chlorthalidone and Olmesartan which belongs to the group of medicines called Thiazide diuretics and Angiotensin-II receptor antagonists respectively. CTD O 12.5/20MG TABLET is indicated for the management of essential hypertension.
Essential hypertension (also known as primary hypertension) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high and as a result, it may lead to severe damage to the walls of blood vessels supplying various important organs. It occurs without any known secondary cause and if it remains unmanageed it can lead to severe problems such as heart attack, heart or kidney failure, stroke or even blindness.
Along management with CTD O 12.5/20MG TABLET follow lifestyle modifications (such as losing weight, quitting smoking or alcohol intake) as advised by your physician along with a healthy balanced diet and regular physical activity (such as walking or swimming).
During the course of the management with CTD O 12.5/20MG TABLET, your doctor might regularly check your blood pressure, kidney function and electrolyte balance to avoid the risk of side effects. Avoid eating grapefruit or consuming grapefruit juice while taking CTD O 12.5/20MG TABLET as it could potentiate the blood pressure-lowering effect of this medicine.
Before taking CTD O 12.5/20MG TABLET, inform your doctor if you have diabetes, liver, kidney or heart disease as a precaution. CTD O 12.5/20MG TABLET is strictly not recommended for use in pregnant or breastfeeding women as it could cause serious harm to the baby.
CTD O 12.5/20MG TABLET is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data. It should be used with extreme caution in elderly patients (aged 65 years or above).
The most common side effects of taking CTD O 12.5/20MG TABLET are headache, dizziness, tiredness, nausea, stomach pain, lack of appetite and indigestion. Consult your doctor if any of the side effects worsen.
Uses Of CTD O 12.5/20MG TABLET
- Manage essential hypertension
How CTD O 12.5/20MG TABLET Works
CTD O 12.5/20MG TABLET effectively reduces elevated blood pressure where olmesartan acts by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increases in blood pressure) at the angiotensin type-I receptors of the vascular smooth muscle and chlorthalidone acts by increasing the urinary excretion of sodium and water by inhibiting sodium-chloride reabsorption in the kidneys, thus leading to a marked decrease in blood pressure.
How to use CTD O 12.5/20MG TABLET
Take CTD O 12.5/20MG TABLET as advised by your physician. Swallow CTD O 12.5/20MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of CTD O 12.5/20MG TABLET
Common
- headache and dizziness
- nausea, indigestion, diarrhoea, stomach pain
- tiredness
- sore throat, runny nose, flu-like symptoms, cough
- chest pain, back pain, joint pain
- urinary tract infection
- swelling of the feet, ankles, hands or arms
- blood in urine
- skin rash
- orthostatic hypertension (feeling dizzy while standing up)
- loss of appetite
- impotence in men
Uncommon
- mood changes, anxiety, depression
- sleeplessness
- dry mouth
- vomiting
- hair loss
- increased sweating
- red patches, itchy skin
- skin discolouration
- increased or decrease weight
- pain, general discomfort
- enlarged breasts in men (gynecomastia)
- increased urination, urinary urgency (at night)
- disorder in passing urine
Rare
- muscle cramps
- kidney problems
- worsening of diabetes
- jaundice (yellowing of the skin or eyes)
- photosensitivity
- breathing problems, palpitations and fainting
- tingling or prickling sensation (usually in arms, hands, legs or feet)
- constipation
Stop taking CTD O 12.5/20MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, mouth and/or larynx)
- severe hypotension (low blood pressure) with light-headedness or fainting
How To Manage Side Effects
Nausea and vomiting:
Try to take CTD O 12.5/20MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own to manage diarrhoea. Consult your doctor if the symptom does not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom does not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Constipation:
Eat fibre-rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom does not improve on its own.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom did not improve on its own.
Warning & Precautions
Pregnancy
CTD O 12.5/20MG TABLET is not recommended for use in pregnant women because it can cause serious harm to the developing fetus. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Breastfeeding
CTD O 12.5/20MG TABLET is not recommended for use in breastfeeding women because it passes through the breast milk and could cause serious harm to the baby. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you experience dizziness, sleepiness or tiredness. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Alcohol
Avoid consumption of alcohol while taking CTD O 12.5/20MG TABLET, as it could aggravate your existing disease condition. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Kidney
CTD O 12.5/20MG TABLET is not recommended for use in patients with severe kidney problems, kidney failure, lack of urine, and kidney stones and should be used with caution in patients with kidney problems. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Liver
CTD O 12.5/20MG TABLET is not recommended for use in patients with severe liver disease, jaundice (yellowing of skin and eyes) or biliary obstruction (a problem in bile drainage) and should be used with caution in patients with liver disease. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Allergy
Do not take CTD O 12.5/20MG TABLET if you are allergic to Chlorthalidone, Olmesartan or any sulphonamide derivatives (Ex. sulfadiazine, sulfamethazine).
Heart Disease
CTD O 12.5/20MG TABLET is not recommended for use in patients with heart failure or attack, cardiogenic shock, narrowing of the aortic heart valve and severe low blood pressure. It should be used with caution in patients with coronary or cerebral arteriosclerosis and obstructive hypertrophic cardiomyopathy (heart muscle becomes abnormally thick). Consult your doctor before taking CTD O 12.5/20MG TABLET.
Others
CTD O 12.5/20MG TABLET is not recommended for use if you have:
- severe fluid-electrolyte imbalance (such as low levels of potassium, sodium or calcium in the blood)
- a history of gout
- unmanageed addison's disease (an endocrine disorder of adrenal glands)
- primary aldosteronism (a disorder due to increased aldosterone production)
- diabetes or diabetes-related kidney problems (Ex. diabetic nephropathy)
Before taking CTD O 12.5/20MG TABLET, inform your physician if you:
- have high blood cholesterol levels
- are on a low-sodium diet
- have severe vomiting or diarrhea
- have hyperkalemia (increased blood potassium levels)
- have metabolic acidosis (increase in plasma acidity)
- have a condition that involves cellular breakdown or damage (Ex. acute limb ischemia (decrease blood flow to lower limb), rhabdomyolysis (severe muscle injury), extended trauma)
- have hyperparathyroidism (overactive parathyroid gland)
- have recently had an anesthetic
Use in pediatrics:
CTD O 12.5/20MG TABLET is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data. Consult your child’s doctor for advice.
Use in geriatrics:
CTD O 12.5/20MG TABLET should be used with extreme caution in elderly patients (aged 65 years or above). Proper dose adjustments and careful monitoring of blood pressure, kidney function and electrolyte balance are required in such patients. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Interactions
A. Drug-Drug interactions:
Before taking CTD O 12.5/20MG TABLET inform to your doctor, if you are taking any of these medicines:
- other medicines used to reduce high blood pressure and other heart problems such as angiotensin-converting enzyme (ACE) inhibitors (Ex. captopril, enalapril), angiotensin receptor blockers (Ex. losartan, valsartan), calcium channel blockers (Ex. nifedipine, diltiazem, verapamil), beta-blockers (Ex. atenolol, propranolol), vasodilators (Ex. nitroglycerin, bosentan), digoxin, methyldopa, guanethidine or aliskiren
- hypericum perforatum (herbal medicine), lithium (used to manage depression or other mental illness)
- non-steroidal anti-inflammatory drugs (used to manage pain or inflammation) Ex. indomethacin
- simvastatin, colesevelam and cholestyramine (used to control high blood cholesterol levels)
- antacids (used to neutralize stomach acid) Ex. aluminium hydroxide, magnesium hydroxide
- ketoconazole, itraconazole or amphotericin (used to manage fungal infections)
- protease inhibitors (used to manage HIV infection) Ex. ritonavir, indinavir, nelfinavir
- certain antibiotics (used to manage bacterial infections) Ex. rifampicin, erythromycin, clarithromycin
- dantrolene (used to manage muscle spasticity)
- immunosuppressant (used to suppress immune function and manage graft rejection) Ex. tacrolimus, sirolimus, temsirolimus, everolimus or cyclosporine
- adrenocorticotropic hormone (used to manage various endocrine disorders)
- corticosteroids (used to manage allergic or inflammatory diseases and immune reactions) such as prednisolone or betamethasone
- anticholinergics (used to reduce stomach spasms or cramps) such as atropine, biperiden or hyoscine butylbromide
- cyclophosphamide or methotrexate (used to manage certain forms of cancer)
- salbutamol or formoterol (used to manage asthma)
- amantadine (a medicine used to manage viral infections or Parkinson’s disease)
- allopurinol (a medicine used to manage gout)
- carbenoxolone (a medicine used to manage stomach ulcers)
- calcium salts or vitamin D (used as a supplement)
- medicines used to manage diabetes (Ex. insulin, chlorpropamide or glibenclamide)
- diazoxide (used to manage low blood glucose levels)
- medicines that can alter blood potassium levels such as potassium-sparing diuretics (Ex. spironolactone, acetazolamide), salt substitutes containing potassium (Ex. losartan potassium)
- heparin (used to manage or manage blood clots)
B. Drug-Food interaction:
CTD O 12.5/20MG TABLET can be taken with or without food. Avoid consumption of grapefruit or grapefruit juice while taking CTD O 12.5/20MG TABLET as it may cause severe decrease in blood pressure.
Overdosage:
If you or anyone else accidentally take too much of CTD O 12.5/20MG TABLET, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of CTD O 12.5/20MG TABLET might include dizziness, excess sleepiness, nausea, hypovolemia, low blood pressure and electrolyte disturbances associated with cardiac arrhythmias and muscle spasms.
Synopsis
| Drug | : | Chlorthalidone, Olmesartan |
| Pharmacological Category | : | Thiazide diuretics, Angiotensin-II receptor antagonists |
| Therapeutic Indication | : | Essential hypertension |
| Dosage Forms | : | Tablet |
More Information
- Keep CTD O 12.5/20MG TABLET out of reach of children
- Store CTD O 12.5/20MG TABLET at room temperature
FAQs About CTD O 12.5/20MG TABLET
Can CTD O 12.5/20MG TABLET be taken during pregnancy?
No, CTD O 12.5/20MG TABLET is strictly not recommended for use in pregnant women because it can cause serious harm to the developing fetus. If you are planning for pregnancy, consult your doctor before taking CTD O 12.5/20MG TABLET.
Can I consume alcohol while taking CTD O 12.5/20MG TABLET?
No, avoid consumption of alcohol while taking CTD O 12.5/20MG TABLET, as it could aggravate your existing disease condition and increase the risk of serious complications such as heart attack, stroke or kidney problems.
Can CTD O 12.5/20MG TABLET be used in patients with kidney problems?
CTD O 12.5/20MG TABLET is not recommended for use in patients with severe kidney problems, kidney failure, lack of urine, kidney stones and should be used with caution in patients with kidney problems. Consult your doctor before taking CTD O 12.5/20MG TABLET.
Can CTD O 12.5/20MG TABLET cause gout?
Yes, CTD O 12.5/20MG TABLET can increase the levels of uric acid in blood in some individuals and so caution should be exercised among patients with kidney disease or a previous history of gout. Kindly consult your doctor before taking CTD O 12.5/20MG TABLET.
Can CTD O 12.5/20MG TABLET cause leg swelling?
Yes, CTD O 12.5/20MG TABLET can cause swollen ankles, feet, legs, hands or arms, although not everybody gets them and so caution should be exercised among patients with kidney or heart disease. Kindly consult your doctor before taking CTD O 12.5/20MG TABLET.
What to do if I forget to take CTD O 12.5/20MG TABLET?
You should take CTD O 12.5/20MG TABLET immediately when you remember. If it is time for your next dose of CTD O 12.5/20MG TABLET skip the dose and follow your regular dose schedule. Do not double the dose of CTD O 12.5/20MG TABLET to match up your missed dose.
References
1. KD. Tripathi. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 559 & 561-562.
2. Thomas Michel and Brian B. Hoffman. Treatment of Myocardial ischemia and Hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 767-770 & 778.
3. Gerald G. Briggs and Roger K. Freeman. C. and O. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 760 & 2852.
4. Dr. G. Chitti Pantulu, Dr. Avinash Shende, Dr. Prathmesh Mule and Dr. A. A. Faruqui. Evaluation of efficacy and safety of oral olmesartan and chlorthalidone fixed dose combination in the management of hypertension in Indian Patients. International journal of current research. [Accessed on 29th October 2022] http://www.journalcra.com/article/evaluation-efficacy-and-safety-oral-olmesartan-and-chlorthalidone-fixed-dose-combination
5. Elena Filipova, Stela Dineva , Katya Uzunova, Velichka Pavlova, Krassimir Kalinov and Toni Vekov. Combining angiotensin receptor blockers with chlorthalidone or hydrochlorothiazide – which is the better alternative? A meta-analysis. Systematic reviews. BMC. 2020. [Accessed on 29th October 2022] https://d-nb.info/1219505919/34
6. Torrent Pharmaceuticals Ltd. Olsar CH. Torrentian.com. [Revised in February 2021]. [Accessed on 29th October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/3004.pdf
Useful Diagnostic Tests
- Kidney function test
Author Details
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